ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(45), P. 44860 - 44875
Published: Nov. 1, 2024
A
diabetic
wound
exemplifies
the
challenge
of
chronic,
nonhealing
wounds.
Elevated
blood
sugar
levels
in
diabetes
profoundly
disrupt
macrophage
function,
impairing
crucial
activities
such
as
phagocytosis,
immune
response,
cell
migration,
and
vessel
formation,
all
essential
for
effective
healing.
Moreover,
persistent
presence
pro-inflammatory
cytokines
reactive
oxygen
species,
coupled
with
a
decrease
anti-inflammatory
factors,
exacerbates
delay
healing
associated
diabetes.
This
review
emphasizes
dysfunctional
inflammatory
responses
underlying
wounds
explores
preclinical
studies
inflammation-modulating
bioactives
biomaterials
that
show
promise
expediting
Additionally,
this
provides
an
overview
selected
clinical
employing
bioactive
molecules,
shedding
light
on
gap
between
extensive
research
limited
field.
Macromolecular Chemistry and Physics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 30, 2024
Abstract
Diabetic
foot
ulcer
has
become
a
heavy
burden
to
the
healthcare
system
with
high
and
growing
incidence
of
diabetes.
Persistent
bacterial
infections
in
diabetic
wounds
can
lead
chronic
inflammation
delayed
wound
healing.
To
address
these
challenges,
dual‐crosslinked
antibacterial
hydrogel
loaded
anti‐inflammatory
compound
asiaticoside
is
developed
this
study.
The
demonstrated
suitable
gelation
properties,
good
biocompatibility,
exceptional
activity.
In
model
on
rats,
asiaticoside‐loaded
alleviate
inflammation,
promote
angiogenesis,
accelerate
Therefore,
shows
considerable
potential
for
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1244 - 1244
Published: Sept. 25, 2024
Excessive
reactive
oxygen
species
(ROS)
in
diabetic
wounds
are
major
contributors
to
chronic
and
impaired
healing,
posing
significant
challenges
regenerative
medicine.
Developing
innovative
drug
delivery
systems
is
crucial
address
these
issues
by
modifying
the
adverse
microenvironment
promoting
effective
wound
healing.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
Effective
regulation
and
reconstruction
of
the
microenvironment
are
critical
for
regeneration
chronic
wounds.
Diabetic
wounds,
in
particular,
pose
a
significant
clinical
challenge
due
to
increased
oxidative
stress
dysfunctional
healing
processes.
In
this
study,
novel
therapeutic
strategy
is
developed
using
3D
copper‐magnesium
bimetallic
antioxidant
nano‐enzymes
(Cu/Mg‐MOF)
mitigate
reactive
oxygen
species
(ROS)
restore
redox
balance
through
electron
transfer.
To
optimize
delivery,
thermo‐sensitive
hydrogel
composed
chitosan
(CS)
ε
‐polylysine
(PL)
designed,
serving
as
an
efficient
carrier
nano‐enzymes.
This
Cu/Mg‐MOF@CS/PL
exhibits
excellent
physical
properties,
including
injectability,
softness,
biocompatibility,
making
it
ideal
application
diabetic
wound
model,
treatment
with
significantly
accelerated
healing,
closure
rate
90.6%
by
day
14,
compared
just
55.4%
untreated
group.
The
effectively
promoted
key
aspects
such
collagen
deposition,
re‐epithelialization,
angiogenesis,
immunomodulation.
These
findings
underscore
potential
promising
system
enhancing
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(45), P. 44860 - 44875
Published: Nov. 1, 2024
A
diabetic
wound
exemplifies
the
challenge
of
chronic,
nonhealing
wounds.
Elevated
blood
sugar
levels
in
diabetes
profoundly
disrupt
macrophage
function,
impairing
crucial
activities
such
as
phagocytosis,
immune
response,
cell
migration,
and
vessel
formation,
all
essential
for
effective
healing.
Moreover,
persistent
presence
pro-inflammatory
cytokines
reactive
oxygen
species,
coupled
with
a
decrease
anti-inflammatory
factors,
exacerbates
delay
healing
associated
diabetes.
This
review
emphasizes
dysfunctional
inflammatory
responses
underlying
wounds
explores
preclinical
studies
inflammation-modulating
bioactives
biomaterials
that
show
promise
expediting
Additionally,
this
provides
an
overview
selected
clinical
employing
bioactive
molecules,
shedding
light
on
gap
between
extensive
research
limited
field.
