Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis DOI Creative Commons
Xiang Li,

Gao He,

Hui Jin

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Immune checkpoint inhibitors have demonstrated remarkable efficacy across various cancer types. However, immune‐related adverse events (irAEs) pose a significant challenge in immunotherapy, particularly the associated pneumonia as primary reaction, which can lead to irreversible pulmonary fibrosis. Additionally, monotherapy with programmed death ligand (PD‐L1) has shown limited effectiveness. Therefore, improve response rate of immunotherapy and reduce fibrosis, this study designed prepared an intelligent nanodrug based on dendritic mesoporous silica nanoparticles (DMSNs) loaded sono‐sensitive agent protoporphyrin IX (PpIX). reactive oxygen species (ROS) sensitive linker is used attach immunotherapeutic drug PD‐L1 inhibitor (aPD‐L1) DMSNs via covalent bonds. The external ultrasound (US) activates PpIX generate ROS, breaks release aPD‐L1 induce sonodynamic therapy (SDT) immunotherapy. This sono‐immnotherapy approach excellent outcomes tumor inhibition, eliciting immune responses, reducing Overall, offers new, efficient, safe method for breast treatment, expands application

Language: Английский

Transformable Supramolecular Self‐Assembled Peptides for Cascade Self‐Enhanced Ferroptosis Primed Cancer Immunotherapy DOI
He Wang,

Di Jiao,

Dexiang Feng

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 10, 2024

Abstract Immunotherapy has received widespread attention for its effective and long‐term tumor‐eliminating ability. However, immunogenic “cold” tumors, such as prostate cancer (PCa), the low immunogenicity of tumor itself is a serious obstacle to efficacy. Here, this work reports strategy enhance PCa by triggering cascade self‐enhanced ferroptosis in cells, turning from “hot”. This develops transformable self‐assembled peptide TEP‐FFG‐CRApY with alkaline phosphatase (ALP) responsiveness glutathione peroxidase 4 (GPX4) protein targeting. self‐assembles into nanoparticles under aqueous conditions transforms nanofibers response ALP during endosome/lysosome uptake promoting lysosomal membrane permeabilization (LMP). On one hand, released TEP‐FFG‐CRAY target GPX4 selectively degrade light irradiation, inducing ferroptosis; on other large amount leaked Fe 2+ further amplify through Fenton reaction. TEP‐FFG‐CRApY‐induced improves cell maturation dendritic cells (DCs) increasing intratumor T‐cell infiltration. More importantly, recovered T secreting amounts interferon‐gamma (IFN‐γ). provides novel molecular design synergistic molecularly targeted therapy tumors.

Language: Английский

Citations

25
Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation DOI Open Access

Wencong Jia,

Ye Wu, Yujie Xie

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Cancer immunotherapy, which leverages immune system components to treat malignancies, has emerged as a cornerstone of contemporary therapeutic strategies. Yet, critical concerns about the efficacy and safety cancer immunotherapies remain formidable. Nanotechnology, especially polymeric nanoparticles (PNPs), offers unparalleled flexibility in manipulation‐from chemical composition physical properties precision control nanoassemblies. PNPs provide an optimal platform amplify potency minimize systematic toxicity broad spectrum immunotherapeutic modalities. In this comprehensive review, basics polymer chemistry, state‐of‐the‐art designs from physicochemical standpoint for encompassing vaccines, situ vaccination, adoptive T‐cell therapies, tumor‐infiltrating cell‐targeted antibodies, cytokine therapies are delineated. Each immunotherapy necessitates distinctively tailored design strategies nanoplatforms. The extensive applications PNPs, investigation their mechanisms action enhanced particularly focused on. profiles clinical research progress discussed. Additionally, forthcoming developments emergent trends nano‐immunotherapeutics poised transform treatment paradigms into clinics explored.

