Self-supervised multimodal learning for group inferences from MRI data: Discovering disorder-relevant brain regions and multimodal links DOI Creative Commons
Alex Fedorov, Eloy Geenjaar, Lei Wu

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 285, P. 120485 - 120485

Published: Dec. 16, 2023

In recent years, deep learning approaches have gained significant attention in predicting brain disorders using neuroimaging data. However, conventional methods often rely on single-modality data and supervised models, which provide only a limited perspective of the intricacies highly complex brain. Moreover, scarcity accurate diagnostic labels clinical settings hinders applicability models. To address these limitations, we propose novel self-supervised framework for extracting multiple representations from multimodal to enhance group inferences enable analysis without resorting labeled during pre-training. Our approach leverages Deep InfoMax (DIM), methodology renowned its efficacy by estimating mutual information need explicit labels. While DIM has shown promise MRI data, potential remains untapped. This work extends allowing us identify disorder-relevant regions explore links. We present compelling evidence our uncovering regions, including hippocampus, caudate, insula, - links with thalamus, precuneus, subthalamus hypothalamus. demonstrate promising capabilities presence across spectrum Alzheimer's phenotypes. Comparative evaluations against state-of-the-art unsupervised based autoencoders, canonical correlation analysis, models highlight superiority proposed method achieving improved classification performance, capturing joint information, interpretability capabilities. The computational efficiency decoder-free strategy enhances practical utility, as it saves compute resources compromising performance. offers step forward addressing challenge understanding disorders, applications research diagnosis.

Language: Английский

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee DOI Creative Commons
Steve Vucic, Kai-Hsiang Chen, Matthew C. Kiernan

et al.

Clinical Neurophysiology, Journal Year: 2023, Volume and Issue: 150, P. 131 - 175

Published: March 30, 2023

The review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR, et al. clinical diagnostic utility of transcranial magnetic stimulation: report an IFCN committee. Clin Neurophysiol 2008;119(3):504-32) on stimulation (TMS) in neurological diseases. Most TMS measures rely motor cortex and recording evoked potentials. Paired-pulse techniques, incorporating conventional amplitude-based threshold tracking, have established neurodegenerative, movement, episodic (epilepsy, migraines), chronic pain functional Cortical hyperexcitability has emerged as aid amyotrophic lateral sclerosis. Single-pulse are stroke, myelopathy even the absence radiological changes. Short-latency afferent inhibition, related to central cholinergic transmission, is reduced Alzheimer's disease. triple technique (TST) may enhance detect upper neuron involvement. potentials can be used perform mapping or preoperative assessment eloquent brain regions before surgical resection tumors. exhibits assessing lumbosacral/cervical nerve root function, especially demyelinating neuropathies, localizing site facial palsies. also high sensitivity detecting subclinical corticospinal lesions multiple Abnormalities conduction time TST correlate with impairment disability MS. Cerebellar cerebellum cerebello-dentato-thalamo-motor cortical pathways. Combining electroencephalography, novel method measure parameters altered disorders, including excitability, effective connectivity, response complexity.

Language: Английский

Citations

110
Alzheimer’s disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression DOI Creative Commons
S. Meftah, Jian Gan

Frontiers in Synaptic Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: March 9, 2023

The synapse has consistently been considered a vulnerable and critical target within Alzheimer’s disease, loss is, to date, one of the main biological correlates cognitive decline disease. This occurs prior neuronal with ample evidence that synaptic dysfunction precedes this, in support idea failure is crucial stage disease pathogenesis. two pathological hallmarks abnormal aggregates amyloid or tau proteins, have had demonstrable effects on physiology animal cellular models There also growing these proteins may synergistic effect neurophysiological dysfunction. Here, we review some findings alterations what know from models. First, briefly summarize human suggest synapses are altered, including how this relates network activity. Subsequently, considered, highlighting mouse pathology role play dysfunction, either isolation examining pathologies interact specifically focuses function observed models, typically measured using electrophysiology calcium imaging. Following loss, it would be impossible imagine not alter oscillatory activity brain. Therefore, discusses underpin aberrant patterns seen patients. Finally, an overview key directions considerations field covered. includes current therapeutics targeted at but methods modulate rescue patterns. Other important future avenues note include non-neuronal cell types such as astrocytes microglia, mechanisms independent will certainly continue for foreseeable future.

