Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(42)
Published: Aug. 3, 2022
Abstract
Luminescence
lifetime
imaging
has
exhibited
significant
advantages
over
traditional
optical
in
terms
of
precise
quantification
detection
because
the
intrinsic
stability
luminescence
lifetimes.
Recently,
great
emphasis
been
put
on
exploration
lanthanide‐doped
nanoparticles
(LnNPs)
with
long‐lived
luminescence.
The
long
LnNPs
not
only
makes
it
easier
to
filter
out
background
signals
during
imaging,
but
also
provides
a
wide
range
tunable
lifetime.
Here,
we
introduce
mechanisms
LnNPs,
key
strategies
for
modulation,
data
acquisition
methods,
and
several
cutting‐edge
applications
systems.
Then
describe
prospects
inspire
efforts
improving
technologies
extending
imaging.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
60(30), P. 16294 - 16308
Published: Aug. 12, 2020
The
development
of
fluorophores
for
the
second
near-infrared
window
(NIR-II,
1000-1700
nm)
represents
an
emerging,
significant,
and
vibrant
field
in
analytic
chemistry,
chemical
biology,
biomedical
engineering.
wavelength,
brightness,
stability
are
three
crucial
factors
that
determine
performance
NIR-II
fluorophore.
Up
to
now,
significant
progress
has
been
made
fluorescence
molecular
probes,
including
synthesis
D-A-D
D-π-A
with
improved
imaging
construction
off-on
probes
ratiometric
via
energy
transfer
or
structure
modification.
In
this
review,
we
summarize
most
recent
advances
engineering
design
strategies
then
highlight
a
selection
bioimaging
biosensing
applications.
We
also
provide
perspectives
on
potential
challenges
opportunities
emerging
field.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2020,
Volume and Issue:
7
Published: Jan. 30, 2020
Fluorescence
imaging
technology
has
gradually
become
a
new
and
promising
tool
for
in
vivo
visualization
detection.
Because
it
can
provide
real-time
sub-cellular
resolution
results,
be
widely
used
the
field
of
biological
detection
medical
treatment.
However,
due
to
limited
depth
(1-2
mm)
self-fluorescence
background
tissue
emitted
visible
region
(400-700
nm),
fails
reveal
complexity
deep
tissues.
The
traditional
near
infrared
wavelength
(NIR-I,
700-950
nm)
is
considered
as
first
window,
because
reduces
NIR
absorption
scattering
from
blood
water
organisms.
fluorescence
bioimaging's
penetration
larger
than
that
light.
In
fact,
NIR-I
bioimaging
still
interfered
by
autofluorescence
(background
noise),
existence
photon
scattering,
which
limits
penetration.
Recent
experimental
simulation
results
show
signal-to-noise
ratio
(SNR)
significantly
improved
at
second
(NIR-II,
1000-1700
also
known
window.
NIR-II
able
explore
deep-tissues
information
range
centimeter,
obtain
micron-level
millimeter
depth,
surpass
performance
imaging.
key
achieve
highly
selective
thanks
functional/targeting
contrast
agent
(probe).
progress
probes
very
limited.
To
date,
there
only
are
few
reports
about
probes,
such
carbon
nanotubes,
Ag2S
quantum
dots
organic
small
molecular
dyes.
this
paper,
we
surveyed
development
agents
their
application
cancer
imaging,
detection,
vascular
diagnosis.
addition,
hotspots
challenges
discussed.
It
expected
our
findings
will
lay
foundation
further
theoretical
research
practical
bioimaging,
well
inspiration
ideas
field.
Chemical Science,
Journal Year:
2020,
Volume and Issue:
12(10), P. 3427 - 3436
Published: June 12, 2020
Aggregation-induced
emission
(AIE)
is
a
cutting-edge
fluorescence
technology,
giving
highly-efficient
solid-state
photoluminescence.
Particularly,
AIE
luminogens
(AIEgens)
with
in
the
range
of
second
near-infrared
window
(NIR-II,
1000-1700
nm)
have
displayed
salient
advantages
for
biomedical
imaging
and
therapy.
However,
molecular
design
strategy
underlying
mechanism
regulating
balance
between
(radiative
pathway)
photothermal
effect
(non-radiative
these
narrow
bandgap
materials
remain
obscure.
In
this
review,
we
outline
latest
achievements
guidelines
photophysical
process
control
developing
highly
efficient
NIR-II
emitters
or
agents
aggregation-induced
attributes.
We
provide
insights
to
optimize
efficiency
by
multi-hierarchical
structures
from
single
molecules
(flexibilization)
aggregates
(rigidification).
also
discuss
crucial
role
intramolecular
motions
balancing
functions
The
superiority
region
demonstrated
fluorescence/photoacoustic
blood
vessels
brain
as
well
ablation
tumor.
Finally,
summary
challenges
perspectives
AIEgens
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(18), P. 14881 - 14910
Published: Sept. 6, 2022
Lateral
flow
assays
(LFAs)
are
currently
the
most
used
point-of-care
sensors
for
both
diagnostic
(e.g.,
pregnancy
test,
COVID-19
monitoring)
and
environmental
pesticides
bacterial
applications.
Although
core
of
LFA
technology
was
developed
several
decades
ago,
in
recent
years
integration
novel
nanomaterials
as
signal
transducers
or
receptor
immobilization
platforms
has
brought
improved
analytical
capabilities.
In
this
Review,
we
present
how
nanomaterial-based
LFAs
can
address
inherent
challenges
(PoC)
diagnostics
such
sensitivity
enhancement,
lowering
detection
limits,
multiplexing,
quantification
analytes
complex
samples.
Specifically,
highlight
strategies
that
synergistically
solve
limitations
current
have
proven
commercial
feasibility.
Finally,
discuss
barriers
toward
commercialization
next
generation
LFAs.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(8)
Published: Jan. 22, 2023
Abstract
Surface‐enhanced
Raman
scattering
(SERS)
is
a
feasible
and
ultra‐sensitive
method
for
biomedical
imaging
disease
diagnosis.
SERS
widely
applied
to
in
vivo
due
the
development
of
functional
nanoparticles
encoded
by
active
molecules
(SERS
nanoprobes)
improvements
instruments.
Herein,
recent
developments
materials
their
biosensing
applications
are
overviewed.
Various
substrates
that
have
been
successfully
used
described.
Then,
cancer
detection
intraoperative
guidance
summarized.
The
role
highly
sensitive
biosensors
guiding
prevention
diseases
discussed
detail.
Moreover,
its
identification
resection
microtumors
as
diagnostic
therapeutic
platform
also
reviewed.
Finally,
progress
challenges
associated
with
materials,
equipment,
clinical
translation
present
evidence
suggests
could
be
practice
future.
