A Forward Vision for Chemodynamic Therapy: Issues and Opportunities

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(7)

Published: Jan. 17, 2023

Abstract Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in field chemodynamic therapy (CDT). However, exact mechanism CDT is obscured by unique tumor chemical environment inevitable nanoparticle‐cell interactions, thus impeding further development. In this Scientific Perspective, significance clarified, complex deconstructed primitive biological research directions based on kinetics signaling pathways are discussed detail. Moreover, beneficial outlooks presented enlighten evolution next‐generation CDT. Hopefully, Perspective can inspire new ideas advances for provide a reference breaking down interdisciplinary barriers nanomedicine.

Language: Английский

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Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 11(2)

Published: Nov. 9, 2021

Abstract Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy, and photothermal are developed used to treat different types of cancer. Recently, chemodynamic therapy (CDT) has been emerged as a novel cancer therapeutic strategy. CDT utilizes Fenton or Fenton‐like reaction generate highly cytotoxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O ) kill cells, which displays promising potentials for treatment. However, the low catalytic efficiency off‐target side effects limit biomedical application CDT. In this regard, various strategies implemented potentiate against tumor, retrofitting microenvironment (e.g., increasing H level, decreasing reductive substances, reducing pH), enhancing nanocatalysts, other strategies. This review aims summarize development these recent progresses nanocatalyst‐mediated antitumor application. The future trend challenges also discussed.

Language: Английский

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Piezotronic Effect-Augmented Cu_2–xO–BaTiO₃ Sonosensitizers for Multifunctional Cancer Dynamic Therapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9304 - 9316

Published: June 14, 2022

Ultrasound (US)-triggered sonodynamic therapy (SDT) based on semiconductor nanomaterials has attracted considerable attention for cancer therapy. However, most inorganic sonosensitizers suffer from low efficiency due to the rapid recombination of electron-hole pairs. Herein, Cu2-xO-BaTiO3 piezoelectric heterostructure was fabricated as a sonosensitizer and chemodynamic agent, simultaneously, improving reactive oxygen species (ROS) generation therapeutic outcome. Under US irradiation, heterojunction with piezotronic effect exhibits high-performance singlet (1O2) hydroxyl radical (•OH) enhance SDT. Moreover, it possesses Fenton-like reaction activity convert endogenous H2O2 into •OH (CDT). The integration SDT CDT substantially boosts ROS cellular mitochondria damage, in vitro vivo results demonstrate high cytotoxicity tumor inhibition murine refractory breast cancer. This work realizes improvement using heterostructures effects.

Language: Английский

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Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 3647 - 3663

Published: March 10, 2022

The nanocatalytic activity of nanozymes provides a vision for tumor treatment. However, the glutathione (GSH)-related antioxidant defense system (ADS) formed on basis excessive GSH in microenvironment limits its catalytic activity. Here, dendritic mesoporous silica nanoparticles (DMSNs) were employed as nanocarrier; ultrasmall Fe3O4 nanoparticles, Mn2+ ions, and glutaminase inhibitor Telaglenastat (CB-839) subsequently integrated into large mesopores DMSNs, forming DMSN/Fe3O4–Mn@CB-839 (DFMC) nanomedicine. This nanomedicine exhibits peroxidase mimicking activities under acidic conditions, which catalyzes decomposition hydrogen peroxide (H2O2) hydroxyl radical (•OH). also promotes formation lipid peroxides, is required ferroptosis. Furthermore, this can effectively deplete existing GSH, thereby enhancing reactive oxygen species (ROS)-mediated therapy. Moreover, introduced CB-839 blocks endogenous synthesis further depletion performance, reduces excretion oxaliplatin (GSH-related resistance) from cells, restoring chemical sensitivity oxaliplatin. dual property significantly weakens GSH-related ADS restores oxaliplatin, leading to high DFMC-induced apoptosis ferroptosis cells. Our developed based nanotechnology clinical drug may aid development

