On the Promise of Photopharmacology Using Photoswitches: A Medicinal Chemist’s Perspective

Journal of Medicinal Chemistry, Journal Year: 2020, Volume and Issue: 63(20), P. 11436 - 11447

Published: June 8, 2020

Photopharmacology is a growing area of endeavor that employs photoswitchable ligands to allow for light-dependent pharmacological activity. By coupling light therapeutic action, improved spatial and temporal selectivity can be achieved subsequently harnessed new concepts in therapy. Tremendous progress has already been made, with photopharmacological agents now reported against wide array target classes results demonstrated range live cell animal models. Several challenges remain, however, especially order photopharmacology truly impact the clinical management disease. This Perspective aims summarize these challenges, particularly attention medicinal chemistry will unavoidably required further translation agents/approaches. clearly defining drug hunters, it hoped research into stimulated, ultimately enabling full realization huge potential this exciting field.

Language: Английский

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PHOTACs enable optical control of protein degradation

Science Advances, Journal Year: 2020, Volume and Issue: 6(8)

Published: Feb. 21, 2020

We present a modular approach to control the small molecule–mediated degradation of cellular proteins interest using light.

Language: Английский

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Molecular rotary motors: Unidirectional motion around double bonds

Proceedings of the National Academy of Sciences, Journal Year: 2018, Volume and Issue: 115(38), P. 9423 - 9431

Published: April 30, 2018

The field of synthetic molecular machines has quickly evolved in recent years, growing from a fundamental curiosity to highly active chemistry. Many different applications are being explored areas such as catalysis, self-assembled and nanostructured materials, electronics. Rotary motors hold great promise for achieving dynamic control functions well powering nanoscale devices. However, these reach their full potential, many challenges still need be addressed. In this paper we focus on the design principles rotary featuring double-bond axle discuss major that ahead us. Although progress been made, further improvements, example terms efficiency, energy input, environmental adaptability, will crucial fully exploit opportunities offer.

Language: Английский

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The Endeavor of Diarylethenes: New Structures, High Performance, and Bright Future

Advanced Optical Materials, Journal Year: 2018, Volume and Issue: 6(6)

Published: Feb. 2, 2018

Abstract Photochromism is a term that describes the photoreversible isomerization between two different states or isomers with distinct performances. Among all photochromic molecule family, diarylethene considered one of most popular star molecules on account its fast photoresponsibility, excellent thermal stability, fatigue resistance, high photoreaction quantum yield, and conversion ratio as well good performances in both solution solid phases. In past decades, development witnessed design, applications, surface/interface assembly, bulky crystals polymers, optic‐electronic devices fabrication, biotechnology. This review mainly focuses latest diarylethenes recent five years commences newly designed molecular structures functional ethene bridges aryl moieties. The application materials science, soft materials, data processing, biomaterials, further discussed prospect. A brief summary given end together some perspectives.

Language: Английский

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New molecular switch architectures

Proceedings of the National Academy of Sciences, Journal Year: 2018, Volume and Issue: 115(38), P. 9414 - 9422

Published: July 16, 2018

In this paper we elaborate on recently developed molecular switch architectures and how these new systems can help with the realization of functions advancement artificial machines. Progress in chemically photoinduced switches motors is summarized contextualized such that reader may gain an appreciation for novel tools have come about past decade. Many offer distinct advantages over commonly employed switches, including improved fidelity, addressability, robustness. Thus, serves as a jumping-off point researchers seeking switching motifs specific applications, or ones address limitations presently available systems.

Language: Английский

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Dynamic control of function by light-driven molecular motors

Nature Reviews Chemistry, Journal Year: 2017, Volume and Issue: 1(12)

Published: Nov. 29, 2017

Language: Английский

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Advances in Application of Azobenzene as a Trigger in Biomedicine: Molecular Design and Spontaneous Assembly

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(26)

Published: May 24, 2021

Abstract Azobenzene is a well‐known derivative of stimulus‐responsive molecular switches and has shown superior performance as functional material in biomedical applications. The results multiple studies have led to the development light/hypoxia‐responsive azobenzene for use. In recent years, long‐wavelength‐responsive been developed. Matching longer wavelength absorption hypoxia‐response characteristics switch unit bio‐optical window large effective stimulus response. addition, used hypoxia‐sensitive connector via biological cleavage under appropriate conditions. This resulted on/off state switching properties such pharmacology fluorescence activity. Herein, advances design fabrication trigger biomedicine are summarized.

Language: Английский

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Optical control of neuronal ion channels and receptors

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(9), P. 514 - 532

Published: July 9, 2019

Language: Английский

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Stiff‐Stilbene Photoswitches: From Fundamental Studies to Emergent Applications

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(32), P. 13192 - 13202

Published: March 28, 2020

Abstract Stiff‐stilbene, a sterically restricted fused ring analogue of stilbene, has been regularly used as model compound in theoretical studies stilbene photoisomerization. Lately, owing to its excellent photoswitching properties, it is increasingly being applied reversibly control the properties and function chemical well biological systems. Stiff‐stilbene photoswitches possess number advantageous including high quantum yield for photoisomerization thermal stability. Furthermore, they undergo large geometrical change upon isomerization their synthesis straightforward. Herein, we provide an overview basic stiff‐stilbene recent applications supramolecular chemistry, catalysis,

Language: Английский

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Computational Design and Synthesis of a Deeply Red-Shifted and Bistable Azobenzene

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(14), P. 6538 - 6547

Published: March 24, 2020

We computationally dissected the electronic and geometrical influences of ortho-chlorinated azobenzenes on their photophysical properties. X-ray analysis provided insight that trans-tetra-ortho-chloro azobenzene is conformationally flexible thus subject to molecular motions. This allows photoswitch adopt a range red-shifted geometries, which account for extended n → π* band tails. On basis our results, we designed di-ortho-fluoro di-ortho-chloro (dfdc) computational evidence superiority this substitution pattern tetra-ortho-chloro azobenzene. Thereafter, synthesized dfdc by ortho-chlorination via 2-fold C–H activation experimentally confirmed its structural properties through UV–vis, NMR, analyses. The advantages include near-bistable isomers an increased separation bands between trans- cis-conformations, generation unusually high levels cis-isomer irradiation with green/yellow light as well red within biooptical window.

Language: Английский

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