Triple‐Combination Therapy with a Multifunctional Yolk–Shell Nanozyme Au@CeO2 Loaded with Dimethyl Fumarate for Periodontitis DOI Creative Commons
Tiancheng Li, Mengmeng Shu,

Cheng Zhu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Abstract Periodontitis, a chronic inflammatory disease, is the leading cause of tooth loss in adults and one most prevalent complex oral conditions. Oxidative stress induced by excessive generation reactive oxygen species (ROS) leads to periodontitis, which closely associated with pathological processes, including mitochondrial dysfunction periodontal cells local immune dysregulation. However, current treatment modalities that target single processes have limited long‐term therapeutic effects. Herein, multifunctional Yolk–Shell nanozyme, Au@CeO 2 ‐dimethyl fumarate (DMF), comprehensively addresses oxidative stress‐induced pathophysiological periodontitis through antioxidant activity, maintenance, modulation mechanisms, described. For material design logic, functionally complementary Au CeO formed an excellent photothermally regulated high‐efficiency also provided ideal drug carrier for DMF. As ‐DMF restores dysregulation, contributes endogenous ROS elimination, thereby achieving stable In rat model, photothermal therapy effectively alleviated ROS‐induced tissue damage restored homeostasis. Altogether, this study presents novel nanozyme managing alveolar bone under prolonged demonstrates importance comprehensive intervention key design.

Language: Английский

Quercetin‐Loaded Bioglass Injectable Hydrogel Promotes m6A Alteration of Per1 to Alleviate Oxidative Stress for Periodontal Bone Defects DOI Creative Commons

Huimin Zhu,

Chao Cai,

Yeke Yu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)

Published: May 15, 2024

Abstract Periodontal disease ranks third among noncommunicable illnesses, behind cancer and cardiovascular disease, is closely related to the occurrence progression of various systemic diseases. However, elucidating processes periodontal promoting bone regeneration remains a challenge. Here, quercetin demonstrated reduce oxidative stress state orofacial mesenchymal stem cells (OMSCs) in vitro affect osteogenic growth OMSCs through molecular mechanisms that mediate m6A change Per1. Nevertheless, limited therapeutic efficacy medication limitations local resulting from small, moist, highly dynamic environment make it challenging treat tissues with medication. Herein, biosafe injectable hydrogel drug‐controlled delivery system constructed as bone‐enhancing factory loaded injury tissues. This drug‐carrying made up nanoscale bioglass microspheres light‐cured hydrogel, allows effective drug particle loading cementation moist environment. Furthermore, demonstrates ability stimulate differentiation Per1‐dependent manner, which ultimately promotes repair, suggesting this has potential for clinical therapy.

Language: Английский

Citations

13
Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies DOI Creative Commons

N. Li,

Jinyu Wang,

Guangxia Feng

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing repair regeneration bone defects. Numerous characteristics should be noticed repair, such as irregular morphology defects, homeostasis between hosts microorganisms cavity complex periodontal structures that facilitate epithelial ingrowth. Therefore, necessitates restoration materials adhere to stringent specific demands. This review starts exploring these particular requirements by introducing bones then summarizes classifications current respect composition structure. Additionally, we discuss modifications including improving mechanical properties, optimizing surface topography pore adding bioactive components elements, compounds, cells their derivatives. Ultimately, organize a range potential optimization strategies future perspectives for enhancing materials, physical environment manipulation, microbial modulation, osteo-immune regulation, smart stimuli-responsive multifaceted approach poly-pathic treatment, hope providing some insights researchers this field. In summary, analyzes demands especially alveolar bone, concludes corresponding biomaterials aims inspire research pursuit more effective treatment outcomes.

