Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Small, Journal Year: 2021, Volume and Issue: 17(12)

Published: Feb. 12, 2021

Abstract Nanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, rapid clearance the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed solve these issues. For example, macrophage or neutrophil membrane coated NPs developed with ability interact tumor tissue suppress cancer progression metastasis. The functionality particles largely depends on surface proteins cells their preserved function during extraction coating process NPs. Proteins outer can render a wide range activities NPs, including prolonged blood circulation, remarkable competency recognizing antigens enhanced better cellular interactions, gradual drug release, reduced toxicity vivo. In this review, nano‐based systems cells‐derived membranous layers, detailed production process, applicability treatment discussed. addition, future perspectives challenges translation also presented.

Language: Английский

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Second Near‐Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 16, 2020

Abstract Immunotherapy has offered new treatment options for cancer; however, the therapeutic benefits are often modest and desired to be improved. A semiconducting polymer nanoadjuvant (SPN II R) with a photothermally triggered cargo release second near‐infrared (NIR‐II) photothermal immunotherapy is reported here. SPN R consists of nanoparticle core as an NIR‐II converter, which doped toll‐like receptor (TLR) agonist adjuvant coated thermally responsive lipid shell. Upon photoirradiation, effectively generates heat not only ablate tumors induce immunogenic cell death (ICD), but also melt layers on‐demand TLR agonist. The combination ICD activation TLR7/TLR8 enhances maturation dendritic cells, amplifies anti‐tumor immune responses. Thus, single R‐mediated inhibits growth both primary distant eliminates lung metastasis in murine mouse model. This study thus provides remote‐controlled smart delivery system synergize photomedicine enhanced cancer treatment.

Language: Английский

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Transformable Nanosensitizer with Tumor Microenvironment‐Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(25), P. 14051 - 14059

Published: April 2, 2021

Abstract Despite the promise of sonodynamic processes in cancer therapy, existing sonosensitizers often fail to regulate generation reactive oxygen species (ROS) against tumors, potentially leading off‐target toxicity normal tissues. We report a transformable core‐shell nanosonosensitizer (TiO 2 @CaP) that reinvigorates ROS and dissolves its CaP shell release Ca 2+ an acidic tumor microenvironment (TME) under ultrasound activation. Thus, TiO @CaP acts as smart specifically induces mitochondrial dysfunction via overloading intracellular ions synergize with process TME. substantially enhances immunogenic cell death, resulting enhanced T‐cell recruitment infiltration into cold (4T1). In conjunction checkpoint blockade therapy (anti‐PD 1), @CaP‐mediated elicits systemic antitumor immunity, regression non‐treated distant tumors inhibition lung metastasis. This work paves way development “smart” TME‐activatable temporospatial control over responses.

Language: Английский

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Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(23), P. 12682 - 12705

Published: July 16, 2020

Immunotherapy that harnesses the power of immune system to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune-related adverse events exist as two major issues immunotherapy. In parallel, a variety electromagnetic nanomaterials generate heat and/or reactive oxygen species triggered by energy have been applied magnetic hyperthermia therapy, sonodynamic photothermal photodynamic radiotherapy, which ability induce immunogenic cell death. This review summarizes recent development nanomedicines in combinational The mechanisms reprogramming immunosuppressive tumor microenvironment sensitizing tumors immunotherapy are highlighted. Furthermore, challenges perspectives discussed.

Language: Английский

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A Polymer Multicellular Nanoengager for Synergistic NIR‐II Photothermal Immunotherapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(14)

Published: Feb. 26, 2021

Abstract Cell‐membrane‐coated nanoparticles (CCNPs) that integrate the biophysiological advantages of cell membranes with multifunctionalities synthetic materials hold great promise in cancer immunotherapy. However, strategies have yet to be revealed further improve their immunotherapeutic efficacy. Herein, a polymer multicellular nanoengager (SPNE) for synergistic second‐near‐infrared‐window (NIR‐II) photothermal immunotherapy is reported. The consists an NIR‐II absorbing as core, which camouflaged fused derived from immunologically engineered tumor cells and dendritic (DCs) vaccine shell. In association high accumulation lymph nodes tumors, engagement ability SPNE enables effective cross‐interactions among cells, DCs, T leading augmented activation relative bare or tumor‐cell‐coated nanoparticles. Upon deep‐tissue penetrating photoirradiation, eradicates induces immunogenic death, eliciting anti‐tumor immunity. Such effect eventually inhibits growth, prevents metastasis procures immunological memory. Thus, this study presents general cell‐membrane‐coating approach develop photo‐immunotherapeutic agents therapy.

