Cancer Nanotechnology,
Journal Year:
2016,
Volume and Issue:
7(1)
Published: Nov. 3, 2016
Radiotherapy
is
currently
used
in
around
50%
of
cancer
treatments
and
relies
on
the
deposition
energy
directly
into
tumour
tissue.
Although
it
generally
effective,
some
deposited
can
adversely
affect
healthy
tissue
outside
volume,
especially
case
photon
radiation
(gamma
X-rays).
Improved
radiotherapy
outcomes
be
achieved
by
employing
ion
beams
due
to
characteristic
curve
which
culminates
a
localised,
high
dose
(in
form
Bragg
peak).
In
addition
radiotherapy,
novel
sensitisers,
such
as
nanoparticles,
have
shown
locally
increase
damaging
effect
both
radiation,
when
are
applied
area.
Amongst
available
nanoparticle
systems,
gold
nanoparticles
become
particularly
popular
several
advantages:
biocompatibility,
well-established
methods
for
synthesis
wide
range
sizes,
possibility
coating
their
surface
with
large
number
different
molecules
provide
partial
control
of,
example,
charge
or
interaction
serum
proteins.
This
gives
full
options
design
parameter
combinations,
optimal
choice
not
always
clear,
partially
lack
understanding
many
processes
that
take
place
upon
irradiation
complicated
systems.
this
review,
we
summarise
mechanisms
action
therapy
photons
ions
presence
absence
well
influence
core
parameters
radiosensitisation
capabilities.
ACS Nano,
Journal Year:
2016,
Volume and Issue:
10(4), P. 4410 - 4420
Published: March 20, 2016
Carbon
dots
(CDs)
are
remarkable
nanocarriers
due
to
their
promising
optical
and
biocompatible
capabilities.
However,
practical
applicability
in
cancer
therapeutics
is
limited
by
insensitive
surface
properties
complicated
tumor
microenvironment
vivo.
Herein,
a
extracellular
microenvironment-responsive
drug
nanocarrier
based
on
cisplatin(IV)
prodrug-loaded
charge-convertible
CDs
(CDs–Pt(IV)@PEG-(PAH/DMMA))
was
developed
for
imaging-guided
delivery.
An
anionic
polymer
with
dimethylmaleic
acid
(PEG-(PAH/DMMA))
the
fabricated
CDs–Pt(IV)@PEG-(PAH/DMMA)
could
undergo
intriguing
charge
conversion
cationic
mildly
acidic
(pH
∼
6.8),
leading
strong
electrostatic
repulsion
release
of
positive
CDs–Pt(IV).
Importantly,
positively
charged
displays
high
affinity
negatively
cell
membrane,
which
results
enhanced
internalization
effective
activation
prodrug
reductive
cytosol.
The
vitro
experimental
confirmed
that
this
possesses
better
therapeutic
efficiency
under
than
normal
physiological
condition
noncharge-convertible
nanocarrier.
vivo
experiments
further
demonstrated
tumor-inhibition
efficacy
low
side
effects
CDs,
proving
its
capability
as
smart
effects.
present
work
provides
strategy
promote
potential
clinical
application
treatment.
Nano Convergence,
Journal Year:
2019,
Volume and Issue:
6(1)
Published: July 14, 2019
Nanotechnology
has
the
potential
to
circumvent
several
drawbacks
of
conventional
therapeutic
formulations.
In
fact,
significant
strides
have
been
made
towards
application
engineered
nanomaterials
for
treatment
cancer
with
high
specificity,
sensitivity
and
efficacy.
Tailor-made
functionalized
specific
ligands
can
target
cells
in
a
predictable
manner
deliver
encapsulated
payloads
effectively.
Moreover,
also
be
designed
increased
drug
loading,
improved
half-life
body,
controlled
release,
selective
distribution
by
modifying
their
composition,
size,
morphology,
surface
chemistry.
