Dynamic changes in glymphatic function in reversible cerebral vasoconstriction syndrome DOI Creative Commons
Chia‐Hung Wu, Yu Kuo, Yu‐Hsiang Ling

et al.

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: Feb. 5, 2024

Abstract Background The pathophysiology of the reversible cerebral vasoconstriction syndrome (RCVS) remains enigmatic and role glymphatics in RCVS has not been evaluated. We aimed to investigate glymphatic dynamics its clinical correlates. Methods prospectively evaluated function patients, with subjects healthy controls (HCs) recruited between August 2020 November 2023, by calculating diffusion-tensor imaging along perivascular space (DTI-ALPS) index under a 3-T MRI. Clinical vascular (transcranial color-coded duplex sonography) investigations were conducted subjects. participants separated into acute (≤ 30 days) remission (≥ 90 groups disease onset MRI interval. time-trend, stage longitudinal analyses DTI-ALPS conducted. Correlations parameters performed. Bonferroni correction was applied ( q = 0.05/11). Results A total 138 patients (mean age, 46.8 years ± 11.8; 128 women) 42 HCs 46.0 4.5; 35 Acute demonstrated lower than p < 0.001) 0.001). continuously increasing trend after demonstrated. when internal carotid arteries resistance six-item Headache Impact test scores higher. In contrast, during 50–100 days onset, higher middle artery flow velocity Conclusions Glymphatic exhibited unique dynamic evolution that temporally coupled different indices headache-related disabilities course. These findings may provide novel insights complex interactions transport, vasomotor control pain modulation.

Language: Английский

Glymphatic system dysfunction predicts amyloid deposition, neurodegeneration, and clinical progression in Alzheimer's disease DOI Creative Commons

Shu‐Yi Huang,

Ya‐Ru Zhang,

Yu Guo

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(5), P. 3251 - 3269

Published: March 19, 2024

Abstract INTRODUCTION Although glymphatic function is involved in Alzheimer's disease (AD), its potential for predicting the pathological and clinical progression of AD sequential association with core biomarkers poorly understood. METHODS Whole‐brain activity was measured by diffusion tensor image analysis along perivascular space (DTI‐ALPS) participants dementia ( n = 47), mild cognitive impairment (MCI; 137), normal controls 235) from Disease Neuroimaging Initiative. RESULTS ALPS index significantly lower than MCI or controls. Lower associated faster changes amyloid positron emission tomography (PET) burden signature region interest volume, higher risk amyloid‐positive transition progression, rates amyloid‐ neurodegeneration‐related decline. Furthermore, associations decline were fully mediated PET brain atrophy. DISCUSSION Glymphatic failure may precede pathology, predicts deposition, neurodegeneration, AD. Highlights The (ALPS) reduced patients (AD) dementia, prodromal AD, preclinical predicted accelerated beta (Aβ) Aβ‐positive transition. decrease occurs before cerebrospinal fluid Aβ42 reaches positive threshold. atrophy, Aβ atrophy link

Language: Английский

Citations

42
The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle DOI Creative Commons
Yu Cai, Yin Zhang,

Shuo Leng

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 192, P. 106426 - 106426

Published: Feb. 6, 2024

The term "glymphatic" emerged roughly a decade ago, marking pivotal point in neuroscience research. glymphatic system, glial-dependent perivascular network distributed throughout the brain, has since become focal of investigation. There is increasing evidence suggesting that impairment system appears to be common feature neurodegenerative disorders, and this exacerbates as disease progression. Nevertheless, factors contributing dysfunction across most disorders remain unclear. Inflammation, however, suspected play role. Dysfunction can lead significant accumulation protein waste products, which trigger inflammation. interaction between inflammation cyclical potentially synergistic. Yet, current research limited, there lack comprehensive models explaining association. In perspective review, we propose novel model inflammation, impaired function, interconnected vicious cycle. By presenting experimental from existing literature, aim demonstrate that: (1) aggravates dysfunction, (2) exacerbated progression, (3) progression promotes Finally, implication proposed discussed.

Language: Английский

Citations

17
Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function DOI Creative Commons
Xiaodan Liu, Giuseppe Barisano, Xingfeng Shao

et al.

Aging and Disease, Journal Year: 2023, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2023

The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was proposed to evaluate glymphatic system (GS) function. However, few studies have validated its reliability and reproducibility. Fifty participants' DTI data from MarkVCID consortium were included in this study. Two pipelines by using DSI studio FSL software developed for processing ALPS index calculation. obtained average of bilateral used testing cross-vendor, inter-rater test-retest R software. demonstrated favorable inter-scanner reproducibility (ICC=0.77 0.95, P< 0.001), (ICC=0.96 1, 0.001) repeatability (ICC=0.89 offering a potential biomarker vivo evaluation GS

