Two-mode sensing strategies based on tunable cobalt metal organic framework active sites to detect Hg2+

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 465, P. 133424 - 133424

Published: Jan. 4, 2024

Language: Английский

---

Multi-site isomerization of synergistically regulated stimuli-responsive AIE materials toward multi-level decryption

Chemical Science, Journal Year: 2024, Volume and Issue: 15(11), P. 3920 - 3927

Published: Jan. 1, 2024

Stimuli-responsive aggregation-induced emission (AIE) materials are highly sensitive and rapidly responsive to external signals, making them ideal solid for anti-counterfeiting encryption. However, the limited conformational packing variations resulting from regio-isomerization with a single substituent restricts stimuli-responsive behavior of these materials. In this work, several AIE-active regio-structural isomers based on salicylaldehyde Schiff base scaffold have been straightforwardly obtained through multiple substitutions bromide triphenylamine moieties. Solvent-effect experiments demonstrate their different orders charge-transfer excited-state intramolecular proton transfer upon photoexcitation, indicating regulation processes via multi-site isomerization. These also mechanochromism acidichromism, allowing adjustable effects. As demonstration, p-Br-TPA both acidichromism can be synergistically utilized multi-level decryption. This study successfully regulates evolution excited states isomerization, offering general approach achieving tunable properties in bases toward

Language: Английский

---

Molecular design and architectonics towards film-based fluorescent sensing

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(13), P. 6960 - 6991

Published: Jan. 1, 2024

This review meticulously traces the development of film-based fluorescent sensors, spotlighting key advancements in molecular design and film structural engineering.

Language: Английский

---

Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 31, 2024

Abstract Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together non‐ideal solvents or within solid matrix. Since the concept of AIE was first introduced 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and life sciences. Of particular note growing interest application systems with near‐infrared (NIR) emissive feature field biomedicine, encompassing detection, imaging, therapeutic interventions. Notably, bibliometric analysis serves as valuable tool to provide researchers comprehensive understanding research achievements developmental trends fields, which crucial for academic research. Herein, we present general overview spanning two decades NIR‐AIE development. With assistance core scientific databases software tools, conducted systematic annual publications citations, most influential countries/regions, leading authors, journals, institutions, well hot topics related NIR forward‐looking predictions. Furthermore, properties biomedical also systematically reviewed.

Language: Английский

---

Enzyme‐Mediated In Situ Self‐Assembly AIE Probes: Mapping the Distribution of Acetylcholinesterase in Aging Mice Brain

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Acetylcholinesterase (AChE) exhibits profound association with the underlying pathological mechanisms of aging‐related disorders. However, revealing spatial distribution AChE among whole‐brain remains an uncharted territory, posing a substantial challenge. Herein, dual regulation strategy to obtain aggregation‐induced emission (AIE)‐activable probe for high‐fidility mapping in brain is proposed. The well‐tailored (AChE‐QM‐2) consists four components: AChE‐specific cleavage unit (dimethylcarbamate), self‐immolative linker ( p ‐hydroxybenzyl alcohol), AIE framework (Py‐QM), and electron‐donor group (EDG). hydrophilic pyridine salt AChE‐QM‐2 improves its dispersity, collaborating EDG lower Δ E S1‐T1 HOMO‐LUMO energy gap, resulting reduced fluorescence quantum yield Φ f ) initial off‐fluorescence state. Moreover, optimizing EDGs further enhance probe's responsive performance extend wavelength. Upon AChE‐activization, undergoes deionization, molecule aggregation increased , triggering amplified signal. has successfully realized monitoring endogenous PC12 cells, tissues living mice. Furthermore, utilizing light‐sheet microscopy, intracranial AChE, providing highly specialized visualization localization within brain, achieved first time. This study satisfactorily demonstrates valuable designing ultra‐sensitive enzymatic probes, highlighting their potential precise analysis fundamental life science research.

