The emerging field of non-invasive brain stimulation in Alzheimer’s disease DOI Creative Commons
Giacomo Koch, Daniele Altomare, Alberto Benussi

et al.

Brain, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Treating cognitive impairment is a holy grail of modern clinical neuroscience. In the past few years, non-invasive brain stimulation increasingly emerging as therapeutic approach to ameliorate performance in patients with and an augmentation persons whose within normal limits. Alzheimer’s disease, better understanding connectivity function has allowed for development different protocols. Recent studies have shown that transcranial methods enhancing plasticity several modalities beneficial effects on functions. Amelioration been preclinical behaviour transgenic mouse models pathology variable severity impairment. While field still grappling issues related standardization target population, frequency, intensity, treatment duration stimulated region, positive outcomes reported functions markers pathology. Here we review most encouraging protocols based repetitive magnetic stimulation, direct current alternating visual-auditory photobiomodulation focused ultrasound, which demonstrated efficacy enhance or slow decline disease. Beneficial are associated modulation specific networks. The promising results obtained targeting key hubs higher-level networks, such frontal-parietal network default mode network. personalization parameters according individual features sheds new light optimizing future applications.

Language: Английский

Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation DOI Creative Commons
Miles Wischnewski, Ivan Alekseichuk, Alexander Opitz

et al.

Trends in Cognitive Sciences, Journal Year: 2022, Volume and Issue: 27(2), P. 189 - 205

Published: Dec. 19, 2022

Transcranial alternating current stimulation (tACS) can modulate human neural activity and behavior. Accordingly, tACS has vast potential for cognitive research brain disorder therapies. The generates oscillating electric fields in the that bias spike timing, causing changes local oscillatory power cross-frequency cross-area coherence. affects performance by modulating underlying single or nested rhythms, distal synchronization, metabolic activity. Clinically, tailored to abnormal oscillations shows promising results alleviating psychiatric neurological symptoms. We summarize findings of mechanisms, its use applications, novel developments personalized stimulation.

Language: Английский

Citations

110
Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee DOI Creative Commons
Steve Vucic, Kai-Hsiang Chen, Matthew C. Kiernan

et al.

Clinical Neurophysiology, Journal Year: 2023, Volume and Issue: 150, P. 131 - 175

Published: March 30, 2023

The review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR, et al. clinical diagnostic utility of transcranial magnetic stimulation: report an IFCN committee. Clin Neurophysiol 2008;119(3):504-32) on stimulation (TMS) in neurological diseases. Most TMS measures rely motor cortex and recording evoked potentials. Paired-pulse techniques, incorporating conventional amplitude-based threshold tracking, have established neurodegenerative, movement, episodic (epilepsy, migraines), chronic pain functional Cortical hyperexcitability has emerged as aid amyotrophic lateral sclerosis. Single-pulse are stroke, myelopathy even the absence radiological changes. Short-latency afferent inhibition, related to central cholinergic transmission, is reduced Alzheimer's disease. triple technique (TST) may enhance detect upper neuron involvement. potentials can be used perform mapping or preoperative assessment eloquent brain regions before surgical resection tumors. exhibits assessing lumbosacral/cervical nerve root function, especially demyelinating neuropathies, localizing site facial palsies. also high sensitivity detecting subclinical corticospinal lesions multiple Abnormalities conduction time TST correlate with impairment disability MS. Cerebellar cerebellum cerebello-dentato-thalamo-motor cortical pathways. Combining electroencephalography, novel method measure parameters altered disorders, including excitability, effective connectivity, response complexity.

Language: Английский

Citations

110
Neural interfaces: Bridging the brain to the world beyond healthcare DOI Creative Commons
Shumao Xu,

Yang Liu,

Hyun‐Jin Lee

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(5)

Published: March 14, 2024

Abstract Neural interfaces, emerging at the intersection of neurotechnology and urban planning, promise to transform how we interact with our surroundings communicate. By recording decoding neural signals, these interfaces facilitate direct connections between brain external devices, enabling seamless information exchange shared experiences. Nevertheless, their development is challenged by complexities in materials science, electrochemistry, algorithmic design. Electrophysiological crosstalk mismatch electrode rigidity tissue flexibility further complicate signal fidelity biocompatibility. Recent closed‐loop brain‐computer while promising for mood regulation cognitive enhancement, are limited accuracy adaptability user interfaces. This perspective outlines challenges discusses progress contrasting non‐invasive invasive approaches, explores dynamics stimulation interfacing. Emphasis placed on applications beyond healthcare, highlighting need implantable high‐resolution capabilities.