Language: Английский

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Chemically and Biologically Engineered Bacteria‐Based Delivery Systems for Emerging Diagnosis and Advanced Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(38)

Published: Aug. 4, 2021

Abstract Bacteria are one of the main groups organisms, which dynamically and closely participate in human health disease development. With integration chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given unique features such their intrinsic biocompatibility motility, bacteria‐based systems drawn wide interest diagnosis treatment diseases, including cancer, infectious kidney failure, hyperammonemia. Notably, at interface biotechnology bacteria, many research opportunities initiated, opening a promising frontier application. Herein, current synergy design principles systems, microbial modulation, clinical translation reviewed, with special focus on advances therapy.

Language: Английский

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Reprogramming the Tumor Microenvironment through Second‐Near‐Infrared‐Window Photothermal Genome Editing of PD‐L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(12)

Published: Feb. 4, 2021

Abstract A photothermal genome‐editing strategy is described to improve immune checkpoint blockade (ICB) therapy by CRISPR/Cas9‐mediated disruption of PD‐L1 and mild‐hyperthermia‐induced activation immunogenic cell death (ICD). This relies on a supramolecular cationic gold nanorod that not only serves as carrier deliver CRISPR/Cas9 targeting , but also harvests the second near‐infrared‐window (NIR‐II) light converts into mild hyperthermia induce both ICD gene expression Cas9. The genomic significantly augments ICB improving conversion dendritic cells T cells, followed promoting infiltration cytotoxic lymphocytes tumors, thereby reprogramming immunosuppressive tumor microenvironment immunoactive one. Such therapeutic modality greatly inhibits activity primary metastatic tumors exhibits long‐term memory effects against rechallenged recurrent tumors. current for synergistic represents an appealing way cancer immunotherapy.

Language: Английский

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Recent advances in overcoming barriers to cell‐based delivery systems for cancer immunotherapy

Exploration, Journal Year: 2022, Volume and Issue: 2(3)

Published: March 15, 2022

Immunotherapy strategies that use cell-based delivery systems have sparked much interest in the treatment of malignancies, owing to their high biocompatibility, excellent tumor targeting capability, and unique biofunctionalities growth process. A variety design principles for immunotherapy, including cell surface decoration, membrane coating, encapsulation, genetically engineered cell, cell-derived exosomes, give cancer immunotherapy great potential improve therapeutic efficacy reduce adverse effects. However, methods is still limited, practical uses are hampered due complex physiological immunological obstacles, such as physical barriers immune infiltration, immunosuppressive microenvironment, upregulation pathways, metabolic restriction. In this review, we present an overview maximize impact, along with anatomical, metabolic, impediments using treat cancer. Following that, a summary novel been created overcome these obstacles immunotherapeutic provided. Also, prospects next-step development concluded end.

Language: Английский

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A “Closed‐Loop” Therapeutic Strategy Based on Mutually Reinforced Ferroptosis and Immunotherapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(13)

Published: Feb. 1, 2022

Abstract The immunosuppression and immune escape of current immunotherapy result in low efficacy, ferroptosis is greatly restricted by the reactive oxygen species (ROS) production efficiency. Here, for first time a “closed‐loop” therapy based on photothermal enhancement stimulated each other multifunctional nanoplatform reported. This platform composed copper silicate iron mesoporous hollow nanospheres, followed situ growth Au nanoparticles loading an adjuvant resiquimod R848. laser irradiation‐mediated heat introduction ions significantly enhance ROS generation, leading to simultaneous depletion glutathione peroxidase 4 (GPX4) (GSH). onset tumor cells thus enhanced response with immunogenic cell death (ICD) triggered, promoting dendritic (DCs) maturation T infiltration. Interferon γ (IFN‐γ) released from CD8 + downregulates expression SLC7A11 GPX4, which turn enhances expression, constituting “closed‐Loop” therapy. Importantly, this system effective both killing primary inhibiting metastasis. proposed therapeutic strategy may provide guidance design future antitumor nanoplatforms.

Language: Английский

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Biomimetic Nanoemulsion for Synergistic Photodynamic‐Immunotherapy Against Hypoxic Breast Tumor

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(19), P. 10647 - 10653

Published: Feb. 8, 2021

Photodynamic therapy (PDT) is commonly used as an "in situ vaccine" to enhance the response rate of PD-1/PD-L1 antibodies. Unfortunately, high cost and adverse effects these antibodies, hypoxic state solid tumors limits efficacy synergistic photodynamic-immunotherapy. Here, we developed a biomimetic nanoemulsion camouflaged with PD-1-expressing cell membrane for photodynamic-immunotherapy against breast tumors. The perfluorocarbon could provide oxygen source PDT Moreover, co-delivering photosensitizer PD-1 protein (substituting PD-L1 antibody) achieves synergy effect immunotherapy. Synergistic completely inhibited primary distant subcutaneous 4T1 tumors, mechanistically by boosting maturation dendritic cells tumor infiltration cytotoxic T lymphocytes.

Language: Английский

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