Phosphorescent Sensor Based on Iridium(III) Complex with Aggregation-Induced Emission Activity for Facile Detection of Volatile Acids DOI Creative Commons
Yutao Pei, Yan Sun, Dongxia Zhu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6041 - 6041

Published: Dec. 22, 2024

Phosphorescent sensors are essential for rapid visual sensing of volatile acids, due to their profound impact on ecosystems and human health. However, solid phosphorescent materials acid-base stimulus response still rare, it is important achieve real-time monitoring acids. In order obtain an efficient acid stimulation, N-H -NH2 substituents introduced into auxiliary ligand synthesize a new cationic Ir(III) complex (Ir-NH). The AIE property Ir-NH leads enhanced emission in the aggregated state, which facilitates construction solid-state sensors. More importantly, introduction molecular structure, reversible switching color under stimulation was successfully achieved. A convenient device prepared using as active material. Our results provide strategy designing with stimulus-responsive properties.

Language: Английский

Complexity made easy: Aggregation‐induced emission small molecules for cancer diagnosis and phototherapies DOI Creative Commons

Luojia Chen,

Si‐Ling Chen,

Yuncong Yuan

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.

Language: Английский

Citations

10
Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics DOI Creative Commons
Lawrence Cho‐Cheung Lee, Kenneth Kam‐Wing Lo

Small Methods, Journal Year: 2024, Volume and Issue: 8(11)

Published: Sept. 25, 2024

Abstract Despite the advent of various medical interventions for cancer treatment, disease continues to pose a formidable global health challenge, necessitating development new therapeutic approaches more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light activate photosensitizer produce cytotoxic reactive oxygen species (ROS) eradicating cells, has emerged as promising approach due its high spatiotemporal precision and minimal invasiveness. However, widespread clinical use PDT faces several challenges, including inefficient production ROS in hypoxic tumor microenvironment, limited penetration depth biological tissues, inadequate accumulation photosensitizers at site. Over past decade, there been increasing interest utilization photofunctional transition metal complexes applications their intriguing photophysical photochemical properties. This review provides an overview current design strategies used innovative phototherapeutics, aiming address limitations associated with achieve The challenges future perspectives on translation are also discussed.

Language: Английский

Citations

6
Self-Chemiluminescence-Triggered Ir(III) Complex Photosensitizer for Photodynamic Therapy against Hypoxic Tumor DOI Creative Commons
Sheng-Nan Liu, Hao Chen,

Qi Wu

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(35), P. 16404 - 16417

Published: Aug. 16, 2024

The limited optical penetration depth and hypoxic tumor microenvironment (TME) are key factors that hinder the practical applications of conventional photodynamic therapy (PDT). To fundamentally address these issues, self-luminescent photosensitizers (PSs) can achieve efficient PDT. Herein, a self-chemiluminescence (CL)-triggered Ir complex PS, namely, IrL2, with low-O2-dependence type I photochemical processes is reported for rational design achieves chemiluminescence resonance energy transfer (CRET) from covalently bonded luminol units to in IrL2 under catalysis H2O2 hemoglobin (Hb) generate O2•– 1O2. Liposome IrL2H nanoparticles (NPs) constructed by loading Hb. intracellular loaded Hb catalyze part IrL2H, Ir2 then excited produce types II reactive oxygen species (ROS) through CRET, inducing cell death, even conditions, promoting apoptosis. used imaging inhibits growth 4T1-bearing mouse models intratumoral injection without external light sources. This work provides new designs transition metal PSs conquer limitations sources TME

Language: Английский

Citations

5
Long-wavelength triggered iridium(iii) complex nanoparticles for photodynamic therapy against hypoxic cancer DOI Creative Commons
Sheng-Nan Liu, Ziwei Wang,

Zihan Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(73), P. 9938 - 9941

Published: Jan. 1, 2024

Nanoparticles incorporating an Ir( iii ) complex are photosensitisers that generate types I and II reactive oxygen species upon 655 nm laser irradiation achieve photodynamic therapy in hypoxic cancer cells by targeting mitochondria.

Language: Английский

Citations

5
Dimerized Pentamethine Cyanines for Synergistically Boosting Photodynamic/Photothermal Therapy DOI Creative Commons

Haiqiao Huang,

Qiang Liu, Jinghui Zhu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Photodynamic therapy (PDT) and photothermal (PTT) have emerged promising applications in both fundamental research clinical trials. However, it remains challenging to develop ideal photosensitizers (PSs) that concurrently integrate high photostability, large near‐infrared absorptivity, efficient therapeutic capabilities. Herein, we reported a sample engineering strategy afford benzene‐fused Cy5 dimer ( Cy‐D‐5 ) for synergistically boosting PDT/PTT applications. Intriguingly, exhibits tendency form J ‐aggregates H phosphate‐buffered saline, which show long‐wavelength absorption band bathochromically shifted 810 nm short‐wavelength hypsochromically 745 nm, respectively, when compared its behavior ethanol (778 nm). Density‐functional theory calculations combined with time‐resolved transient optical spectroscopy analysis reveal the fused low Δ E ST (0.51 eV) non‐radiative transition rates (12.6 times greater than of clinically approved PS‐indocyanine green [PS‐ ICG ]). Furthermore, demonstrates higher photosensitizing ability produce 1 O 2 , stronger conversion efficiency η = 64.4%), photostability . These properties enable achieve complete tumor ablation upon 808 laser irradiation, highlighting potential as powerful dual‐function phototherapeutic agent. This work may offer practical other existing dyes red‐shifted spectral range various phototherapy

