Synthesis of Copper Peroxide Nanodots for H₂O₂ Self-Supplying Chemodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(25), P. 9937 - 9945

Published: June 2, 2019

Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular H2O2 into hydroxyl radical (•OH), but endogenous is insufficient achieve satisfactory anticancer efficacy. Despite tremendous efforts, engineering CDT agents with specific and efficient self-supplying ability remains a great challenge. Here, we report the fabrication of copper peroxide (CP) nanodot, which first example Fenton-type metal nanomaterial, its use as an activatable agent for enhanced H2O2. The CP nanodots were prepared through coordination Cu2+ aid hydroxide ion, could be reversed acid treatment. After endocytosis tumor cells, acidic environment endo/lysosomes accelerated dissociation nanodots, allowing simultaneous release catalytic accompanied reaction between them. resulting •OH induced lysosomal membrane permeabilization lipid peroxidation thus caused cell death via lysosome-associated pathway. In addition pH-dependent generation property, small particle size showed high accumulation after intravenous administration, enabled effective growth inhibition minimal side effects in vivo. Our work not only provides paradigm fabricating nanomaterials, also presents new strategy improve

Language: Английский

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Nanomaterials for cancer therapy: current progress and perspectives

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: May 31, 2021

Abstract Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction multi-drug resistance and stem-like cells growth. Nanomaterials are materials in the nanorange 1–100 nm which possess unique optical, magnetic, electrical properties. used cancer therapy can be classified into several main categories. Targeting cells, tumor microenvironment, immune system, these nanomaterials have been modified for wide range therapies to overcome toxicity enhance drug capacity well bioavailability. Although number studies has increasing, approved nano-drugs not increased much over years. To better improve clinical translation, further research needed targeted delivery by nano-carriers reduce toxicity, permeability retention effects, minimize shielding effect protein corona. This review summarizes novel fabricated use, discusses current limitations obstacles that hinder translation from provides suggestions more efficient adoption therapy.

Language: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

ACS Nano, Journal Year: 2019, Volume and Issue: 13(4), P. 4267 - 4277

Published: March 22, 2019

The integration of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic (CDT) holds great promise for enhanced anticancer effects. Herein, we report biodegradable cancer cell membrane-coated mesoporous copper/manganese silicate nanospheres (mCMSNs) with homotypic targeting ability to the lines ROS generation through singlet (1O2) production glutathione (GSH)-activated Fenton reaction, showing excellent CDT/PDT synergistic therapeutic We demonstrate that mCMSNs are able relieve tumor hypoxia microenvironment by catalytic decomposition endogenous H2O2 O2 further react produce toxic 1O2 a 635 nm laser irradiation. GSH-triggered biodegradation can simultaneously generate Fenton-like Cu+ Mn2+ ions deplete GSH efficient hydroxyl radical (•OH) production. specific recognition cells were also revealed. Notably, relieving depletion disrupts (TME) cellular antioxidant defense system, achieving exceptional cancer-targeting effects in vitro vivo. growth was significantly inhibited. Moreover, released act as an advanced contrast agent magnetic resonance imaging (MRI). Thus, together photosensitizers, provider MRI along modulating TME allow realize MRI-monitored therapy. It provides paradigm rationally design TME-responsive ROS-involved strategies based on single polymetallic nanomaterial

Language: Английский

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Biomedicine Meets Fenton Chemistry

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(4), P. 1981 - 2019

Published: Jan. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Language: Английский

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Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Journal Year: 2020, Volume and Issue: 35, P. 100946 - 100946

Published: Aug. 13, 2020

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Bioinspired Construction of a Nanozyme-Based H₂O₂ Homeostasis Disruptor for Intensive Chemodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(11), P. 5177 - 5183

Published: Feb. 26, 2020

The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents a straightforward and secure supplying ability remains great challenge. Inspired by balance generation elimination cancer cells, herein, nanozyme-based homeostasis disruptor fabricated to elevate through facilitating production restraining for enhanced CDT. In formulation, superoxide dismutase-mimicking activity can convert O2•– H2O2, promoting H2O2. Simultaneously, suppression catalase depletion glutathione weaken transformation H2O. Thus, well-defined system could perturb give rise accumulation cells. raised would ultimately amplify Fenton-like reaction-based efficiency. Our work not only paves way engineer alternative intensive but also provides new insights into construction bioinspired materials.

Language: Английский

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Journal Year: 2021, Volume and Issue: 18(6)

Published: Nov. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Language: Английский

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GSH‐Depleted PtCu₃ Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 30(4)

Published: Nov. 13, 2019

Abstract The ultrahigh concentration of glutathione (GSH) inside tumors destroys reactive oxygen species (ROS)‐based therapy, improving the outcome chemodynamic therapy (CDT)‐enhanced sonodynamic (SDT) by depleting GSH is full great challenge. Herein, PtCu 3 nanocages are first reported as acting a sonosensitizer with highly efficient ROS generation under ultrasound irradiation. In addition, can act horseradish peroxidase‐like nanozymes, catalyzing decomposition H 2 O into • OH acidic conditions for CDT. Surprisingly, another kind nanozyme, mimicking peroxidase (GSH‐Px), which plays an important role in accelerating depletion oxidizing molecules, further weakening capacity tumor cells scavenging GSH. Both vitro and vivo studies demonstrate that perform well reducing level CDT‐enhanced SDT. Moreover, utilizing high absorption near‐infrared region strong X‐ray attenuation ability, able to conduct photoacoustic/computed tomography dual‐modal imaging‐guided combined cancer therapy. It worth mentioning cause minimal toxicity normal tissues at therapeutic doses. This work highlights use effective SDT via depletion.

Language: Английский

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