Dynamic Adjust of Non‐Radiative and Radiative Attenuation of AIE Molecules Reinforces NIR‐II Imaging Mediated Photothermal Therapy and Immunotherapy DOI Creative Commons
Zhenjie Wang, Ling Yu,

Yuehua Wang

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(8)

Published: Jan. 22, 2022

Due to the aggregation-caused quenching effect and near-infrared I poor penetration capabilities of common fluorescent molecules, their applications in visualized imaging photoactivated treatment are limited. Therefore, new II (NIR-II) molecule (named TST), which had abilities aggregation-induced emission (AIE) photothermal therapy synthesized. Moreover, order further improve its yield therapeutic effect, camptothecin prodrug (CPT-S-PEG) novel immune checkpoint inhibitor AZD4635 used co-assemble with TST into nanoparticles for drug delivery. On account strong interaction TST, intramolecular rotation is limited, thereby inhibiting non-radiation attenuation promoting fluorescence generation when intact. As uptake by cancer cells, redox sensitive CPT-S-PEG degraded disintegrate. The released enhances non-radiative expedites conversion because removal constraint camptothecin. Furthermore, induces immunogenic cell death cells releases abundant ATP tumor microenvironment recruit cells. However, superfluous converted immunosuppressive adenosine through CD39-CD73-A2AR pathway. disintegration just blocks this pathway timely, achieving favorable synergistic therapy, chemotherapy, immunotherapy.

Language: Английский

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics DOI

Yishen Liu,

Yang Li, Seyoung Koo

et al.

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

Citations

376
Near-infrared luminescence high-contrast in vivo biomedical imaging DOI Open Access
Ying Chen, Shangfeng Wang, Fan Zhang

et al.

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(1), P. 60 - 78

Published: Jan. 19, 2023

Language: Английский

Citations

277
Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy DOI
Hui Li, Yujun Kim,

Hyoje Jung

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(21), P. 8957 - 9008

Published: Jan. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Language: Английский

Citations

218
The Chemistry of Organic Contrast Agents in the NIR‐II Window DOI
Jing Mu, Ming Xiao, Yu Shi

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(14)

Published: Dec. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Language: Английский

Citations

217
Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance DOI
Mingze Xu,

Yuming Qi,

G.H. Liu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20825 - 20849

Published: Nov. 3, 2023

Understanding the in vivo transport of nanoparticles provides guidelines for designing nanomedicines with higher efficacy and fewer side effects. Among many factors, size plays a key role controlling their behaviors due to existence various physiological thresholds within body size-dependent nano-bio interactions. Encouraged by evolving discoveries nanoparticle-size-dependent biological effects, we believe that it is necessary systematically summarize size-scaling laws nanoparticle vivo. In this review, summarized effect on along journey body: begin administration via different delivery routes, followed targeting intended tissues including tumors other organs, eventually clearance through liver or kidneys. We outlined tools investigating as well. Finally, discussed how may leverage tackle some challenges nanomedicine translation also raised important size-related questions remain be answered future.

Language: Английский

Citations

207
NIR-II bioimaging of small organic molecule DOI Creative Commons

Yingbin Su,

Bing Yu, Song Wang

et al.

Biomaterials, Journal Year: 2021, Volume and Issue: 271, P. 120717 - 120717

Published: Feb. 16, 2021

Language: Английский

Citations

192
Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT DOI
Lina Feng,

Chunbin Li,

Lingxiu Liu

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4162 - 4174

Published: March 1, 2022

Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy acceptor planarization and donor rotation proposed to design I photosensitizers (PSs) photothermal reagents. Acceptor can not only enforce intramolecular charge transfer redshift NIR absorption but also PSs from photochemical pathways. Donor optimizes conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, 2TPEVDPP, with different number rotors were prepared. Experimental results showed that compounds excellent PSs, corresponding 2TPEVDPP nanoparticles (NPs) most possessed highest PCE. The photophysical properties NPs are particularly suitable for in vivo fluorescence imaging-guided synergistic PDT/PTT therapy. helpful exploiting phototherapeutic reagents high efficacy PDT PTT.

Language: Английский

Citations

192
Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging DOI
Hanchen Shen, Feiyi Sun, Xinyan Zhu

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(33), P. 15391 - 15402

Published: Aug. 10, 2022

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) using small-molecule dyes has high potential for clinical use. However, many NIR-II suffer from emission quenching effect and extremely low quantum yields (QYs) practical usage forms. The AIE strategy been successfully utilized to develop with donor–acceptor (D–A) structures acceptable QYs aggregate state, but there is still large room QY improvement. Here, we rationally designed a emissive dye named TPE-BBT its derivative (TPEO-BBT) by changing electron-donating triphenylamine unit tetraphenylethylene (TPE). Their nanoparticles exhibited ultrahigh relative of 31.5% 23.9% water, respectively. By an integrating sphere, absolute was measured be 1.8% water. Its crystals showed 10.4%, which highest value among organic small molecules reported so far. optimized D–A interaction higher rigidity state are believed two key factors QY. Finally, photoluminescence (PL) chemiluminescence (CL) bioimaging through successive CL resonance energy transfer Förster processes. realized excellent PL quality mouse blood vessels local arthrosis inflammation mice signal-to-background ratio 130. Thus, design presented here brings new possibilities development bright technologies.

Language: Английский

Citations

186
Fluorescent probes for the detection of disease-associated biomarkers DOI
Wei‐Tao Dou, Hai‐Hao Han, Adam C. Sedgwick

et al.

Science Bulletin, Journal Year: 2022, Volume and Issue: 67(8), P. 853 - 878

Published: Jan. 17, 2022

Language: Английский

Citations

183
Carbon dots: mysterious past, vibrant present, and expansive future DOI
Boyang Wang, Geoffrey I. N. Waterhouse, Siyu Lu

et al.

Trends in Chemistry, Journal Year: 2022, Volume and Issue: 5(1), P. 76 - 87

Published: Nov. 10, 2022

Language: Английский

Citations

163