Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(29)
Published: June 25, 2024
Emerging
infectious
diseases
like
coronavirus
pneumonia
(COVID-19)
present
significant
challenges
to
global
health,
extensively
affecting
both
human
society
and
the
economy.
Extracellular
vesicles
(EVs)
have
demonstrated
remarkable
potential
as
crucial
biomedical
tools
for
COVID-19
diagnosis
treatment.
However,
due
limitations
in
performance
titer
of
natural
vesicles,
their
clinical
use
remains
limited.
Nonetheless,
EV-inspired
strategies
are
gaining
increasing
attention.
Notably,
biomimetic
inspired
by
EVs,
possess
specific
receptors
that
can
act
"Trojan
horses,"
preventing
virus
from
infecting
host
cells.
Genetic
engineering
enhance
these
enabling
them
carry
more
receptors,
significantly
specificity
absorbing
novel
coronavirus.
Additionally,
inherit
numerous
cytokine
parent
cells,
allowing
effectively
mitigate
"cytokine
storm"
adsorbing
pro-inflammatory
cytokines.
Overall,
this
strategy
offers
new
avenues
treatment
emerging
diseases.
Herein,
review
systematically
summarizes
current
applications
COVID-19.
The
status
associated
with
implementation
also
discussed.
goal
is
provide
insights
into
design
expand
application
combating
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(4), P. 4478 - 4492
Published: Jan. 19, 2024
Small-molecule
dyes
for
fluorescence
imaging
in
the
second
near-infrared
region
(NIR-II,
900-1880
nm)
hold
great
promise
clinical
applications.
Constructing
donor-acceptor-donor
(D-A-D)
architectures
has
been
recognized
to
be
a
feasible
strategy
achieve
NIR-II
fluorescence.
However,
development
of
via
such
scheme
is
hampered
by
lack
high-performance
electron
acceptors
and
donors.
Diketopyrrolopyrrole
(DPP),
as
classic
organic
optoelectronic
material,
enjoys
strong
light
absorption,
high
quantum
yield
(QY),
facile
derivatization.
Nevertheless,
its
application
field
hindered
limited
electron-withdrawing
ability
aggregation-caused
quenching
(ACQ)
effect
resulting
from
planar
structure
DPP.
Herein,
with
DPP
an
acceptor
through
donor
engineering,
we
have
successfully
designed
synthesized
DPP-based
dye
named
T-27,
which
D-A
interaction
confers
excellent
NIR
absorption
high-brightness
tail
emission.
By
strategically
introducing
long
alkyl
chains
on
unit
increase
intermolecular
spacing
reduce
influence
solvent
molecules,
T-27
exhibits
improved
anti-ACQ
aqueous
solutions.
After
being
encapsulated
into
DSPE-PEG2000,
nanoparticles
(NPs)
show
relative
QY
3.4%
water,
representing
highest
value
among
reported
date.
The
outstanding
photophysical
properties
NPs
enable
multimode
NIR-IIa
bioimaging
under
808
nm
excitation.
As
such,
can
distinguish
mouse
femoral
vein
artery
cerebral
vascular
microscopic
penetrating
depth
800
μm,
demonstrating
capability
high-resolution
deep-tissue
imaging.
This
work
holds
significant
potential
provides
new
developing
bright
dyes.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(17)
Published: March 5, 2024
By
combining
bioimaging
and
photodynamic
therapy
(PDT),
it
is
possible
to
treat
cancer
through
a
theranostic
approach
with
targeted
action
for
minimum
invasiveness
side
effects.
Thermally
activated
delayed
fluorescence
(TADF)
probes
have
gained
recent
interest
in
theranostics
due
their
ability
generate
singlet
oxygen
(
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(2)
Published: Jan. 4, 2024
Abstract
Fluorescence
imaging,
a
key
technique
in
biological
research,
frequently
utilizes
fluorogenic
probes
for
precise
imaging
living
systems.
Tetrazine
is
an
effective
emission
quencher
probe
designs,
which
can
be
selectively
damaged
upon
bioorthogonal
click
reactions,
leading
to
considerable
enhancement.
Despite
significant
efforts
increase
the
enhancement
ratio
(
I
AC
/
BC
)
of
tetrazine‐functionalized
probes,
influence
molecular
aggregation
on
properties
has
been
largely
overlooked
these
designs.
In
this
study,
we
reveal
that
ultrahigh
realized
aggregate
system
when
tetrazine
paired
with
aggregation‐induced
(AIE)
luminogens.
amplifies
its
quenching
efficiency
and
drastically
reduce
background
emissions.
Subsequent
reactions
damage
trigger
AIE,
considerably
enhanced
.
We
further
showcase
capability
ultra‐fluorogenic
systems
selective
multiple
organelles
cells.
term
unique
fluorogenicity
AIE
luminogen‐quencher
complexes
amplified
dark‐bright
states
as
“Matthew
effect”
emission,
potentially
providing
universal
approach
attain
diverse
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 2, 2024
Abstract
Phototheranostics
has
garnered
sustained
attention
due
to
its
significant
potential
for
revolutionizing
conventional
cancer
treatment
strategies.
