Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1314, P. 138843 - 138843
Published: June 2, 2024
Language: Английский
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 5, 2024
Language: Английский
Citations
14
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 2, 2024
Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.
Language: Английский
Citations
10
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153395 - 153395
Published: June 22, 2024
Language: Английский
Citations
4
Polyoxometalates, Journal Year: 2025, Volume and Issue: 4(1), P. 9140074 - 9140074
Published: March 1, 2025
In recent years, polyoxometalates have been systematically studied in the treatment of diabetes, tumor, cancer, inflammation and other diseases vitro vivo, their main therapeutic mechanisms are related to generation reactive oxygen species causing oxidative stress. The site production is mitochondria, therefore, mechanism may be mitochondrial biosynthesis. This paper describes one diabetes mellitus, which involves increase species, resulting stress; at same time, preliminarily as antioxidants antitumor mellitus tumors, antioxidant properties provide an additional possibility for future a drug disease treatment; on basis study stress biomolecule due it, associating therapy actually closely through biosynthesis regulation relationship between mitochondria its impact three aspects order in-depth role drugs aspects.
Language: Английский
Citations
0
Journal of Clinical and Translational Hepatology, Journal Year: 2025, Volume and Issue: 000(000), P. 000 - 000
Published: Jan. 2, 2025
Fluorescence navigation is a novel technique for accurately identifying hepatocellular carcinoma (HCC) lesions during hepatectomy, enabling real-time visualization. Indocyanine green-based fluorescence guidance has been commonly used to demarcate HCC lesion boundaries, but it cannot distinguish between benign and malignant liver tumors. This review focused on the clinical applications limitations of indocyanine green, as well recent advances in fluorescent probes fluorescence-guided surgery HCC. It covers traditional imaging such enzymes, reactive oxygen species, sulfur pH-sensitive probes, followed by an introduction aggregation-induced emission probes. Aggregation-induced exhibit strong fluorescence, low background signals, excellent biocompatibility, high photostability aggregate state, show no dilute solutions. Design strategies these may offer insights developing identification surgery.
Language: Английский
Citations
0
Aggregate, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
ABSTRACT The aberrant behavior of lipid droplets (LDs) is often indicative cellular dysfunction, which may contribute to the development a range diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and atherosclerosis (AS). Consequently, there an urgent need develop fluorescence probes targeting LDs monitor progression disease. In this study, unanticipated one‐pot boron tribromide (BBr₃)/boron trichloride (BCl₃)‐promoted cyclization reaction was discovered, yielding bromo‐/chloro‐substituted triphenylamine (TPA) derivative ( TPA‐Br / TPA‐Cl ). successfully transformed into new TPA‐containing donor‐acceptor (D–A) molecules show typical aggregation induced emission (AIE) property. Among these AIE emitters, TPA‐N shows most promising specificity, lowest toxicity best photo‐stability. Ex vivo studies further demonstrate that can be used image fatty AS plaque quickly effectively.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101564 - 101564
Published: Feb. 8, 2025
Therapeutic resistance is a major challenge in clinical cancer theranostics, often leading to treatment failure and increased patient mortality. Breaking this therapeutic deadlock, enhancing the efficacy of treatments, ultimately improving survival rates are both highly desirable significantly challenging goals. Herein, we have developed new fluorescent luminogen, QM-DMAC, which features aggregation-induced emission (AIE), exceptional viscosity-responsive properties. The AIE-active QM-DMAC can specifically stain lysosomes tumor cells, offering high signal-to-noise ratio enabling specific visualization variations lysosomal viscosity, such as those induced by inflammation or autophagy. Furthermore, effectively generates reactive oxygen species (ROS) under white light irradiation, precisely induces ROS-mediated membrane permeabilization (LMP) lysosome rupture. This causes severe cell damage restores sensitivity cells radiotherapy chemotherapy. Thus, serves efficient lysosome-targeting photosensitizer an excellent sensitizer. innovative "lysosome hijacking" strategy maximizes photodynamic therapy, conquering boosting synergistic effect when integrated with conventional It provides novel approach design theranostic agents for theranostics.
Language: Английский
Citations
0
Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112720 - 112720
Published: Feb. 1, 2025
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 23, 2025
Abstract Photodynamic immunotherapy presents a non‐invasive strategy characterized by spatiotemporal control and minimal side effects to induce immunogenic cell death (ICD). This approach significantly enhances the release of tumor‐associated antigens damage‐associated molecular patterns, thereby improving cancer outcomes. However, hypoxia antioxidant defenses at tumor sites considerably diminish efficacy photodynamic immunotherapy. In this work, covalent warhead, alkyneamide, is introduced into an AIE photosensitizer develop novel photosensitizer, MBTP‐PA, which targets redox systems facilitates ferroptosis‐ pyroptosis‐mediated thiol‐yne click reactions. The interacts with intracellular thiol compounds such as cysteine glutathione, disrupting system alleviating hypoxia. results in enhanced therapy (PDT) compared non‐covalent MBTP‐A. Furthermore, conjunction PDT, reaction can activate ICD through ferroptosis pyroptosis, enhancing anti‐tumor immunity. Notably, vivo injection MBTP‐PA nanoparticles site led elimination primary tumors, inhibiting distal tumors exhibiting effects. Therefore, work not only integrates reactions cellular systems, but also paves way for developing photosensitizers.
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137190 - 137190
Published: March 7, 2025
Language: Английский
Citations
0