Language: Английский

Citations

33
The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis DOI Creative Commons

Serhat V. Okar,

Fengling Hu, Russell T. Shinohara

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 30, 2023

Perivascular spaces have been involved in neuroinflammatory and neurodegenerative diseases. Upon a certain size, these can become visible on magnetic resonance imaging (MRI), referred to as enlarged perivascular (EPVS) or MRI-visible (MVPVS). However, the lack of systematic evidence etiology temporal dynamics MVPVS hampers their diagnostic utility MRI biomarker. Thus, goal this review was summarize potential etiologies evolution MVPVS.In comprehensive literature search, out 1,488 unique publications, 140 records assessing etiopathogenesis were eligible for qualitative summary. 6 included meta-analysis assess association between brain atrophy.Four overarching partly overlapping proposed: (1) Impairment interstitial fluid circulation, (2) Spiral elongation arteries, (3) Brain atrophy and/or myelin loss, (4) Immune cell accumulation space. The patients with diseases did not support an volume measures [R: -0.15 (95%-CI -0.40-0.11)]. Based few mostly small studies tumefactive vascular diseases, is slow.Collectively, study provides high-grade dynamics. Although several emergence proposed, they are only partially supported by data. Advanced methods should be employed further dissect MVPVS. This benefit implementation biomarker.https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=346564, identifier CRD42022346564.

Language: Английский

Citations

28
Glymphatic function plays a protective role in ageing-related cognitive decline DOI Creative Commons
Junjun Wang, Ying Zhou,

Kemeng Zhang

et al.

Age and Ageing, Journal Year: 2023, Volume and Issue: 52(7)

Published: June 15, 2023

The glymphatic pathway, characterised as a cerebral drainage system, influences cognitive function in neurodegenerative diseases; however, evidence is limited normal ageing population. aim of this study was to investigate the effect on ageing-related decline.

Language: Английский

Citations

27
The glymphatic system as a potential biomarker and therapeutic target in secondary progressive multiple sclerosis DOI
Yuji Tomizawa, Akifumi Hagiwara,

Yasunobu Hoshino

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 83, P. 105437 - 105437

Published: Jan. 8, 2024

Language: Английский

Citations

10
The glymphatic system and multiple sclerosis: An evolving connection DOI Creative Commons
Alaa Alghanimy, Lorraine M. Work, William M. Holmes

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 83, P. 105456 - 105456

Published: Jan. 21, 2024

Language: Английский

Citations

10
Cognitive Impairment Is Related to Glymphatic System Dysfunction in Pediatric Multiple Sclerosis DOI Creative Commons
Monica Margoni, Elisabetta Pagani, Alessandro Meani

et al.

Annals of Neurology, Journal Year: 2024, Volume and Issue: 95(6), P. 1080 - 1092

Published: March 13, 2024

Objective The aim of this study was to investigate whether, compared pediatric healthy controls (HCs), the glymphatic system is impaired in multiple sclerosis (MS) patients according their cognitive status, and assess its association with clinical disability MRI measures brain structural damage. Method s Sixty‐five MS (females = 62%; median age 15.5 [interquartile range, IQR 14.5;17.0] years) 23 age‐ sex‐matched HCs 44%; 14.1 [IQR 11.8;16.2] underwent neurological, neuropsychological 3.0 Tesla assessment, including conventional diffusion tensor imaging (DTI). We calculated along perivascular space (DTI‐ALPS) index, a proxy function. Cognitive impairment (Co‐I) defined as at least 2 domains. Results No significant differences DTI‐ALPS index were found between cognitively preserved (Co‐P) (estimated mean difference [EMD] −0.002 [95% confidence interval −0.069; 0.065], FDR‐p 0.956). Compared Co‐P patients, Co‐I (n 20) showed significantly lower (EMD −0.136 −0.214; −0.058], ≤ 0.004). In HCs, no associations observed normalized brain, cortical thalamic volumes, normal‐appearing white matter (NAWM) fractional anisotropy (FA) diffusivity (MD) (FDR‐p ≥ 0.348). higher WM lesion volume (LV), NAWM MD, volume, FA associated 0.016). Random Forest selected (relative importance [RI] 100%), LV (RI 59.5%) MD 57.1%) intelligence quotient 51.3%) informative predictors (out‐of‐bag area under curve 0.762). Interpretation Glymphatic dysfunction occurs MS, focal lesions, irreversible tissue loss accumulation impairment. ANN NEUROL 2024;95:1080–1092

Language: Английский

Citations

10
Enlarged choroid plexus in relapsing-remitting multiple sclerosis may lead to brain structural changes through the glymphatic impairment DOI
Yan Xie,

Hongquan Zhu,

Yihao Yao

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 85, P. 105550 - 105550

Published: March 11, 2024

Language: Английский

Citations

9
Comparative analysis of glymphatic system alterations in multiple sclerosis and neuromyelitis optica spectrum disorder using MRI indices from diffusion tensor imaging DOI Creative Commons
Minchul Kim, Inpyeong Hwang, Jung‐Hyun Park

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: April 1, 2024

The glymphatic system is a glial-based perivascular network that promotes brain metabolic waste clearance. Glymphatic dysfunction has been observed in both multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), indicating the role of neuroinflammation system. However, little known about how two diseases differently affect human present study aims to evaluate diffusion MRI-based measures by contrasting MS NMOSD.

Language: Английский

Citations

9