Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 31, 2024
Cancer
stem
cells,
characterized
by
high
tumorigenicity
and
drug-resistance,
are
often
responsible
for
tumor
progression
metastasis.
Aldehyde
dehydrogenases,
overexpressed
in
cancer
cells
enriched
tumors,
present
a
potential
target
specific
anti-cancer
treatment.
In
this
study,
we
report
self-assembled
nano-prodrug
composed
of
aldehyde
dehydrogenases
activatable
photosensitizer
disulfide-linked
all-trans
retinoic
acid
diagnosis
targeted
treatment
tumors.
The
can
load
with
self-assemble
into
stable
nano-prodrug,
which
be
disassembled
level
glutathione.
As
the
released
photosensitizer,
dehydrogenase
catalyzes
oxidation
aldehydes
to
carboxyl
under
microenvironment,
activating
generation
reactive
oxygen
species
fluorescence
emission.
This
leads
direct
killing
is
accompanied
noticeable
enhancement
real-time
monitoring
microenvironment.
Moreover,
acid,
as
differentiation
agent,
reduce
stemness
improve
offering
synergistic
effect
enhanced
inhibition
vivo
growth
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
34, P. 414 - 421
Published: Jan. 10, 2024
Tumor
hypoxia
diminishes
the
effectiveness
of
traditional
type
II
photodynamic
therapy
(PDT)
due
to
oxygen
consumption.
Type
I
PDT,
which
can
operate
independently
oxygen,
is
a
viable
option
for
treating
hypoxic
tumors.
In
this
study,
we
have
designed
and
synthesized
JSK@PEG-IR820
NPs
that
are
responsive
tumor
microenvironment
(TME)
enhance
PDT
through
glutathione
(GSH)
depletion.
Our
approach
aims
expand
sources
therapeutic
benefits
by
promoting
generation
superoxide
radicals
(O
The
designability
and
high
reactivity
of
nanotechnology
provide
strategies
for
antitumor
therapy
by
regulating
the
redox
state
in
tumor
cells.
Here,
we
synthesize
a
kind
vanadium
dioxide
nanoparticle
encapsulated
bovine
serum
albumin
containing
disulfide
bonds
(VSB
NPs)
photothermal-enhanced
ferroptosis
pyroptosis
effects.
Mechanism
studies
show
that
can
effectively
consume
overexpressed
glutathione
(GSH)
microenvironment,
leading
to
decrease
peroxidase
4
(GPX4)
activity.
Simultaneously,
tetravalent
induce
catalytic
reaction
H2O2,
producing
plenty
toxic
hydroxyl
radicals
(·OH)
singlet
oxygen
(1O2),
cell
ferroptosis.
In
addition,
consumption
also
lead
degradation
nanoparticles
into
high-valent
vanadates,
activating
thermal
protein
domain-associated
3
(NLRP3)
inflammasomes
causing
pyroptosis.
It
is
worth
mentioning
VSB
NPs
not
only
ablate
cells
under
near-infrared
light
irradiation
but
further
disrupt
homeostasis
thereby
enhancing
induced
biodegradable
vanadium-based
nanomaterials.
This
strategy,
based
on
biological
effects
regulate
cells,
provides
possibilities
cancer
treatment.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(29)
Published: Aug. 9, 2023
Despite
advances
in
cancer
therapy,
the
existence
of
self-renewing
stem
cells
(CSC)
can
lead
to
tumor
recurrence
and
radiation
resistance,
resulting
treatment
failure
high
mortality
patients.
To
address
this
issue,
a
near-infrared
(NIR)
laser-induced
synergistic
therapeutic
platform
has
been
developed
by
incorporating
aggregation-induced
emission
(AIE)-active
phototheranostic
agents
sulfur
dioxide
(SO2
)
prodrug
into
biocompatible
hydrogel,
namely
TBH,
suppress
malignant
CSC
growth.
Outstanding
hydroxyl
radical
(·OH)
generation
photothermal
effect
AIE
agent
actualizes
Type
I
photodynamic
therapy
(PDT)
through
660
nm
NIR
laser
irradiation.
Meanwhile,
large
amount
SO2
is
released
from
thermo-sensitive
TBH
gel,
which
depletes
upregulated
glutathione
consequentially
promotes
·OH
for
PDT
enhancement.
Thus,
hydrogel
diminish
under
irradiation
finally
restrain
after
radiotherapy
(RT).
