Chemical Physics Impact,
Journal Year:
2024,
Volume and Issue:
9, P. 100682 - 100682
Published: July 10, 2024
Protein-based
biomaterials
such
as
thin
films
have
an
edge
over
synthetic
and
bio-based
polymers,
due
to
their
biodegradability
in
addition
other
interesting
properties.
Proteins
can
be
utilized
create
materials
with
specific
functional
characteristics.
We
report
the
preparation
of
transparent
human
serum
albumin
presence
CTAB-capped
gold
nanorods
different
compositions
protein
well
plasticizer
i.e.,
sorbitol.
The
mechanical
properties,
surface
topology,
morphology,
molecular
structure,
moisture
content,
total
soluble
material,
biodegradability,
antibacterial
activity
optical
properties
been
investigated.
Gold
act
crosslinkers
sorbitol
a
increases
plasticity
hardness
films.
deposited
are
biodegradable,
water
flexible
nature.
AFM
images
reveal
pattern
on
average
heights
increase
roughness
NINT
studies
show
increased
elastic
modulus
same
amount
but
higher
amounts
protein.
Fourier
Transform
Infrared
spectroscopy
indicate
change
structure
films,
terms
hydrogen
bonding
network
that
impacts
content
Most
importantly
property,
modulated
by
composition
used.
features
enhanced
pave
path
for
potential
applications
study
shows
optimization
is
crucial
achieve
desired
film
material
required
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(9), P. 5916 - 5926
Published: Feb. 21, 2024
Investigation
of
charge
transfer
needs
analytical
tools
that
could
reveal
this
phenomenon,
and
enables
understanding
its
effect
at
the
molecular
level.
Here,
we
show
how
combination
using
gold
nanoclusters
(AuNCs)
different
spectroscopic
techniques
be
employed
to
investigate
thiolated
molecules
on
nanoparticles
(AuNP@Mol).
It
was
found
in
molecule
affected
by
AuNCs,
evidenced
amplification
surface-enhanced
Raman
scattering
(SERS)
signal
changes
fluorescence
lifetime
AuNCs.
Density
functional
theory
(DFT)
calculations
further
revealed
AuNCs
amplify
process
level
pumping
electrons
surface
AuNPs.
Finite
element
method
(FEM)
simulations
also
showed
electromagnetic
enhancement
mechanism
along
with
chemical
determines
SERS
improvement
molecule.
This
study
provides
a
mechanistic
insight
into
investigation
between
organic
inorganic
compounds,
which
is
great
importance
designing
new
nanocomposite
systems.
Additionally,
work
demonstrates
potential
as
powerful
tool
used
nanochemistry,
material
science,
energy,
biomedical
fields.
Journal of Molecular Liquids,
Journal Year:
2024,
Volume and Issue:
398, P. 124240 - 124240
Published: Feb. 11, 2024
In
the
biological
milieu,
nanoparticles
(NPs)
interact
with
different
biomolecules,
particularly
proteins,
leading
to
formation
of
an
interfacial
corona,
which
gives
rise
a
new
identity
affecting
NP
biodistribution,
cytotoxicity
and
fate.
The
surface
coating
NPs
plays
key
role
in
regulating
such
biocorona
composition.
We
here
investigated
interactions
between
bovine
serum
albumin
(BSA)
fibrinogen
(FIB)
gold
nanorods
(Au
NRs)
bearing
coatings
(cetyltrimethylammonium
bromide,
CTAB,
carboxylic
acid
amine-terminated
polyethylene
glycols
(PEGs).
It
was
revealed
that
CTAB-coated
both
proteins
high
affinity
(ca.
108-109
M−1)
whereas
for
PEG
ones
extent
protein
binding
decreases
thanks
stealth
properties
PEG,
but
corona
is
still
formed,
affinities
104-106
M−1.
addition,
present
results
indicated
thicknesses
coronas
aggregation
behavior
AuNPs
were
closely
related
their
structure.
also
found
BSA
FIB
underwent
conformational
changes
upon
adsorption
depending
on
surface-modified
Au
NRs.
Hence,
these
findings
offered
important
insights
into
essence
toward
development
safe
effective
nanomaterials.
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(3)
Published: Jan. 4, 2024
Abstract
Polymer‐coated
nanoparticles
are
widely
studied
in
the
context
of
nanomedicine
and
it
is
therefore
utmost
importance
to
understand
not
only
how
their
structure
but
also
colloidal
dynamics
affected
by
physiologically
relevant
conditions.
