Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(19)
Published: Feb. 26, 2022
Small-molecule-based
second
near-infrared
(NIR-II)
activatable
fluorescent
probes
can
potentially
provide
a
high
target-to-background
ratio
and
deep
tissue
penetration.
However,
most
of
the
reported
NIR-II
small-molecule
exhibit
poor
versatility
owing
to
lack
general
stable
optically
tunable
group.
In
this
study,
we
designed
NIRII-HDs,
novel
dye
scaffold
optimized
for
probe
development.
particular,
NIRII-HD5
showed
best
optical
properties
such
as
proper
pKa
value,
excellent
stability,
brightness,
which
be
beneficial
in
vivo
imaging
with
contrast.
To
demonstrate
applicability
dye,
three
target-activatable
ROS,
thiols,
enzymes.
Using
these
probes,
not
only
realized
reliable
different
diseases
mouse
models
but
also
evaluated
redox
potential
liver
during
injury
fidelity.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(1), P. 209 - 268
Published: Oct. 19, 2021
In
vivo
imaging
in
the
second
near-infrared
window
(NIR-II,
1000-1700
nm),
which
enables
us
to
look
deeply
into
living
subjects,
is
producing
marvelous
opportunities
for
biomedical
research
and
clinical
applications.
Very
recently,
there
has
been
an
upsurge
of
interdisciplinary
studies
focusing
on
developing
versatile
types
inorganic/organic
fluorophores
that
can
be
used
noninvasive
NIR-IIa/IIb
(NIR-IIa,
1300-1400
nm;
NIR-IIb,
1500-1700
nm)
with
near-zero
tissue
autofluorescence
deeper
penetration.
This
review
provides
overview
reports
published
date
design,
properties,
molecular
imaging,
theranostics
fluorophores.
First,
we
summarize
design
concepts
up-to-date
functional
biomaterials,
order
single-walled
carbon
nanotubes
(SWCNTs),
quantum
dots
(QDs),
rare-earth-doped
nanoparticles
(RENPs),
organic
(OFs).
Then,
these
novel
modalities
applications
brought
by
superior
fluorescent
properties
are
reviewed.
Finally,
challenges
perspectives
future
translation,
aiming
at
boosting
application
progress
NIR-IIa
NIR-IIb
technology
highlighted.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(10), P. 3406 - 3426
Published: Jan. 1, 2021
Small-molecule
based
fluorescent
probes
are
increasingly
important
for
the
detection
and
imaging
of
biological
signaling
molecules
due
to
their
simplicity,
high
selectivity
sensitivity,
whilst
being
non-invasive,
suitable
real-time
analysis
living
systems.
With
this
perspective
we
highlight
sensing
mechanisms
including
Förster
resonance
energy
transfer
(FRET),
intramolecular
charge
(ICT),
photoinduced
electron
(PeT),
excited
state
proton
(ESIPT),
aggregation
induced
emission
(AIE)
multiple
modality
fluorescence
approaches
dual/triple
(DSM
or
TSM).
Throughout
remaining
challenges
suggest
potential
directions
development
towards
improved
small-molecule
biosensing.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(18)
Published: March 27, 2021
Abstract
The
study
of
purely
organic
room‐temperature
phosphorescence
(RTP)
has
drawn
increasing
attention
because
its
considerable
theoretical
research
and
practical
application
value.
Currently,
RTP
materials
with
both
high
efficiency
(Φ
P
>
20%)
a
long
lifetime
(τ
10
s)
in
air
are
still
scarce
due
to
the
lack
related
design
guidance.
Here,
new
strategy
increase
performance
by
integrating
host
guest
one
doping
system
form
triplet
exciplex,
is
reported.
With
these
materials,
high‐contrast
labeling
tumors
living
mice
encrypted
patterns
thermal
printing
successfully
realized
taking
advantage
afterglow
time
(up
25
min
aqueous
media)
(43%).
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: April 22, 2021
Abstract
J-aggregation
is
an
efficient
strategy
for
the
development
of
fluorescent
imaging
agents
in
second
near-infrared
window.
However,
design
J-aggregates
challenging
due
to
lack
suitable
dyes.
Herein,
we
report
meso
-[2.2]paracyclophanyl-3,5-bis-
N
,
-dimethylaminostyrl
BODIPY
(PCP-BDP2)
as
example
dye
with
induced
fluorescence.
PCP-BDP2
shows
emission
maximum
at
1010
nm
state.
Mechanism
studies
reveal
that
steric
and
conjugation
effect
PCP
group
on
play
key
roles
behavior
photophysical
properties
tuning.
Notably,
can
be
utilized
lymph
node
fluorescence-guided
surgery
nude
mouse,
which
demonstrates
their
potential
clinical
application.
This
study
alternate
platform
developing
agents.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
60(2), P. 800 - 805
Published: Sept. 16, 2020
Abstract
Organic
dye
based
NIR‐II
fluorescent
probes,
owing
to
their
high
signal‐to‐background
ratio
and
deeper
penetration,
are
highly
useful
for
deep‐tissue
high‐contrast
imaging
in
vivo.
However,
it
is
still
a
challenge
design
activatable
probes.
Here,
novel
class
of
polymethine
dyes
(NIRII‐RTs),
with
bright
(quantum
yield
up
2.03
%),
stable,
anti‐solvent
quenching
emission,
together
large
Stokes
shifts,
was
designed.
Significantly,
the
NIRII‐RT3
NIRII‐RT4,
equipped
carboxylic
acid
group,
can
serve
as
effective
platforms
bioimaging
probes
contrast.
As
proof
concept,
series
target‐activatable
NIRII‐RT
(NIRII‐RT‐pH,
NIRII‐RT‐ATP
NIRII‐RT‐Hg)
pH,
adenosine
triphosphate
(ATP),
metal‐ion
detection,
were
synthesized.