Language: Английский

Citations

22
Frequency-specific and state-dependent neural responses to brain stimulation DOI
Huichun Luo,

Xiaolai Ye,

Huiting Cai

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

2
The impact of gamma transcranial alternating current stimulation (tACS) on cognitive and memory processes in patients with mild cognitive impairment or Alzheimer's disease: A literature review DOI Creative Commons
Nicole R. Nissim,

Duc Viet Pham,

T Poddar

et al.

Brain stimulation, Journal Year: 2023, Volume and Issue: 16(3), P. 748 - 755

Published: April 5, 2023

Highlights•40 Hz tACS enhances gamma oscillations and memory performance in MCI/AD patients.•Active 40 increases spectral power patients over sham.•Gamma stimulation may aid clearance of tau mouse models AD patients.AbstractBackgroundTranscranial alternating current (tACS)—a noninvasive brain technique that modulates cortical through entrainment—has been demonstrated to alter oscillatory activity enhance cognition healthy adults. TACS is being explored as a tool improve patient populations with mild cognitive impairment (MCI) Alzheimer's disease (AD).ObjectiveTo review the growing body literature findings obtained from application MCI or AD, highlighting effects on function, memory, cognition. Evidence use animal also discussed. Important parameters are underscored for consideration protocols aim apply therapeutic MCI/AD.FindingsThe has shown promising results improvement processes impacted MCI/AD. These data demonstrate potential an interventional stand-alone alongside pharmacological and/or other behavioral interventions MCI/AD.ConclusionsWhile evidenced encouraging results, this function pathophysiology remains be fully determined. This explores highlights need continued research course by reinstating activity, improving processing, delaying progression, remediating abilities

Language: Английский

Citations

42
Cognitive and Neuropathophysiological Outcomes of Gamma-tACS in Dementia: A Systematic Review DOI Creative Commons
Valerio Manippa, Annalisa Palmisano, Michael A. Nitsche

et al.

Neuropsychology Review, Journal Year: 2023, Volume and Issue: 34(1), P. 338 - 361

Published: March 6, 2023

Abstract Despite the numerous pharmacological interventions targeting dementia, no disease-modifying therapy is available, and prognosis remains unfavorable. A promising perspective involves tackling high-frequency gamma-band (> 30 Hz) oscillations involved in hippocampal-mediated memory processes, which are impaired from early stages of typical Alzheimer’s Disease (AD). Particularly, positive effects entrainment on mouse models AD have prompted researchers to translate such findings into humans using transcranial alternating current stimulation (tACS), a methodology that allows endogenous cortical frequency-specific manner. This systematic review examines state-of-the-art use gamma-tACS Mild Cognitive Impairment (MCI) dementia patients shed light its feasibility, therapeutic impact, clinical effectiveness. search two databases yielded 499 records resulting 10 included studies total 273 patients. The results were arranged single-session multi-session protocols. Most demonstrated cognitive improvement following gamma-tACS, some showed neuropathological markers, suggesting feasibility these anyhow far strong evidence available for models. Nonetheless, small number their wide variability terms aims, parameters, measures, make it difficult draw firm conclusions. We discuss methodological limitations studies, proposing possible solutions future avenues improve research dementia.

Language: Английский

Citations

31
Transcranial Magneto-Acoustic Stimulation Attenuates Synaptic Plasticity Impairment through the Activation of Piezo1 in Alzheimer’s Disease Mouse Model DOI Creative Commons
Fangxuan Chu,

Ruxin Tan,

Xin Wang

et al.

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

The neuropathological features of Alzheimer's disease include amyloid plaques. Rapidly emerging evidence suggests that Piezo1, a mechanosensitive cation channel, plays critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure, but the importance Piezo1-mediated mechanotransduction brain functions is less appreciated. However, apart from stimulation, Piezo1 channels are strongly modulated by voltage. We assume may play converting and electrical signals, which could induce phagocytosis degradation Aβ, combined effect stimulation superior to single stimulation. Hence, we design transcranial magneto-acoustic (TMAS) system, based on ultrasound (TUS) within magnetic field combines coupling electric force ultrasound, applied it test above hypothesis 5xFAD mice. Behavioral tests, vivo electrophysiological recordings, Golgi-Cox staining, enzyme-linked immunosorbent assay, immunofluorescence, immunohistochemistry, real-time quantitative PCR, Western blotting, RNA sequencing, cerebral blood flow monitoring were used assess whether TMAS can alleviate symptoms AD mouse model activating Piezo1. treatment enhanced autophagy promote β-amyloid activation microglial alleviated neuroinflammation, synaptic plasticity impairment, neural oscillation abnormalities mice, showing stronger than ultrasound. inhibition with an antagonist, GsMTx-4, prevented these beneficial effects TMAS. This research indicates transform TMAS-related into biochemical signals identifies favorable mice mediated