Language: Английский

Citations

6
Injectable hydrogels with ROS-triggered drug release enable the co-delivery of antibacterial agent and anti-inflammatory nanoparticle for periodontitis treatment DOI Creative Commons

Yujing Zhu,

Z.Y. Xiu,

Xingyu Jiang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 12, 2025

Periodontitis, a chronic inflammatory disease caused by bacteria, is characterized localized reactive oxygen species (ROS) accumulation, leading to an response, which in turn leads the destruction of periodontal supporting tissues. Therefore, antibacterial, scavenging ROS, reducing regulating microenvironment, and alleviating alveolar bone resorption are effective methods treat periodontitis. In this study, we developed ROS-responsive injectable hydrogel modifying hyaluronic acid with 3-amino phenylboronic (PBA) reacting it poly(vinyl alcohol) (PVA) form borate bond. addition, encapsulated antibacterial agent minocycline hydrochloride (MH) Fe-Quercetin anti-inflammatory nanoparticles (Fe-Que NPs) for on-demand drug release response periodontitis microenvironment. This (HP-PVA@MH/Fe-Que) exhibited highly properties. Moreover, modulating Nrf2/NF-κB pathway, effectively eliminated ROS promoted macrophage polarization M2 phenotype, inflammation enhancing osteogenic differentiation potential human ligament stem cells (hPDLSCs) Animal studies showed that HP-PVA@MH/Fe-Que significantly reduced loss enhanced factor expression killing bacteria inhibiting inflammation. Thus, had efficient ROS-scavenging, anti-inflammatory, resorption-alleviation abilities, showing excellent application healing.

Language: Английский

Citations

0
Enhancing osteogenic properties with gelatin/chitosan hydrogel encapsulating lithium-coated titanium oxide hollow sphere particles loaded with quercetin DOI
Quanpeng Wang,

Liang Zhang

Biomedical Materials, Journal Year: 2025, Volume and Issue: 20(2), P. 025038 - 025038

Published: Jan. 24, 2025

Metallic oxides especially lithium and titanium are well known for their osteogenic properties. When combined in the right proportions, metallic can have an even greater impact. However, releasing ions from lead to oxidative stress, which is harmful cell growth. By reducing we enhance these ions' therapeutic bone-forming In our study, developed a novel combination of oxide coated with release simultaneously. We engineered hollow sphere particles carry quercetin (QC), natural antioxidant. These were then incorporated into gelatin/chitosan-based hydrogel, was further functionalized carbon nanotubes induced conductivity improved mechanical drug experiments, found that QC released steadily contrast control group where mixed hydrogel indicating significance secondary carrier. Additionally, cytotoxicity tests demonstrated importance delivering alongside (Li) ions, as this reduced toxicity enhanced activity. Finally, study showed containing drug-loaded could promote bone formation, evidenced by differentiation studies. This innovative approach holds promise improving non-load-bearing regeneration therapies future.

Language: Английский

Citations

0
Construction of a Microenvironment‐Responsive Antibacterial Hydrogel Packed With Immunomodulatory Carbonized Polymer Dots for Periodontitis Treatment From Multiple Perspectives DOI
Nuo Li, Xiangyu Yan, Mingyue Cheng

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Periodontitis is an increasingly prevalent oral inflammatory disease, whose treatment faces potent challenges because of recurrent bacterial infections, excessive reactive oxygen species (ROS) production, as well unrelenting inflammation‐induced alveolar bone resorption during the pathological process. Herein, we present rational design and construction a multifunctional hydrogel platform composed quaternized chitosan/oxidized dextran (QCS/OD) component with high bactericidal activity immunomodulatory carbonized polymer dots from resveratrol (RSV‐CPDs) for periodontitis treatment. Such RSV‐CPDs@QCS/OD (RCQD) hydrogels exhibit characteristics including shape adaptability, self‐healing properties, pH‐responsibility, enabling it to adapt irregularly shaped periodontal tissues, degrade gradually in mildly acidic microenvironment periodontitis, release RSV‐CPDs controlled manner. Significantly, RCQD can effectively suppress proliferation bacteria alleviate oxidative stress, relieve inflammation via activating Nrf2/NF‐κB signaling pathway, ultimately fostering favorable environment regeneration both soft hard tissue. Overall, this study highlights great potential treating by addressing practical needs tissue regeneration.