Language: Английский

---

A rapid and specific fluorescent probe based on aggregation-induced emission enhancement for mercury ion detection in living systems

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 465, P. 133331 - 133331

Published: Dec. 21, 2023

Language: Английский

---

Fluorogenic Reactions in Chemical Biology: Seeing Chemistry in Cells

Chemical & Biomedical Imaging, Journal Year: 2023, Volume and Issue: 1(7), P. 590 - 619

Published: May 30, 2023

Among the recent development of click chemistry and bioorthogonal chemistry, fluorogenic reactions occupy a unique place in that fluorescence is generated from nonfluorescent reactants, thereby rendering them highly useful convenient no-wash live-cell imaging. This topic was extensively reviewed 2010 by Wang et al. ( Chem. Soc. Rev. 2010, 39, 1233−1239) 2014 Lin Curr. Opin. Biol. 2014, 21, 89−95). review presents comprehensive up-to-date overview on past decade. The are classified into four major categories basis mechanisms generation. Representative examples each type discussed briefly terms structure, mechanism, advantages. We describe latest applications chemical biology. In end, future opportunities challenges this field tentatively proposed.

Language: Английский

---

Revealing Mitochondrion–Lysosome Dynamic Interactions and pH Variations in Live Cells with a pH-Sensitive Fluorescent Probe

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(45), P. 16609 - 16617

Published: Nov. 2, 2023

Mitochondrion–lysosome interactions have garnered significant attention in recent research. Numerous studies shown that mitochondrion–lysosome interactions, including contact (MLC) and mitophagy, are involved various biological processes pathological conditions. Single fluorescent probes termed a pivotal chemical tool unraveling the intricate spatiotemporal interorganelle interplay live cells. However, current tools insufficient to deeply understand dynamic related diseases, Moreover, rational design of dual-targeting is intractable. Herein, we designed synthesized pH-sensitive probe called INSA, which could simultaneously light up mitochondria (red emission) lysosomes (green for their internal pH differences. Employing successfully recorded long-term between mitochondria. More importantly, increasing ferroptotic cells were also revealed by INSA. Further, observed variations during ferroptosis first time. In brief, this work not only introduced INSA disclosure interplays but pioneered visualization organellar alternation specific disease model.

Language: Английский

---

Hybrid Encoding Strategy of Multi-Stimulus Response Aggregation-Induced Emission Hydrogels for Advanced Information Encryption and Safety

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(2), P. 1422 - 1428

Published: Jan. 9, 2024

Optical information encryption is closely related to security, and smart hydrogels with tunable optical properties under external stimuli have received much attention as storage materials. However, it still challenging achieve complex camouflage large-capacity in hydrogel systems. Herein, a hybrid encoding strategy afforded by an aggregation-induced emission (AIE) fluorescent multi-stimuli responsiveness pioneered feasible alternative for multiple strategies. More specifically, the photoluminescence intensity of system can be independently or mutually tuned specific stimuli, including solvent (DMSO/H2O), pH (NaOH/HCl), metal ions (Fe3+/EDTA2–), leading precise protection decoding encrypted information. That is, only correct stimulus sequence unlock stored real information, thus enabling functionality multilayer on-demand decryption We envisage that present carrying showcasing AIE through stimulation regulation exhibits great potential secure writing anticounterfeit encryption.

Language: Английский

---

Two AIE-Ligand-Based 2-D Luminescent Metal–Organic Frameworks as Fe³⁺ Sensors

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(18), P. 8342 - 8350

Published: April 19, 2024

The design and synthesis of high-performance sensors are very important but remain great challenges. In this work, a new aggregation-induced-emission (AIE) molecule 4,4′-(((9H-fluoren-9-ylidene)methylene)bis(4,1-phenylene))dipyridine (L) was successfully synthesized first developed as functional ligand to construct two isomorphic metal–organic frameworks (MOFs) [M(L)(OBBA)]n [M2+ = Cd2+ (1), Co2+ (2); H2OBBA 4,4′-oxybisbenzoic acid]. They adopt [M2(COO)4] flywheel clusters, OBBA2– bridges, terminal L ligands building units form 2-D networks with Lewis base active cites (uncoordinated pyridyl N). Both 1 2 exhibit excellent water, pH, thermal stabilities extremely efficient Fe3+ sensing abilities in the water environment. quenching constants detection limits reach best levels reported so far. mechanism toward is studied depth, difference their performance also explained.

Language: Английский

---