Language: Английский

Citations

2
Dual‐Pronged Attack: pH‐Driven Membrane‐Anchored NIR Dual‐Type Nano‐Photosensitizer Excites Immunogenic Pyroptosis and Sequester Immune Checkpoint for Enhanced Prostate Cancer Photo‐Immunotherapy DOI Creative Commons
He Wang,

Zhangxin He,

Yijian Gao

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)

Published: Aug. 6, 2023

Prostate cancer (PCa) is a frustrating immunogenic "cold" tumor and generally receives unsatisfied immunotherapy outcomes in the clinic. Pyroptosis an excellent cell death form that can effectively activate antitumor immune response, promote cytotoxic T-lymphocyte infiltration, convert tumors from to "hot." However, vivo application of pyroptosis drugs seriously limited, upregulation PD-L1 caused by photo-immunotherapy further promotes escape. Herein, new nano-photosensitizer (YBS-BMS NPs-RKC) with pH-response integrating induction checkpoint blockade developed. The pH-responsive polymer equipped membrane anchoring peptide RKC used as carrier encapsulated near-infrared-activated semiconductor photosensitizer YBS PD-1/PD-L1 complex small molecule inhibitor BMS-202. pH-driven membrane-anchoring activation YBS-BMS NPs-RKC clearly demonstrated. In vitro studies have shown this dual-pronged therapy stimulates powerful response suppress primary progression evokes long-term memory inhibit relapse metastasis. This work provides effective self-synergistic platform for PCa idea developing more biocompatible photo-controlled inducers.

Language: Английский

Citations

39
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics DOI

Yifan Di,

Ruizhu Deng,

Zhu Liu

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

Citations

37
Targeting novel regulated cell death: Ferroptosis, pyroptosis and necroptosis in anti‐PD‐1/PD‐L1 cancer immunotherapy DOI Creative Commons
Li Yu, Ke Huang, Yixiang Liao

et al.

Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(8)

Published: April 9, 2024

Abstract Chemotherapy, radiotherapy, and immunotherapy represent key tumour treatment strategies. Notably, immune checkpoint inhibitors (ICIs), particularly anti‐programmed cell death 1 (PD1) ligand (PD‐L1), have shown clinical efficacy in immunotherapy. However, the limited effectiveness of ICIs is evident due to many cancers exhibiting poor responses this treatment. An emerging avenue involves triggering non‐apoptotic regulated (RCD), a significant mechanism driving cancer diverse treatments. Recent research demonstrates that combining RCD inducers with significantly enhances their antitumor across various types. The use anti‐PD‐1/PD‐L1 activates CD8 + T cells, prompting initiation novel forms, such as ferroptosis, pyroptosis, necroptosis. functions mechanisms anti‐PD1/PD‐L1 therapy remain insufficiently explored. This review summarises roles necroptosis It emphasises synergy between nanomaterials PD‐1/PD‐L1 induce different Furthermore, targeting signalling pathways combination therapies holds promise prospective strategy for

Language: Английский

Citations

13
Utilization of aggregation‐induced emission materials in urinary system diseases DOI Creative Commons

Haodong Xu,

Xin Chen, He Wang

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(5)

Published: May 10, 2024

Abstract With the development of aggregation‐induced emission (AIE) materials, drawbacks conventional fluorescence materials subjected to aggregation‐caused quenching (ACQ) have been resolved. This has allowed for improvement novel AIE fluorescent that exhibit enhanced photostability, a higher signal‐to‐noise ratio, and better imaging quality. Meanwhile, phototherapeutic effect garnered widespread attention in realm tumor treatment. The distinct physiological anatomical characteristics urinary system make it suitable use materials. Additionally, AIE‐based phototherapy provides superior solution deal with weaknesses treatments urologic neoplasms. In this review, scientific advancement on diseases since emergence concept is reviewed detail. review highlights promise biomarkers detection, (FLI) vivo vitro, phototherapy, synergistic therapy from both diagnostic therapeutic viewpoints. It firmly believed hold immense untapped potential diagnosis treatment disease, as well all human body.