By
applying
probe,
real‐time
monitoring
drug‐induced
hepatotoxicity
realized.
Accounts of Materials Research,
Journal Year:
2021,
Volume and Issue:
2(8), P. 644 - 654
Published: July 26, 2021
ConspectusRoom
temperature
phosphorescence
(RTP)
materials,
which
could
respond
to
external
stimuli,
such
as
force,
heat,
light,
electric
filed,
etc.,
have
drawn
increasing
attention
for
their
broad
application
prospects,
especially
in
the
fields
of
anticounterfeiting,
sensors,
data
storage,
and
so
on.
In
comparison
with
traditional
fluorescence
ones,
RTP
materials
show
much
longer
emission
lifetimes,
can
be
even
caught
by
naked
eye.
Thus,
change
lifetime
under
an
stimulus
also
a
potential
monitoring
parameter,
addition
color
intensity.
other
words,
number
visual
parameters
increase
from
two
three
would
greatly
facilitate
practical
applications.
Until
now,
been
typically
limited
metal-containing
inorganic
particularly
rare-earth
phosphors.
Their
emissions
are
governed
slow
liberation
trapped
charge
carriers
isolated
traps
impurities,
defects,
or
ions
through
thermal
stimulation
low
luminescence
efficiency.
However,
these
suffer
some
intrinsic
disadvantages,
including
high
cost,
toxicity,
instability
aqueous
environments.
order
solve
problems,
purely
organic
should
good
choice.
kinds
really
scarce
ones
response
characteristic.To
develop
effect,
we
scientists
tried
lot.
Luckily,
progresses
made.
this
Account,
present
our
recent
progress
on
stimulus-responsive
room
mainly
focusing
internal
mechanism
First,
fundamental
knowledge
is
described
illustrate
importance
main
principles
effect.
Then,
typical
based
different
mechanisms
discussed.
Mainly,
were
introduced,
namely,
single-component
multicomponent
ones.
Correspondingly,
dynamic
property
occurred
distinct
mechanisms.
For
changes
molecular
structure,
packing,
conformation,
played
significant
role
corresponding
As
changed
oxygen
concentration
matrix
intermolecular
distance
between
components
found
more
during
process.
Accordingly,
applications
explored
processes.
With
classification
mechanisms,
design
strategy
well
proposed,
thus
guiding
further
development
research
field.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(15), P. 14347 - 14405
Published: July 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(6), P. 2601 - 2607
Published: Feb. 5, 2021
Semiconductor
quantum
dots
(QDs)
with
photoluminescence
(PL)
emission
at
900–1700
nm
(denoted
as
the
second
near-infrared
window,
NIR-II)
exhibit
much-depressed
photon
absorption
and
scattering,
which
has
stimulated
extensive
researches
in
biomedical
imaging
NIR
devices.
However,
it
is
very
challenging
to
develop
NIR-II
QDs
a
high
yield
(PLQY)
excellent
biocompatibility.
Herein,
we
designed
synthesized
an
alloyed
silver
gold
selenide
(AgAuSe)
QD
bright
from
820
1170
achieved
record
absolute
PLQY
of
65.3%
978
among
without
toxic
element
long
lifetime
4.58
μs.
It
proved
that
are
mainly
attributed
prevented
nonradiative
transition
excitons,
probably
resulted
suppressing
cation
vacancies
crystal
defects
mobility
Ag
ions
by
alloying
Au
atoms.
These
high-PLQY
nontoxic
heavy
metal
great
application
potential
bioimaging,
light
emitting
diodes
(LEDs),
photovoltaic
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(41), P. 17136 - 17143
Published: Oct. 11, 2021
Fluorescence
bioimaging
through
the
second
near-infrared
window
(NIR-II,
1000–1700
nm)
has
attracted
much
attention
due
to
its
deep
penetration
and
high
contrast.
However,
exploring
new
fluorescent
materials,
especially
small
molecular
fluorophores
with
long
wavelength
brightness,
is
still
quite
challenging.
By
expanding
π-conjugation
enhancing
intramolecular
charge
transfer
effect,
herein
we
report
a
series
of
xanthene-based
NIR-II
dyes,
named
VIXs.
Among
these
VIX-4
exhibits
best
performance
fluorescence
emission
at
1210
nm
brightness
been
used
for
dynamically
imaging
blood
flow
mice
200
fps.
virtue
spatiotemporal
resolution
dynamic
imaging,
can
distinguish
directly
artery
vein
direction
measure
volume
by
videos.
This
study
provides
not
only
an
effective
tool
spatial
temporal
but
also
promising
conjugated
skeleton
dyes.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(16), P. 5607 - 5651
Published: Jan. 1, 2023
Since
their
inception,
rhodamine
dyes
have
been
extensively
applied
in
biotechnology
as
fluorescent
markers
or
for
the
detection
of
biomolecules
owing
to
good
optical
physical
properties.
Accordingly,
they
emerged
a
powerful
tool
visualization
living
systems.
In
addition
fluorescence
bioimaging,
molecular
design
derivatives
with
disease
therapeutic
functions
(e.g.,
cancer
and
bacterial
infection)
has
recently
attracted
increased
research
attention,
which
is
significantly
important
construction
libraries
diagnostic
integration.
However,
reviews
focusing
on
integrated
strategies
dye-based
diagnosis
treatment
wide
application
are
extremely
rare.
this
review,
first,
brief
history
development
dyes,
transformation
from
bioimaging
therapy,
concept
optics-based
integration
its
significance
human
presented.
Next,
systematic
review
several
excellent
rhodamine-based
well
treatment,
Finally,
challenges
practical
future
outlook
clinical
translation
also
discussed.