Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging

JAMA Neurology, Journal Year: 2021, Volume and Issue: 78(10), P. 1187 - 1187

Published: Aug. 30, 2021

Importance

Disrupted sleep is common in aging and associated with cognition. Age-related changes to are multiple causes, including early Alzheimer disease pathology (amyloid β [Aβ]), depression, cardiovascular disease.

Objective

To investigate the associations between self-reported duration brain Aβ burden as well demographic, cognitive, lifestyle variables adults normal

Design, Setting, Participants

This cross-sectional study obtained data from participants Anti-Amyloid Treatment Asymptomatic Alzheimer's Disease (A4) study, which being conducted 67 sites United States, Canada, Australia, Japan. The sample for this analysis consisted of individuals aged 65 85 years who underwent an positron emission tomography (PET) scan, had complete apolipoprotein E (APOE) genotype data, were identified clinically (per a Clinical Dementia Rating score 0) cognitively unimpaired Mini-Mental State Examination 25 30 Logical Memory Delayed Recall test 6 18). Data analyzed April 3, 2020, June 20, 2021.

Main Outcomes Measures

outcome was nightly (grouped by short duration: ≤6 hours, 7-8 long ≥9 hours) compared demographic characteristics, (as measured fluorine 18–labeled-florbetapir PET scan), objective subjective cognitive function measures, variables.

Results

4417 included 2618 women (59%) mean (SD) age 71.3 (4.7) years. Self-reported shorter linearly higher (β [SE] = –0.01 [0.00];P .005), reduced cognition that mostly memory domains. No difference found groups 0.00 [0.01];P .99). However, duration, both durations body mass index (short vs 0.48 [0.17],P .01; 0.97 [0.31],P .002), depressive symptoms 0.31 [0.05],P < .001; 0.39 [0.09],P .001), daytime napping 2.66 [0.77],P 3.62 [1.38],P .01). Long worse performance across

Conclusions Relevance

In outcomes older adults, such greater burden, symptoms, index, decline, emphasizing importance maintaining adequate sleep.

Language: Английский

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Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years

Current Biology, Journal Year: 2020, Volume and Issue: 30(21), P. 4291 - 4298.e3

Published: Sept. 3, 2020

Language: Английский

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The Rotterdam Study. Design update and major findings between 2020 and 2024

European Journal of Epidemiology, Journal Year: 2024, Volume and Issue: 39(2), P. 183 - 206

Published: Feb. 1, 2024

Language: Английский

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Neurodegenerative disease of the brain: a survey of interdisciplinary approaches

Journal of The Royal Society Interface, Journal Year: 2023, Volume and Issue: 20(198)

Published: Jan. 1, 2023

Neurodegenerative diseases of the brain pose a major and increasing global health challenge, with only limited progress made in developing effective therapies over last decade. Interdisciplinary research is improving understanding these this article reviews such approaches, particular emphasis on tools techniques drawn from physics, chemistry, artificial intelligence psychology.

Language: Английский

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Sleep characteristics and risk of Alzheimer’s disease: a systematic review and meta-analysis of longitudinal studies

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(7), P. 3782 - 3793

Published: April 24, 2024

Language: Английский

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Impaired 24-h activity patterns are associated with an increased risk of Alzheimer’s disease, Parkinson’s disease, and cognitive decline

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 14, 2024

Abstract Background Sleep-wake regulating circuits are affected during prodromal stages in the pathological progression of both Alzheimer’s disease (AD) and Parkinson’s (PD), this disturbance can be measured passively using wearable devices. Our objective was to determine whether accelerometer-based measures 24-h activity associated with subsequent development AD, PD, cognitive decline. Methods This study obtained UK Biobank data from 82,829 individuals wrist-worn accelerometer aged 40 79 years a mean (± SD) follow-up 6.8 0.9) years. Outcomes were accelerometer-derived (derived by cosinor, nonparametric, functional principal component methods), incident AD PD diagnosis (obtained through hospitalization or primary care records), prospective longitudinal testing. Results One hundred eighty-seven progressed 265 PD. Interdaily stability (a measure regularity, hazard ratio [HR] per SD increase 1.25, 95% confidence interval [CI] 1.05–1.48), diurnal amplitude (HR 0.79, CI 0.65–0.96), mesor (mean activity; HR 0.77, 0.59–0.998), most active 10 h 0.75, 0.61–0.94), risk AD. Diurnal 0.28, 0.23–0.34), 0.13, 0.10–0.16), least 5 0.24, 0.08–0.69), 0.20, 0.16–0.25) Several additionally predictive test performance. Conclusions In community-based study, metrics elevated accelerated These findings suggest rhythm integrity, as affordable, non-invasive devices, may serve scalable early marker neurodegenerative disease.