While
being
one
of
the
most
commonly
employed
strategies
constructing
phototheranostic
systems
by
engineering
integration
photosensitizers
(PSs)
into
nanosystems,
nano‐PSs
face
challenges
including
complexity
in
preparation
process,
low
delivery
efficiency,
and
toxicity
issues.
Contrastingly,
burgeoning
popularity
small
molecule
PSs
characterized
aggregation‐induced
emission
(AIE)
become
evident
arena
phototheranostics.
This
preference
is
underscored
their
well‐defined
structures,
adjustable
photophysical
properties,
toxicity.
Therefore,
acquiring
profound
insights
pioneering
strides
achievable
through
a
solitary
PS
with
AIE
tumor
phototheranostics
paramount
scientific
significance.
In
this
review,
we
will
discuss
recent
progress
properties
diagnosis
phototherapies
representative
examples,
guided
ethos
“Complexity
made
easy”.
We
also
look
forward
future
development
direction
molecules,
central
objective
advancing
research
focal
emphasis
on
simplicity,
expeditiousness,
safety.
FlexMat.,
Journal Year:
2024,
Volume and Issue:
1(2), P. 173 - 192
Published: June 14, 2024
Abstract
Purely
organic
room
temperature
phosphorescence
(RTP)
materials
have
shown
broad
application
prospects
in
light‐emitting
diodes
(OLEDs)
due
to
their
theoretical
100%
exciton
utilization,
cost‐effectiveness,
and
flexibility.
In
recent
years,
with
the
deepening
of
research,
various
luminescent
mechanisms
been
proposed,
RTP
made
significant
progress,
which
effectively
applied
OLEDs.
This
article
comprehensively
reviews
research
progress
OLEDs
introduces
development
a
series
high‐efficiency
from
perspective
molecular
design
strategies
photophysical
properties.
These
conclusions
draw
roadmap
address
inherent
challenges
utilizing
specifically
advance
investigation
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(36), P. 25144 - 25154
Published: Aug. 27, 2024
Near-infrared
II
(NIR-II)
imaging
and
photothermal
therapy
hold
tremendous
potential
in
precision
diagnosis
treatment
within
biological
organisms.
However,
a
significant
challenge
is
the
shortage
of
NIR-II
fluorescent
probes
with
both
high
conversion
coefficient
(PCE)
fluorescence
quantum
yield
(Φ
ACS Nano,
Journal Year:
2025,
Volume and Issue:
19(1), P. 1070 - 1079
Published: Jan. 2, 2025
Deciphering
neuronal
circuits
is
pivotal
for
deepening
our
understanding
of
functions
and
advancing
treatments
neurological
disorders.
Conventional
tracers
suffer
from
restrictions
such
as
limited
penetration
depth,
high
immunogenicity,
inadequacy
long-term
in
vivo
imaging.
In
this
context,
we
introduce
an
aggregation-induced
emission
luminogen
(AIEgen),
MeOTFVP,
engineered
enhanced
tracing
MeOTFVP
strategically
designed
to
target
cell
membranes
by
integrating
into
the
phospholipid
bilayer
through
its
amphipathy.
The
donor–acceptor
molecular
skeleton
facilitates
a
red
shift
photoluminescence
near-infrared
(NIR)
spectrum,
significantly
improving
tissue
penetration.
affinity
membranes,
coupled
with
deep
penetration,
allows
precise
paw-dorsal
root
ganglia
(DRG)
circuit
detailed
imaging
sciatic
nerve.
This
study
showcases
application
dual-function
tracer,
propelling
forward
possibilities
advanced
using
AIEgens.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
25(9), P. 3445 - 3454
Published: Feb. 24, 2025
Glioblastoma
is
the
most
common
and
devastating
brain
tumor
owing
to
its
high
invasiveness
high-frequency
drug
resistance.
Near
infrared-II
(NIR-II)
imaging-guided
phototherapy
based
on
polymer
luminogens
provides
a
promising
remedy
against
drug-resistant
glioma,
but
it
difficult
maximize
photoenergy
utilization.
Herein,
we
designed
series
of
semiconducting
polymers
boost
visualization
ablation
glioblastoma.
By
subtly
engineering
side
chains
or
substituents
phenothiazine
thiophene
moieties,
an
NIR-II
luminogen
with
high-quality
fluorescence
performance,
good
solubility,
superior
photothermal
conversion,
balanced
reactive
oxygen
species
generation
achieved.
The
optimal
possesses
branched
alkyl
chain
tetraphenylethylene
pendant
manipulate
equilibrium
between
radiative
nonradiative
energy-dissipating
channels.
High-sensitivity
imaging
was
used
monitor
blood-brain
barrier
penetration
glioma
cell
targeting
apolipoprotein
E-modified
nanoparticles.
NIR
irradiation
triggers
maximizes
photon
utilization
in
prominent
photodynamic/photothermal
synergistic
therapy
orthotopic