Language: Английский

Citations

73
Frontotemporal Dementia, Where Do We Stand? A Narrative Review DOI Open Access
Annibale Antonioni,

Emanuela Maria Raho,

Piervito Lopriore

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11732 - 11732

Published: July 21, 2023

Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it accounts for up to 10% middle-age-onset dementias and entails social, economic, emotional burden the patients caregivers. It characterised by (at least initially) selective degeneration frontal and/or temporal lobe, generally leading behavioural alterations, speech disorders, psychiatric symptoms. Despite recent advances, given its extreme heterogeneity, an overview that can bring together all data currently available still lacking. Here, we aim provide state art on pathogenesis this disease, starting with established findings integrating them more ones. In particular, advances in genetics field will be examined, assessing relation both clinical manifestations histopathological findings, as well considering link other diseases, such amyotrophic lateral sclerosis (ALS). Furthermore, current diagnostic criteria explored, including neuroimaging methods, nuclear medicine investigations, biomarkers biological fluids. Of note, promising information provided neurophysiological i.e., electroencephalography non-invasive brain stimulation techniques, concerning alterations networks neurotransmitter systems reviewed. Finally, experimental therapies considered.

Language: Английский

Citations

50
Differential Connectivity Patterns of Mild Cognitive Impairment in Alzheimer's and Parkinson's Disease: A Large-scale Brain Network Study DOI

Juzhou Wang,

Xiaolu Li,

Huize Pang

et al.

Academic Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Unlocking the Potential of Repetitive Transcranial Magnetic Stimulation in Alzheimer’s Disease: A Meta-Analysis of Randomized Clinical Trials to Optimize Intervention Strategies DOI Creative Commons
Sha Li,

Xiaoyong Lan,

Yumei Liu

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 98(2), P. 481 - 503

Published: March 1, 2024

Background: Repetitive transcranial magnetic stimulation (rTMS) is an advanced and noninvasive technology that uses pulse to treat cognitive impairment. However, its specific effects have always been mixed with those of training, the optimal parameter for Alzheimer’s disease (AD) intervention still ambiguous. Objective: This study aimed summarize therapeutic pure rTMS on AD, excluding influence develop a preliminary treatment plan. Methods: Between 1 January 2010 28 February 2023, we screened randomized controlled clinical trials from five databases (PubMed, Web Science, Embase, Cochrane, ClinicalTrials. gov). We conducted meta-analysis systematic review outcomes parameters. Result: A total 4,606 articles were retrieved. After applying inclusion exclusion criteria, 16 articles, comprising 655 participants (308 males 337 females), included in final analysis. The findings revealed significantly enhances both global ability (p = 0.0002, SMD 0.43, 95% CI 0.20–0.66) memory 0.009, 0.37, 0.09–0.65). Based follow-up periods at least 6 weeks, following protocols demonstrated efficacy AD: sites (single or multiple targets), frequency (20 Hz), time (1–2 s), interval (20–30 single pulses (≤2500), (>20000), duration (≥3 weeks), sessions (≥20). Conclusions: suggests may be effective option patients potential capabilities should further developed future.

