Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Feb. 29, 2024
Abstract
The
photochemical
properties
of
Electron
Donor-Acceptor
(EDA)
complexes
present
exciting
opportunities
for
synthetic
chemistry.
However,
these
strategies
often
require
an
inert
atmosphere
to
maintain
high
efficiency.
Herein,
we
develop
EDA
complex
photocatalytic
system
through
rational
design,
which
overcomes
the
oxygen-sensitive
limitation
traditional
systems
and
enables
aerobic
oxygenation
reactions
dioxygen
activation.
mild
oxidation
transfers
electrons
from
donor
effective
catalytic
acceptor
upon
visible
light
irradiation,
are
subsequently
captured
by
molecular
oxygen
form
superoxide
radical
ion,
as
demonstrated
specific
fluorescent
probe,
dihydroethidine
(DHE).
Furthermore,
this
visible-light
mediated
oxidative
protocol
is
successfully
applied
in
boronic
acids.
We
believe
that
activation
strategy
enabled
not
only
provides
a
practical
approach
but
also
promotes
design
application
photocatalysis
under
ambient
conditions.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 2487 - 2649
Published: Nov. 9, 2021
Redox
processes
are
at
the
heart
of
synthetic
methods
that
rely
on
either
electrochemistry
or
photoredox
catalysis,
but
how
do
and
catalysis
compare?
Both
approaches
provide
access
to
high
energy
intermediates
(e.g.,
radicals)
enable
bond
formations
not
constrained
by
rules
ionic
2
electron
(e)
mechanisms.
Instead,
they
1e
mechanisms
capable
bypassing
electronic
steric
limitations
protecting
group
requirements,
thus
enabling
chemists
disconnect
molecules
in
new
different
ways.
However,
while
providing
similar
intermediates,
differ
several
physical
chemistry
principles.
Understanding
those
differences
can
be
key
designing
transformations
forging
disconnections.
This
review
aims
highlight
these
similarities
between
comparing
their
underlying
principles
describing
impact
electrochemical
photochemical
methods.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(2), P. 2429 - 2486
Published: Oct. 6, 2021
Alkoxy
radicals
are
highly
reactive
species
that
have
long
been
recognized
as
versatile
intermediates
in
organic
synthesis.
However,
their
development
has
impeded
due
to
a
lack
of
convenient
methods
for
generation.
Thanks
advances
photoredox
catalysis,
enabling
facile
access
alkoxy
from
bench-stable
precursors
and
free
alcohols
under
mild
conditions,
research
interest
this
field
renewed.
This
review
comprehensively
summarizes
the
recent
progress
radical-mediated
transformations
visible
light
irradiation.
Elementary
steps
radical
generation
either
or
central
reaction
development;
thus,
each
section
is
categorized
discussed
accordingly.
Throughout
review,
we
focused
on
different
mechanisms
well
impact
synthetic
utilizations.
Notably,
catalytic
abundant
still
early
stage,
providing
intriguing
opportunities
exploit
diverse
paradigms.
Angewandte Chemie International Edition,
Journal Year:
2019,
Volume and Issue:
59(3), P. 1346 - 1353
Published: Oct. 31, 2019
Abstract
Conventionally,
sulfones
are
prepared
by
oxidation
of
sulfides
with
strong
oxidants.
Now,
a
multicomponent
reductive
cross‐coupling
involving
an
inorganic
salt
(sodium
metabisulfite)
for
the
straightforward
construction
is
disclosed.
Both
intramolecular
and
intermolecular
cross‐couplings
were
comprehensively
explored,
diverse
accessible
from
corresponding
alkyl
aryl
halides.
Intramolecular
cyclic
systematically
obtained
five‐
to
twelve‐membered
rings.
Naturally
occurring
aliphatic
systems,
such
as
steroids,
saccharides,
amino
acids,
highly
compatible
SO
2
‐insertion
cross‐coupling.
Four
clinically
applied
drug
molecules,
which
include
multiple
heteroatoms
functional
groups
active
hydrogens,
successfully
via
late‐stage
insertion.
Mechanistic
studies
show
that
radicals
sulfonyl
both
involved
intermediates
in
this
transformation.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(14), P. 8067 - 8101
Published: Jan. 1, 2021
Molecular
oxygen
as
a
green,
inexpensive
oxidant
and
source
has
displayed
lots
of
advantages
compared
to
other
oxidants.
This
review
introduces
the
recent
advances
radical
processes
in
molecular
oxygen-mediated
oxygenation
reactions.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2022,
Volume and Issue:
10(2), P. 671 - 677
Published: Jan. 3, 2022
Sulfur-containing
molecules
are
increasingly
crucial
in
chemistry-related
fields
and
widely
applied
life
science,
material
food
pharmaceutical
science.
This
perspective
focuses
on
the
introduction
of
green
sulfurizing
reagents
sustainable
methodologies
to
realize
diverse
kinds
functionalized
transformations
synthetic
applications.
The
text
is
organized
according
structure
sulfur-containing
corresponding
method.
It
expected
be
interest
organic
chemistry
professionals
who
wish
better
understand
insights
applications
organosulfur
transformations.
ChemPlusChem,
Journal Year:
2022,
Volume and Issue:
87(4)
Published: Feb. 15, 2022
Sulfoxides
constitute
one
of
the
most
important
functional
groups
in
organic
chemistry
found
numerous
pharmaceuticals
and
natural
products.
are
usually
obtained
from
oxidation
corresponding
sulfides.
Among
various
oxidants,
oxygen
or
air
considered
greenest
sustainable
reagent.
Photochemistry
photocatalysis
is
increasingly
applied
new,
as
well
traditional,
yet
demanding,
reaction,
like
aerobic
sulfides
to
sulfoxides,
since
has
provided
means
access
them
mild
effective
ways.
In
this
review,
we
will
summarize
photochemical
protocols
that
have
been
developed
for
employing
oxidant.
The
aim
review
present:
i)
a
historical
overview,
ii)
key
mechanistic
studies
proposed
mechanisms
iii)
categorize
different
catalytic
systems
literature.