Language: Английский

Citations

0
Up-regulation of m6A writer METTL14 inhibits tumorigenesis by suppressing glycolysis in colorectal cancer DOI Creative Commons
Lulu Li, Rong Zhang,

Yongsheng Li

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 20, 2025

Colorectal cancer (CRC) is a common malignant tumor. N6-Methyladenosine (m6A) modification plays an important role in the regulation of glycolysis tumor cells and may be potential target for therapy. The METTL14, m6A writer, CRC was investigated through functional assays including cell viability, colony formation, glycolysis-related measurements (glucose uptake, lactate production, extracellular acidification rate (ECAR) oxygen consumption (OCR)). gene regulated by METTL14 m6A-dependent manner identified using molecular biology techniques. In addition, overexpressing were subcutaneously injected into mice to verify regulatory effect on growth vivo. Our data suggested that up-regulated lines, over-expression suppressed proliferation glycolysis. Meanwhile, ATF2 level significantly binding relationship between further verified. METTL14-m6A participates also tumorigenesis nude mice. Intervention with mediated modifications or its associated protein provide new strategies

Language: Английский

Citations

0
Investor Reactions to Sovereign Debt Restructuring: Empirical Evidence from Sri Lanka DOI
R. M. R. P. Wijesooriya, Sampath Kongahawatte, Miyuki Shehara Peiris

et al.

South Asian Journal of Management, Journal Year: 2025, Volume and Issue: 31(4), P. 7 - 30

Published: Feb. 13, 2025

Language: Английский

Citations

0
Injectable Gypsogenin‐Based Composite Hydrogel Enhances Osteoporotic Bone Regeneration by Alleviating Oxidative Injury via Promoting AMPKα Phosphorylation DOI
Yang Zheng,

Rongtai Sun,

Meichun Han

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Osteoporosis is characterized by an imbalance between osteoblasts and osteoclasts coupling excessive oxidative stress in the bone microenvironment that impairs defect healing increases risk of non‐union. In this study, injectable gypsogenin (GN)‐based organic–inorganic composite hydrogel (CCT/nHA@GN) developed to treat osteoporotic defects. The made grafting sodium citrate (SC) nano‐hydroxyapatite (nHA)/GN nanoparticles onto carboxymethylated chitosan (CMCS). GN a natural small‐molecule saponin, which shows biocompatibility anti‐oxidant properties. resulting well‐defined porous structure, favorable degradability, controlled drug‐release properties, suitable rheological characteristics. Importantly, it reverses differentiation fate marrow‐derived mesenchymal stem cells (BMSCs) from patients promotes angiogenesis human umbilical vein endothelial (HUVECs). Furthermore, activates AMPKα‐FOXO3a‐CAT/MnSOD signaling pathway via AMPKα phosphorylation, thereby augmenting antioxidant capacity, promoting osteogenesis, inhibiting osteoclastogenesis, ultimately rectifying disrupted microenvironment. vivo studies reveal volume total (BV/TV) ratio bones regenerated with CCT/nHA@GN 2.85 times higher than control group. conclusion, these findings suggest can be promising alternative material for treatment

Language: Английский

Citations

0
Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration DOI Creative Commons
Xiao Wang, Jia Zeng, Donglin Gan

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)

Published: Nov. 27, 2024

Abstract Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics regeneration. However, the widespread application of bioactive is limited by their low accumulation and short half-lives in vivo. Hydrogels emerged as ideal carriers to address these challenges, offering potential prolong retention times at lesion sites, extend vivo mitigate side effects, avoid burst release, promote adsorption under physiological conditions. This review systematically summarizes recent advances development molecule-loaded hydrogels regeneration, encompassing applications cranial defect repair, femoral periodontal regeneration with underlying diseases. Additionally, this discusses current strategies aimed improving release profiles through stimuli-responsive delivery, carrier-assisted sequential delivery. Finally, elucidates existing challenges future directions hydrogel encapsulated field

Language: Английский

Citations

3
Global research trends of nanomaterials application in periodontitis and peri-implantitis: a bibliometric analysis DOI Creative Commons

Chongqing Yu,

Dan Zheng,

Chi Xu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36187 - e36187

Published: Aug. 1, 2024

The application of nanomaterials (NMs) in the treatment periodontitis and peri-implantitis has shown multifunctional benefits, such as antibacterial properties, immune regulation, promotion osteogenesis. However, a comprehensive bibliometric analysis to evaluate global scientific production this field not yet been conducted.

Language: Английский

Citations

1