Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 261, P. 113067 - 113067
Published: Nov. 19, 2024
Language: Английский
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 684, P. 47 - 59
Published: Jan. 4, 2025
Language: Английский
Citations
2
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 125 - 139
Published: Jan. 1, 2025
Photo-immunotherapy faces challenges from poor immunogenicity and low response rate due to hypoxic microenvironment. This study presents Rh-PTZ, a small organic molecule with D-π-A structure, that simultaneously amplifies mitochondria-targeted type-I PDT-dependent immune stimulation for the treatment of cancer. The hydrophobic Rh-PTZ was encapsulated into F127 prepare nanoparticles (Rh-PTZ NPs). ROS generation ability, mitochondrial targeting capacity, ICD triggering effect mediated by NPs under LED light irradiation were investigated. Based on 4T1 subcutaneous tumor model, in vivo biological safety assessment, NIR fluorescent imaging, efficacy PDT assessed. could efficiently accumulate site induce O2 •- •OH burst situ irradiation, thereby causing severe dysfunction. can amplify stress-caused immunogenic cell death (ICD) stimulate response, promote maturation sufficient dendritic cells (DCs), enhance infiltration cells, alleviate immunosuppressive mitochondria-targeting holds promise photo-immunotherapy hypoxia overcoming limitations traditional immunotherapy.
Language: Английский
Citations
1
Bioactive Materials, Journal Year: 2024, Volume and Issue: 39, P. 336 - 353
Published: May 25, 2024
While mild hyperthermia holds great potential in the treatment of solid tumors, thermal stress-triggered self-repairing autophagy significantly compromises its efficacy. To circumvent this obstacle, an injectable hydrogel (NO-Gel) composed thermosensitive poly(ethylene glycol)-polypeptide copolymers modified with abundant NO donors on their side chains is developed. Meanwhile, ferrimagnetic Zn
Language: Английский
Citations
8
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(20), P. 25788 - 25798
Published: May 8, 2024
Phototherapy, represented by photodynamic therapy (PDT) and photothermal (PTT), has great potential in tumor treatment. However, the presence of antioxidant glutathione (GSH) heat shock proteins (HSPs) expression caused high temperature can weaken effects PDT PTT. Here, a multifunctional nanocomplex BT&GA@CL is constructed to realize enhanced synergistic PDT/PTT. Cinnamaldehyde liposomes (CLs) formed cinnamaldehyde dimer self-assembly were loaded with gambogic acid (GA) an aggregation-induced emission molecule BT obtain BT&GA@CL. As drug carrier, CL consume release drugs responsively. The released aggregates simultaneously act as both agent photosensitizer achieve PTT under 660 nm laser irradiation. Specifically, GA HSP90 inhibitor attenuate PTT-induced protein expression, thereby weakening tolerance cells temperatures enhancing Such modulates content GSH cells, thus PTT, ultimately achieving goal efficient combined suppression.
Language: Английский
Citations
6
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 5, 2024
Abstract Type I photodynamic therapy (PDT) generates reactive oxygen species (ROS) through oxygen‐independent photoreactions, making it a promising method for treating hypoxic tumors. However, the superoxide anion (O 2 ∙ – ) generated usually exhibits low oxidation capacity, restricting antitumor efficacy of PDT in clinical practice. Herein, photoactivated self‐assembled nanoreactor ( 1 ‐NBS@CeO is designed integration type and cerium oxide (CeO nanozymes inducing cascade‐amplified oxidative stress The constructed though co‐assembly an amphiphilic peptide ‐NBS) CeO , giving well‐dispersed spherical nanoparticles with enhanced dismutase (SOD)‐like peroxidase (POD)‐like activities. Following light irradiation, undergoes photoreactions to O which further catalyzed by nanoreactors, ultimately forming hypertoxic hydroxyl radical (∙OH) reactions. treatment using results elevation intracellular ROS depletion GSH content A375 cells, thereby mitochondrial dysfunction triggering apoptosis ferroptosis tumor cells. Importantly, intravenous administration alongside irradiation showcases enhances satisfactory biocompatibility vivo. Together, facilitates achieving efficacious PDT, holds great promise developing therapeutic modules towards
Language: Английский
Citations
4
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Despite its therapeutic potential, photodynamic therapy faces several key limitations in clinical applications, including poor drug delivery and insufficient tumor selectivity. We engineered RFYFYR-Ce6-RFYFYR (R-Ce6-R), a twin-tail peptide–photosensitizer conjugate that self-assembles into nanostructures for improved cancer treatment. By incorporating arginine-rich peptide sequences, this design not only enhances cellular internalization but also promotes peroxynitrite (ONOO–) formation, amplifying the effect. Our studies revealed R-Ce6-R achieves 33-fold higher potency than unmodified Ce6, with an IC50 of 0.18 μM. The demonstrated selective accumulation tissue, robust ROS generation, complete regression animal models while maintaining favorable safety profile. These results establish as innovative approach advancing
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216540 - 216540
Published: Feb. 27, 2025
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113601 - 113601
Published: March 5, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 18, 2025
Photodynamic therapy (PDT) has gained significant attention due to its non-invasive nature, low cost, and ease of operation. Nanoscale metal-organic frameworks (nMOFs) incorporating porphyrins, chlorins, bacteriochlorins have emerged as one the most prominent photoactive materials for tumor PDT. These nMOFs could enhance water solubility, stability loading efficiency photosensitizers (PSs). Their highly ordered porous structure facilitates O2 diffusion enhances generation 1O2 from hydrophobic bacteriochlorins, thereby improving their efficacy phototherapy. This review provides insights into PDT effects derived bacteriochlorins. It overviews design strategies, types reactive oxygen species (ROS), ROS efficiency, unique biological processes involved in inhibiting cell proliferation, focusing on mechanism by which molecular leads enhanced photochemical properties. Finally, highlights new possibilities offered bacteriochlorins-based PDT, emphasizing how optimized can further improve bioapplication porphyrin derivatives represented PSs. With ongoing research technological advancements, we anticipate that this will garner increased scientific researchers toward porphyrin-based nMOFs, elevating potential a approach treatment malignant tumors.
Language: Английский
Citations
0
ChemPhotoChem, Journal Year: 2024, Volume and Issue: 8(9)
Published: April 30, 2024
Abstract Hypoxic tumor microenvironments pose significant challenges to the clinical translation of cancer photodynamic therapy (PDT). While heavy atom‐free Type‐I boron dipyrromethenes (BODIPYs) photosensitizers can alleviate this challenge by reducing oxygen dependency, but they remain scarce. Herein, heavy‐atom‐free α,meso ‐linked bisBODIPYs were designed and synthesized. These exhibit remarkable red‐shifted emission (λemmax ~670 nm), large Stokes shifts (~4480 cm −1 ) are capable producing both superoxide anion (O 2 ⋅ − singlet ( 1 O in solution cells. Additionally, offer a wide PDT treatment window, ranging from 0.26 83.5 μM. Furthermore, these also demonstrate superior two‐photon fluorescence, promising for surgical navigation integrating diagnosis with treatment.
Language: Английский
Citations
3