Nanomedicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 19
Published: Nov. 15, 2024
The
treatment
of
cancer
has
become
a
profoundly
intricate
procedure.
Traditional
methods,
including
chemotherapy,
surgery
and
radiotherapy,
have
been
utilized,
while
notable
progress
achieved
in
recent
years.
Among
targeted
therapies
for
cancer,
folic
acid
(FA)
conjugated
metal-based
nanoparticles
(NP)
emerged
as
an
innovative
strategy,
namely
photodynamic
therapy
(PDT)
photothermal
(PTT).
These
NP
exploit
the
strong
attraction
between
FA
folate
receptors,
which
are
excessively
produced
several
cells,
order
to
enable
precise
administration
improved
effectiveness
treatment.
During
PDT,
functionalized
with
used
photosensitizers
activated
by
light,
produce
reactive
oxygen
species
that
cause
cells
undergo
apoptosis.
Within
framework
PTT,
these
effectively
transform
light
energy
into
concentrated
heat,
specifically
targeting
destroying
tumor
cells.
This
review
examines
fundamental
mechanisms
improve
PDT
PTT
simultaneously
presenting
important
findings
demonstrate
FA-functionalized
MNP
laboratory
animal
models.
In
addition,
paper
also
discusses
problems
potential
directions
their
clinical
translation.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Skin
cancer
is
a
potentially
life-threatening
disease
resulting
from
DNA
damage,
where
early
detection
critical
to
improving
survival
rates.
This
study
introduces
an
advanced
hybrid
deep
learning
framework
designed
enhance
the
accuracy
of
skin
classification,
distinguishing
between
benign
and
malignant
lesions.
Our
approach
begins
with
data
pre-processing
improve
input
quality,
followed
by
training
two
high-performing
pre-trained
models,
InceptionV3
DenseNet121.
We
then
apply
weighted
sum
rule
for
fusion
model
predictions,
leading
high
generalizability
across
datasets.
On
primary
dataset,
our
achieved
92.27%
accuracy,
90.80%
precision,
92.33%
sensitivity,
92.22%
specificity,
91.57%
F1
score.
Notably,
also
demonstrated
robustness
on
external
achieving
93.45%
91.87%
93.04%
93.18%
92.30%
score,
outperforming
existing
models.
offers
reliable,
highly
generalizable
solution
automated
diagnosis
represents
valuable
contribution
methods,
potential
patient
outcomes
significantly.
Nano Select,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 18, 2024
ABSTRACT
Photothermal
therapy
(PTT)
has
emerged
as
a
promising
alternative
to
conventional
cancer
treatments
such
radiation
therapy,
chemotherapy,
and
surgery.
PTT
uses
light‐absorbing
nanomaterials
induce
localized
hyperthermia
selectively
eliminate
cells,
thus
offering
advantages
over
traditional
interventions.
This
literature
review
focuses
on
nanoparticles
for
PTT,
their
heating
properties,
functions
in
theragnostic
applications
photothermal
treatment.
It
highlights
the
fundamental
principles,
recent
spectroscopic
developments
diagnosis
treatment
monitoring,
clinical
advancements
near‐infrared
(NIR)
nanoparticle‐mediated
emerging
numerical
methods
preclinical
planning
of
PTT.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1574 - 1574
Published: Feb. 13, 2025
Near-infrared
light
(NIR)-responsive
metal-based
nanoparticles
(NPs)
could
be
used
for
tumour
therapy.
We
examined
how
platinum
(Pt),
gold
(Au),
and
core-shell
Pt-Au
NPs
affect
the
viability
of
human
hepatocellular
carcinoma
(HCC)
cell
lines
(Hep3B,
HepG2,
Huh7D-12)
alone
in
combination
with
NIR
exposure.
In
addition,
expression
immune
checkpoint
molecules
(ICMs)
on
cells
was
analysed.
revealed
that
cytotoxicity
programmed
death
induction
Au
toward
HCC
enhanced
by
960
nm
a
different
way.
were
only
particles
resulted
an
additional
temperature
increase
up
to
2
°C
after
NIR.
