Lubricant Strategies in Osteoarthritis Treatment: Transitioning from Natural Lubricants to Drug Delivery Particles with Lubricant Properties

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(3), P. 1268 - 1292

Published: Sept. 19, 2024

Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degradation, leading to pain and functional impairment. A key contributor OA progression the decline in lubrication. In physiological conditions, synovial fluid (SF) macromolecules like hyaluronic acid (HA), phospholipids, lubricin play crucial role boundary lubrication of articular cartilage. early OA, damage triggers inflammation, altering SF composition compromising layer. This increases friction between mating interfaces, worsening degradation local inflammation. Therefore, early-stage restoration (by injecting different classes compounds formulations) could alleviate, potentially reverse, progression. light this, broad variety lubricants have been investigated for their ability reduce joints promote repair clinical preclinical studies. review examines recent advancements lubricant-based therapy focusing on natural, bioinspired, alternative products. Starting from currently applied therapy, mainly based natural as HA, we will present modified versions, either hydrogel form or with specific biomimetic moieties aim reducing clearance enhancing lubricating properties. Finally, most advanced formulation, represented strategies, be proposed. Particular emphasis placed those ones involving new types hydrogels, microparticles, nanoparticles, liposomes, which are under investigation The potential application particles liposomes foster transition Drug Delivery Systems (DDSs) lubricant features; provide more complete treatments, simultaneously providing replacement sustained release payloads active agents directly at level. Within each category, examine relevant studies, highlighting challenges future prospects.

Language: Английский

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Kojic acid alleviates osteoarthritis by attenuating inflammation and restoring impaired autophagy through regulating NF-κB and PI3K/AKT/mTOR signaling pathways: An in vivo and in vitro study

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114022 - 114022

Published: Jan. 6, 2025

Osteoarthritis (OA) is the most prevalent joint disorder globally, causing a substantial and increasing socioeconomic burden. Kojic acid (KA) presented potential biological roles in regulating inflammation autophagy, which was implicated OA progression. However, its role chondrocytes has not been reported. To do so, this study aims to explore chondroprotective effect of KA elucidate regulatory mechanisms. IL-1β vitro used induce OA-like phenotypes. Cell viability measured by cell counting kit-8 assay. RT-qPCR, western blotting, as well immunofluorescence staining were assess protein RNA expression inflammatory (COX2 iNOS), catabolic (MMP13 MMP3), anabolic (collagen II, aggrecan SOX9), signaling pathways factors. Destabilized medial meniscus (DMM) surgery adopted build model vivo. After consecutive 8 weeks intra-articular injection KA, X-ray, μ-CT, histological staining, immunohistochemistry evaluate effects on articular cartilage did affect chondrocyte viability. notably elevated factors expression, simultaneously, inhibited vitro. Mechanistically, significantly suppressed activated NF-κB PI3K/AKT/mTOR pathways. Moreover, impaired autophagy restored KA. Inhibition 3-MA diminished Intra-articular can alleviate DMM-induced damage Collectively, our work first demonstrate that osteoarthritis attenuatinginflammationand restoring through relevant This vivo provides strong evidence supportingKA novel valuable approach for treating OA.

Language: Английский

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Evaluation of Physicochemical Properties of Polymeric Systems for Potential Applications in Cartilage Tissue Engineering

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2057 - 2057

Published: Feb. 26, 2025

This study investigates the physicochemical properties of hydrogels based on PVA and PVP crosslinked with PEGDA, focusing their swelling capacity, surface roughness, incubation behavior, structural modifications upon bioactive component incorporation. Swelling analysis demonstrated that amount molecular weight PEGDA significantly influences hydrogels' sorption properties, highest coefficient observed for samples 2 mL (575 g/mol) due to a looser network structure, while lowest was recorded 2.5 (700 g/mol), indicating denser network. Surface roughness revealed increasing crosslinker led higher both before after incubation, containing 575 g/mol being more susceptible changes in an environment. FT-IR spectroscopy confirmed presence characteristic functional groups, providing insight into chemical stability hydration hydrogels. Modification mixture (glucosamine, chondroitin, MSM) by spectral analysis, successful integration without compromising hydrogel matrix. The modified potential applications regenerative medicine, particularly joint disease treatment cartilage tissue repair.

Language: Английский

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Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156697 - 156697

Published: March 1, 2025

Osteoarthritis is a chronic degenerative joint disease marked by chondrocyte senescence and extracellular matrix degradation. Vaccarin, flavonoid with anti-inflammatory antioxidant properties, has not been previously investigated for its therapeutic potential in osteoarthritis. To evaluate the of Vaccarin osteoarthritis elucidate underlying mechanisms. This study utilized vitro cultures RNA sequencing to identify relevant pathways, followed validation at genetic, protein, metabolic levels using multiple approaches. Additionally, effects were assessed vivo destabilization medial meniscus (DMM)-induced mouse model human cartilage samples from patients. effectively ameliorated both vitro. Transcriptomic indicated significant downregulation serum amyloid A2 (SAA2) expression following treatment. Multi-omics analysis, validated specimens, that SAA2 minimally secreted healthy articular but serves as crucial biomarker Asian populations. Mechanistically, inhibits c-Jun N-terminal kinase (JNK) phosphorylation, thereby reducing mitigating inflammation senescence. Notably, inflammatory conditions upregulate chondrocytes via JNK pathway. Elevated contribute mitochondrial dysfunction chondrocytes, leading increased reactive oxygen species (ROS) production exacerbating progression. identifies target suggests presents promising treatment avenue.

