Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 18, 2024
Due
to
the
inadequate
photothermal
conversion
efficiency
(PCE),
most
agents
(PTAs)
have
be
used
under
high-power
near-infrared
(NIR)
irradiation,
which
significantly
exceeds
medical
safety
standards,
for
achieving
effective
therapy
(PTT)
in
antitumor
treatment.
This
hinders
practical
PTT
application.
Herein,
three
acceptor-donor-acceptor(A-D-A)-type
molecules
are
synthesized
based
on
cyclopentadithiophene
unit
develop
PTAs.
By
incorporating
large-size
Si
atom
A-D-A
molecules,
photosensitizer
displays
an
increased
packing
distance
aggregate
state,
leading
a
blue-shifted
absorption
spectrum
that
better
matches
medial
laser
wavelength.
Also,
incorporation
strategy
elevates
nonradiative
decay
rate
constants
(k
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5632 - 5632
Published: May 22, 2024
Photothermal
therapy
(PTT)
is
a
promising
cancer
modality
with
significant
advantages
such
as
precise
targeting,
convenient
drug
delivery,
better
efficacy,
and
minimal
adverse
effects.
effectively
absorbs
the
photothermal
transducers
in
near-infrared
region
(NIR),
which
induces
effect
to
work.
Although
PTT
has
role
tumor
therapy,
it
also
suffers
from
low
conversion
efficiency,
biosafety,
incomplete
elimination.
Therefore,
use
of
nanomaterials
themselves
photosensitizers,
targeted
modification
improve
targeting
or
combined
other
therapies
can
therapeutic
effects
reduce
side
Notably,
noble
metal
have
attracted
much
attention
because
they
strong
surface
plasmon
resonance
an
effective
absorbance
light
at
specific
wavelengths.
be
used
excellent
photosensitizers
mediate
its
efficiency.
This
paper
provides
comprehensive
review
key
played
by
therapy.
It
describes
major
challenges
encountered
during
implementation
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Feb. 20, 2025
The
progression
of
malignant
tumors
leads
to
the
development
secondary
in
various
organs,
including
bones,
brain,
liver,
and
lungs.
This
metastatic
process
severely
impacts
prognosis
patients,
significantly
affecting
their
quality
life
survival
rates.
Research
efforts
have
consistently
focused
on
intricate
mechanisms
underlying
this
corresponding
clinical
management
strategies.
Consequently,
a
comprehensive
understanding
biological
foundations
tumor
metastasis,
identification
pivotal
signaling
pathways,
systematic
evaluation
existing
emerging
therapeutic
strategies
are
paramount
enhancing
overall
diagnostic
treatment
capabilities
for
tumors.
However,
current
research
is
primarily
metastasis
within
specific
cancer
types,
leaving
significant
gaps
our
complex
cascade,
organ-specific
tropism
mechanisms,
targeted
treatments.
In
study,
we
examine
sequential
processes
elucidate
driving
organ-tropic
systematically
analyze
tumors,
those
tailored
organ
involvement.
Subsequently,
synthesize
most
recent
advances
technologies
challenges
opportunities
encountered
pertaining
bone
metastasis.
Our
objective
offer
insights
that
can
inform
future
practice
crucial
field.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 23, 2024
Abstract
Hyaluronic
acid
(HA)
is
a
naturally
occurring
polysaccharide
found
in
the
extracellular
matrix
with
broad
applications
disease
treatment.
HA
possesses
good
biocompatibility,
biodegradability,
and
ability
to
interact
various
cell
surface
receptors.
Its
wide
range
of
molecular
weights
modifiable
chemical
groups
make
it
an
effective
drug
carrier
for
delivery.
Additionally,
overexpression
specific
receptors
on
surfaces
many
states
enhances
accumulation
drugs
at
pathological
sites
through
receptor
binding.
In
this
review,
modification
drugs,
major
proteins,
latest
advances
receptor‐targeted
nano
delivery
systems
(DDS)
treatment
tumors
inflammatory
diseases
are
summarized.
Furthermore,
functions
varying
vivo
selection
methods
different
discussed.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(11)
Published: Dec. 31, 2023
Abstract
Tumor
metastasis
remains
a
leading
factor
in
the
failure
of
cancer
treatments
and
patient
mortality.
