Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112401 - 112401
Published: March 1, 2025
Language: Английский
Advanced Science, Journal Year: 2023, Volume and Issue: 10(34)
Published: Oct. 23, 2023
The development of bioactive scaffolds by mimicking bone tissue extracellular matrix is promising for regeneration. Herein, inspired the composition, a novel pearl powder (PP) hybrid fish gelatin methacrylate (GelMa) hydrogel scaffold loaded with vascular endothelial growth factor (VEGF) regeneration presented. With help microfluidic-assisted 3D printing technology, composition and structure can be accurately controlled to meet clinical requirements. combination skin GelMa PP also endowed good biocompatibility, cell adhesion, osteogenic differentiation ability. Moreover, release VEGF enables promote angiogenesis. Thus, in proposed could accelerated under synergic effect osteogenesis angiogenesis, which has been proved rat skull defect model. These features indicate that will an ideal candidate applications.
Language: Английский
Citations
50
Materials Today Bio, Journal Year: 2024, Volume and Issue: 24, P. 100945 - 100945
Published: Jan. 4, 2024
Cell growth and metabolism require an adequate supply of oxygen. However, obtaining sufficient oxygen from the blood circulating around diabetic wounds is challenging. Nevertheless, achieving a continuous stable required for these to heal. Hence, in this study, we report novel antibacterial oxygen-producing silk fibroin methacryloyl hydrogel microneedle (MN) patch comprising tips encapsulated with calcium peroxide catalase base coated Ag nanoparticles (AgNPs). The tip MN continuously releases inhibits production reactive species. This accelerates wound healing by promoting cellular accretion migration, macrophage M2 polarization, angiogenesis. AgNPs at effectively combat microbial infection, further facilitating repair. These findings suggest that using multifunctional may be promising strategy clinical settings.
Language: Английский
Citations
23
ACS Nano, Journal Year: 2024, Volume and Issue: 18(12), P. 8777 - 8797
Published: March 15, 2024
Stem cell-derived extracellular vesicles (EVs) show great potential for promoting bone tissue regeneration. However, normal EVs (Nor-EVs) have a limited ability to direct tissue-specific Therefore, it is necessary optimize the osteogenic capacity of EV-based systems repairing extensive defects. Herein, we that hydrogels loaded with osteoinductive dental pulp stem (Ost-EVs) enhanced remodeling, resulting in 2.23 ± 0.25-fold increase expression morphogenetic protein 2 (BMP2) compared hydrogel control group. Moreover, Ost-EVs led higher alkaline phosphatase (ALP) (1.88 0.16 relative Nor-EVs) and formation orange-red calcium nodules (1.38 0.10 vitro. RNA sequencing revealed showed significantly high miR-1246 expression. An ideal implant should also adhere surrounding moist tissues. In this study, were drawn mussel-inspired adhesive modification, where carrier was crafted from hyaluronic acid (HA) polyethylene glycol derivatives, showcasing impressive adhesion, self-healing capabilities, promote growth. The modified HA (mHA) responsive environmental stimuli, making an effective delivering EVs. ectopic osteogenesis animal model, Ost-EV/hydrogel system effectively alleviated inflammation, accelerated revascularization, promoted mineralization. We further used rat femoral condyle defect model evaluate situ Ost-EVs/hydrogel system. Collectively, our results suggest combined biomaterial-based hold promising treating
Language: Английский
Citations
20
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129734 - 129734
Published: Jan. 26, 2024
Language: Английский
Citations
18
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 355 - 371
Published: March 6, 2024
Language: Английский
Citations
17
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 9, 2023
Hyaluronic acid (HA) is widely distributed in human connective tissue, and its unique biological physicochemical properties ability to facilitate structure repair make it a promising candidate for three-dimensional (3D) bioprinting the field of tissue regeneration biomedical engineering. Moreover, HA an ideal raw material bioinks engineering because histocompatibility, non-immunogenicity, biodegradability, anti-inflammatory properties, anti-angiogenic modifiability. Tissue multidisciplinary focusing on vitro reconstructions mammalian tissues, such as cartilage engineering, neural skin other areas that require further clinical applications. In this review, we first describe modification methods, cross-linking strategies derivatives then critically discuss strengths, shortcomings, feasibility each method. Subsequently, reviewed practical applications outcomes bioink 3D bioprinting. Finally, challenges opportunities development provide research references insights.
Language: Английский
Citations
27
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 19, 2024
The bone defect caused by fracture, tumor, infection, and other causes is not only a problematic point in clinical treatment but also one of the hot issues current research. development tissue engineering provides new way to repair defects. Many animal experimental rising application studies have shown their excellent prospects. construction rapid vascularization tissue-engineered main bottleneck critical factor repairing establishment vascular networks early after biomaterial implantation can provide sufficient nutrients transport metabolites. If slow formation local network results lack blood supply, osteogenesis process will be delayed or even unable form bone. researchers modified scaffold material changing physical chemical properties material, loading growth sustained release system, combining it with trace elements so that promote angiogenesis induced regeneration, which beneficial whole regeneration. This article reviews microenvironment methods improving materials promoting vascularization.
Language: Английский
Citations
14
Biomaterials Research, Journal Year: 2024, Volume and Issue: 28
Published: Jan. 1, 2024
Tissue damage and functional abnormalities in organs have become a considerable clinical challenge. Organoids are often applied as disease models drug discovery screening. Indeed, several studies shown that organoids an important strategy for achieving tissue repair biofunction reconstruction. In contrast to established stem cell therapies, high relevance. However, conventional approaches limited the application of regenerative medicine. Engineered might capacity overcome these challenges. Bioengineering—a multidisciplinary field applies engineering principles biomedicine—has bridged gap between medicine promote human health. More specifically, bioengineering been accelerate their translation. this review, beginning with basic concepts organoids, we describe strategies cultivating engineered discuss multiple modes create conditions breakthroughs organoid research. Subsequently, on reconstruction presented. Finally, highlight limitations challenges hindering utilization applications. Future research will focus using advanced tools personalized
Language: Английский
Citations
12
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)
Published: Jan. 16, 2024
Targeting macrophages can facilitate the site-specific repair of critical bone defects. Herein, a composite hydrogel, gelatin-Bletilla striata polysaccharide-mesoporous bioactive glass hydrogel (GBMgel), is constructed via self-assembly mesoporous on polysaccharide structures, through Schiff base reaction. GBMgel efficiently capture and drive recruitment seed stem cells vascular budding required for regeneration in early stages injury, observed sustained release inorganic silicon ions further enhances matrix deposition, mineralization, maturation. Moreover, use macrophage-depleted rat calvarial defect models confirms that GBMgel, with ligand-selective macrophage targeting, increases area proportion mature bone. Mechanistic studies reveal upregulates TLR4/NF-κB MAPK pathways JAK/STAT3 pathway later stages; thus initiating polarization at different time points. In conclusion, this study based endogenous self-healing properties macrophages, which cell homing, provides research theoretical basis upon tissue be reshaped regenerated using body's immune power, providing new strategy treatment
Language: Английский
Citations
9
Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Language: Английский
Citations
1