Language: Английский

Citations

5
Boosting Type-I ROS Production of Molecular Photosensitizers Using Bridge-Assisted Superexchange Coupling DOI Creative Commons
Lei Chen,

Shirong Yan,

Wu-Jie Guo

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Bridge-assisted superexchange coupling capable of long-range electron transfer proves to be effective for charge separation. However, the exploitation this photochemical process in engineering reactive oxygen species (ROS) production remains unexplored. Herein, piperazine serves as a bridging unit facilitate cascade from donor site (CO) acceptor (CN) within COCN molecule, ultimately boosting generation superoxide radicals (O

Language: Английский

Citations

4
Nanoscale Metal‐Organic Framework Leveraging Water, Oxygen, and Hydron Peroxide to Generate Reactive Oxygen Species for Cancer Therapy DOI Open Access
Zhong‐Hong Zhu, Le Zhang,

Shaorui Jia

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Spatiotemporally increasing intracellular reactive oxygen species (ROS) level represents a promising and effective antitumor approach, but is significantly hindered by insufficient ROS sources within the tumor. Herein, Cu‐porphyrin based nanoscale metal‐organic framework (nMOF) Cu II MOF reported, which inherently integrates chemodynamic therapy (CDT), photodynamic (PDT), photocatalytic capabilities to generate storm for cancer immunotherapy. Unlike conventional porphyrin‐based MOFs, features nearly orthogonally aligned porphyrin skeletons, minimizing π–π stacking preventing self‐quenching. The Fenton‐like reaction of depletes glutathione (GSH) catalyzes H 2 O hydroxyl radical (·OH) CDT. Intriguingly, its unique topology energy levels enable photocatalyze splitting into ·OH, overcoming limitations oxygen/H dependence in PDT Moreover, reduced I MOF, formed during reaction, exhibits further enhanced lighted‐triggered generation. Thus, developed nanosheets can utilize , as source remarkable through synergetic CDT/PDT/photocatalytic combination. Both vitro vivo experiments demonstrate that spatiotemporally generated could effectively provoke ferroptosis immunogenic cell death, eliciting substantial anti‐tumor immune response

Language: Английский

Citations

0
An Albumin‐Photosensitizer Supramolecular Assembly with Type I ROS‐Induced Multifaceted Tumor Cell Deaths for Photodynamic Immunotherapy DOI Creative Commons
Jingtian Zhang,

Di Jiao,

Xinwen Qi

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photodynamic therapy holds great potentials in cancer treatment, yet its effectiveness hypoxic solid tumor is limited by the oxygen‐dependence and insufficient oxidative potential of conventional type II reactive oxygen species (ROS). Herein, study reports a supramolecular photosensitizer, BSA@TPE‐BT‐SCT NPs, through encapsulating aggregation‐enhanced emission photosensitizer bovine serum albumin (BSA) to significantly enhance ROS, particularly less oxygen‐dependent I ROS for photodynamic immunotherapy. The abundant generated NPs induce multiple forms programmed cell death, including apoptosis, pyroptosis, ferroptosis. These multifaceted deaths synergistically facilitate release damage‐associated molecular patterns antitumor cytokines, thereby provoking robust immunity. Both vitro vivo experiments confirmed that elicited immunogenic dendritic maturation, activate T cell, reduce myeloid‐derived suppressor cells, leading inhibition both primary distant tumors. Additionally, BSA@TPE‐BT‐SCP also exhibited excellent performance humanized mice model, evidenced reduction senescent cells among these activated cells. findings advance development photosensitizers unveil important role enhancing immunogenicity.

Language: Английский

Citations

0
Acceptor Elongation Boosted Intersystem Crossing Affords Efficient NIR Type‐I and AIE‐Active Photosensitizers for Targeting Ferroptosis‐Based Cancer Therapy DOI Open Access

Yilin Zhu,

Rongyuan Zhang, Xu‐Min Cai

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Photosensitizers (PSs) featuring type I reactive oxygen species (ROS) generation and aggregation‐induced emission (AIE) activity offer a promising solution to achieve non‐invasive precise theranostics. However, the reported AIE luminogens (AIEgens) with both characteristic strong type‐I ROS are still scarce structure‐property relationship is unclear. Herein, an innovative acceptor elongation boosted intersystem crossing (AEBIC) design strategy has been proposed endow AIEgen producibility. The results indicate that obtained exhibit aggregation‐enhanced efficacy, which verified by experimental theoretical results. Mechanistic study reveal promoted dual‐channel pathway enhance (ISC) process due differences in triplet configurations, can be further amplified aggregation. afforded AIE‐PS show lipid droplet‐anchored induce ferroptosis through destroying cellular redox homeostasis increasing lethal levels of peroxidation. Finally, targeting ferroptosis‐based cancer therapy realized excellent anti‐tumor effect.

Language: Английский

Citations

0
Photochemical bomb: Precision nuclear targeting to activate cGAS-STING pathway for enhanced bladder cancer immunotherapy DOI
Dexiang Feng,

Xiaoying Kang,

He Wang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123126 - 123126

Published: Jan. 1, 2025

Language: Английский

Citations

0