Sleep characteristics and risk of Alzheimer’s disease: a systematic review and meta-analysis of longitudinal studies

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(7), P. 3782 - 3793

Published: April 24, 2024

Language: Английский

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Sleep disorders increase the risk of dementia, Alzheimer’s disease, and cognitive decline: a meta-analysis

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Sleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, neurodegenerative diseases such Alzheimer’s disease (AD) vascular impairment dementia (VCID). However, the extent specificity of these associations remain uncertain. This meta-analysis evaluates impact common disorders on risk developing decline. A comprehensive search literature was conducted identify prospective cohort studies assessing risk. Studies reporting estimates for AD, or decline associated with insomnia, other (e.g., restless legs syndrome, circadian rhythm excessive daytime sleepiness) were included. Meta-analyses performed using a random-effects model calculate pooled hazard ratios (HRs) 95% confidence intervals (CIs). Thirty-nine included, subgroup analyses showing between all-cause apnea (HR 1.33, CI 1.09–1.61), 1.36, 1.19–1.55), 1.24–1.43). Obstructive increased AD 1.45, 1.24–1.69), though its association did not reach statistical significance 1.35, 0.99–1.84). Insomnia significantly both 1.59, 1.01–2.51) 1.49, 1.27–1.74). highlights critical role in risk, emphasizing need early detection management disturbances. Targeted interventions could play pivotal reducing among high-risk populations.

Language: Английский

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Differential Associations of 6 Adiposity Indices With Dementia in Older Adults: The MIND-China Study

Journal of the American Medical Directors Association, Journal Year: 2023, Volume and Issue: 24(9), P. 1412 - 1419.e4

Published: Aug. 2, 2023

Language: Английский

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Associations of sleep timing and time in bed with dementia and cognitive decline among Chinese older adults: A cohort study

Journal of the American Geriatrics Society, Journal Year: 2022, Volume and Issue: 70(11), P. 3138 - 3151

Published: Sept. 21, 2022

The longitudinal associations of sleep timing and time in bed (TIB) with dementia cognitive decline older adults are unclear.This population-based cohort study used data from 1982 participants who were aged ≥60 years, free dementia, living rural communities western Shandong, China. At the baseline (2014) follow-up (2018) examinations, parameters assessed using standard questionnaires. Cognitive function was measured Mini-Mental State Examination (MMSE). Dementia diagnosed following DSM-IV criteria, NIA-AA criteria for Alzheimer disease (AD). Data analyzed restricted cubic splines, Cox proportional-hazards models, general linear models.During mean 3.7 97 (68 AD). Restricted spline curves showed J-shaped duration, TIB, rise risk, a reverse association mid-sleep time. When categorized into tertiles, multivariable-adjusted hazard ratio (HR) incident 1.69 (95%CI 1.01-2.83) duration >8 hours (vs. 7-8 h), 2.17 (1.22-3.87) bedtime before 9 p.m. 10 or later), 2.00 (1.23-3.24) 1 a.m. 1-1.5 a.m.). Early significantly associated AD (HR range: 2.25-2.51; p < 0.05). Among individuals at follow-up, long early time, late prolonged TIB advanced to greater MMSE score (p These statistically evident mainly among men 60-74 years.Long an increased risk only people years men.

Language: Английский

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Association of objective sleep duration with cognition and brain aging biomarkers in older adults

Brain Communications, Journal Year: 2024, Volume and Issue: 6(3)

Published: Jan. 1, 2024

Abstract The neuropathological mechanisms underlying the association between sleep duration and mild cognitive impairment remain poorly understood. This population-based study included 2032 dementia-free people (age ≥ 60 years; 55.1% women) derived from participants in Multimodal Interventions to Delay Dementia Disability Rural China; of these, data were available 841 for Alzheimer’s plasma biomarkers (e.g. amyloid-β, total tau neurofilament light chain), 1044 serum microvascular soluble adhesion molecules) 834 brain MRI whiter matter, grey hippocampus, lacunes, enlarged perivascular spaces white matter hyperintensity WMH). We used electrocardiogram-based cardiopulmonary coupling analysis measure duration, a neuropsychological test battery assess function Petersen’s criteria define impairment. Data analysed with multivariable logistic general linear models. In sample (n = 2032), 510 defined impairment, including 438 amnestic 72 non-amnestic Long (&gt;8 versus 6–8 h) was significantly associated increased likelihoods lower scores global cognition, verbal fluency, attention executive (Bonferroni-corrected P &lt; 0.05). subsamples, long higher amyloid-β40 tau, amyloid-β42/amyloid-β40 ratio smaller volume Sleep not serum-soluble molecules, volume, lacunes (P &gt; neurodegenerative pathologies may represent common pathways linking low cognition older adults.