A
characteristic
feature
cytosol
cells
very
high
concentration
proteins
among
other
matrix
components,
often
termed
macromolecular
crowding.
Here,
poly(ethylene
glycol)
(PEG)‐coated
gold
presence
bovine
serum
albumin
(BSA)
concentrations
ranging
from
0
265
mg/mL
with
X‐ray
photon
correlation
spectroscopy.
For
protein–nanoparticle
mixtures
BSA
concentrations,
comparable
intracellular
levels,
a
significant
deviation
apparent
viscosity
expectations
for
pure
solutions
found.
The
findings
strongly
indicate
that
nanoscopic
viscous
properties
dense
protein
significantly
nanoparticles.
At
these
stability
samples
depends
on
molecular
weight
coating
PEG–ligand,
whereas
at
lower
no
differences
observed.
Enumeration
and
phenotypic
profiling
of
circulating
tumor
cells
(CTCs)
provide
critical
information
for
clinical
diagnosis
treatment
monitoring
in
cancer.
To
achieve
this
goal,
an
integrated
system
is
needed
to
efficiently
isolate
CTCs
from
patient
samples
sensitively
evaluate
their
phenotypes.
Such
integration
would
comprise
a
high-throughput
single-cell
processing
unit
the
isolation
manipulation
sensitive
multiplexed
quantitation
detect
clinically
relevant
signals
these
cells.
Surface-enhanced
Raman
scattering
(SERS)
has
been
used
as
analytical
method
molecular
vitro
cancer
diagnosis.
More
recently,
its
multiplexing
capability
power
create
distinct
signatures
against
targets
have
garnered
attention.
Here,
we
share
our
insights
into
combined
microfluidics
SERS
realizing
CTC
isolation,
enumeration,
detection
translation
perspective.
We
highlight
key
operational
factors
microfluidic
samples.
further
discuss
microfluidic-SERS
utility
paradigm
shift
CTC-based
prognostication.
Finally,
summarize
challenges
attempt
look
forward
what
lies
ahead
us
potentially
translating
technique
real
applications.
Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(10), P. 291 - 291
Published: Sept. 30, 2024
Gold
nanoparticles
(AuNPs)
have
gained
significant
attention
in
the
biomedical
field
owing
to
their
versatile
properties.
AuNPs
can
be
customized
by
modifying
size,
shape
and
surface
characteristics.
In
recent
years,
extensive
research
has
explored
integration
of
into
various
dental
materials,
including
titanium,
polymethylmethacrylate
(PMMA)
resin
composites.
This
review
aims
summarize
advancements
application
modified
materials
assess
effects
on
related
cellular
processes
field.
Relevant
articles
published
English
association
with
were
identified
through
a
systematic
search
PubMed/MEDLINE,
Embase,
Scopus
ScienceDirect
databases
from
January
2014
April
2024.
Future
prospects
for
utilization
dentistry
are
surveyed.
The Analyst,
Journal Year:
2024,
Volume and Issue:
149(6), P. 1774 - 1783
Published: Jan. 1, 2024
Surface-enhanced
Raman
scattering
(SERS)
nanotags
functionalized
with
lectins
as
the
biological
recognition
element
can
be
used
to
target
carbohydrate
portion
of
carbohydrate-carrying
molecules
(glycoconjugates).
Advanced Optical Materials,
Journal Year:
2024,
Volume and Issue:
12(28)
Published: July 31, 2024
Abstract
Over
the
past
three
decades,
plasmonic
nanostructures,
particularly
spherical
ones,
have
seen
remarkable
advancements.
Recently,
attention
has
shifted
toward
anisotropic
nanoparticles,
especially
star‐shaped/branched
structures
such
as
nanostars
(PNS),
due
to
their
distinct
properties.
PNS
offers
superior
electromagnetic
enhancement
effects,
larger
surface
areas,
and
well
non‐linear
unusual
photothermal
properties,
setting
them
apart
from
counterparts.
Despite
significant
progress
in
synthetic
methods
characterization
of
particles,
challenges
remain
transitioning
technology
into
practical
use.
In
this
perspective
article,
distinctive
attributes
biosensing
applications
are
discussed,
beginning
with
an
exploration
synthesis
methodologies.
Their
optoelectronic
properties
examined
discussed
how
these
influence
interaction
different
molecules
a
perspective.
With
focus
on
PNS,
detailed
insights
offered
unique
current
applications,
future
potential.
By
fostering
discussion
understanding
development,
article
aims
facilitate
translation
encouraging
targeted
improvements
