The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.

Language: Английский

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Dual Metabolism-Disrupted Nanoparticles for Reprogramming the Immune Microenvironment to Potentiate Cuproptosis Immunotherapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101799 - 101799

Published: April 1, 2025

Language: Английский

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Synthesis of Closely‐Contacted Cu₂O‐CoWO₄ Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 21, 2024

Abstract Cuproptosis offers a promising and selective therapeutic strategy for cancer therapy. To fully realize its potential, the development of novel cuproptosis agents achievement efficient copper release are critical steps forward. Herein, closely‐contacted Cu 2 O‐CoWO 4 nanosheet heterojunctions (CCW‐NH) successfully synthesized using an in‐situ process The ions from CCW‐NH can be triggered by ultrasound irradiation, primarily due to generation superoxide radicals as sonodynamic via Z‐scheme charge transfer mechanism. When subjected combined effects laser effective is increased 1.7 times compared untreated group, significantly enhancing efficiency cuproptosis. And incorporation L‐arginine into temperature‐sensitive injectable hydrogel (HP‐CCW@LA) ultimately achieved tumor inhibition rate up 95.1%. L‐arginine, serving reducing agent, enabled sustained highly active + during treatment. Notably, after treating tumors with HP‐CCW@LA, microenvironment leveraged promote ion conversion, which potential monitoring therapy efficacy through magnetic resonance imaging. This work integrated new evaluation.

Language: Английский

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Immunomodulating Sonocatalytic Nanoagents with Dual‐Functional Ir‐N Centers and Narrow Bandgap for Reversing Immunosuppression and Potentiating Ovarian Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(46)

Published: July 1, 2024

Abstract The heterogeneity and immunosuppression microenvironment of ovarian cancer seriously restrict the efficiency monomodal treatment. Emerging multimodal therapy strategies based on sonodynamic with enhanced antitumor effects have attracted intensive attention in quest to combat cancer. However, exploring highly efficient sonosensitizers integrating chemodynamic/sonodynamic/immunotherapies reversing immunosuppressive tumor (TME) capacity is urgently desired but remains challenging. Here, a facile strategy designed synthesize immunomodulating sonocatalytic nanoagents (IrT‐SCN) dual‐functional Ir‐N centers narrow bandgap for potentiating immunotherapy. IrT‐SCN 2 4 conjugated networks show reduced bandgap, moderate interaction H O , production reactive oxygen species (ROS). Such ROS capabilities include: 1) utilizing TME catalytically generate potent as well abundant superoxide anion (•O − ) singlet ( 1 radicals; 2) external ultrasound (US) irradiation can also boost simultaneously; 3) M1 polarization tumor‐associated macrophages immune effect promote outcome This finding provides proof‐of‐concept evidence future development oncological treatments other ROS‐related biomedical fields.

Language: Английский

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Bioengineering nanomaterials for tumor therapy and anti-metastasis

Progress in Materials Science, Journal Year: 2024, Volume and Issue: unknown, P. 101375 - 101375

Published: Sept. 1, 2024

Language: Английский

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