In
comparison,
mice
that
were
only
treated
with
RT
relapsed
rapidly.
These
findings
reveal
double-boosting
protocol,
combination
AIE-mediated
gas
provides
novel
strategy
inhibiting
growth
RT,
presents
great
potential
clinical
treatment.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 923 - 923
Published: April 22, 2024
This
review
critically
evaluates
advancements
in
multifunctional
hydrogels,
particularly
focusing
on
their
applications
osteoarthritis
(OA)
therapy.
As
research
evolves
from
traditional
natural
materials,
there
is
a
significant
shift
towards
synthetic
and
composite
known
for
superior
mechanical
properties
enhanced
biodegradability.
spotlights
novel
such
as
injectable
microneedle
technology,
responsive
which
have
revolutionized
OA
treatment
through
targeted
efficient
therapeutic
delivery.
Moreover,
it
discusses
innovative
hydrogel
including
protein-based
superlubricating
potential
to
reduce
joint
friction
inflammation.
The
integration
of
bioactive
compounds
within
hydrogels
augment
efficacy
also
examined.
Furthermore,
the
anticipates
continued
technological
deeper
understanding
hydrogel-based
therapies.
It
emphasizes
provide
tailored,
minimally
invasive
treatments,
thus
highlighting
critical
role
advancing
dynamic
field
biomaterial
science
management.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(29)
Published: June 3, 2024
Abstract
Exploring
efficient
and
low‐toxicity
radiosensitizers
to
break
through
the
bottleneck
of
radiation
tolerance,
immunosuppression
poor
prognosis
remains
one
critical
developmental
challenges
in
radiotherapy.
Nanoheterojunctions,
due
their
unique
physicochemical
properties,
have
demonstrated
excellent
radiosensitization
effects
energy
deposition
lifting
tumor
radiotherapy
inhibition.
Herein,
they
doped
selenium
(Se)
into
prussian
blue
(PB)
construct
a
nano‐heterojunction
(Se@PB),
which
could
promote
increase
Fe
2+
/Fe
3+
ratio
conversion
Se
high
valence
state
with
introduction.
The
‐Se‐Fe
electron
transfer
chain
accelerates
rate
on
surface
nanoparticles,
turn
endows
it
X‐ray
transport
capability,
enhances
physical
sensitivity.
Furthermore,
Se@PB
induces
glutathione
(GSH)
depletion
accumulation
pro‐Fenton
reaction,
thereby
disturbs
redox
balance
cells
biochemical
sensitivity
As
an
radiosensitizer,
effectively
induced
mitochondrial
dysfunction
DNA
damage,
promotes
cell
apoptosis
synergistic
cervical
cancer
This
study
elucidates
mechanism
Se‐doped
nanoheterojunction
from
perspective
biochemistry
provides
low‐toxic
strategy
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(6), P. 3673 - 3692
Published: May 8, 2024
Copper
(Cu)
and
Cu-based
nanomaterials
have
received
tremendous
attention
in
recent
years
because
of
their
unique
physicochemical
properties
good
biocompatibility
the
treatment
various
diseases,
especially
cancer.
To
date,
researchers
designed
fabricated
a
variety
integrated
nanocomplexes
with
distinctive
nanostructures
applied
them
cancer
therapy,
mainly
including
chemotherapy,
radiotherapy
(RT),
photothermal
therapy
(PTT),
chemodynamic
(CDT),
photodynamic
(PDT),
cuproptosis-mediated
etc.
Due
to
limited
effect
single
method,
development
composite
diagnostic
nanosystems
that
integrate
PTT,
CDT,
PDT,
other
treatments
is
great
significance
offers
potential
for
next
generation
anticancer
nanomedicines.
In
view
rapid
field
this
review
focuses
on
current
state
research
nanomaterials,
followed
by
discussion
combined
therapy.
Moreover,
challenges
future
prospects
clinical
translation
are
proposed
provide
some
insights
into
design
nanotherapeutic
platforms.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(31), P. 20313 - 20323
Published: July 24, 2024
The
self-renewal
and
differentiation
properties
of
cancer
stem
cells
(CSCs)
result
in
chemoresistance
breast
cancer.
Even
though
numerous
drugs
have
been
developed
to
target
CSCs,
they
suffered
from
inefficient
delivery
accumulation
at
the
focal
site.
Here,
a
thermoresponsive
hydrogel
is
by
coencapsulating
aggregation-induced
emission
(AIE)-active
photothermal
agent
thioridazine
(THZ),
demonstrating
controllable
system
triggered
AIE
augment
THZ-mediated
CSC
ablation.
