Triple‐Combination Therapy with a Multifunctional Yolk–Shell Nanozyme Au@CeO2 Loaded with Dimethyl Fumarate for Periodontitis DOI Creative Commons
Tiancheng Li, Mengmeng Shu,

Cheng Zhu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Abstract Periodontitis, a chronic inflammatory disease, is the leading cause of tooth loss in adults and one most prevalent complex oral conditions. Oxidative stress induced by excessive generation reactive oxygen species (ROS) leads to periodontitis, which closely associated with pathological processes, including mitochondrial dysfunction periodontal cells local immune dysregulation. However, current treatment modalities that target single processes have limited long‐term therapeutic effects. Herein, multifunctional Yolk–Shell nanozyme, Au@CeO 2 ‐dimethyl fumarate (DMF), comprehensively addresses oxidative stress‐induced pathophysiological periodontitis through antioxidant activity, maintenance, modulation mechanisms, described. For material design logic, functionally complementary Au CeO formed an excellent photothermally regulated high‐efficiency also provided ideal drug carrier for DMF. As ‐DMF restores dysregulation, contributes endogenous ROS elimination, thereby achieving stable In rat model, photothermal therapy effectively alleviated ROS‐induced tissue damage restored homeostasis. Altogether, this study presents novel nanozyme managing alveolar bone under prolonged demonstrates importance comprehensive intervention key design.

Language: Английский

Solubilization techniques used for poorly water-soluble drugs DOI Creative Commons

Bing Xie,

Yaping Liu, Xiaotong Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716

Published: Sept. 2, 2024

About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.

Language: Английский

Citations

12
Anti‐Acidification and Immune Regulation by Nano‐Ceria‐Loaded Mg–Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy DOI Creative Commons
Hao Fu, Yuedong Guo,

Wenming Fang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(6)

Published: Dec. 8, 2023

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease featuring an abnormal immune microenvironment and resultant accumulation of hydrogen ions (H + ) produced by activated osteoclasts (OCs). Currently, clinic RA therapy can hardly achieve sustained or efficient therapeutic outcomes due to the failures in generating sufficient modulation manipulating H that deteriorates bone damage. Herein, highly effective modulatory nanocatalytic platform, nanoceria‐loaded magnesium aluminum layered double hydroxide (LDH‐CeO 2 ), proposed for enhanced based on acid neutralization metal ion inherent bioactivity. Specifically, mild alkaline LDH initiates significant M2 repolarization macrophages triggered elevated antioxidation effect CeO via neutralizing excessive microenvironment, thus resulting recruitment regulatory T cell (Treg) suppressions helper 17 (Th 17) plasma cells. Moreover, osteogenic activity stimulated Mg released from LDH, thereby promoting damaged healing. The encouraging adjuvant‐induced model mice demonstrate high feasibility such concept, which provides novel modality bone‐repairing effects inorganic material.

Language: Английский

Citations

18
Supramolecular Engineering of Nanoceria for Management and Amelioration of Age‐Related Macular Degeneration via the Two‐Level Blocking of Oxidative Stress and Inflammation DOI Creative Commons
Mingyu Xu, Yifan Zhou, Yufeng Xu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Age‐related macular degeneration (AMD), characterized by choroidal neovascularization (CNV), is the global leading cause of irreversible blindness. Current first‐line therapeutics, vascular endothelial growth factor (VEGF) antagonists, often yield incomplete and suboptimal vision improvement, necessitating exploration novel efficacious therapeutic approaches. Herein, a supramolecular engineering strategy to construct moringin (MOR) loaded α‐cyclodextrin (α‐CD) coated nanoceria (M@CCNP) constructed, where hydroxy newly formed carbonyl groups α‐CD interact with surface via O─Ce conjunction isothiocyanate group MOR inserts deeply into cavity host–guest interaction. By exploiting recycling reactive oxygen species (ROS) scavenging capability anti‐inflammation properties MOR, two‐level strike during AMD pathogenesis can be precisely blocked M@CCNP. Remarkably, excellent efficacy CNV observed in vivo, achieving over 80% reduction 60% leakage area. In summary, engineered provides an efficient approach for amelioration blocking strike, presents significant potential as exceptional drug delivery platform, particularly ROS‐related diseases.

Language: Английский

Citations

0
Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis DOI Creative Commons

Qiaoxuan Wang,

Juan Ji,

Ding Huang

et al.

BME Frontiers, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 1, 2025

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by joint swelling and bone destruction. Despite an incomplete understanding of its genesis, RA tightly linked to the intricate immunological milieu, involving disruptions in molecular signaling imbalance between innate adaptive immune systems. With advancements biomaterials science, role treatment has evolved from mere drug delivery systems therapeutic microenvironment modulators, providing drug-independent strategies for RA. In this review, we will delve into RA, focusing on contributions immunity, damage-associated patterns (DAMPs), cytokines, pathways disease’s pathogenesis inflammation. We provide detailed analysis applications novel nonpharmaceutical treatment, categorized 3 key mechanisms: biofactor pathway regulation, endogenous gas adjustment, cell modulation. The composition, form, principles, efficacy these be explored. thorough discussion topics offer fresh viewpoint guide future research directions.

