International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135931 - 135931
Published: Sept. 1, 2024
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(23)
Published: March 15, 2024
Abstract Bioenergetic therapy is emerging as a promising therapeutic approach. However, its effectiveness restricted by metabolic plasticity, tumor cells switch phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) to compensate for energy. Herein, Metformin (MET) BAY‐876 (BAY) co‐loaded CuFe 2 O 4 (CF) nanoplatform (CFMB) developed boost energy deprivation synchronous interventions of OXPHOS bioenergetic synergetic with chemodynamic/photothermal (CDT/PTT). The MET can simultaneously restrain inhibiting hexokinase (HK2) activity damaging mitochondrial function deprive energy, respectively. Besides, BAY blocks glucose uptake transporter 1 (GLUT1) expression, further potentiating the repression thus achieving much more depletion tumorigenic sources. Interestingly, upregulated antioxidant glutathione (GSH) in cancer triggers CFMB degradation release Cu + /Fe 2+ catalyzing tumor‐overexpressed H hydroxyl radical (∙OH), both impairing GSH‐depletion amplified CDT. Furthermore, upon near‐infrared (NIR) light irradiation, has photothermal conversion capacity kill PTT improve ∙OH production enhanced In vivo experiments have manifested that remarkably suppressed growth mice without systemic toxicity. This study provides new modality paradigm bioenergetic‐related therapies.
Language: Английский
Citations
14
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract In this study, an electret‐inspired, charge‐injected hydrogel called QOSP (QCS/OD/SDI/PANI/PS/Plasma) that promotes scar‐free healing of bacteria‐infected burns through bioelectrical stimulation and immune modulation, is presented. The hydrogel, composed quaternized chitosan (QCS), oxidized dextran (OD), sulfadiazine (SDI), polystyrene (PS), polyaniline nanowires (PANI), forms a conductive network capable storing releasing electric charges, emulating electret‐like mechanism. This structure delivers signals continuously, enhancing wound by regulating responses minimizing fibrosis. mouse model second‐degree infected with Staphylococcus aureus (SA) Pseudomonas aeruginosa (PA), the accelerates 32% reduces bacterial load 60%, significantly inhibited scar formation 40% compared to controls. modulates Th1/Th2 balance toward Th1‐dominant antifibrotic state chitosan, thereby reducing collagen deposition 35%. Electro‐dielectric characterization reveals dielectric constant 6.2, 34% improvement in conductivity (3.33 × 10 −5 S/m) 30 °C increase thermal stability. Proteomic analysis highlights 50% down‐regulation pro‐inflammatory pro‐fibrotic pathways, suggesting controlled response conducive healing. study underscores potential bioelectrically active hydrogels as novel approach for treating wounds prone scarring.
Language: Английский
Citations
1
Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103260 - 103260
Published: June 28, 2024
Tumor metabolic reprogramming requires high levels of adenosine triphosphate (ATP) to maintain treatment resistance, which poses major challenges chemotherapy and photothermal therapy. Especially, ATP promote copper ion efflux for limiting the curative effect cuproptosis. Here, an H
Language: Английский
Citations
5
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 374, P. 194 - 204
Published: Aug. 15, 2024
Language: Английский
Citations
5
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154569 - 154569
Published: Aug. 5, 2024
Language: Английский
Citations
4
Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101447 - 101447
Published: Jan. 5, 2025
Chemodynamic therapy (CDT) is an emerging antitumor strategy utilizing iron-initiated Fenton reaction to destroy tumor cells by converting endogenous H2O2 into highly toxic hydroxyl radical (OH). However, the intratumoral overexpressed glutathione (GSH) and deficient acid greatly reduce CDT efficacy because of OH scavenging decreased production efficiency. Even worse, various physiological barriers, especially in glioma, further put brakes on targeted delivery agents. Herein, exploring thiol potential 5,5'-dithiobis-2-nitrobenzoic (DTNB), we have constructed a tailored biomimetic nanoreactor improve glioma through synchronous GSH exhaustion acidity elevation. The was fabricated employing DTNB drive nano-assembly BSA molecules, followed loading carrier onto cell surface neutrophils via disulfide-thiol exchange. Upon sensing inflammatory signal, hijacked efficiently targets site, which then dually depletes disulfide bond stabilizing nanostructure following liberated Fe (III). In particular, simultaneously released can not only consume residual GSH, but also produce 5-thio-2-nitrobenzoic (TNB) promptly, resulting accelerated reaction. Through vitro vivo experiments, demonstrate exhaustive regulation chemistry could potentially serve as novel for glioma.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106642 - 106642
Published: Jan. 1, 2025
Language: Английский
Citations
0
Drug Resistance Updates, Journal Year: 2025, Volume and Issue: unknown, P. 101208 - 101208
Published: Jan. 1, 2025
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 2, 2025
Higher and richer nutrient requirements are typical features that distinguish tumor cells from AU: cells, ensuring adequate substrates energy sources for cell proliferation migration. Therefore, deprivation strategies based on targeted technologies can induce impaired viability in which more sensitive than normal cells. In this review, nutrients required by related metabolic pathways introduced, anti-tumor developed to target described. addition the nutritional characteristics of other microenvironment (including macrophages, neutrophils, natural killer T cancer-associated fibroblasts) new also summarized. conclusion, recent advances targeting blockade reviewed, challenges prospects these discussed, theoretical significance optimizing clinical application nutrition strategies.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis usually asynchronous due to opposite effect transport them. Herein, systematic glucose deprivation, by inhibiting upstream uptake promoting downstream consumption, is proposed synchronously evoke ferroptosis. As an example, Au nanodots Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles (FeOOH@Fe-Ap@Au NSs) employed regulate SLC7A11/GSH/GPX4 axis performing disulfidptosis- ferroptosis-mediated therapy synchronously. In this scenario, exhibit oxidase-like activity when consuming massive glucose. Meanwhile, Ap can inhibit downregulating 1, depriving fundamentally. The systematical deprivation limits supplement NADPH suppresses axis, thus solving contradiction addition, efficient delivery exogenous iron ions FeOOH@Fe-Ap@Au NSs self-supplied H2O2 through nanodots-catalytic oxidation facilitate Fenton reaction therewith help amplify a result synchronous occurrence ferroptosis, good efficacy in ovarian cancer therapeutic model.
Language: Английский
Citations
0