Language: Английский

Citations

6
Targeting Lysosome for Enhanced Cancer Photodynamic/Photothermal Therapy in a “One Stone Two Birds” Pattern DOI

Quanwei Sun,

Jinming Yang, Qinghua Wu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 16(1), P. 127 - 141

Published: Dec. 20, 2023

Highly immunogenic programmed death of tumor cells, such as cell (ICD) and pyroptosis, strengthens antitumor responses thus represents a promising target for cancer immunotherapy. However, the development ICD pyroptosis inducers remains challenging, their efficiency is typically compromised by self-protective autophagy. Here, we report potent pyroptosis-inducing strategy coupling combined photodynamic/photothermal therapy (PTT/PDT) to biological processes in cells. For this purpose, rationally synthesize lysosomal-targeting boron-dipyrromethene dimer (BDPd) with intense NIR absorption/emission, high reactive oxygen species (ROS) yield, photothermal abilities, which can be self-assembled Pluronic F127, producing lysosomal-acting nanomicelles (BDPd NPs) facilitate internalization BDPd generation intracellular ROS. Owing favorable ability morpholine group on BDPd, NPs accumulate lysosome induce robust lysosomal damage cells upon 660 nm laser irradiation, results synergetic induction via activating NLRP3/GSDMD caspase-3/GSDME pathways simultaneously. More importantly, PTT/PDT-induced autophagic degradation was blocked due dysfunction lysosomes. Either intratumorally or intravenously, injected could markedly inhibit growth established tissues activation, provoke local systemic immune responses, prolong survival time mouse triple-negative breast model. Collectively, work boost therapeutic potential PTT/PDT phototherapeutic reagents subcellular organelles, creating "one stone two birds" pattern.

Language: Английский

Citations

13
Synergistic Potential of Nanomedicine in Prostate Cancer Immunotherapy: Breakthroughs and Prospects DOI Creative Commons

Yueyao Jiang,

Chengran Wang,

Chuancheng Zu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9459 - 9486

Published: Oct. 1, 2024

Given the global prevalence of prostate cancer in men, it is crucial to explore more effective treatment strategies. Recently, immunotherapy has emerged as a promising due its unique mechanism action and potential long-term effectiveness. However, limited efficacy prompted renewed interest developing strategies improve outcomes. Nanomedicine offers novel perspective on with size effects surface properties. By employing targeted delivery, controlled release, enhanced immunogenicity, nanoparticles can be synergized nanomedicine platforms amplify effectiveness treating cancer. Simultaneously, nanotechnology address limitations challenges immune escape tumor microenvironment regulation. Additionally, synergistic combining other therapies offer clinical Innovative applications include smart nanocarriers, stimulus-responsive systems, precision medicine approaches overcome translational obstacles immunotherapy. This review highlights transformative enhancing emphasizes need for interdisciplinary collaboration drive research forward.

Language: Английский

Citations

5
Engineering materials for pyroptosis induction in cancer treatment DOI Creative Commons
Jiayi Liu,

Taili Chen,

XianLing Liu

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 30 - 45

Published: Nov. 7, 2023

Cancer remains a significant global health concern, necessitating the development of innovative therapeutic strategies. This research paper aims to investigate role pyroptosis induction in cancer treatment. Pyroptosis, form programmed cell death characterized by release pro-inflammatory cytokines and formation plasma membrane pores, has gained attention as potential target for therapy. The objective this study is provide comprehensive overview current understanding its discusses concept relationship with other forms death, such apoptosis necroptosis. It explores immune activation combination also reviews use natural, biological, chemical, multifunctional composite materials cells. molecular mechanisms underlying these are discussed, along their advantages challenges findings highlight novel strategy treatment insights into different involved induction.

Language: Английский

Citations

12
A multifunctional CaCO3 bioreactor coated with coordination polymers enhances cancer immunotherapy DOI
Weiguo Chen,

Yishuang Lu,

Xiaoya Sun

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 780 - 796

Published: March 21, 2024

Language: Английский

Citations

4