A Single‐Atom Manganese Nanozyme Mn‐N/C Promotes Anti‐Tumor Immune Response via Eliciting Type I Interferon Signaling

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 2, 2024

Tumor microenvironment (TME)-induced nanocatalytic therapy is a promising strategy for cancer treatment, but the low catalytic efficiency limits its therapeutic efficacy. Single-atom catalysts (SACs) are new type of nanozyme with incredible efficiency. Here, single-atom manganese (Mn)-N/C constructed. Mn-N/C catalyzes conversion cellular H

Language: Английский

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Tumor Microenvironment‐Driven Structural Transformation of Vanadium‐Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal efficiency and kinetics in the microenvironment (TME). Herein, this study draws inspiration from electronic structure transition metal vanadium, proposing leverage TME specific-features induce structural transformations sheet-like vanadium carbide MXenzymes (TVMz). These trigger cascading reactions that amplify oxidative stress, thereby significantly enhancing multimodal therapy. Specifically, engineered HTVMz, coated with hyaluronic acid, exhibits good stability generates thermal effect under NIR-II laser irradiation. The effect, combined characteristics, facilities transformation into ultra-small oxide nanozymes (VOx). enlarged surface area VOx substantially enhances ROS regeneration amplifies which promotes lysosomal permeability induces endoplasmic reticulum stress. high-valent interacts intracellular glutathione, disrupting redox homeostasis intensifying stress further. amplifications accelerate apoptosis, ferroptosis, suppress HSP90 expression. Consequently, heightened sensitivity HTVMz synergistically cell death via pathways. This presents an innovative strategy therapy by manipulating structures, advancing field

Language: Английский

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Polyvalent Aptamer Nanodrug Conjugates Enable Efficient Tumor Cuproptosis Therapy Through Copper Overload and Glutathione Depletion

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(44), P. 30033 - 30045

Published: Oct. 28, 2024

Cuproptosis, a recently identified form of copper-dependent cell death, shows promising tumor suppressive effects with minimal drug resistance. However, its therapeutic efficacy is hampered by dependence on copper ions and the glutathione (GSH)-rich microenvironment in tumors. Here, we have developed polyvalent aptamer nanodrug conjugates (termed CuPEs@PApt) nucleosome-like structure to improve cuproptosis therapy exploiting mitochondrial overload GSH depletion. Polyvalent (PApt), comprising epithelial adhesion molecule aptamers for targeting repetitive PolyT sequences chelation, facilitates efficient loading targeted delivery peroxide-Elesclomol nanodots (CuPEs). Upon internalization cells, Elesclomol released from CuPEs@PApt accumulates mitochondria initiate cuproptosis, while lysosomal degradation CuP generates exogenous Cu2+ H2O2, triggering Fenton-like reaction depletion enhance cuproptosis. In vitro vivo experiments confirm this strategy inducing immunogenic latter contributing activation antitumor immune response synergistic growth inhibition.

Language: Английский

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Manganese-based nanomaterials promote synergistic photo-immunotherapy: green synthesis, underlying mechanisms, and multiple applications

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(17), P. 4097 - 4117

Published: Jan. 1, 2024

Manganese-based nanoparticles exhibit the multiple roles of immune adjuvants, photosensitizers and photothermal agents in photo-immunotherapy, enhancing anti-tumor immunity through ways.

Language: Английский

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A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Doxorubicin (DOX), a potent antineoplastic agent, is commonly associated with cardiotoxicity, necessitating the development of strategies to reduce its adverse effects on cardiac function. Previous research has demonstrated strong correlation between DOX‐induced cardiotoxicity and activation oxidative stress pathways. This work introduces novel antioxidant therapeutic approach, utilizing libraries tannic acid N‐acetyl‐L‐cysteine‐protected bimetallic cluster nanozymes. Through extensive screening for antioxidative enzyme‐like activity, an optimal nanozyme (AuRu) identified that possess remarkable characteristics, mimicking catalase‐like enzymes. Theoretical calculations reveal surface interactions prepared nanozymes simulate hydrogen peroxide decomposition process, showing these readily undergo OH⁻ adsorption O₂ desorption. To enhance targeting, atrial natriuretic peptide conjugated AuRu nanozyme. These cardiac‐targeted nanozymes, their anchoring capability, effectively cardiomyocyte ferroptosis PANoptosis without compromising tumor treatment efficacy. Thus, approach demonstrates significant reductions in chemotherapy‐induced cell death improvements function, accompanied by exceptional vivo biocompatibility stability. study presents promising avenue preventing offering potential clinical benefits cancer patients.

Language: Английский

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Metal-organic frameworks derived emerging theranostic platforms

Nano Today, Journal Year: 2024, Volume and Issue: 58, P. 102404 - 102404

Published: July 24, 2024

Language: Английский

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TME-responsive nanocomposite hydrogel with targeted capacity for enhanced synergistic chemoimmunotherapy of MYC-amplified osteosarcoma

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 83 - 99

Published: Jan. 14, 2025

Language: Английский

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Ce Single Atom with Cascaded Self‐Circulating Enzyme‐Like Activities and Photothermal Activities for Cancer Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Specific regulation of the tumor microenvironment (TME) is a potential strategy for therapy. Although many TME‐responsive nanozymes have been developed therapy, limited substrates affect therapeutic effect. In this study, cerium single‐atom (Ce SAs) are prepared by immobilizing (Ce) using zeolitic imidazolate framework‐8 (ZIF‐8) as precursor. The reversible conversion between Ce 3+ and 4+ endows SAs with multiple enzyme‐like activities, such peroxidase (POD)‐like activity, oxidase (OD)‐like catalase (CAT)‐like glucose (GOD)‐like glutathione (GSH‐Px)‐like activity. All above enzyme activities give cascade self‐circulation properties can be used therapy in TME. addition, also photothermal properties, which achieve (PTT) cells under 808 nm near‐infrared (NIR) irradiation. Combining self‐cycling SAs, synergistic makes attractive efficacy treatment.

Language: Английский

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Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential improving cancer immunotherapy by altering tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate system to specifically recognize destroy cells. Combined immunotherapeutic agents, can amplify anti-cancer integrating remodeling immunogenic cell death (ICD). This review offers a thorough discussion about various involved immunity, including those mimicking catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD). It also discusses challenges future directions for translating nanozyme platforms into clinical applications, enhancing susceptibility cells immunotherapy. Nanozyme-based strategies substantial oncology, offering new effective options management.

Language: Английский

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Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, survival rates some cancers have increased. Nevertheless, due to complexity mechanisms underlying tumors, cancer remains a serious public health issue that threatens population globally. Manganese (Mn) is an essential trace element for human body. Its regulatory role tumor biology has received much attention recent years. Developments nanotechnology led emergence Mn-based nanoparticles great potential use diagnosis cancers. nanomaterials can be integrated with conventional techniques, including chemotherapy, radiation therapy, gene augment their therapeutic effectiveness. Further, play synergistic emerging strategies such as immunotherapy, photothermal photodynamic electromagnetic hyperthermia, sonodynamic chemodynamic intervention therapy. Moreover, enhance both precision diagnostics capability combined treatment. This article examines roles associated Mn field physiology biology, focus on application prospects

Language: Английский

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