Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Multifunctional sonosensitizers in sonodynamic cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(11), P. 3244 - 3261

Published: Jan. 1, 2020

Phototherapy, including photodynamic therapy and photothermal therapy, has the potential to treat several types of cancer.

Language: Английский

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Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme‐Catalyzed Cascade Reaction

Advanced Science, Journal Year: 2018, Volume and Issue: 6(3)

Published: Nov. 28, 2018

Abstract Emerging nanocatalytic tumor therapies based on nontoxic but catalytically active inorganic nanoparticles (NPs) for intratumoral production of high‐toxic reactive oxygen species have inspired great research interest in the scientific community. Nanozymes exhibiting natural enzyme‐mimicking catalytic activities been extensively explored biomedicine, mostly biomolecular detection, yet much fewer researches are available specific therapy. This study reports construction an efficient biomimetic dual nanozyme‐based nanoplatform, which triggers cascade reactions microenvironment responsive therapy ultrasmall Au and Fe 3 O 4 NPs coloaded dendritic mesoporous silica NPs. as unique glucose oxidase‐mimic nanozyme specifically catalyze β‐D‐glucose oxidation into gluconic acid H 2 , while produced is subsequently catalyzed by peroxidase‐mimic to liberate hydroxyl radicals inducing tumor‐cell death typical Fenton‐based reaction. Extensive vitro vivo evaluations demonstrated high nanocatalytic‐therapeutic efficacy with a desirable tumor‐suppression rate (69.08%) these biocompatible composite nanocatalysts. Therefore, this work paves way rationally designing nanozymes multienzymatic achieving therapeutic excellent biosafety simultaneously.

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: May 2, 2019

Abstract Combined checkpoint blockade (e.g., PD1/PD-L1) with traditional clinical therapies can be hampered by side effects and low tumour-therapeutic outcome, hindering broad translation. Here we report a combined modality based on integrating nanosonosensitizers-augmented noninvasive sonodynamic therapy (SDT) checkpoint-blockade immunotherapy. All components of the nanosonosensitizers (HMME/R837@Lip) are clinically approved, wherein liposomes act as carriers to co-encapsulate sonosensitizers (hematoporphyrin monomethyl ether (HMME)) immune adjuvant (imiquimod (R837)). Using multiple tumour models, demonstrate that combining SDT anti-PD-L1 induces an anti-tumour response, which not only arrests primary progression, but also prevents lung metastasis. Furthermore, treatment strategy offers long-term immunological memory function, protect against rechallenge after elimination initial tumours. Therefore, this work represents proof-of-concept combinatorial therapeutics tumours-therapeutic

Language: Английский

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Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Jan. 17, 2020

Hypoxia of solid tumor compromises the therapeutic outcome photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting ruthenium as active catalytic site anchored in metal-organic framework Mn3[Co(CN)6]2 with encapsulated chlorin e6 (Ce6), which serves catalase-like nanozyme for generation. Coordination-driven self-assembly organic linkers metal ions presence biocompatible polymer generates nanoscale network adaptively encapsulates Ce6. The resulted SAE possesses well-defined morphology, uniform size distribution high loading capacity. When conducting situ generation through reaction between endogenous H2O2 Ru species SAE, hypoxia microenvironment is relieved. Our study demonstrates promising efficient sites cancer treatment.

Language: Английский

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(47)

Published: Oct. 16, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such deeper penetration depth, absence of phototoxicity, fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks the facile engineering nature nanotechnology, numerous novel nanoplatforms being applied this emerging field tackle these barriers achieve continuous innovations. In particular, combination other treatment strategies superior efficacy improving anticancer activity relative that monotherapies alone. Therefore, it is necessary summarize nanomaterial-assisted combinational cancer applications. Herein, design principles achieving synergistic effects based on nanomaterial methods highlighted. The ultimate goals stimulate better-quality combined schemes provide innovative ideas perspectives promoting future transformation clinical application.

Language: Английский

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Piezocatalytic Tumor Therapy by Ultrasound‐Triggered and BaTiO₃‐Mediated Piezoelectricity

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(29)

Published: June 14, 2020

Abstract Ultrasound theranostics features non‐invasiveness, minor energy attenuation, and high tissue‐penetrating capability, is playing ever‐important roles in the diagnosis therapy of diseases clinics. Herein, ultrasound employed as a microscopic pressure resource to generate reactive oxygen species (ROS) for piezocatalytic tumor under catalytic mediation by piezoelectric tetragonal BaTiO 3 (T‐BTO). Under ultrasonic vibration, electrons holes are unpaired they separated piezoelectricity, resulting establishment strong built‐in electric field, which subsequently catalyzes generation ROS such toxic hydroxyl ( • OH) superoxide radicals O 2 − ) situ eradication. This modality shows intriguing advantages over typical sonoluminescence‐activated sonodynamic therapy, more stable sensitizers dynamical control redox reaction outcomes. Furthermore, according finite element modeling simulation, field capable modulating band alignment make energetically favorable. Both detailed vitro cellular level evaluation vivo xenograft assessment have demonstrated that an injectable T‐BTO‐nanoparticles‐embedded thermosensitive hydrogel will substantially induce irradiation‐triggered cytotoxicity eradication, accompanied therapeutic biosafety vivo.

Language: Английский

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Ultrafine Titanium Monoxide (TiO_1+x) Nanorods for Enhanced Sonodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(14), P. 6527 - 6537

Published: March 19, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT) that enables noninvasive treatment of large internal tumors has attracted widespread interest. For improvement in the therapeutic responses to SDT, more effective and stable sonosensitizers are still required. Herein, ultrafine titanium monoxide nanorods (TiO1+x NRs) with greatly improved sono-sensitization Fenton-like catalytic activity were fabricated used for enhanced SDT. TiO1+x NRs an rodlike structure successfully prepared then modified polyethylene glycol (PEG). Compared conventional sonosensitizer, TiO2 nanoparticles, PEG–TiO1+x resulted much efficient US-induced generation reactive oxygen species (ROS) because oxygen-deficient NR, which predominantly serves as charge trap limit recombination US-triggered electron–hole pairs. Interestingly, also exhibit horseradish-peroxidase-like nanozyme can produce hydroxyl radicals (•OH) from endogenous H2O2 tumor enable chemodynamic (CDT). Because their passive retention post intravenous injection, be a sonosensitizer CDT agent highly ablation under US treatment. In addition, no significant long-term toxicity was found treated mice. This work highlights new type titanium-based nanostructure great performance

Language: Английский

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(10)

Published: Jan. 28, 2020

Abstract Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO 2 , MnO, Mn O 3 4 x ) their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, representative progresses MONs synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, are mainly introduced. First, five kinds primary synthetic methods presented, thermal decomposition method, exfoliation strategy, permanganates reduction adsorption–oxidation hydro/solvothermal. Second, preparations hollow composite materials summarized specially. Then, chemical toxicity discussed. Next, diagnostic imaging sensing outlined. Finally, some rational designs photodynamic therapy, photothermal chemodynamic sonodynamic radiotherapy, magnetic hyperthermia, chemotherapy, gene starvation ferroptosis, immunotherapy, various combination highlighted.

Language: Английский

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