Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing DOI Creative Commons

Yifeng Ou,

Tian‐Bing Ren, Lin Yuan

et al.

Chemical & Biomedical Imaging, Journal Year: 2023, Volume and Issue: 1(3), P. 220 - 233

Published: May 18, 2023

Organic polymethine fluorophores with emission in the NIR-II window (1000–1700 nm) are receiving enormous attention biomolecular medicine and bioimaging, attributed to high absorption coefficients, bright emission, excellent biocompatibility, molecule adjustability. Recently, researchers have devoted significant effort designing improving making notable progress fluorescence imaging performance. This review summarizes recent developments molecular engineering design mentality of probes highlights their extensive bioimaging biosensing applications. Furthermore, we elucidate potential challenges perspectives these dyes chemical biomedicine imaging, which may stimulate further development high-performance dye contrast agents for future clinical

Language: Английский

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance DOI
Mingze Xu,

Yuming Qi,

G.H. Liu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20825 - 20849

Published: Nov. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Language: Английский

Citations

207
Near-unity NIR phosphorescent quantum yield from a room-temperature solvated metal nanocluster DOI

Wan-Qi Shi,

Linlin Zeng,

Ruilin He

et al.

Science, Journal Year: 2024, Volume and Issue: 383(6680), P. 326 - 330

Published: Jan. 18, 2024

Metal nanoclusters have emerged as promising near-infrared (NIR)-emissive materials, but their room-temperature photoluminescence quantum yield (PLQY), especially in solution, is often low (<10%). We studied the photophysics of Au

Language: Английский

Citations

123
Near infrared fluorescent probes for detecting and imaging active small molecules DOI

Caiping Ding,

Tian‐Bing Ren

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215080 - 215080

Published: Feb. 21, 2023

Language: Английский

Citations

118
Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics DOI
Shubham Roy,

Neelanjana Bag,

Souravi Bardhan

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

Citations

87
NIR-II light in clinical oncology: opportunities and challenges DOI
Zeyu Zhang, Yang Du, Xiaojing Shi

et al.

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(6), P. 449 - 467

Published: May 1, 2024

Language: Английский

Citations

82
Near-infrared II fluorescence imaging DOI
E. Schmidt, Zihao Ou, Erving Ximendes

et al.

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: April 4, 2024

Language: Английский

Citations

73
Intervalence charge transfer of Cr3+-Cr3+ aggregation for NIR-II luminescence DOI Creative Commons
Shengqiang Liu,

Jingxuan Du,

Zhen Song

et al.

Light Science & Applications, Journal Year: 2023, Volume and Issue: 12(1)

Published: July 25, 2023

The increasing demand for high-contrast biological imaging, non-destructive testing, and infrared night vision can be addressed by the development of high-performance NIR light-emitting materials. Unlike lanthanide (Ln3+) with sharp-line multiplets isolated Cr3+ NIR-I emission, this study reports first-ever NIR-II broadband luminescence based on intervalence charge transfer (IVCT) Cr3+-Cr3+ aggregation in gallate magentoplumbite. In particular, LaMgGa11O19:0.7Cr3+ exhibits dual-emission (NIR-I, 890 nm NIR-II, 1200 nm) a full width at half maximum (FWHM) 626 under 450 blue LED excitation. Moreover, anti-thermal quenching behavior (432% @ 290 K), attributed to energy among multiple centers. Cryogen absorption spectra, lifetimes decay (2.3 ms), electron paramagnetic experiments reveal → Cr2+-Cr4+ IVCT transition. application imaging as an optical contrast agent, is demonstrated. This work provides new insights into UV-NIR excitation aggregation.

Language: Английский

Citations

72
Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region DOI
Yang Yang,

Qunying Jiang,

Fan Zhang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

Citations

64
Adding Flying Wings: Butterfly-Shaped NIR-II AIEgens with Multiple Molecular Rotors for Photothermal Combating of Bacterial Biofilms DOI
Dingyuan Yan, Yue Huang, Jianyu Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(47), P. 25705 - 25715

Published: Nov. 16, 2023

The ever-increasing threats of multidrug-resistant bacteria and their biofilm-associated infections have bred a desperate demand for alternative remedies to combat them. Near-infrared (NIR)-absorbing photothermal agent (PTAs)-mediated therapy (PTT) is particularly attractive biofilm ablation thanks its superiorities noninvasive intervention, satisfactory antibacterial efficiency, less likelihood develop resistance. Herein, three butterfly-shaped aggregation-induced emission luminogens (AIEgens) with balanced nonradiative decay (for conducting PTT) radiative supplying fluorescence in the NIR-II optical window) are rationally designed imaging-assisted obliteration bacterial biofilms. After being encapsulated into cationic liposomes, AIEgens-fabricated nanoparticles can eradicate wide spectrum biofilms formed by Gram-positive (methicillin-resistant Staphylococcus aureus Enterococcus faecalis) Gram-negative (Escherichia coli Pseudomonas aeruginosa) upon an 808 nm laser irradiation. In vivo experiments firmly demonstrate that AIE liposomes excellent biocompatibility perform well both P. aeruginosa biofilm-induced keratitis mouse model MSRA skin infection model.

Language: Английский

Citations

56
Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window DOI
Baisong Chang, Jie Chen,

Jiasheng Bao

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 13966 - 14037

Published: Nov. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Language: Английский

Citations

46