International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
22(1), P. 56 - 56
Published: Dec. 23, 2020
In
various
diseases,
there
is
an
increased
production
of
the
free
radicals
needed
to
carry
out
certain
physiological
processes
but
their
excessive
amounts
can
cause
oxidative
stress
and
cell
damage.
Enzymes
play
a
major
role
in
transformations
associated
with
radicals.
One
them
nitric
oxide
synthase
(NOS),
which
catalyzes
formation
(NO).
This
enzyme
exists
three
forms
(NOS1,
NOS2,
NOS3),
each
encoded
by
different
gene.
The
following
work
presents
most
important
information
on
NOS
isoforms
human
body,
including
NO
synthesis
tissues
cells,
intercellular
signaling
activities
supporting
immune
system
regulating
blood
vessel
functions.
pathological
conditions
such
as
obesity,
diabetes
heart
disease
considered.
Attention
also
paid
influence
polymorphisms
these
genes,
encoding
particular
isoforms,
development
pathologies
inhibitors
treatment
patients.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2019,
Volume and Issue:
2019, P. 1 - 13
Published: Oct. 13, 2019
Reactive
oxygen
species-
(ROS-)
induced
lipid
peroxidation
plays
a
critical
role
in
cell
death
including
apoptosis,
autophagy,
and
ferroptosis.
This
fundamental
conserved
mechanism
is
based
on
an
excess
of
ROS
which
attacks
biomembranes,
propagates
chain
reactions,
subsequently
induces
different
types
death.
A
highly
evolved
sophisticated
antioxidant
system
exists
that
acts
to
protect
the
cells
from
oxidative
damage.
In
this
review,
we
discussed
how
propagate
reactions
products
initiate
apoptosis
autophagy
current
models.
We
also
during
ferroptosis,
summarized
pathological
conditions
illness.
aim
bring
more
global
integrative
sight
know
ROS-induced
occurs
among
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: June 3, 2020
Oxidative
stress
is
associated
with
many
acute
and
chronic
inflammatory
diseases,
yet
limited
treatment
currently
available
clinically.
The
development
of
enzyme-mimicking
nanomaterials
(nanozymes)
good
reactive
oxygen
species
(ROS)
scavenging
ability
biocompatibility
a
promising
way
for
the
ROS-related
inflammation.
Herein
we
report
simple
efficient
one-step
ultrasmall
Cu
Advanced Science,
Journal Year:
2020,
Volume and Issue:
8(3)
Published: Dec. 20, 2020
Abstract
Reactive
oxygen
species
(ROS)
play
an
essential
role
in
physiological
and
pathological
processes.
Studies
on
the
regulation
of
ROS
for
disease
treatments
have
caused
wide
concern,
mainly
involving
topics
ROS‐regulating
therapy
such
as
antioxidant
triggered
by
scavengers
ROS‐induced
toxic
mediated
ROS‐elevation
agents.
Benefiting
from
remarkable
advances
nanotechnology,
a
large
number
nanomaterials
with
ability
are
developed
to
seek
new
effective
ROS‐related
nanotherapeutic
modalities
or
nanomedicines.
Although
considerable
achievements
been
made
ROS‐based
nanomedicines
treatments,
some
fundamental
but
key
questions
rational
design
principle
held
low
regard.
Here,
can
serve
initial
framework
scientists
technicians
optimize
nanomedicines,
thereby
minimizing
gap
biomedical
application
during
stage.
Herein,
overview
current
progress
ROS‐associated
is
summarized.
And
then,
particularly
addressing
these
known
strategies
therapy,
several
principles
presented.
Finally,
future
perspectives
also
discussed
depth
development
Nature Communications,
Journal Year:
2018,
Volume and Issue:
9(1)
Published: Dec. 17, 2018
Acute
kidney
injury
(AKI)
is
a
common
reactive
oxygen
species
(ROS)-related
renal
disease
that
causes
numerous
deaths
annually,
yet
only
supportive
treatment
currently
available
in
the
clinics.
