Flexible Conformally Bioadhesive MXene Hydrogel Electronics for Machine Learning‐Facilitated Human‐Interactive Sensing

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: March 29, 2024

Wearable epidermic electronics assembled from conductive hydrogels are attracting various research attention for their seamless integration with human body conformally real-time health monitoring, clinical diagnostics and medical treatment, human-interactive sensing. Nevertheless, it remains a tremendous challenge to simultaneously achieve bioadhesive remarkable self-adhesiveness, reliable ultraviolet (UV) protection ability, admirable sensing performance high-fidelity epidermal electrophysiological signals along timely photothermal therapeutic performances after diagnostic sensing, as well efficient antibacterial activity hemostatic effect potential therapy. Herein, hydrogel-based sensor, featuring superior self-adhesiveness excellent UV-protection performance, is developed by dexterously assembling conducting MXene nanosheets network biological hydrogel polymer stably attaching onto skin high-quality recording of high signal-to-noise ratios (SNR) low interfacial impedance intelligent diagnosis smart human-machine interface. Moreover, sign language gesture recognition platform based on collected electromyogram (EMG) designed hassle-free communication hearing-impaired people the help advanced machine learning algorithms. Meanwhile, possesses capability, biocompatibility, effective hemostasis properties promising bacterial-infected wound bleeding.

Language: Английский

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Hydro‐Sensitive, In Situ Ultrafast Physical Self‐Gelatinizing, and Red Blood Cells Strengthened Hemostatic Adhesive Powder with Antibiosis and Immunoregulation for Wound Repair

Advanced Science, Journal Year: 2023, Volume and Issue: 11(4)

Published: Nov. 30, 2023

Immediate and effective hemostatic treatments for complex bleeding wounds are an urgent clinical demand. Hemostatic materials with characteristics of adhesion, sealing, anti-infection, concrescence promotion have drawn growing concerns. However, pure natural multifunctional in situ ultrafast self-gelation rarely reported. In this study, a hydro-sensitive collagen/tannic acid (ColTA) powder is developed that can self-gel to form adhesive by the non-covalent crosslinking between tannic (TA) collagen (Col) liquids. The physical interactions endow ColTA instantaneous formation high adhesion at various substrate surfaces. Crucially, shows enhanced performance presence blood due electrostatic red cells, conducive sealing rapid hemostasis. biocompatible hemocompatible effectively control seal caudal vein, liver, heart, femoral arteries rats. Furthermore, low-cost ready-to-use also possesses good antibacterial inhibiting biofilm ability, efficiently regulate immune response NF-κB pathway promote wound repair, making it highly promising material great potential biomedical applications.

Language: Английский

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Procoagulant, antibacterial and antioxidant high-strength porous hydrogel adhesives in situ formed via self-gelling hemostatic microsheets for emergency hemostasis and wound repair

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122936 - 122936

Published: Oct. 31, 2024

Language: Английский

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pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123322 - 123322

Published: Jan. 1, 2025

Language: Английский

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Enhancing Wound Recovery: A Self-Gelling Powder for Improved Hemostasis and Healing

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1795 - 1795

Published: June 25, 2024

A novel self-gelatinizing powder was designed to accelerate wound healing through enhanced hemostasis and tissue recovery. Significantly, this research addresses the critical need for innovative management solutions by presenting a approach. Carboxymethylcellulose calcium (CMC-Ca) synthesized using an ion exchange method, lysine (Lys) integrated physical mixing augment material’s functional characteristics. The prepared underwent comprehensive evaluation its self-gelling capacity, gelation time, adhesion, swelling rate, coagulation efficiency, hemostatic effectiveness, promotion. Results indicate that exhibited remarkable water absorption capabilities, absorbing liquid up 30 times weight achieving rapid within 3 min. inclusion of Lys notably powder’s gel-forming properties. time determined be 4 s rotational rheometer, with rapidly forming stable gel on skin surface. Furthermore, in mouse injury model, near-complete recovery observed 14 days, underscoring impressive self-healing attributes promising application prospects management.

