Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(15)
Published: June 18, 2020
Abstract
Nanotheranostics,
which
combines
optical
multiplexed
disease
detection
with
therapeutic
monitoring
in
a
single
modality,
has
the
potential
to
propel
field
of
nanomedicine
toward
genuine
personalized
medicine.
Currently
employed
mainstream
modalities
using
gold
nanoparticles
(AuNPs)
diagnosis
and
treatment
are
limited
by
lack
specificity
issues
associated
systemic
toxicity.
Light‐mediated
nanotheranostics
offers
relatively
non‐invasive
alternative
for
cancer
AuNPs
specific
shapes
sizes
that
absorb
near
infrared
(NIR)
light,
inducing
plasmon
resonance
enhanced
tumor
generating
localized
heat
ablation.
Over
last
decade,
significant
progress
been
made
nanotheranostics,
however
main
biological
translational
barriers
leading
new
paradigm
anti‐cancer
stem
from
molecular
complexities
an
incomplete
mechanistic
understanding
utilization
Au‐NPs
living
systems.
This
work
provides
comprehensive
overview
on
biological,
physical
facing
development
nanotheranostics.
It
will
also
summarise
recent
advances
engineering
AuNPs,
their
unique
characteristics
and,
importantly,
tunability
achieve
desired
optical/photothermal
properties.
Advanced Science,
Journal Year:
2019,
Volume and Issue:
6(17)
Published: July 22, 2019
Recent
advances
of
plasmonic
nanoparticles
include
fascinating
developments
in
the
fields
energy,
catalyst
chemistry,
optics,
biotechnology,
and
medicine.
The
photothermal
properties
metallic
are
enormous
interest
biomedical
because
their
strong
tunable
optical
response
capability
to
manipulate
effect
by
an
external
light
source.
To
date,
most
applications
using
have
focused
on
therapy;
however,
fully
realize
potential
these
particles
for
clinical
other
applications,
fundamental
need
be
better
understood
controlled,
effect-based
diagnosis,
treatment,
theranostics
should
thoroughly
explored.
This
Progress
Report
summarizes
recent
understanding
nanoparticles,
particularly
sensing,
imaging,
therapy,
drug
delivery,
discusses
future
directions
fields.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
32(13)
Published: July 28, 2019
Abstract
2D
nanomaterials
with
unique
nanosheet
structures,
large
surface
areas,
and
extraordinary
physicochemical
properties
have
attracted
tremendous
interest.
In
the
area
of
nanomedicine,
research
on
graphene
its
derivatives
for
diverse
biomedical
applications
began
as
early
2008.
Since
then,
many
other
types
nanomaterials,
including
transition
metal
dichalcogenides,
carbides,
nitrides
carbonitrides,
black
phosphorus
nanosheets,
layered
double
hydroxides,
metal–organic
framework
been
explored
in
nanomedicine
over
past
decade.
particular,
a
makes
highly
efficient
drug
delivery
nanoplatforms.
The
optical
and/or
X‐ray
attenuation
can
be
harnessed
phototherapy
or
radiotherapy
cancer.
Furthermore,
by
integrating
functional
nanoparticles
utilizing
their
inherent
physical
properties,
may
also
engineered
nanoprobes
multimodal
imaging
tumors.
shown
substantial
potential
cancer
theranostics.
Herein,
latest
progress
development
theranostic
is
summarized.
Current
challenges
future
perspectives
applied
are
discussed.
Small,
Journal Year:
2021,
Volume and Issue:
18(6)
Published: Nov. 2, 2021
Abstract
Chemodynamic
therapy
(CDT),
a
novel
cancer
therapeutic
strategy
defined
as
the
treatment
using
Fenton
or
Fenton‐like
reaction
to
produce
•OH
in
tumor
region,
was
first
proposed
by
Bu,
Shi,
and
co‐workers
2016.
Recently,
with
rapid
development
of
nanomaterials,
CDT
has
attracted
tremendous
attention
because
its
unique
advantages:
1)
It
is
tumor‐selective
low
side
effects;
2)
process
does
not
depend
on
external
field
stimulation;
3)
it
can
modulate
hypoxic
immunosuppressive
microenvironment;
4)
cost
low.
In
addition
Fe‐involved
strategies,
reaction‐mediated
strategies
have
also
been
proposed,
which
are
based
many
other
metal
elements
including
copper,
manganese,
cobalt,
titanium,
vanadium,
palladium,
silver,
molybdenum,
ruthenium,
tungsten,
cerium,
zinc.
Moreover,
combined
therapies
like
chemotherapy,
radiotherapy,
phototherapy,
sonodynamic
therapy,
immunotherapy
for
achieving
enhanced
anticancer
effects.
Besides,
there
studies
that
extend
application
antibacterial
field.
This
review
introduces
latest
advancements
nanomaterials‐involved
from
2018
present
proposes
current
limitations
well
future
research
directions
related
ACS Nano,
Journal Year:
2019,
Volume and Issue:
13(5), P. 5785 - 5798
Published: April 16, 2019
Understanding
how
nanoparticles
are
eliminated
from
the
body
is
required
for
their
successful
clinical
translation.
Many
promising
nanoparticle
formulations
in
vivo
medical
applications
large
(>5.5
nm)
and
nonbiodegradable,
so
they
cannot
be
renally.
A
proposed
pathway
these
hepatobiliary
elimination,
but
transport
has
not
been
well-studied.
Here,
we
explored
barriers
that
determined
elimination
of
through
route.
The
route
usually
following
pathway:
(1)
liver
sinusoid,
(2)
space
Disse,
(3)
hepatocytes,
(4)
bile
ducts,
(5)
intestines,
(6)
out
body.
We
discovered
interaction
with
nonparenchymal
cells
(e.g.,
Kupffer
sinusoidal
endothelial
cells)
determines
fate.
Each
step
contains
can
sequester
chemically
or
physically
alter
nanoparticles,
which
influences
fecal
elimination.
showed
removal
increased
by
>10
times.
Combining
our
results
those
prior
studies,
start
to
build
a
systematic
view
pathways
as
it
relates
particle
size
other
design
parameters.
This
critical
engineering
medically
useful
translatable
nanotechnologies.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(4), P. 6008 - 6029
Published: April 1, 2021
The
constant
advent
of
major
health
threats
such
as
antibacterial
resistance
or
highly
communicable
viruses,
together
with
a
declining
antimicrobial
discovery,
urgently
requires
the
exploration
innovative
therapeutic
approaches.
Nowadays,
strategies
based
on
metal
nanoparticle
technology
have
demonstrated
interesting
outcomes
due
to
their
intrinsic
features.
In
this
scenario,
there
is
an
emerging
and
growing
interest
in
copper-based
nanoparticles
(CuNPs).
Indeed,
pure
metallic
form,
oxides,
combination
sulfur,
CuNPs
peculiar
behaviors
that
result
effective
activity
associated
stimulation
essential
body
functions.
Here,
we
present
critical
review
state
art
regarding
vitro
vivo
evaluations
absorption,
distribution,
metabolism,
excretion,
toxicity
(ADMET)
assessments.
Considering
potentiality
treatments,
within
Review
encounter
need
summarize
provide
expected
perspectives
contributions
infectious
disease
management.