To
address
this,
silver‐induced
absorption
red‐shifted
core‐shell
nano‐particle
is
developed,
surface‐modified
with
triphenylphosphonium
bromide
(TPP)
hyaluronic
acid
(HA)
to
obtain
novel
nanodiagnosis‐treatment
agent
(Ag@CuS‐TPP@HA).
This
diagnosis‐treatment
can
dual‐targets
cells
mitochondria,
exhibits
maximal
light
at
1064
nm,
thereby
enhancing
nesr‐infrared
II
(NIR‐II)
photoacoustic
(PA)
signal
photothermal
effects
under
nm
laser
irradiation.
Additionally,
silver
Ag@CuS‐TPP@HA
catalyze
Fenton‐like
reactions
H
2
O
tumor
tissue,
yielding
reactive
oxygen
species
(ROS).
The
ROS
production,
coupled
enhanced
effects,
instigates
immunogenic
cell
death
(ICD),
substantial
release
tumor‐associated
antigens
(TAAs)
damage‐associated
molecular
patterns,
which
have
improved
immune
suppression
microenvironment
boosting
checkpoint
blockade
therapy,
thus
stimulating
systemic
antitumor
response.
Hence,
Ag@CuS‐TPP@HA,
as
diagnostic‐treatment
agent,
not
only
accomplishes
targeted
NIR‐II
PA
imaging
tissue
addresses
challenge
accurate
diagnosis
deep
vivo,
but
it
also
leverages
ROS/photothermal
therapy
enhance
blockade,
eliminating
primary
tumors
effectively
inhibiting
distant
growth.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 22, 2025
It
is
urgent
to
exploit
multifunctional
materials
and
combined
approaches
for
efficient
antitumor
effects.
Copper-based
metal–organic
frameworks
(Cu-MOFs)
have
excellent
performances
in
catalysis,
biocompatibility,
photothermal
conversion,
regulate
metabolism,
which
make
them
attract
more
attention
application.
Therefore,
this
review,
representative
ligands,
synthetic
methods,
mechanism,
applications
of
Cu-MOFs
were
provided.
Special
emphasis
placed
on
the
recent
drug
carriers,
therapy,
tumor
imaging,
theranostic,
are
summarized
with
examples.
Finally,
we
presented
dilemma
faced
by
offered
a
new
perspective
future
Hopefully,
review
may
serve
as
reference
further
development
application
Cu-MOFs.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
Hydrogen
sulfide
(H
2
S)
is
a
vital
gaseous
signaling
molecule
that
plays
central
role
in
various
physiological
and
pathological
processes.
Given
the
complementary
advantages
of
fluorescence
(FL)
photoacoustic
(PA)
imaging,
there
growing
demand
for
dual‐ratiometric
probes
enable
precise
vivo
monitoring
H
S
levels.
In
this
study,
use
2‐mercapto‐1,3,4‐thiadiazole
(MTD)
as
novel
recognition
group
presented
first
time,
following
conjugation
with
cyanine
dyes
to
obtain
new
PA
probe
Cy‐MTD.
To
achieve
Cy‐MTD
incorporated
into
down‐conversion
nanoparticle
(DCNP),
resulting
creation
pioneering
NIR‐II
FL/NIR‐I
nanoprobe
DCNP@Cy‐MTD.
undergoes
blueshift
absorption
from
840
670
nm
after
reaction
S,
enabling
NIR‐I
ratiometric
imaging
by
measuring
ratio
signal
at
(PA
/PA
).
addition,
due
strong
≈840
overlapping
between
spectrum
808
excitation
band
DCNP,
nm‐excited
FL
emission
(F
1550
nm,808Ex
)
DCNP
DCNP@Cy‐MTD
quenched
through
competitive
absorption,
while
it
restored
upon
interaction
because
Using
stable
under
980
nm,980Ex
reference
signal,
/F
achieved.
The
response
features
offer
significant
advancement
over
traditional
single‐signal
or
single‐modality
techniques.
By
providing
enhanced
accuracy
reliability,
allows
diagnosis
hepatitis
surpassing
capabilities
conventional
histopathological
methods,
which
provides
way
more
effective
diagnostic
strategies
liver
diseases.