Regarding
phenotype,
not
all
experienced
changes
phenotype.
itself
trigger
alterations,
while
did
significantly
most
ICMs,
such
as
PD-L1,
HVEM,
CD70,
ICOS-L,
Ox40-L,
TNFRSF9.
The
prominent
ICMs
HepG2
cells.
conclude
thermotherapeutic
effect
NP
application
beneficial
multimodal
therapy
settings
liver
cancer
selected
patients.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 13, 2025
Photothermal
therapy
(PTT),
a
popular
local
treatment
that
uses
heat
to
ablate
tumors,
has
limited
efficacy
in
addressing
metastatic
and
deeply
located
tumors
when
used
alone.
Integrating
PTT
with
immunotherapy
not
only
yields
synergistic
effect
but
also
promotes
cancer
regression
confers
the
benefit
of
immune
memory,
which
can
surmount
challenges
faced
by
isolation.
Metal-based
nanomaterials,
renowned
for
their
superior
photothermal
conversion
efficiency
distinctive
photochemical
properties,
have
been
extensively
researched
applied
field
PTT.
This
review
summarizes
latest
developments
combination
therapies,
specific
focus
on
checkpoint
(ICT)
treatment,
including
comprehensive
overview
recent
advancements
noble
metal-based
2D
transition
metal
chalcogenides
(TMDCs)-based
agents,
anticancer
combining
blockades
(anti-CTLA-4
anti-PD-L1)
therapy.
The
goal
this
is
present
an
application,
current
future
prospects
agents
combined
ICT
treatment.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42738 - e42738
Published: Feb. 1, 2025
In
recent
decades,
significant
attention
has
been
directed
towards
gold
nanoparticles
due
to
their
exceptional
properties,
capturing
the
interest
of
researchers
globally.
Their
unique
characteristics,
such
as
localized
surface
plasmon
resonance,
high
area
volume
ratio,
biocompatibility,
and
facile
functionalization,
render
them
highly
suitable
for
diverse
applications,
ranging
from
optoelectronics
sensing
surface-enhanced
spectroscopies
biomedical
uses,
particularly
in
realm
photothermal
therapy.
Plasmonic
therapy,
an
emerging
technology,
garnered
substantial
its
potential
cancer
treatment
management.
This
approach
employs
agents,
nanoparticles,
which
absorb
light
near-infrared
region.
When
these
agents
accumulate
within
cells,
absorbed
photon
energy
is
converted
into
heat,
inducing
local
hyperthermia.
effect
selectively
eliminates
damaged
cells
adjacent
while
sparing
normal
cells.
Various
shapes
sizes
have
proven
well-suited
candidates
paper
provides
overview
distinctive
properties
nanoparticles.
It
delves
functionalization
techniques
crucial
ensuring
cells'
effective
retention
targeting
this
context,
present
reviews
applications
with
different
plasmonic
encompassing
nanospheres,
nanorods,
nanoshells,
nanostars,
nanocages.
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Nanocarriers
have
been
extensively
utilized
to
improve
the
stability
of
photothermal
agents
in
vivo,
enhance
delivery
efficiency,
and
reduce
drug
side
effects.
However,
challenges,
such
as
low
safety
carrier
materials,
insufficient
loading
therapeutic
agents,
complex
preparation
procedures,
still
persist.
In
this
study,
agent
IR780
was
encapsulated
network
TA-Fe3+
(TF)
which
self-assembled
by
tannic
acid
(TA)
Fe3+
synthesize
an
acid-responsive
multifunctional
nanophotothermal
TF@IR780
(TR).
slightly
acidic
tumor
microenvironment
(TME),
shell
TF
is
degraded,
internal
exposed.
On
one
hand,
can
solubility
vivo
significantly
increase
uptake
efficiency
cells.
other
exhibits
magnetic
resonance
imaging
(MRI)
functionality,
combined
with
fluorescence
endows
TR
multimodal
capabilities.
addition,
easy
release
photosensitizers
through
response
pH
environment
TME,
achieves
precise
damage
mitochondria
mitochondrial
anchoring
light
regulation.
This
overcomes
drawbacks
traditional
treatment
methods,
poor
specificity,
demonstrates
efficient
controllable
antitumor
activity.