Development
of
antioxidants
with
high
accumulation
rates
kidneys
highly
desired
to
help
prevent
AKI.
Here
we
report
molybdenum-based
polyoxometalate
(POM)
nanoclusters
preferential
uptake
as
novel
nano-antioxidants
for
protection.
These
POM
nanoclusters,
readily
variable
valence
state
molybdenum
ions,
possess
capability
scavenge
detrimental
ROS.
Our
results
demonstrate
can
efficiently
alleviate
clinical
symptoms
mice
subjected
AKI,
verified
by
dynamic
PET
imaging
68Ga-EDTA,
serum
tests,
tissue
staining,
and
biomarkers
detection
kidneys.
The
protective
effect
against
AKI
living
animals
suggests
exploring
their
use
patients,
well
patients
other
ROS-related
diseases.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(12)
Published: April 29, 2020
Abstract
The
manifestation
of
acute
kidney
injury
(AKI)
is
associated
with
poor
patient
outcomes,
treatment
options
limited
to
hydration
or
renal
replacement
therapies.
onset
AKI
often
a
surfeit
reactive
oxygen
species.
Here,
it
shown
that
selenium‐doped
carbon
quantum
dots
(SeCQDs)
have
broad‐spectrum
antioxidant
properties
and
prominent
accumulation
in
both
healthy
mice.
Due
these
properties,
SeCQDs
treat
prevent
two
clinically
relevant
cases
induced
murine
models
by
either
rhabdomyolysis
cisplatin
using
only
1
50
µg
per
mouse,
respectively.
attenuation
confirmed
blood
serum
measurements,
tissue
staining,
biomarkers.
therapeutic
efficacy
exceeds
amifostine,
drug
approved
the
Food
Drug
Administration
also
acts
scavenging
free
radicals.
findings
indicate
show
great
potential
as
option
for
possibly
other
ROS‐related
diseases.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(31)
Published: May 13, 2021
Abstract
In
human
systems,
reactive
oxygen
species
(ROS)
significantly
affect
different
physiological
activities
and
play
critical
roles
in
diverse
living
processes.
It
is
widely
known
that
excessive
ROS
generation
inflammatory
tissues
can
further
deteriorate
the
localized
tissue
injury
cause
chronic
diseases.
Though
promising
for
reducing
levels,
many
antioxidant
molecules
natural
enzymes
suffer
from
abundant
intrinsic
limitations.
Recently,
a
series
of
biocatalytic
or
nanostructures
have
been
designed
with
distinctive
scavenging
capabilities,
which
show
to
overcome
these
kernel
challenges.
this
timely
review,
most
recent
advances
engineering
are
summarized.
First,
principles
corresponding
methods
testing
various
enzymatic
carefully
concluded.
Subsequently,
rationally
high
efficiencies
comprehensively
discussed,
especially
on
catalytic
activities,
mechanisms,
structure‐function
relationships.
After
that,
representative
applications
biotherapeutics
summarized
detail.
At
last,
primary
challenges
future
perspectives
emerging
research
frontier
also
outlined.
believed
progress
review
will
offer
cutting‐edge
understanding
guidance
high‐performance
broad
biotherapeutic
applications.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(16), P. 4886 - 4886
Published: Aug. 12, 2021
Numerous
plant
compounds
and
their
metal-ion
complexes
exert
antioxidative,
anti-inflammatory,
anticancer,
other
beneficial
effects.
This
review
highlights
the
different
bioactivities
of
flavonoids,
chromones,
coumarins
metal-ions
due
to
structural
characteristics.
In
addition
insight
into
most
studied
antioxidative
properties
these
compounds,
first
part
provides
a
comprehensive
overview
exogenous
endogenous
sources
reactive
oxygen
nitrogen
species,
oxidative
stress-mediated
damages
lipids
proteins,
on
protective
roles
antioxidant
defense
systems,
including
plant-derived
antioxidants.
Additionally,
covers
anti-inflammatory
antimicrobial
activities
which
support
its
application
in
medicine,
pharmacy,
cosmetology.