To
date,
polymeric
nanomaterials,
metallic
nanoparticles,
carbon-based
materials,
liposomes,
dendrimers
developed
as
smart
delivery
systems
treatment,
demonstrating
enhanced
pharmacokinetic
pharmacodynamic
profiles
over
formulations
due
nanoscale
size
unique
physicochemical
characteristics.
The
data
present
literature
suggest
that
nanotechnology
will
provide
next-generation
platforms
management
anticancer
therapy.
Therefore,
this
critical
review,
we
summarize
range
which
are
currently
being
employed
therapies
discuss
fundamental
role
properties
management.
We
further
elaborate
on
topical
progress
date
toward
nanomaterial
engineering
therapy,
including
current
strategies
targeting
release
efficient
administration.
issues
nanotoxicity,
is
an
often-neglected
feature
nanotechnology.
Finally,
attempt
challenges
nanotherapeutics
outlook
future
important
field.
ACS Nano,
Journal Year:
2018,
Volume and Issue:
12(8), P. 8423 - 8435
Published: July 17, 2018
Coating
the
nanoparticle
surface
with
cancer
cell
recognizing
ligands
is
expected
to
facilitate
specific
delivery
of
nanoparticles
diseased
cells
in
vivo.
While
this
targeting
strategy
appealing,
no
nanoparticle-based
active
formulation
for
solid
tumor
treatment
had
made
it
past
phase
III
clinical
trials.
Here,
we
quantified
cell-targeting
efficiencies
Trastuzumab
(Herceptin)
and
folic
acid
coated
gold
silica
multiple
mouse
models.
Surprisingly,
showed
that
less
than
14
out
1
million
(0.0014%
injected
dose)
intravenously
administrated
were
delivered
targeted
cells,
only
2
100
interacted
nanoparticles.
The
majority
intratumoral
either
trapped
extracellular
matrix
or
taken
up
by
perivascular
associated
macrophages.
low
efficiency
significant
uptake
noncancer
suggest
need
re-evaluate
process
therapeutic
mechanisms
using
quantitative
methods.
This
will
be
important
developing
strategies
deliver
emerging
therapeutics
such
as
genome
editing,
nucleic
therapy,
immunotherapy
nanocarriers.
Bioactive Materials,
Journal Year:
2020,
Volume and Issue:
6(7), P. 1973 - 1987
Published: Dec. 26, 2020
The
tumor
development
and
metastasis
are
closely
related
to
the
structure
function
of
microenvironment
(TME).
Recently,
TME
modulation
strategies
have
attracted
much
attention
in
cancer
immunotherapy.
Despite
preliminary
success
immunotherapeutic
agents,
their
therapeutic
effects
been
restricted
by
limited
retention
time
drugs
TME.
Compared
with
traditional
delivery
systems,
nanoparticles
unique
physical
properties
elaborate
design
can
efficiently
penetrate
specifically
deliver
major
components
In
this
review,
we
briefly
introduce
substitutes
including
dendritic
cells,
macrophages,
fibroblasts,
vasculature,
tumor-draining
lymph
nodes
hypoxic
state,
then
review
various
targeting
these
applications
therapy.
addition,
could
be
combined
other
therapies,
chemotherapy,
radiotherapy,
photodynamic
therapy,
however,
nanoplatform
system
may
not
effective
all
types
tumors
due
heterogeneity
different
individuals.
changes
at
stages
during
required
further
elucidated
so
that
more
individualized
nanoplatforms
designed.
Nature Communications,
Journal Year:
2015,
Volume and Issue:
6(1)
Published: Dec. 2, 2015
Abstract
To
date,
numerous
inorganic
nanocarriers
have
been
explored
for
drug
delivery
systems
(DDSs).
However,
the
clinical
application
of
formulations
has
often
hindered
by
their
toxicity
and
failure
to
biodegrade.
We
describe
here
a
transformable
liquid-metal
nanomedicine,
based
on
core–shell
nanosphere
composed
liquid-phase
eutectic
gallium-indium
core
thiolated
polymeric
shell.