Language: Английский

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Association of Rest-Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population: Prospective Cohort Study

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e55211 - e55211

Published: March 16, 2024

Background The relationship between 24-hour rest-activity rhythms (RARs) and risk for dementia or mild cognitive impairment (MCI) remains an area of growing interest. Previous studies were often limited by small sample sizes, short follow-ups, older participants. More are required to fully explore the link disrupted RARs MCI in middle-aged adults. Objective We leveraged UK Biobank data examine how RAR disturbances correlate with developing Methods analyzed 91,517 participants aged 43 79 years. Wrist actigraphy recordings used derive nonparametric metrics, including activity level most active 10-hour period (M10) its midpoint, least 5-hour (L5) relative amplitude (RA) cycle [RA=(M10-L5)/(M10+L5)], interdaily stability, intradaily variability, as well acrophase (cosinor analysis). Cox proportional hazards models associations baseline subsequent incidence MCI, adjusting demographic characteristics, comorbidities, lifestyle factors, shiftwork status, genetic Alzheimer's disease. Results During follow-up up 7.5 years, 555 developed dementia. increased those lower M10 (hazard ratio [HR] 1.28, 95% CI 1.14-1.44, per 1-SD decrease), higher L5 (HR 1.15, 1.10-1.21, increase), RA 1.23, 1.16-1.29, 1.32, 1.17-1.49, variability 1.14, 1.05-1.24, increase) advanced midpoint 0.92, 0.85-0.99, advance). These similar people <70 >70 non–shift workers, they independent cardiovascular factors. No significant observed acrophase. Conclusions Based on findings from a large middle-to-older adults objective assessment almost 8-years follow-up, we suggest that suppressed fragmented daily precede onset may serve biomarkers preclinical

Language: Английский

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Tau and β-Amyloid Burden Predict Actigraphy-Measured and Self-Reported Impairment and Misperception of Human Sleep

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(36), P. 7687 - 7696

Published: July 21, 2021

Alzheimer9s disease is associated with poor sleep, but the impact of tau and β-amyloid (Aβ) pathology on sleep remains largely unknown. Here, we test hypothesis that Aβ predict unique impairments in objective self-perceived human under real-life, free-living conditions. Eighty-nine male female cognitively healthy older adults received ¹⁸F-FTP-tau ¹¹C-PIB-Aβ PET imaging, 7 nights actigraphy questionnaire measures, neurocognitive assessment. Tau burden, not Aβ, was markedly worse sleep. In contrast, were self-reported quality. Of clinical relevance, burden predicted a perceptual mismatch between subject evaluation, individuals underestimating their The magnitude this further by executive function. Thus, early-stage deposition are linked distinct phenotypes real-world impairment, one includes cognitive misperception own health. SIGNIFICANCE STATEMENT disruption, often before significant memory decline. real-life patterns behavior have potential to serve as window into early progression. 89 adults, found wristwatch actigraphy-measured quality, both independently predictive Furthermore, greater more likely underestimate quality underestimation These data support role impairment key marker disease, offer possibility may be an affordable scalable tool quantifying disease-related behavioral changes.

Language: Английский

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Self-reported sleep characteristics associated with dementia among rural-dwelling Chinese older adults: a population-based study

BMC Neurology, Journal Year: 2022, Volume and Issue: 22(1)

Published: Jan. 3, 2022

Abstract Background Sleep characteristics associated with dementia are poorly defined and whether their associations vary by demographics APOE genotype among older adults unclear. Methods This population-based cross-sectional study included 4742 participants (age ≥ 65 years, 57.1% women) living in rural China. parameters were measured using the self-rated questionnaires of Pittsburgh Quality Index Epworth Sleepiness Scale. Global cognitive function was assessed Mini-Mental State Examination (MMSE). Dementia diagnosed following Diagnostic Statistical Manual Mental Disorders, Fourth Edition, criteria, National Institute on Aging-Alzheimer’s Association criteria for Alzheimer’s disease (AD). Data analysed multiple logistic general linear regression models. Results 173 (115 AD). Multivariable-adjusted odds ratio (OR) 1.71 (95%CI, 1.07-2.72) sleep duration ≤4 h/night (vs. > 6-8 h/night), 0.76 (0.49-1.18) 4-6 h/night, 1.63 (1.05-2.55) 8 1.11 (1.03-1.20) lower efficiency (per 10% decrease), 1.85 (1.19-2.89) excessive daytime sleepiness. Very short (≤4 efficiency, sleepiness significantly being AD (multivariable-adjusted OR range = 1.12-2.07; p < 0.05). The problems evident mainly young-old (65-74 years) or ε4 carriers. Among dementia-free participants, these a MMSE score. Conclusions Self-reported characterized very long duration, low sleepiness, especially people Trial registration ChiCTR1800017758 (Aug 13, 2018).

Language: Английский

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Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents

Aging and Disease, Journal Year: 2022, Volume and Issue: 13(1), P. 87 - 87

Published: Jan. 1, 2022

Alzheimer's disease (AD) is a current public health challenge and will remain until the development of an effective intervention. However, developing treatment for requires thorough understanding its etiology, which currently lacking. Although several studies have shown association between oxidative damage AD, only few clarified specific mechanisms involved. Herein, we reviewed recent preclinical clinical that indicated significance in as well potential antioxidants. factors regulate stress centered our investigation on apolipoprotein E gut microbiome. Apolipoprotein E, particularly E-ε4, can impair structural facets mitochondria. This, turn, minimize mitochondrial functionality result progressive build-up free radicals, eventually leading to stress. Similarly, microbiome influence significant degree via metabolite, trimethylamine N-oxide. Given various roles these two modulating stress, also discuss possible relationship them provide future research directions.

Language: Английский

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