Language: Английский

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Gender-and age-specific associations of sleep duration and quality with cognitive impairment in community-dwelling older adults in Anhui Province, China

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 5, 2024

Objective To examine associations of sleep duration and quality with cognitive impairment in older adults the moderating role gender age these associations. Methods This community-based cross-sectional study included 4,837 participants aged 60 years above. Cognitive function was assessed using Chinese version Mini-Mental State Examination (MMSE), were grouped based on presence impairment. The Pittsburgh Sleep Quality Index (PSQI). Multivariate logistic regression models used to analyze have also been explored. Results (mean ± SD) 71.13 5.50 years. Of all adults, 1,811 (37.44%) detected as impairment, 1755 (36.8%) had poor quality. Among those 51.09% female. proportion is significantly higher symptoms depression (49.73%, 273/549) ( χ 2 = 41.275, p &lt; 0.001) than without depressive symptoms. After adjustment for multiple confounding factors crucial covariate (depressive symptoms), odds ratios (OR) (95% confidence interval [CI]) (with 7–7.9 h regarded reference group) individuals a &lt;6, 6–6.9, 8–8.9, ≥ 9 1.280 (1.053–1.557), 1.425 (1.175–1.728), 1.294 (1.068–1.566), 1.360 (1.109–1.668), respectively. Subgroup analysis showed V-shaped association between night males ≤ 0.05), stronger 60–80 With regard quality, fully adjusted OR (95%CI) 1.263 (1.108–1.440). According scores subscales PSQI, daytime dysfunction associated an increased risk (OR: 1.128, 95%CI: 1.055–1.207). revealed statistically significant correlation (including dysfunction) different groups, being females 1.287, 1.080–1.534) 81–97 2.128, 1.152–3.934). For group ratio other groups. Conclusion present that inadequate or excessive especially males, who exhibited association. well dysfunction, exhibiting strongest

Language: Английский

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The prevalence of mild cognitive impairment and dementia among rural dwellers: A systematic review and meta-analysis

Geriatric Nursing, Journal Year: 2024, Volume and Issue: 56, P. 74 - 82

Published: Feb. 1, 2024

Language: Английский

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Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

Background The choroid plexus (CP) is involved in neurodegenerative diseases. However, the association of CP with cardiovascular risk factors and cerebral small vessel disease older adults remains unclear. Methods Results This population‐based study included 1263 participants (60 years older) from MIND‐China (Multimodal Interventions to Delay Dementia Disability Rural China) substudy (2018–2020), which 111 individuals completed diffusion tensor imaging examination. volume was automatically segmented. White matter hyperintensities (WMHs), enlarged perivascular spaces (EPVS), microbleeds, lacunes were assessed following Standards for Reporting Vascular Changes on Neuroimaging 1. Peak width skeletonized mean diffusivity free water derived images. We used linear regression models evaluate between factors, WMH volumes, metrics, logistic examine EPVS, lacunes. increased age ( P <0.001). Men (β coefficient=0.47 [95% CI, 0.29–0.64]) diabetes coefficient=0.16 0.01–0.31]) had larger volumes than women without diabetes, respectively <0.05). Greater significantly associated total periventricular moderate severe EPVS basal ganglia <0.05) but not deep WMHs, centrum semiovale, lacunes, or microbleeds. In subsample, higher peak white Conclusions An global likelihoods impaired integrity, suggesting that an may represent a precursor disease.

Language: Английский

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Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 7, 2025

Sleep is a crucial lifestyle factor with impacts on mental and cognitive health. The associations between objectively measured sleep risk of incident dementia are not yet fully understood. To evaluate the device-measured duration regularity explore whether moderates association dementia. Population-based prospective cohort study 82,391 adults aged 43 to 79 years from UK Biobank accelerometry subsample, collected 2013 2015, followed up 2022. Device-based (h/day) index (SRI), metric ranging 0-100 that quantifies person's (with greater value indicating higher consistency), were calculated wrist-worn data recorded over course one week. Incident all-cause cases obtained national hospital admission, primary care mortality 30 November We used Cox proportional hazard models estimate ratios (HRs) for after adjustment common demographic clinical covariates. Over mean follow-up 7.9 years, 694 occurred. observed U-shaped dementia, only short (< 7 h) being significantly associated median sleepers 6.5 h, compared reference point h was HR 1.19 (95%CI 1.01,1.40) negatively in near-linear fashion (linear p = 0.01, non-linear 0.57). When we dichotomized regularity, those group (SRI ≥ 70) had an 0.74 0.63, 0.87) lower < 70). beneficial present among participants long (≥ 8 duration. Assuming causal, maintaining regular pattern may help offset deleterious inadequate Interventions aimed at improving be viable option people able achieve recommended hours sleep.

Language: Английский

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The effects of sleep duration on the risk of dementia incidence in short and long follow-up studies: a systematic review and meta-analysis

Sleep Medicine, Journal Year: 2024, Volume and Issue: 124, P. 522 - 530

Published: Oct. 20, 2024

Language: Английский

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