This
formulation
can
be
simply
produced
through
sonication-mediated
method
with
bioconjugation
flexibility.
The
resulting
nanoparticles
loaded
doxorubicin
(Dox)
an
average
diameter
107
nm
demonstrate
capability
fuse
subsequently
degrade
under
mildly
acidic
condition,
which
facilitates
release
Dox
in
endosomes
after
cellular
internalization.
Equipped
hyaluronic
acid,
tumour-targeting
ligand,
this
displays
enhanced
chemotherapeutic
inhibition
towards
xenograft
tumour-bearing
mice.
liquid
metal-based
DDS
fusible
degradable
behaviour
physiological
conditions
provides
new
strategy
engineering
theranostic
agents
low
toxicity.
Nano Letters,
Journal Year:
2018,
Volume and Issue:
18(12), P. 7609 - 7618
Published: Nov. 1, 2018
Chemodynamic
therapy
(CDT)
can
efficiently
destroy
tumor
cells
via
Fenton
reaction
in
the
presence
of
H2O2
and
a
robust
catalyst.
However,
it
has
faced
severe
challenges
including
limited
amounts
inefficiency
catalysts.
Here,
an
adenosine
triphosphate
(ATP)-responsive
autocatalytic
nanosystem
(GOx@ZIF@MPN),
incorporated
with
glucose
oxidase
(GOx)
zeolitic
imidazolate
framework
(ZIF)
then
coated
metal
polyphenol
network
(MPN),
was
designed
synthesized
for
ablation
self-supplied
TA-mediated
acceleration
Fe(III)/Fe(II)
conversion.
In
ATP-overexpressed
cells,
outer
shell
MPN
GOx@ZIF@MPN
degraded
into
Fe(III)
tannic
acid
(TA)
internal
GOx
exposed.
Then,
reacted
endogenous
to
produce
plenty
H2O2,
TA
reduced
Fe(II),
which
is
much
more
vigorous
catalyst
reaction.
Subsequently,
self-produced
catalyzed
by
Fe(II)
generate
highly
toxic
hydroxyl
radical
(•OH)
Fe(III).
The
produced
low
catalytic
activity
quickly
reactive
mediated
TA,
forming
accelerated
conversion
guarantee
efficient
reaction-mediated
CDT.
This
might
provide
good
paradigm
effective
treatment.
Surface Science Reports,
Journal Year:
2017,
Volume and Issue:
72(1), P. 1 - 58
Published: Feb. 1, 2017
Nanostructures
of
diverse
chemical
nature
are
used
as
biomarkers,
therapeutics,
catalysts,
and
structural
reinforcements.
The
decoration
with
surfactants
has
a
long
history
is
essential
to
introduce
specific
functions.
definition
in
this
review
very
broad,
following
its
lexical
meaning
"surface
active
agents",
therefore
includes
traditional
alkyl
modifiers,
biological
ligands,
polymers,
other
surface
molecules.
systematically
covers
covalent
non-covalent
interactions
such
various
types
nanomaterials,
including
metals,
oxides,
layered
materials,
polymers
well
their
applications.
major
themes
(i)
molecular
recognition
noncovalent
assembly
mechanisms
on
the
nanoparticle
nanocrystal
surfaces,
(ii)
grafting
techniques
multi-step
modification,
(iii)
dispersion
properties
reactions,
(iv)
use
influence
crystal
growth,
(v)
incorporation
biorecognition
material-targeting
functionality.
For
materials
classes,
similarities
differences
surfactant
assembly,
function,
performance
applications
described
comparative
way.
Major
factors
that
lead
differentiation
energy,
chemistry
pH
sensitivity,
degree
regularity
defects
cores
shell.
broad
range
modifications
sensors,
nanomaterials
for
catalysis,
energy
conversion
storage,
nanoparticles
composites
cement,
purification
systems
classical
detergents.
Design
principles
optimize
nanostructures
discussed.
concludes
challenges
opportunities.
