Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy

Biomaterials, Journal Year: 2020, Volume and Issue: 265, P. 120456 - 120456

Published: Oct. 15, 2020

Language: Английский

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Near‐Infrared Photoactivatable Semiconducting Polymer Nanoblockaders for Metastasis‐Inhibited Combination Cancer Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(46)

Published: Sept. 30, 2019

Inhibition of protein biosynthesis is a promising strategy to develop new therapeutic modalities for cancers; however, noninvasive precise regulation this cellular event in living systems has been rarely reported. In study, semiconducting polymer nanoblockader (SPNB ) developed that can inhibit intracellular synthesis upon near-infrared (NIR) photoactivation synergize with photodynamic therapy (PDT) metastasis-inhibited cancer therapy. SPNB self-assembled from an amphiphilic which grafted poly(ethylene glycol) conjugated blockader through singlet oxygen (1 O2 cleavable linker. Such designed molecular structure not only enables generation 1 under NIR photoirradiation PDT, but also permits blockaders terminate translation. Thereby, exerts synergistic action afford enhanced efficacy tumor ablation. More importantly, -mediated inhibition precisely and remotely downregulates the expression levels metastasis-related proteins tissues, eventually contributing complete lung metastasis. This study thus proposes photoactivatable protherapeutic design

Language: Английский

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A Phototheranostic Strategy to Continuously Deliver Singlet Oxygen in the Dark and Hypoxic Tumor Microenvironment

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(23), P. 8833 - 8838

Published: Jan. 13, 2020

Continuous irradiation during photodynamic therapy (PDT) inevitably induces tumor hypoxia, thereby weakening the PDT effect. In PDT-induced providing singlet oxygen from stored chemical energy may enhance cell-killing effect and boost therapeutic Herein, we present a phototheranostic (DPPTPE@PEG-Py NPs) prepared by using 2-pyridone-based diblock polymer (PEG-Py) to encapsulate semiconducting, heavy-atom-free pyrrolopyrrolidone-tetraphenylethylene (DPPTPE) with high singlet-oxygen-generation ability both in dichloromethane water. The PEG-Py can trap 1 O2 generated DPPTPE under laser form stable intermediate of endoperoxide, which then release dark, hypoxic microenvironment. Furthermore, fluorescence-imaging-guided phototherapy demonstrates that this could completely inhibit growth help irradiation.

Language: Английский

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Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(43)

Published: Aug. 7, 2020

Abstract Cancer immunotherapy has received tremendous attention in the past decade owing to its clinical successes with use of immune‐checkpoint inhibition and chimeric antigen receptor T cell therapy. However, only a small proportion patients have benefited from these immunotherapeutic drugs, which raised concerns about low response rate immune‐related adverse events. Nanomedicines served as paradigm for preferential tumor accumulation but still confront issues such poor circulation insufficient accumulation. By virtue coating nanoparticles membranes diverse sources, active proteins on can impart variety desired functionalities or supplementary therapeutic effects nanoparticles, providing ways enhanced cancer immunotherapy. In this review, recent advances membrane camouflaged applied improved are discussed basis different sources corresponding working mechanisms. These biomimetic potentially deliver agents designated sites actively engage particular stages immunity cycle, eliciting antitumor less off‐target toxicities.

Language: Английский

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Nanoplatform-based cascade engineering for cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(24), P. 9057 - 9094

Published: Jan. 1, 2020

This review provides a comprehensive overview of the recent advances in nanoplatform-based cascade engineering for cancer therapy, by concentrating on design smart nanoplatforms and implementation specific processes.

Language: Английский

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