ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
8(1), P. 446 - 456
Published: Dec. 31, 2024
The
multiple
enzymatic
properties
of
the
Au3+-modified
metal–organic
framework
(Au3+-MOFs)
have
made
it
a
functional
catalytic
system
for
antitumor
treatment.
However,
in
face
insufficient
substrates
tumor
tissue,
is
still
impossible
to
achieve
efficient
treatment
tumors.
Herein,
Au3+-MOFs
loaded
with
hyaluronic
acid
(HA)-modified
calcium
peroxide
nanoparticles
(CaO2
NPs)
were
used
construct
nanozyme
(Au3+-MOF/CaO2/HA)
substrate
self-supplied
and
parallel
catalytic/calcium-overload-mediated
therapy
cancer.
Due
specific
targeted
ability
retention
(EPR)
effect
HA,
built
can
effectively
accumulate
at
site.
oxidase-like
(OXD)
activity
peroxidase-like
(POD)
Au3+-MOFs,
superoxide
radical
anion
(O2•–)
hydroxyl
radicals
(·OH)
cooperatively
formed
(PCT)
Subsequently,
CaO2
NPs
decomposed
Ca2+,
H2O2,
O2
weak
acidic
environment
microenvironment
(TME).
Thus,
self-supplementation
as
well
H2O2
was
achieved,
alleviating
deficiency
Au3+-MOF
substrate.
In
addition,
Ca2+
lead
oxidative
stress
calcification
calcium-overload-mediated
(COMT)
promote
necrosis
vivo.
An
effective
paradigm
PCT/COMT
self-supplying
has
been
successfully
established
considerably
enhanced
therapeutic
efficacy.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(19)
Published: March 14, 2024
Abstract
Cryotherapy
leverages
controlled
freezing
temperature
interventions
to
engender
a
cascade
of
tumor‐suppressing
effects.
However,
its
bottleneck
lies
in
the
standalone
ineffectiveness.
A
promising
strategy
is
using
nanoparticle
therapeutics
augment
efficacy
cryotherapy.
Here,
cold‐responsive
nanoplatform
composed
upconversion
nanoparticles
coated
with
silica
–
chlorin
e6
hyaluronic
acid
(UCNPs@SiO
2
‐Ce6‐HA)
designed.
This
employed
integrate
cryotherapy
photodynamic
therapy
(PDT)
order
improve
skin
cancer
treatment
synergistic
manner.
The
appeared
enhance
brightness
by
suppressing
thermal
quenching.
low‐temperature
afforded
2.45‐fold
enhancement
luminescence
UCNPs
and
3.15‐fold
increase
UCNPs@SiO
‐Ce6‐HA
nanoplatforms.
Ex
vivo
tests
porcine
skins
subsequent
validation
mouse
tumor
tissues
revealed
effective
HA‐mediated
transdermal
delivery
designed
nanoplatforms
deep
tissues.
After
delivery,
resulted
optimized
79%
combination
These
findings
underscore
Cryo‐PDT
as
truly
integrated
paradigm
warrant
further
exploring
interplay
between
PDT
bright
unlock
their
full
potential
therapy.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
review
provides
a
comprehensive
summary
of
the
dysregulation
redox
metabolism
in
cancer
cells
and
advantages
latest
advances
nanomaterial-assisted
metabolic
regulation
therapy.
The
development
of
lanthanide-doped
upconversion
nanoparticle
(UCNP)-based
imaging
with
minimal
autofluorescence
and
improved
penetration
depth
is
important
in
medical
applications.
Exogenous
nanocarriers
readily
adsorb
plasma
proteins
following
intravenous
administration
(<0.5
min),
resulting
the
formation
a
protein
corona
on
fixed
surface.
facilitates
UCNP
interception
by
immune
system,
preventing
targeted
delivery
to
disease
sites.
In
this
study,
we
report
novel
surface-camouflaging
strategy
using
lanthanide
hydroxyl
carbonate
that
slowly
dissolved
physiological
phosphate
serum.
"self-consuming"
inorganic-shell-modified
UCNPs
(denoted
as
UCSP-PEG)
effectively
reduce
adhesion
more
than
90%
through
dissociation
effect
associated
amphiphilic
poly(ethylene
glycol)
(PEG)-modified
determined
an
ex
vivo
assay.
UCSP-PEG
exhibits
prolonged
blood
circulation
time
(t1/2
=
73.9
±
9.5
185
times
camouflage
materials
without
"stealth"
feature,
can
employ
upconverted
luminescence
(UCL)
monitor
tumor-related
vessels
for
at
least
120
min.
Based
superior
optical
properties
UCSP-PEG,
application
UCL
dual-channel
stereoscope
magnification
system
has
enabled
observation
capillaries
high
resolution,
offering
powerful
tool
monitoring
biological
activities
fine
tissue
level.
This
work
provides
nanovehicle,
resisting
based
significantly
advance
target-specific
cancer
diagnosis.
Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 6, 2025
Precision
phototherapy
requires
tight
control
over
several
therapeutic
steps,
which
traditional
methods
often
struggle
to
achieve.
Here,
this
study
reports
an
orthogonal
trichromatic
upconversion
nanoparticle
with
a
rather
simple
nanoarchitecture,
NaErF4@NaYbF4@NaYbF4:Nd@NaYF4:Yb,Tm.
Unlike
conventional
designs
that
rely
on
multiple
activators
and
complicated
multi-shelled
structures
(up
six
nanoshells),
the
reported
triple-shelled
UCNPs
utilize
only
two
activator
ions
(Er3⁺
Tm3⁺)
but
still
enables
release
red,
green,
blue
colors
in
response
three
different
NIR
light
excitations,
thus
significantly
reducing
structural
complexity
synthetic
workload.
Integrating
these
photosensitizers
nitric
oxide
(NO)
donors
further
achieve
precision
photodynamic
therapy,
allows
for
step-wise
throughout
entire
PDT
process
by
independent
activation
of
bioimaging,
photochemical
internalization,
respiration
prohibition
via
NO
release,
ROS
generation
specific
illuminations.
Both
vitro
vivo
results
demonstrate
high
efficiency
presented
methodology,
highlighting
its
great
potential
light-activated
phototherapy.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
Abstract
Cold
temperatures
exhibit
a
broader
safety
margin
than
hyperthermia,
thereby
enhancing
their
controllability
and
compatibility
within
biological
systems.
Nanomaterials
with
diverse
structures
rich
functionalities
can
respond
to
cold
temperatures,
converting
physical
signals
from
environments
into
actionable
effects.
The
advancement
of
nanomaterials
nanotechnology
has
expanded
the
impact
on
systems,
fostering
emergence
cryomedicine
as
multidisciplinary
field.
In
this
review,
temperature‐responsive
are
categorized
thermally
conductive
nanomaterials,
phase‐change
temperature‐sensitive
polymer
pyroelectric
thermoelectric
nanomaterials.
methods
devices
for
applying
summarized,
emphasis
intelligent
temperature
equipment.
Furthermore,
biomedical
applications
summarized
discussed,
including
cryoablation,
drug
delivery,
cell
cryopreservation,
catalytic
therapy,
antimicrobial
biosensing,
electronic
skin.
Finally,
perspectives
challenges
potential
solutions
in
biomedicine
provided,
aiming
offer
insights
cryomedicine.
