Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2045 - 2045
Published: Sept. 9, 2024
Applying cold to a bone injury can aid healing, though its mechanisms are complex. This study investigates how therapy impacts repair optimize healing. Cold was applied rodent model, with the physiological responses analyzed. Vasoconstriction mediated by an increase in transient receptor protein channels (TRPs), potential ankyrin 1 (TRPA1;
Language: Английский
Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515
Published: Jan. 1, 2025
Language: Английский
Citations
2
Advanced Science, Journal Year: 2024, Volume and Issue: 11(19)
Published: March 14, 2024
Abstract Cryotherapy leverages controlled freezing temperature interventions to engender a cascade of tumor‐suppressing effects. However, its bottleneck lies in the standalone ineffectiveness. A promising strategy is using nanoparticle therapeutics augment efficacy cryotherapy. Here, cold‐responsive nanoplatform composed upconversion nanoparticles coated with silica – chlorin e6 hyaluronic acid (UCNPs@SiO 2 ‐Ce6‐HA) designed. This employed integrate cryotherapy photodynamic therapy (PDT) order improve skin cancer treatment synergistic manner. The appeared enhance brightness by suppressing thermal quenching. low‐temperature afforded 2.45‐fold enhancement luminescence UCNPs and 3.15‐fold increase UCNPs@SiO ‐Ce6‐HA nanoplatforms. Ex vivo tests porcine skins subsequent validation mouse tumor tissues revealed effective HA‐mediated transdermal delivery designed nanoplatforms deep tissues. After delivery, resulted optimized 79% combination These findings underscore Cryo‐PDT as truly integrated paradigm warrant further exploring interplay between PDT bright unlock their full potential therapy.
Language: Английский
Citations
14
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.
Language: Английский
Citations
9
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 16, 2025
The development of lanthanide-doped upconversion nanoparticle (UCNP)-based imaging with minimal autofluorescence and improved penetration depth is important in medical applications. Exogenous nanocarriers readily adsorb plasma proteins following intravenous administration (<0.5 min), resulting the formation a protein corona on fixed surface. facilitates UCNP interception by immune system, preventing targeted delivery to disease sites. In this study, we report novel surface-camouflaging strategy using lanthanide hydroxyl carbonate that slowly dissolved physiological phosphate serum. "self-consuming" inorganic-shell-modified UCNPs (denoted as UCSP-PEG) effectively reduce adhesion more than 90% through dissociation effect associated amphiphilic poly(ethylene glycol) (PEG)-modified determined an ex vivo assay. UCSP-PEG exhibits prolonged blood circulation time (t1/2 = 73.9 ± 9.5 185 times camouflage materials without "stealth" feature, can employ upconverted luminescence (UCL) monitor tumor-related vessels for at least 120 min. Based superior optical properties UCSP-PEG, application UCL dual-channel stereoscope magnification system has enabled observation capillaries high resolution, offering powerful tool monitoring biological activities fine tissue level. This work provides nanovehicle, resisting based significantly advance target-specific cancer diagnosis.
Language: Английский
Citations
1
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141446 - 141446
Published: Jan. 1, 2025
Language: Английский
Citations
0
Small Methods, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Precision phototherapy requires tight control over several therapeutic steps, which traditional methods often struggle to achieve. Here, this study reports an orthogonal trichromatic upconversion nanoparticle with a rather simple nanoarchitecture, NaErF4@NaYbF4@NaYbF4:Nd@NaYF4:Yb,Tm. Unlike conventional designs that rely on multiple activators and complicated multi-shelled structures (up six nanoshells), the reported triple-shelled UCNPs utilize only two activator ions (Er3⁺ Tm3⁺) but still enables release red, green, blue colors in response three different NIR light excitations, thus significantly reducing structural complexity synthetic workload. Integrating these photosensitizers nitric oxide (NO) donors further achieve precision photodynamic therapy, allows for step-wise throughout entire PDT process by independent activation of bioimaging, photochemical internalization, respiration prohibition via NO release, ROS generation specific illuminations. Both vitro vivo results demonstrate high efficiency presented methodology, highlighting its great potential light-activated phototherapy.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161784 - 161784
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113729 - 113729
Published: April 1, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Abstract Cold temperatures exhibit a broader safety margin than hyperthermia, thereby enhancing their controllability and compatibility within biological systems. Nanomaterials with diverse structures rich functionalities can respond to cold temperatures, converting physical signals from environments into actionable effects. The advancement of nanomaterials nanotechnology has expanded the impact on systems, fostering emergence cryomedicine as multidisciplinary field. In this review, temperature‐responsive are categorized thermally conductive nanomaterials, phase‐change temperature‐sensitive polymer pyroelectric thermoelectric nanomaterials. methods devices for applying summarized, emphasis intelligent temperature equipment. Furthermore, biomedical applications summarized discussed, including cryoablation, drug delivery, cell cryopreservation, catalytic therapy, antimicrobial biosensing, electronic skin. Finally, perspectives challenges potential solutions in biomedicine provided, aiming offer insights cryomedicine.
Language: Английский
Citations
0
Published: Aug. 29, 2024
Applying cold to a bone injury can aid healing, though its mechanisms are complex. This study investigates how therapy impacts repair optimize healing. Cold was applied rodent model, with physiological responses analyzed. Vasoconstriction mediated by an increase in TRP channels, TRPA1 (p=0.012) and TRPM8 (p&lt;0.001), within cortical defects enhancing sensory response blood flow regulation. exposure also elevated hypoxia (p &lt; 0.01) VEGF expression 0.001), promoting angiogenesis vital for regeneration. Increased of osteogenic proteins PGC-1α = 0.039) RBM3 (p&lt;0.008) suggests stimulated reparative processes. Enhanced osteoblast differentiation ALP presence at days 5 (three-fold, p=0.014) 10 (two-fold, p=0.010) were observed, along increased osteocalcin (OCN) day p 0.010) indicating mature osteoblasts capable mineralization. These findings highlight therapy's multifaceted effects on repair, offering insights therapeutic strategies.
Language: Английский
Citations
2