Language: Английский

Citations

7
Real-time cortical dynamics during motor inhibition DOI Creative Commons
Elias Paolo Casula, Valentina Pezzopane,

Andrea Roncaioli

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 3, 2024

Abstract The inhibition of action is a fundamental executive mechanism human behaviour that involve complex neural network. In spite the progresses made so far, many questions regarding brain dynamics occurring during are still unsolved. Here, we used novel approach optimized to investigate real-time effective dynamics, which combines transcranial magnetic stimulation (TMS) with simultaneous electroencephalographic (EEG) recordings. 22 healthy volunteers performed motor Go/NoGo task TMS hand-hotspot primary cortex (M1) and whole-scalp EEG We reconstructed source-based spatiotemporal cortical activity cortico-cortical connectivity throughout task. Our results showed task-dependent bi-directional change in theta/gamma supplementary (SMA) M1 that, when participants were instructed inhibit their response, resulted an increase specific TMS-evoked potential (N100), likely due GABA-mediated inhibition. Interestingly, these changes linearly related reaction times, asked produce response. addition, perturbation revealed long-lasting modulation SMA–M1 natural frequencies, i.e. alpha/beta activity. Some shared by animal models shed new light on physiological mechanisms humans.

Language: Английский

Citations

6
Transcranial Magnetic Stimulation Across the Lifespan: Impact of Developmental and Degenerative Processes DOI Creative Commons
Lindsay M. Oberman, Alberto Benussi

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(6), P. 581 - 591

Published: July 29, 2023

Transcranial magnetic stimulation (TMS) has emerged as a pivotal non-invasive technique for investigating cortical excitability and plasticity across the lifespan, offering valuable insights into neurodevelopmental neurodegenerative processes. In this review, we explore impact of TMS applications on our understanding normal development, healthy aging, disorders, adult-onset diseases. By presenting key developmental milestones age-related changes in measures, provide foundation maturation neurotransmitter systems trajectory cognitive functions throughout lifespan. Building foundation, paper delves pathophysiology including autism spectrum attention deficit hyperactivity disorder, Tourette's syndrome adolescent depression. Highlighting recent findings altered circuits dysfunctional plasticity, underscores potential tool unraveling underlying mechanisms informing future therapeutic interventions. We also review emerging role treating most common disorders late-onset outlining NIBS techniques these discuss growing body evidence supporting their use tools symptom management potentially slowing disease progression. The gained from studies have advanced both diseased states, ultimately development more targeted diagnostic strategies wide range neuropsychiatric conditions.

Language: Английский

Citations

15
Sex difference in brain functional connectivity of hippocampus in Alzheimer’s disease DOI

Jordan N. Williamson,

Shirley A. James, Péter Mukli

et al.

GeroScience, Journal Year: 2023, Volume and Issue: 46(1), P. 563 - 572

Published: Sept. 24, 2023

Language: Английский

Citations

13
Efficacy of rTMS for poststroke epilepsy and its effects on patients’ cognitive function and depressive status DOI Creative Commons

Minting Hu,

Bailing Qin,

Tong Li

et al.

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 12, 2024

Abstract Objective This study aimed to investigate the efficacy of rTMS in treatment poststroke epilepsy and effect on patients’ cognitive function depressive status. Methods One hundred twenty-one patients with mild impairment status admitted Department Neurology Second People’s Hospital Nanning from January 1, 2017, April 31, 2023, were selected divided into group (treated group) control group. MMSE scores HAMD recorded before after treatment. The frequency EEG spiky waves within 24 h any clinical seizure form (the number seizures 1 month treatment) changes observed indices calculated. differences between data two groups analyzed, further assess rTMS’ effects cognition depression. Results Compared drug alone, significantly decreased epileptiform discharges stroke, especially lesions frontal, temporal, parietal lobes. can effectively reduce mood disorders, such as depression, for frontal temporal results this experiment suggest that does not increase adverse effects. Conclusion reduces while improving depression epilepsy. Therefore, we low-frequency be used an adjunctive provide some ideas references

Language: Английский

Citations

4
The role of parvalbumin interneuron dysfunction across neurodegenerative dementias DOI
Carmelo Smeralda,

Siddhartha Pandit,

Sonia Turrini

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102509 - 102509

Published: Sept. 1, 2024

Language: Английский

Citations

4