Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(4), P. 1004 - 1076

Published: Dec. 11, 2018

An updated comprehensive review to help researchers understand nanozymes better and in turn advance the field.

Language: Английский

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Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(6), P. 4357 - 4412

Published: Feb. 25, 2019

Because of the high catalytic activities and substrate specificity, natural enzymes have been widely used in industrial, medical, biological fields, etc. Although promising, they often suffer from intrinsic shortcomings such as cost, low operational stability, difficulties recycling. To overcome these shortcomings, researchers devoted to exploration artificial enzyme mimics for a long time. Since discovery ferromagnetic nanoparticles with horseradish peroxidase-like activity 2007, large amount studies on nanozymes constantly emerging next decade. Nanozymes are one kind nanomaterials enzymatic properties. Compared enzymes, advantages stability durability, which fields. A thorough understanding possible mechanisms will contribute development novel high-efficient nanozymes, rational regulations great significance. In this review, we systematically introduce classification, mechanism, regulation well recent research progress field biosensing, environmental protection, disease treatments, past years. We also propose current challenges their future focus. anticipate review may be significance understand properties mimicking activities.

Language: Английский

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Nanozyme: An emerging alternative to natural enzyme for biosensing and immunoassay

TrAC Trends in Analytical Chemistry, Journal Year: 2018, Volume and Issue: 105, P. 218 - 224

Published: May 26, 2018

Language: Английский

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Polydopamine Nanoparticles as Efficient Scavengers for Reactive Oxygen Species in Periodontal Disease

ACS Nano, Journal Year: 2018, Volume and Issue: 12(9), P. 8882 - 8892

Published: July 20, 2018

Antioxidative therapy has been considered an efficient strategy for the treatment of a series excessive reactive oxygen species (ROS)-triggered diseases, including oxidative-stress-induced periodontal disease. However, current natural enzymes and nanozymes often show their high specificity toward given ROS have insufficient antioxidative effects against multiple generated in diseases process. Meanwhile, multienzyme-based antioxidant defense systems are usually confined by complicated synthesis as well potential unwanted residue toxicity. Various supports highly needed to immobilize antioxidants during biorelated usages due low operational stability difficulty reuse. To overcome these limitations, we develop high-performance platform using biodegradable polydopamine nanoparticles (PDA NPs) smart scavengers oxidative stress-induced Although PDA-based materials well-known eliminate both vitro vivo, performance disease relative mechanisms yet be well-explored. In this study, PDA NPs can act dental specialties with ideal outcomes. Spectroscopic experiments provide strong evidence roles scavenging suppressing ROS-induced inflammation reactions. addition above investigations, results from murine periodontitis model clearly demonstrate feasibility robust which remove decrease without any side effects. Taken together, our present study will valuable insight into development safe platforms further biomedical uses.

Language: Английский

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Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation

ACS Nano, Journal Year: 2018, Volume and Issue: 12(4), P. 3780 - 3795

Published: April 3, 2018

Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low tissue-penetrating depth traditional phototriggered therapies, but SDT efficacy is still not satisfactorily high in combating cancer at current stage. Here we report on augmenting based catalytic nanomedicine, which takes efficient features nanoenzymes to modulate tumor microenvironment (TME). The multifunctional nanosonosensitizers have been successfully constructed by integration a MnO x component with biocompatible/biodegradable hollow mesoporous organosilica nanoparticles, followed conjugation protoporphyrin (as sonosensitizer) and cyclic arginine-glycine-aspartic pentapeptide targeting peptide). composite nanosonosensitizer acts as an inorganic nanoenzyme for converting tumor-overexpressed hydrogen peroxide (H2O2) molecules into oxygen enhancing level subsequently, has demonstrated facilitate SDT-induced reactive species production enhance subsequently. targeted accumulation these efficiently suppressed growth U87 xenograft nude mice after US-triggered treatment. vivo biocompatibility easy excretion from body also evaluated guarantee their future clinical translation, TME-responsive T1-weighted magnetic resonance imaging capability provides potential therapeutic guidance monitoring during SDT.

Language: Английский

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Recent Advances in Nanozymes: From Matters to Bioapplications

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(14)

Published: Dec. 16, 2021

Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute

Language: Английский

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Superoxide dismutase nanozymes: an emerging star for anti-oxidation

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(35), P. 6939 - 6957

Published: Jan. 1, 2021

This review summarizes catalytic mechanisms, regulatory factors, measurement methods and various applications of SOD-like nanozymes, as well proposes the current challenges prospects in development nanozymes.

Language: Английский

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Scavenging of reactive oxygen and nitrogen species with nanomaterials

Nano Research, Journal Year: 2018, Volume and Issue: 11(10), P. 4955 - 4984

Published: May 26, 2018

Language: Английский

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Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis

Nano Letters, Journal Year: 2019, Volume and Issue: 19(5), P. 2812 - 2823

Published: March 25, 2019

Ischemic stroke is a devastating disease and one of the leading causes mortality worldwide. Overproduction reactive oxygen nitrogen species (RONS) following ischemic insult known as key factor in exacerbating brain damage. Thus, RONS scavengers that can block excessive production have great therapeutic potential. Herein, we propose an efficient treatment strategy which artificial nanozyme with multienzyme activity drives neuroprotection against primarily by scavenging RONS. Specifically, through facile, Bi3+-assisted, template-free synthetic strategy, developed hollow Prussian blue nanozymes (HPBZs) to scavenge rat model stroke. The comprehensive characteristics HPBZs were explored. Apart from attenuating oxidative stress, also suppressed apoptosis counteracted inflammation both vitro vivo, thereby contributing increased tolerance injury minimal side effects. This study provides proof concept for novel class neuroprotective nanoagents might be beneficial other RONS-related disorders.

Language: Английский

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Ice Inhibition for Cryopreservation: Materials, Strategies, and Challenges

Advanced Science, Journal Year: 2021, Volume and Issue: 8(6)

Published: Feb. 1, 2021

Abstract Cryopreservation technology has developed into a fundamental and important supporting method for biomedical applications such as cell‐based therapeutics, tissue engineering, assisted reproduction, vaccine storage. The formation, growth, recrystallization of ice crystals are the major limitations in cell/tissue/organ cryopreservation, cause fatal cryoinjury to cryopreserved biological samples. Flourishing anti‐icing materials strategies can effectively regulate suppress crystals, thus reducing damage promoting cryopreservation efficiency. This review first describes basic cryodamage mechanisms process. recent development chemical ice‐inhibition molecules, including cryoprotectant, antifreeze protein, synthetic polymer, nanomaterial, hydrogel, their summarized. advanced engineering strategies, trehalose delivery, cell encapsulation, bioinspired structure design inhibition, further discussed. Furthermore, external physical field technologies used inhibiting both cooling thawing processes systematically reviewed. Finally, current challenges future perspectives inhibition high‐efficiency proposed.

Language: Английский

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