Language: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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Ceria‐Based Therapeutic Antioxidants for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 16, 2023

Abstract The growing interest in nanomedicine over the last 20 years has carved out a research field called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are employed to intervene disease‐critical biomolecular processes. Among many kinds of catalytic/enzyme‐mimetic investigated thus far, ceria nanoparticles stand from others owing their unique scavenging properties against biologically noxious free radicals, including reactive oxygen species (ROS) and nitrogen (RNS), exerting enzyme mimicry nonenzymatic activities. Much effort been made utilize as self‐regenerating antioxidative anti‐inflammatory agents for various diseases, given detrimental effects ROS RNS therein that need alleviation. In this context, review is intended provide an overview what makes merit attention disease therapy. introductory part describes characteristics oxygen‐deficient metal oxide. pathophysiological roles then presented, well mechanisms nanoparticles. Representative examples recent ceria‐nanoparticle‐based therapeutics summarized categorization into organ types, followed discussion on remaining challenges future directions.

Language: Английский

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Oxygen‐Vacancy‐Rich Piezoelectric BiO_2−x Nanosheets for Augmented Piezocatalytic, Sonothermal, and Enzymatic Therapies

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(29)

Published: April 14, 2023

Abstract Piezocatalytic therapy is a new‐emerging reactive oxygen species (ROS)‐enabled therapeutic strategy that relies on built‐in electric field and energy‐band bending of piezoelectric materials activated by ultrasound (US) irradiation. Despite becoming hot topic, material development mechanism exploration are still underway. Herein, as‐synthesized oxygen‐vacancy‐rich BiO 2− x nanosheets (NSs) demonstrate outstanding properties. Under US, piezo‐potential 0.25 V for NSs sufficient to tilt the conduction band be more negative than redox potentials O 2 / • − , /H H OH, which initiates cascade reaction ROS generation. Moreover, exhibit peroxidase oxidase‐like activities augment production, especially in ‐overexpressed tumor microenvironment. Density functional theory calculations show generated vacancies favorable adsorption increasing carrier density produce ROS. Furthermore, quick movement electrons enables an excellent sonothermal effect, example, rapid rise temperature nearly 65 °C upon US with low power (1.2 W cm −2 ) short time (96 s). Therefore, this system realizes multimode synergistic combination piezocatalytic, enzymatic, therapies, providing new direction defect engineering‐optimized therapy.

Language: Английский

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Nanomaterials-modulated Fenton reactions: Strategies, chemodynamic therapy and future trends

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 466, P. 142960 - 142960

Published: April 15, 2023

Language: Английский

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Reactive oxygen species-powered cancer immunotherapy: Current status and challenges

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 356, P. 623 - 648

Published: March 21, 2023

Language: Английский

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Ferritin‐Hijacking Nanoparticles Spatiotemporally Directing Endogenous Ferroptosis for Synergistic Anticancer Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(51)

Published: Oct. 10, 2022

Abstract Existing ferroptosis as an iron‐dependent form of regulated cell death primarily relies on importing exogenous iron. However, the excessive employment toxic materials may cause potential adverse effects human health. Herein, a ferritin‐hijacking nanoparticle (Ce6‐PEG‐HKN 15 ) is fabricated, by conjugating ferritin‐homing peptide HKN with photosensitizer chlorin e6 (Ce6) for endogenous without introducing Fenton‐reactive metals. Once internalized, designed Ce6‐PEG‐HKN NPs can specifically accumulate around ferritin. With laser irradiation, activated Ce6 in nanoparticles potently generates reactive oxygen species (ROS) surrounding Abundant ROS not only helps to destroy iron storage protein and activate but also directly kill tumor cells. In turn, released partially interacts intracellular excess H 2 O produce , thereby enhancing photodynamic therapy further amplifying oxidative stress. Overall, this work highlights possibility via spatiotemporally destroying ferritin, offering paradigm synergistic ferroptosis–photodynamic antitumor therapy.

Language: Английский

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