Language: Английский

Citations

0
CD19 chimeric antigen receptor‐T cell therapy in murine immune thrombocytopenia DOI Open Access

Fengjiao Han,

Zhengqi Jiang,

Qiuyu Guo

et al.

British Journal of Haematology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Summary Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antiplatelet autoantibodies, with many patients refractory or relapsing on conventional treatments. GPIbα, important autoantigen in ITP, notably linked to refractoriness, highlighting the need for novel We assessed CD19 chimeric antigen receptor (CAR)‐T cell therapy's potential a modified murine model targeting GPIbα. CAR‐T infusion accelerated platelet count recovery compared control group, effectively depleted + B cells and CD138 plasma cells, markedly reduced anti‐GPIbα autoantibodies vivo. In vitro both spleens of mice ITP patients. therapy significantly altered T‐cell subsets, increasing regulatory T helper 1 17 populations, suggesting role modulating immune response sustained remission. Monitoring body/spleen weights temperature showed no significant cytokine release syndrome, indicating favourable safety profile. These promising results support as treatment option particularly GPIbα‐positive autoantibody Further clinical studies are warranted assess efficacy this approach human

Language: Английский

Citations

0
ZnFe Layered Double Hydroxide Nanosheets Loaded with Cu Single‐Atom Nanozymes with Multi‐Enzyme‐Like Catalytic Activities as an Effective Treatment for Bacterial Keratitis DOI Creative Commons
Keke Wang, Yuan Miao, Pengxiu Dai

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Bacterial keratitis (BK) is a type of corneal inflammation resulting from bacterial infection in the eye. Although nanozymes have been explored as promising materials wound healing, currently available lack sufficient catalytic activity and ability to penetrate biofilms, limiting their efficacy against treatment BK. To remedy this, ZnFe layered double hydroxide (ZnFe‐LDH) nanosheets are loaded with Cu single‐atom (Cu‐SAzymes) aminated dextran (Dex‐NH 2 ), formation nanozyme DT‐ZnFe‐LDH@Cu, which possesses peroxidase (POD)‐, oxidase (OXD)‐, catalase (CAT)‐like activities. This enables generate reactive oxygen species (ROS), such hydroxyl radicals ( • OH), superoxide anion radical (O •− singlet 1 O ) hydrogen peroxide (H thereby killing bacteria causing infections. The surface Dex‐NH enabled DT‐ZnFe‐LDH@Cu biofilm adsorb onto extracellular polymeric substances (EPS) produced by biofilm. Additionally, successfully repaired P. aeruginosa ‐infected injury BK rabbit model more effectively than commercially tobramycin eye drops. was enabled, part, reduce promoting polarization pro‐inflammatory macrophages (M1) anti‐inflammatory (M2) decrease expression α‐smooth muscle actin (α‐SMA) promote healing without scar formation. study provides an innovative concept for holds great scientific value clinical application potential.

Language: Английский

Citations

0
Multifunctional MXene-Based Hydrogel Remodels Regenerative Microenvironment and Facilitates Neurogenesis of Endogenous Neural Stem Cells for Spinal Cord Injury Recovery DOI
P. L. Zhu, Lu Ge,

Tong Luo

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
MgMn-LDHzyme assisted electrochemical sensor for high-performance point-of-care detection of adrenaline in urine and sweat DOI

Z Li,

Ting Liu, Chenyu Wang

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113711 - 113711

Published: April 1, 2025

Language: Английский

Citations

0
Next-generation aluminum adjuvants: Immunomodulatory layered double hydroxides NanoAlum reengineered from first-line drugs DOI Creative Commons
Zhenwei Su, Hamza Boucetta, Jiahui Shao

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4665 - 4682

Published: Sept. 14, 2024

Aluminum adjuvants (Alum), approved by the US Food and Drug Administration, have been extensively used in vaccines containing recombinant antigens, subunits of pathogens, or toxins for almost a century. While Alums typically elicit strong humoral immune responses, their ability to induce cellular mucosal immunity is limited. As an alternative, layered double hydroxide (LDH), widely antacid, has emerged as novel class potent nano-aluminum (NanoAlum), demonstrating advantageous physicochemical properties, biocompatibility adjuvanticity both responses. In this review, we summarize compare advantages disadvantages Alum NanoAlum these properties performance adjuvants. Moreover, propose key features ideal demonstrate that LDH promising candidate summarizing its current progress immunotherapeutic cancer treatments. Finally, conclude review offering our integrated perspectives about remaining challenges future directions NanoAlum's application preclinical/clinical settings.

Language: Английский

Citations

2
Antimicrobial Efficacy of Cubic, Single-Leaf, and Flower-like Zeolitic Imidazolate Frameworks DOI
Yanning Zhang,

Shixin Cai,

Xinzhang Li

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Language: Английский

Citations

1