Language: Английский

Citations

30
Induced neural phase precession through exogenous electric fields DOI Creative Commons
Miles Wischnewski, Harry Tran, Zhihe Zhao

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 24, 2024

Abstract The gradual shifting of preferred neural spiking relative to local field potentials (LFPs), known as phase precession, plays a prominent role in coding. Correlations between the precession and behavior have been observed throughout various brain regions. As such, is suggested be global mechanism that promotes neuroplasticity. However, causal evidence neuroplastic mechanisms are lacking so far. Here we show link LFP dynamics precession. In three experiments, modulated LFPs humans, non-human primate, computational models using alternating current stimulation. We continuous stimulation motor cortex oscillations humans lead shift maximal corticospinal excitability by ~90°. Further, exogenous induced subset entrained neurons (~30%) primate. Multiscale modeling realistic circuits suggests stimulation-induced driven NMDA-mediated synaptic plasticity. Altogether, experiments provide mechanistic for neocortical process. Alternating current-induced consequently plasticity crucial development novel therapeutic neuromodulation methods.

Language: Английский

Citations

12
Theta-tACS modulates cerebellar-related motor functions and cerebellar-cortical connectivity DOI Creative Commons
Andrea Guerra, Giulia Paparella, Massimiliano Passaretti

et al.

Clinical Neurophysiology, Journal Year: 2024, Volume and Issue: 158, P. 159 - 169

Published: Jan. 4, 2024

To evaluate the effects of cerebellar transcranial alternating current stimulation (tACS) delivered at cerebellar-resonant frequencies, i.e., theta (θ) and gamma (γ), on upper limb motor performance cerebellum-primary cortex (M1) connectivity, as assessed by cerebellar-brain inhibition (CBI), in healthy subjects. Participants underwent cerebellar-tACS while performing three cerebellar-dependent tasks: (i) rhythmic finger-tapping, (ii) arm reaching-to-grasp ('grasping') (iii) reaching-to-point ('pointing') an object. Also, we evaluated possible changes CBI during cerebellar-tACS. θ-tACS decreased movement regularity tapping task increased duration pointing compared to sham- γ-tACS. Additionally, effectiveness (greater inhibition). The effect rhythm correlated with less corresponded greater CBI. Cerebellar-tACS θ frequency modulates cerebellar-related behavior this is, least part, mediated inhibitory output onto M1. may be due modulation neurons that resonate rhythm. These findings contribute a better understanding physiological mechanisms control provide new evidence non-invasive brain stimulation.

Language: Английский

Citations

10
Clinical and diagnostic implications of Alzheimer’s disease copathology in Lewy body disease DOI
Lorenzo Barba, Samir Abu‐Rumeileh, Henryk Barthel

et al.

Brain, Journal Year: 2024, Volume and Issue: 147(10), P. 3325 - 3343

Published: July 11, 2024

Concomitant Alzheimer's disease (AD) pathology is a frequent event in the context of Lewy body (LBD), occurring approximately half all cases. Evidence shows that LBD patients with AD copathology show an accelerated course, greater risk cognitive decline and overall poorer prognosis. However, LBD-AD cases may heterogeneous motor non-motor phenotypes higher dementia and, consequently, be not rarely misdiagnosed. In this review, we summarize current understanding by discussing synergistic effects neuropathological changes their clinical relevance. Furthermore, provide extensive overview neuroimaging fluid biomarkers under assessment for use possible diagnostic prognostic values. can predicted vivo means CSF, MRI PET markers, whereas most promising technique to date identifying different biological tissues α-synuclein seed amplification assay. Pathological imaging CSF are associated likelihood but do always mirror severity as pure AD. Implementing blood-based might allow faster screening copathology, thus improving sensitivity LBD-AD. Finally, discuss literature on novel candidate being exploited investigate other aspects neurodegeneration, such neuroaxonal injury, glial activation synaptic dysfunction. The thorough characterization should taken into account when considering differential diagnoses syndromes, evaluation individual level, guide symptomatic disease-modifying therapies.

Language: Английский

Citations

10