GeroScience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 29, 2024
Post-COVID
syndrome
manifests
with
numerous
neurological
and
cognitive
symptoms,
the
precise
origins
of
which
are
still
not
fully
understood.
As
females
older
adults
more
susceptible
to
developing
this
condition,
our
study
aimed
investigate
how
post-COVID
alters
intrinsic
brain
dynamics
in
whether
biological
sex
training
might
modulate
these
effects,
a
specific
focus
on
females.
The
participants,
aged
between
60
75
years,
were
divided
into
three
experimental
groups:
healthy
old
female,
female
male.
They
underwent
an
adaptive
task-switching
protocol.
We
analysed
multiscale
entropy
spectral
power
density
resting-state
EEG
data
collected
before
after
assess
neural
signal
complexity
oscillatory
power,
respectively.
found
no
difference
males
training,
indicating
that
similarly
affected
both
sexes.
However,
was
effective
only
males,
by
modulating
local
processing
capacity.
This
improvement
further
evidenced
comparing
females,
wherein
latter
group
showed
increased
finer
timescale
(1-30
ms)
higher
frequency
band
(11-40
Hz)
but
differences
disappeared
following
training.
Our
results
suggest
syndrome,
there
is
pronounced
shift
from
global
processing,
potentially
contributing
accelerated
aging
condition.
seems
offer
promising
intervention
method
for
changes
dynamics,
especially
among
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(6), P. 789 - 789
Published: March 10, 2024
Recent
research
exploring
the
relationship
between
gut
and
brain
suggests
that
condition
of
microbiota
can
influence
cognitive
health.
A
well-balanced
may
help
reduce
inflammation,
which
is
linked
to
neurodegenerative
conditions.
Prebiotics,
probiotics,
symbiotics
are
nutritional
supplements
functional
food
components
associated
with
gastrointestinal
well-being.
The
bidirectional
communication
gut–brain
axis
essential
for
maintaining
homeostasis,
pre-,
pro-,
potentially
affecting
various
functions
such
as
attention,
perception,
memory.
Numerous
studies
have
consistently
shown
incorporating
into
a
healthy
diet
lead
improvements
in
mood.
Maintaining
support
optimal
function,
crucial
disease
prevention
our
fast-paced,
Westernized
society.
Our
results
indicate
benefits
older
individuals
probiotic
supplementation
but
not
who
good
adequate
levels
physical
activity.
Additionally,
it
appears
there
patients
mild
impairment
Alzheimer’s
disease,
while
mixed
seem
arise
younger
healthier
individuals.
However,
important
acknowledge
individual
responses
vary,
use
these
dietary
should
be
tailored
each
individual’s
unique
health
circumstances
needs.
Journal of Experimental Neurology,
Journal Year:
2024,
Volume and Issue:
5(2), P. 42 - 64
Published: Jan. 1, 2024
Alzheimer’s
Disease
(AD)
and
Disease-Related
Dementia
(ADRD)
are
the
primary
causes
of
dementia
that
has
a
devastating
effect
on
quality
life
is
tremendous
economic
burden
healthcare
system.
The
accumulation
extracellular
beta-amyloid
(Aβ)
plaques
intracellular
hyperphosphorylated
tau-containing
neurofibrillary
tangles
(NFTs)
in
brain
hallmarks
AD.
They
also
thought
to
be
underlying
cause
inflammation,
neurodegeneration,
atrophy,
cognitive
impairments
accompany
discovery
APP,
PS1,
PS2
mutations
increase
Aβ
production
families
with
early
onset
familial
AD
led
development
numerous
transgenic
rodent
models
These
have
provided
new
insight
into
role
AD;
however,
they
do
not
fully
replicate
pathology
patients.
Familial
patients
elevate
represent
only
small
fraction
In
contrast,
those
late-onset
sporadic
constitute
majority
cases.
This
observation,
along
failure
previous
clinical
trials
targeting
or
Tau
modest
success
recent
using
monoclonal
antibodies,
reappraisal
view
sole
factor
pathogenesis
More
studies
established
cerebral
vascular
dysfunction
one
earliest
changes
seen
AD,
67%
candidate
genes
linked
expressed
vasculature.
Thus,
there
an
increasing
appreciation
contribution
National
Institute
Aging
(NIA)
Foundation
recently
prioritized
it
as
focused
research
area.
review
summarizes
strengths
limitations
most
commonly
used
animal
current
views
about
versus
cerebrovascular
Aging Medicine,
Journal Year:
2024,
Volume and Issue:
7(5), P. 649 - 667
Published: Oct. 1, 2024
Abstract
Alzheimer's
disease
(AD)
is
a
neurodegenerative
that
characterized
by
amyloid
plaques,
neurofibrillary
tangles,
and
neuronal
loss.
Early
cerebral
body
iron
dysregulation
accumulation
interact
with
AD
pathology,
particularly
in
the
precuneus,
crucial
functional
hub
cognitive
functions.
Quantitative
susceptibility
mapping
(QSM),
novel
post‐processing
approach,
provides
insights
into
tissue
levels
oxygen
metabolism
reveals
abnormal
early
AD.
Increased
deposition
precuneus
can
lead
to
oxidative
stress,
neuroinflammation,
accelerated
neurodegeneration.
Metabolic
disorders
(diabetes,
non‐alcoholic
fatty
liver
(NAFLD),
obesity),
genetic
factors,
small
vessel
pathology
contribute
precuneus.
Therefore,
line
growing
of
literature
region
patients
AD,
QSM
as
neuroimaging
method
could
serve
non‐invasive
biomarker
track
progression,
complement
other
imaging
modalities,
aid
diagnosis
monitoring.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 4, 2024
Alzheimer's
Disease
(AD)
is
increasingly
recognized
as
being
associated
with
metabolic
disorders,
including
Metabolic
Associated
Steatotic
Liver
(MASLD).
This
study
aimed
to
assess
the
relative
risk
of
AD
in
individuals
MASLD.
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
21(3)
Published: March 1, 2025
Abstract
INTRODUCTION
Post‐menopausal
women
constitute
about
two‐thirds
of
those
with
Alzheimer's
disease
(AD).
Menopause
increases
dementia
risk
by
heightening
the
likelihood
metabolic
disease,
a
well‐known
factor
for
dementia.
We
aimed
to
determine
effects
menopause
and
high‐fat
diet
(HF)
on
cognitive
pathological
outcomes
in
an
AD
mouse
model.
METHODS
At
3
months
old,
App
NL‐F
mice
received
4‐vinylcyclohexene
diepoxide
(menopause
model)
or
vehicle
were
placed
control
(10%
fat)
HF
(60%
until
10
old.
RESULTS
An
interaction
between
led
impaired
recognition
memory.
No
observed
amyloid
pathology.
However,
induced
alterations
microglial
response,
white
matter,
hippocampal
neurogenesis.
DISCUSSION
This
work
highlights
need
model
endocrine
aging
animal
models
contributes
further
understanding
health
context
AD.
Highlights
The
combination
early
onset
impairment.
increased
pathology
hippocampus.
increase
microglia
density
decrease
myelin
corpus
callosum.
altered
neurogenesis
diet‐dependent
manner.
