Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(18), P. 7752 - 7778
Published: Jan. 1, 2022
Ferroptosis
is
an
iron-dependent,
non-apoptotic
form
of
programmed
cell
death
driven
by
excessive
lipid
peroxidation
(LPO).
Mounting
evidence
suggests
that
the
unique
modality
involved
in
development
and
progression
several
diseases
including
cancer,
cardiovascular
(CVDs),
neurodegenerative
disorders,
etc.
However,
pathogenesis
signalling
pathways
ferroptosis
are
not
fully
understood,
possibly
due
to
lack
robust
tools
for
highly
selective
sensitive
imaging
analytes
complex
living
systems.
Up
now,
various
small-molecule
fluorescent
probes
have
been
applied
as
promising
chemosensors
studying
through
tracking
biomolecules
or
microenvironment-related
parameters
vitro
vivo.
In
this
review,
we
comprehensively
reviewed
recent
ferroptosis,
with
a
focus
on
analytes,
design
strategies
bioimaging
applications.
We
also
provided
new
insights
overcome
major
challenges
emerging
field.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(1), P. 209 - 268
Published: Oct. 19, 2021
In
vivo
imaging
in
the
second
near-infrared
window
(NIR-II,
1000-1700
nm),
which
enables
us
to
look
deeply
into
living
subjects,
is
producing
marvelous
opportunities
for
biomedical
research
and
clinical
applications.
Very
recently,
there
has
been
an
upsurge
of
interdisciplinary
studies
focusing
on
developing
versatile
types
inorganic/organic
fluorophores
that
can
be
used
noninvasive
NIR-IIa/IIb
(NIR-IIa,
1300-1400
nm;
NIR-IIb,
1500-1700
nm)
with
near-zero
tissue
autofluorescence
deeper
penetration.
This
review
provides
overview
reports
published
date
design,
properties,
molecular
imaging,
theranostics
fluorophores.
First,
we
summarize
design
concepts
up-to-date
functional
biomaterials,
order
single-walled
carbon
nanotubes
(SWCNTs),
quantum
dots
(QDs),
rare-earth-doped
nanoparticles
(RENPs),
organic
(OFs).
Then,
these
novel
modalities
applications
brought
by
superior
fluorescent
properties
are
reviewed.
Finally,
challenges
perspectives
future
translation,
aiming
at
boosting
application
progress
NIR-IIa
NIR-IIb
technology
highlighted.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(21), P. 20825 - 20849
Published: Nov. 3, 2023
Understanding
the
in
vivo
transport
of
nanoparticles
provides
guidelines
for
designing
nanomedicines
with
higher
efficacy
and
fewer
side
effects.
Among
many
factors,
size
plays
a
key
role
controlling
their
behaviors
due
to
existence
various
physiological
thresholds
within
body
size-dependent
nano-bio
interactions.
Encouraged
by
evolving
discoveries
nanoparticle-size-dependent
biological
effects,
we
believe
that
it
is
necessary
systematically
summarize
size-scaling
laws
nanoparticle
vivo.
In
this
review,
summarized
effect
on
along
journey
body:
begin
administration
via
different
delivery
routes,
followed
targeting
intended
tissues
including
tumors
other
organs,
eventually
clearance
through
liver
or
kidneys.
We
outlined
tools
investigating
as
well.
Finally,
discussed
how
may
leverage
tackle
some
challenges
nanomedicine
translation
also
raised
important
size-related
questions
remain
be
answered
future.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
61(14)
Published: Dec. 7, 2021
Abstract
Optical
imaging,
especially
fluorescence
and
photoacoustic
is
a
non‐invasive
imaging
approach
with
high
spatial
temporal
resolution
sensitivity,
compared
to
positron
emission
tomography
(PET)
or
magnetic
resonance
(MRI).
Due
the
merits
of
using
second
near‐infrared
(NIR‐II)
window,
like
deeper
penetration
depth,
signal‐to‐noise
ratio,
resolution,
low
tissue
damage,
researchers
have
devoted
great
effort
developing
contrast
agents
NIR‐II
absorption
emission.
In
this
Review,
we
summarize
recently
developed
organic
luminescent
materials,
ranging
from
small
molecules
conjugated
polymers.
Then,
systematically
introduce
engineering
strategies
describe
performance
classified
by
skeleton
cores.
Finally,
elucidate
challenges
prospects
these
dyes
for
potential
clinical
applications.
We
expect
our
summary
can
inspire
expand
spectrum
diverse
bioapplications.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(3), P. 4162 - 4174
Published: March 1, 2022
Tumor
hypoxia
seriously
impairs
the
therapeutic
outcomes
of
type
II
photodynamic
therapy
(PDT),
which
is
highly
dependent
upon
tissue
oxygen
concentration.
Herein,
a
facile
strategy
acceptor
planarization
and
donor
rotation
proposed
to
design
I
photosensitizers
(PSs)
photothermal
reagents.
Acceptor
can
not
only
enforce
intramolecular
charge
transfer
redshift
NIR
absorption
but
also
PSs
from
photochemical
pathways.
Donor
optimizes
conversion
efficiency
(PCE).
Accordingly,
three
3,6-divinyl-substituted
diketopyrrolopyrrole
(DPP)
derivatives,
2TPAVDPP,
TPATPEVDPP,
2TPEVDPP,
with
different
number
rotors
were
prepared.
Experimental
results
showed
that
compounds
excellent
PSs,
corresponding
2TPEVDPP
nanoparticles
(NPs)
most
possessed
highest
PCE.
The
photophysical
properties
NPs
are
particularly
suitable
for
in
vivo
fluorescence
imaging-guided
synergistic
PDT/PTT
therapy.
helpful
exploiting
phototherapeutic
reagents
high
efficacy
PDT
PTT.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(33), P. 15391 - 15402
Published: Aug. 10, 2022
Fluorescence
imaging
in
the
second
near-infrared
window
(NIR-II,
1000–1700
nm)
using
small-molecule
dyes
has
high
potential
for
clinical
use.
However,
many
NIR-II
suffer
from
emission
quenching
effect
and
extremely
low
quantum
yields
(QYs)
practical
usage
forms.
The
AIE
strategy
been
successfully
utilized
to
develop
with
donor–acceptor
(D–A)
structures
acceptable
QYs
aggregate
state,
but
there
is
still
large
room
QY
improvement.
Here,
we
rationally
designed
a
emissive
dye
named
TPE-BBT
its
derivative
(TPEO-BBT)
by
changing
electron-donating
triphenylamine
unit
tetraphenylethylene
(TPE).
Their
nanoparticles
exhibited
ultrahigh
relative
of
31.5%
23.9%
water,
respectively.
By
an
integrating
sphere,
absolute
was
measured
be
1.8%
water.
Its
crystals
showed
10.4%,
which
highest
value
among
organic
small
molecules
reported
so
far.
optimized
D–A
interaction
higher
rigidity
state
are
believed
two
key
factors
QY.
Finally,
photoluminescence
(PL)
chemiluminescence
(CL)
bioimaging
through
successive
CL
resonance
energy
transfer
Förster
processes.
realized
excellent
PL
quality
mouse
blood
vessels
local
arthrosis
inflammation
mice
signal-to-background
ratio
130.
Thus,
design
presented
here
brings
new
possibilities
development
bright
technologies.