Upon
near-infrared
laser
stimuli,
effect
induces
deformation
for
burst
drug
release.
precise
situ
tumor
administration
accelerates
diffusion
deep
lesions.
Thus,
THZ
can
invade
tumors
provoke
massive
apoptosis
via
dopamine
receptor
blockage
oxidative
stress
induction.
Consequently,
effective
inhibition
significant
suppression
recurrence
metastasis
are
demonstrated
mice
with
We
believe
that
this
intelligent
hydrogel-based
represents
promising
treatment
strategy
metastatic
clinical
potential.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(14), P. 5461 - 5491
Published: Jan. 1, 2024
Gas
therapy,
a
burgeoning
clinical
treatment
modality,
has
garnered
widespread
attention
to
treat
variety
of
pathologies
in
recent
years.
The
advent
nanoscale
gas
drug
therapy
represents
novel
therapeutic
strategy,
particularly
demonstrating
immense
potential
the
realm
oncology.
This
comprehensive
review
navigates
landscape
gases
endowed
with
anti-cancer
properties,
including
hydrogen
(H
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 991 - 1020
Published: Jan. 1, 2025
Owing
to
its
high
prevalence,
colossal
potential
of
chemoresistance,
metastasis,
and
relapse,
breast
cancer
(BC)
is
the
second
leading
cause
cancer-related
fatalities
in
women.
Several
treatments
(eg,
chemotherapy,
surgery,
radiations,
hormonal
therapy,
etc.)
are
conventionally
prescribed
for
treatment
BC;
however,
these
associated
with
serious
systemic
aftermaths.
In
this
research,
we
aimed
design
a
multiprong
targeting
strategy
concurrent
action
against
different
phenotypes
BC
(MCF-7
SK-BR-3)
tumor-associated
macrophages
(TAMs)
relapse-free
BC.
Paclitaxel
(PTX)
tamoxifen
(TMX)
co-loaded
chitosan
(CS)
nanoparticles
(NPs)
were
prepared
using
ionic-gelation
method
optimized
Design
Expert®
software
by
controlling
material
attributes.
For
selective
through
CD44-receptors
that
heavily
expressed
on
cells
TAMs,
fabricated
NPs
(PTX-TMX-CS-NPs)
functionalized
hyaluronic
acid
(HA)
as
ligand.
The
HA-PTX-TMX-CS-NPs
exhibited
desired
physicochemical
properties
(PS
~230
nm,
PDI
0.30,
zeta
~21.5
mV),
smooth
spherical
morphology,
encapsulation
efficiency
(PTX
~72%
TMX
~97%),
good
colloidal
stability,
biphasic
release
kinetics.
Moreover,
lowest
cell
viability
depicted
MCF-7
(~25%),
SK-BR-3
(~20%),
RAW
264.7
induction
apoptosis,
cycle
arrest,
enhanced
internalization,
alleviation
migration
proved
superior
anticancer
compared
unfunctionalized
other
control
medicines.
HA-functionalization
promising
CD44-receptors-mediated
TAMs
mitigate
progression,
relapse
Overcoming
tumor
antioxidant
defenses
remains
a
critical
challenge
for
reactive-oxygen-species-mediated
therapies.
To
address
this
problem,
herein,
theranostic
nanomedicine
designated
as
CCM@MIB
has
been
elaborately
constructed.
Homologous
cancer
cell
membrane
(CCM)
camouflage
significantly
enhances
the
selective
accumulation
of
at
sites.
In
response
to
microenvironment
(TME),
controllably
releases
Mn
ions
and
sulfur
dioxide
(SO2)
molecules.
The
released
catalyze
self-oxidation
isoniazid
generate
highly
toxic
•OH,
while
SO2
produced
by
benzothiazole
sulfinate
effectively
disrupts
defense
systems.
catalase-like
activity
endowed
increased
intracellular
•O2–
level
induced
further
promote
•OH
production.
Therefore,
such
an
intellectual
combination
non-Fenton-type
catalytic
therapy
gas
amplifies
oxidative
stress
efficiently
suppresses
growth.
Additionally,
TME-activated
magnetic
resonance
imaging
contrast
performance
is
beneficial
guiding
antitumor
treatment.
This
considerate
strategy
designed
in
our
work
provides
ingenious
paradigm
development
efficient