Language: Английский

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Injectable vancomycin loaded hyaluronic acid-chitosan hydrogel for the treatment of Staphylococcus aureus septic arthritis

Carbohydrate Research, Journal Year: 2025, Volume and Issue: 550, P. 109384 - 109384

Published: Jan. 13, 2025

Language: Английский

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Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 17, 2025

Osteoarthritis is one of the most common degenerative joint diseases, which seriously affects life middle-aged and elderly people. Traditional treatments such as surgical treatment systemic medication, often do not achieve expected or optimal results, leads to severe trauma a variety side effects. Therefore, there an urgent need develop novel therapeutic options overcome these problems. Hydrogels are widely used in biomedical tissue repairing platform for loading drugs, proteins stem cells. In recent years, smart-responsive hydrogels have achieved excellent results drug delivery systems osteoarthritis. This review focuses on advances endogenous stimuli (including enzymes, pH, reactive oxygen species temperature, etc.) responsive exogenous light, shear, ultrasound magnetism, osteoarthritis treatment. Finally, current limitations application future prospects smart summarized.

Language: Английский

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Impact of hydrogel-based airway management strategies on ventilator-associated pneumonia: clinical applications and future directions

Frontiers in Materials, Journal Year: 2025, Volume and Issue: 12

Published: March 28, 2025

This review discusses the current applications of hydrogels in management airway lung injury and ventilator-associated pneumonia (VAP), with a particular focus on their potential impact clinical practice. Research indicates that hydrogel technology can not only enhance promote tissue repair but also significantly reduce risk infection. For instance, trials have shown hydrogel-coated endotracheal tubes are effective at reducing incidence VAP, related data indicating reduction up to 30%. Furthermore, we analyze limitations research propose directions for future development hydrogel-based therapies this important field respiratory medicine.

Language: Английский

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Injectable Hydrogel Technologies for Bone Disease Treatment

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Injectable hydrogels represent a highly promising approach for localized drug delivery systems (DDSs) in the management of bone-related conditions such as osteoporosis, osteonecrosis, osteoarthritis, osteomyelitis, and osteosarcoma. Their appeal lies their biocompatibility, adjustable mechanical properties, capacity to respond external stimuli, including pH, temperature, light, redox potential, ionic strength, enzymatic activity. These features enable enhanced targeted bioactive agents. This mini-review evaluates synthesis injectable well recent advancements treating range bone disorders, focusing on mechanisms sustained DDSs delivering drugs, nanoparticles, growth factors, cells (e.g., stem cells). Moreover, it highlights clinical studies disease treatment. Additionally, emphasizes potential synergy between hydrogel-based point-of-care technologies, which are anticipated play pivotal role future therapies. have transform treatment by facilitating precise, sustained, minimally invasive therapeutic delivery. Nevertheless, significant challenges, long-term scalability, reproducibility, precise regulation release kinetics, must be addressed unlock fully. Addressing these challenges will not only advance therapy but also open new avenues regenerative medicine personalized healthcare.

Language: Английский

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Recent Advances in Hydrogel Technology in Delivering Mesenchymal Stem Cell for Osteoarthritis Therapy

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 858 - 858

Published: July 17, 2024

Osteoarthritis (OA), a chronic joint disease affecting over 500 million individuals globally, is characterized by the destruction of articular cartilage and inflammation. Conventional treatments are insufficient for repairing damaged tissue, necessitating novel therapeutic approaches. Mesenchymal stem cells (MSCs), with their potential differentiation self-renewal, hold great promise as treatment OA. However, challenges such MSC viability apoptosis in ischemic environment hinder effectiveness. Hydrogels biocompatibility degradability offer three-dimensional scaffold that support cell differentiation, making them ideal delivery OA treatment. This review discusses pathological features OA, properties MSCs, associated therapy, methods hydrogel preparation functionalization. Furthermore, it highlights advantages hydrogel-based systems while providing insights into future research directions clinical this approach.

Language: Английский

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Polymeric Microneedle Drug Delivery Systems: Mechanisms of Treatment, Material Properties, and Clinical Applications—A Comprehensive Review

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2568 - 2568

Published: Sept. 11, 2024

Our comprehensive review plunges into the cutting-edge advancements of polymeric microneedle drug delivery systems, underscoring their transformative potential in realm transdermal administration. scrutiny centers on substrate materials pivotal for construction and core properties that dictate efficacy. We delve distinctive interplay between microneedles dermal layers, mechanisms by which this synergy enhances absorption precision targeting. Moreover, we examine acupoint-target organ-ganglion nexus, an innovative strategy steers concentration to specific targets, offering a paradigm medicine. A thorough analysis clinical applications systems is presented, highlighting adaptability impact across spectrum therapeutic domains. This also accentuates systems' promise bolster patient compliance, attributed minimally invasive painless mode delivery. present forward-looking strategies aimed at optimizing stimulation sites amplify benefits. The anticipation set introduction superior biocompatible with advanced mechanical properties, customizing cater specialized demands. In parallel, deliberate safety boosting loading capacities solidifying efficacy microneedle-based therapeutics. summation, role technology contemporary healthcare, charting course future investigative endeavors developmental strides within burgeoning field.

Language: Английский

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