Language: Английский

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Durable and Robust Antibacterial Polypropylene Hernia Mesh for Abdominal Wall Defect Repair

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(20), P. 25686 - 25697

Published: May 13, 2024

Polypropylene (PP) mesh is commonly used in repairing abdominal wall hernia (AWH). However, the use of synthetic prosthesis comes with risk developing a prosthetic infection, resulting delayed healing, secondary surgery, and potentially increased mortality. To address these issues, facile surface functionalization strategy for PP based on phytic acid (PA) polyhexamethylene guanidine (PHMG) was constructed through one-step co-deposition process, referred to as PA/PHMG coating. The development coating mainly attributed affinity PA electrostatic interactions between PHMG. could be completed within 4 h under mild conditions. prepared coatings surfaces exhibited desirable biocompatibility toward mammalian cells excellent antibacterial properties against notorious "superbug" methicillin-resistant Staphylococcus aureus (MRSA) tetracycline-resistant Escherichia coli (TRE). PA/PHMG-coated meshes showed killing ratios over 99% MRSA an infected repair model. Furthermore, histological immunohistochemical analysis revealed significantly attenuated degree neutrophil infiltration group, decreased bacterial numbers alleviating inflammatory response at implant sites. Meanwhile, pristine effective tissue repair, group exhibiting enhanced angiogenesis compared meshes, suggesting superior restoration. Additionally, highest PHMG weight ratio (PA/PHMG(3)) long-term robustness phosphate-buffered saline (PBS) immersion still exceeding 95% after 60 days PBS immersion. present work provides promising approach implants.

Language: Английский

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Near-Infrared Responsive Nanocomposite Hydrogel Dressing with Anti-Inflammation and Pro-Angiogenesis for Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34720 - 34731

Published: June 27, 2024

Anti-inflammatory and angiogenesis are two important factors in wound healing. Wound dressings with anti-inflammation vascularization essential to address complex interventions, expensive treatments, uncontrolled release mechanisms. Based on the above considerations, we designed a near-infrared (NIR)-responsive hydrogel dressing, which is composed of mPDA-DFO@LA nanoparticles (mPDA: dopamine hydrochloride nanoparticles, DFO: deferoxamine, LA: lauric acid), valsartan (abbreviated as Va), dopamine–hyaluronic acid hydrogel. The dressing demonstrated injectability, bioadhesive, photothermal properties. results indicated obtained by releasing Va can appropriately regulate macrophage phenotype transformation from M1 M2, resulting an anti-inflammatory environment. In addition, DFO encapsulated LA be sustainably released into site NIR irradiation, further prevents excessive neovascularization. Notably, vivo mPDA-DFO@LA/Va significantly enhanced recovery, achieving healing rate up 96% after 11 days treatment. Therefore, this NIR-responsive anti-inflammation, vascularization, on-demand programmed drug will promising for infection.

Language: Английский

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Wet Tissue Interfacial Water Triggers Ultrafast In Situ Gelation of Sprayable Dry Powder for Postoperative Anti‐Adhesion

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Abstract Postoperative adhesions complicate the majority of surgical procedures, imposing an excess medical burden. The segregation injured tissue from healthy is considered optimal therapeutic strategy. However, achieving hemostasis while preventing in immediate postoperative setting continues to pose a significant challenge. This paper presents situ formation asymmetrically adhesive hydrogel barrier via sprayable dry powder (SDP) that enables interfacial water‐induced, ultra‐rapid gelation. Owing SDP hydrophilicity and interstitial spaces between particles, it can rapidly efficiently absorb water, thereby facilitating smooth cross‐linking material functional groups groups. In addition, becomes less after gelation as layer water forms on surface hydrogel, enhancing its anti‐adhesion properties. Animal experiment outcomes demonstrate exhibits asymmetric properties before gelation, successfully adhesions. As result, heralds novel approach development adhesives simultaneously mitigate promptly arrest bleeding.

Language: Английский

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3D Electrospun nanofiber sponges of insect chitosan/pullulan/citric acid embedded with ZnMOF in situ for enhanced healing of MRSA-infected wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155388 - 155388

Published: Sept. 1, 2024

Language: Английский

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Self-sacrificial bioenzyme-reinforced injectable hydrogel bone adhesives for enhancing diabetic fracture healing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160255 - 160255

Published: Feb. 1, 2025

Language: Английский

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