Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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A Bioinspired Five‐Coordinated Single‐Atom Iron Nanozyme for Tumor Catalytic Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(15)

Published: Feb. 1, 2022

Single-atom nanozymes (SAzymes) represent a new research frontier in the biomedical fields. The rational design and controllable synthesis of SAzymes with well-defined electronic geometric structures are essential for maximizing their enzyme-like catalytic activity therapeutic efficacy but remain challenging. Here, melamine-mediated pyrolysis activation strategy is reported fabrication iron-based SAzyme containing five-coordinated structure (FeN5 ), identified by transmission electron microscopy imaging X-ray absorption fine analyses. FeN5 exhibits superior peroxidase-like owing to optimized coordination structure, corresponding efficiency Fe-species 7.64 3.45 × 105 times higher than those traditional FeN4 Fe3 O4 nanozyme, respectively, demonstrated steady-state kinetic assay. In addition, mechanism jointly disclosed experimental results density functional theory studies. as-synthesized demonstrates significantly enhanced antitumor effect vitro vivo due excellent under tumor microenvironment.

Language: Английский

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Low temperature photothermal therapy: Advances and perspectives

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 454, P. 214330 - 214330

Published: Dec. 2, 2021

Language: Английский

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Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry

Chemical Science, Journal Year: 2021, Volume and Issue: 13(4), P. 863 - 889

Published: Nov. 29, 2021

Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is most significant feature of chemodynamic (CDT). Owing to mild acid and overexpressed H2O2 TME, more cytotoxic hydroxyl radicals (˙OH) are generated cells via Fenton-like reactions. Without external stimulus drug resistance generation, reactive oxygen species (ROS)-mediated CDT exhibits a specific desirable anticancer effect has been seen as promising strategy therapy. However, optimizing treatment efficiency TME still challenging because limited catalytic agents strong antioxidant capacity TME. Hence, scientists trying their best design fabricate many with excellent activity remodeling optimal CDT. In this perspective, latest progress discussed, some representative examples presented. Consequently, strategies further guided by provided. Most importantly, several feasible ways developing future offered reference.

Language: Английский

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Strategies for enhancing cancer chemodynamic therapy performance

Exploration, Journal Year: 2022, Volume and Issue: 2(2)

Published: March 7, 2022

Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H

Language: Английский

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Tumor‐Microenvironment‐Responsive Cascade Reactions by a Cobalt‐Single‐Atom Nanozyme for Synergistic Nanocatalytic Chemotherapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(48)

Published: Aug. 16, 2022

Nanocatalytic therapy, involving the nanozyme-triggered production of reactive oxygen species (ROS) in tumor microenvironment (TME), has demonstrated potential but nanozymes still face challenges activity and specificity that compromise therapeutic efficacy. Herein, we report a strategy based on single-atom nanozyme to initiate cascade enzymatic reactions TME for tumor-specific treatment. The cobalt-single-atom nanozyme, with Co-N coordination N-doped porous carbon (Co-SAs@NC), displays catalase-like decomposes cellular endogenous H2 O2 produce , subsequent oxidase-like converts into cytotoxic superoxide radicals efficiently kill cells. By incorporation doxorubicin, therapy achieves significantly enhanced antitumor effect vivo. Our findings show TME-specific catalytic combined chemotherapy is promising efficient therapy.

Language: Английский

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“Electron Transport Chain Interference” Strategy of Amplified Mild-Photothermal Therapy and Defect-Engineered Multi-Enzymatic Activities for Synergistic Tumor-Personalized Suppression

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(17), P. 9488 - 9507

Published: March 31, 2023

Arming activatable mild-photothermal therapy (PTT) with the property of relieving tumor thermotolerance holds great promise for overcoming traditional mild PTT limitations such as thermoresistance, insufficient therapeutic effect, and off-target heating. Herein, a mitochondria-targeting, defect-engineered AFCT nanozyme enhanced multi-enzymatic activity was elaborately designed microenvironment (TME)-activatable phototheranostic agent to achieve remarkable anti-tumor via "electron transport chain (ETC) interference synergistic adjuvant therapy". Density functional theory calculations revealed that effect among multi-enzyme active centers endows nanozymes excellent catalytic activity. In TME, open sources H2O2 can be achieved by superoxide dismutase-mimicking nanozymes. response dual stimuli acidity, peroxidase-mimicking not only catalyzes accumulation generate ·OH but also converts loaded 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) into its oxidized form strong near-infrared absorption, specifically unlocking photothermal photoacoustic imaging properties. Intriguingly, undesired thermoresistance cells greatly alleviated owing reduced expression heat shock proteins enabled NADH POD-mimicking AFCT-mediated depletion consequent restriction ATP supply. Meanwhile, accumulated facilitate both apoptosis ferroptosis in cells, resulting outcomes combination TME-activated PTT.

Language: Английский

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Defect engineering in nanozymes

Materials Today, Journal Year: 2021, Volume and Issue: 52, P. 327 - 347

Published: Nov. 29, 2021

Language: Английский

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A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(40)

Published: July 30, 2022

Abstract Cuproptosis is a very newly recognized regulated cell death modality that distinct from known mechanisms and shows enormous prospect in cancer treatment. However, its efficacy copper‐dependent restricted by strictly copper metabolism. Herein, novel copper/iron hybrid hollow amorphous metal organic framework (HaMOF) developed as an oxidative stress amplifier metabolic disrupter for synergistic cuproptosis/ferroptosis/apoptosis anticancer therapy. The HaMOF fabricated Cu 2+ , 3,3′‐dithiobis(propionohydrazide) Fe 3+ via unsaturated coordination‐etching integration strategy, then doxorubicin loaded followed surface decoration with hyaluronan. obtained DOX@Fe/CuTH exhibits tumor microenvironment‐triggered catalytic therapeutic property, wherein it can amplify cellular simultaneously boosting H 2 O production depleting glutathione. Moreover, cause mitochondrial dysfunction downregulate the expressions of transporter ATP7A iron FPN 1, thereby leading to disorders high retentions cytoplasm •OH generation. overloaded lipoylated protein dihydrolipoamide S‐acetyltransferase aggregation lead cuproptosis. Collectively, both augmented induce potent ferroptosis, which synergizes cuproptosis DOX‐mediated apoptosis efficiently suppress growth. This bimetallic nanoplatform provides new paradigm boost cuproptosis‐related therapies.

Language: Английский

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Microenvironment-driven sequential ferroptosis, photodynamic therapy, and chemotherapy for targeted breast cancer therapy by a cancer-cell-membrane-coated nanoscale metal-organic framework

Biomaterials, Journal Year: 2022, Volume and Issue: 283, P. 121449 - 121449

Published: March 1, 2022

Language: Английский

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