NIRII‐HDs: A Versatile Platform for Developing Activatable NIR‐II Fluorogenic Probes for Reliable In Vivo Analyte Sensing DOI

Zuojia Qin,

Tian‐Bing Ren, Huijie Zhou

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(19)

Published: Feb. 26, 2022

Small-molecule-based second near-infrared (NIR-II) activatable fluorescent probes can potentially provide a high target-to-background ratio and deep tissue penetration. However, most of the reported NIR-II small-molecule exhibit poor versatility owing to lack general stable optically tunable group. In this study, we designed NIRII-HDs, novel dye scaffold optimized for probe development. particular, NIRII-HD5 showed best optical properties such as proper pKa value, excellent stability, brightness, which be beneficial in vivo imaging with contrast. To demonstrate applicability dye, three target-activatable ROS, thiols, enzymes. Using these probes, not only realized reliable different diseases mouse models but also evaluated redox potential liver during injury fidelity.

Language: Английский

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics DOI

Yishen Liu,

Yang Li, Seyoung Koo

et al.

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

Citations

376

Fluorescent small organic probes for biosensing DOI Creative Commons
Xue Tian, Lloyd C. Murfin, Luling Wu

et al.

Chemical Science, Journal Year: 2021, Volume and Issue: 12(10), P. 3406 - 3426

Published: Jan. 1, 2021

Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity sensitivity, whilst being non-invasive, suitable real-time analysis living systems. With this perspective we highlight sensing mechanisms including Förster resonance energy transfer (FRET), intramolecular charge (ICT), photoinduced electron (PeT), excited state proton (ESIPT), aggregation induced emission (AIE) multiple modality fluorescence approaches dual/triple (DSM or TSM). Throughout remaining challenges suggest potential directions development towards improved small-molecule biosensing.

Language: Английский

Citations

375

High Performance of Simple Organic Phosphorescence Host–Guest Materials and their Application in Time‐Resolved Bioimaging DOI
Yunsheng Wang, Heqi Gao, Jie Yang

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(18)

Published: March 27, 2021

Abstract The study of purely organic room‐temperature phosphorescence (RTP) has drawn increasing attention because its considerable theoretical research and practical application value. Currently, RTP materials with both high efficiency (Φ P > 20%) a long lifetime (τ 10 s) in air are still scarce due to the lack related design guidance. Here, new strategy increase performance by integrating host guest one doping system form triplet exciplex, is reported. With these materials, high‐contrast labeling tumors living mice encrypted patterns thermal printing successfully realized taking advantage afterglow time (up 25 min aqueous media) (43%).

Language: Английский

Citations

368

J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging DOI Creative Commons
Kang Li,

Xingchen Duan,

Zhiyong Jiang

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 22, 2021

Abstract J-aggregation is an efficient strategy for the development of fluorescent imaging agents in second near-infrared window. However, design J-aggregates challenging due to lack suitable dyes. Herein, we report meso -[2.2]paracyclophanyl-3,5-bis- N , -dimethylaminostyrl BODIPY (PCP-BDP2) as example dye with induced fluorescence. PCP-BDP2 shows emission maximum at 1010 nm state. Mechanism studies reveal that steric and conjugation effect PCP group on play key roles behavior photophysical properties tuning. Notably, can be utilized lymph node fluorescence-guided surgery nude mouse, which demonstrates their potential clinical application. This study alternate platform developing agents.

Language: Английский

Citations

222

A General Strategy for Development of Activatable NIR‐II Fluorescent Probes for In Vivo High‐Contrast Bioimaging DOI
Tian‐Bing Ren, Zhiyao Wang, Zhen Xiang

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(2), P. 800 - 805

Published: Sept. 16, 2020

Abstract Organic dye based NIR‐II fluorescent probes, owing to their high signal‐to‐background ratio and deeper penetration, are highly useful for deep‐tissue high‐contrast imaging in vivo. However, it is still a challenge design activatable probes. Here, novel class of polymethine dyes (NIRII‐RTs), with bright (quantum yield up 2.03 %), stable, anti‐solvent quenching emission, together large Stokes shifts, was designed. Significantly, the NIRII‐RT3 NIRII‐RT4, equipped carboxylic acid group, can serve as effective platforms bioimaging probes contrast. As proof concept, series target‐activatable NIRII‐RT (NIRII‐RT‐pH, NIRII‐RT‐ATP NIRII‐RT‐Hg) pH, adenosine triphosphate (ATP), metal‐ion detection, were synthesized. By applying probe, real‐time monitoring drug‐induced hepatotoxicity realized.

Language: Английский

Citations

214

Stimulus-Responsive Room Temperature Phosphorescence Materials: Internal Mechanism, Design Strategy, and Potential Application DOI Open Access
Jie Yang, Manman Fang, Zhen Li

et al.

Accounts of Materials Research, Journal Year: 2021, Volume and Issue: 2(8), P. 644 - 654

Published: July 26, 2021

ConspectusRoom temperature phosphorescence (RTP) materials, which could respond to external stimuli, such as force, heat, light, electric filed, etc., have drawn increasing attention for their broad application prospects, especially in the fields of anticounterfeiting, sensors, data storage, and so on. In comparison with traditional fluorescence ones, RTP materials show much longer emission lifetimes, can be even caught by naked eye. Thus, change lifetime under an stimulus also a potential monitoring parameter, addition color intensity. other words, number visual parameters increase from two three would greatly facilitate practical applications. Until now, been typically limited metal-containing inorganic particularly rare-earth phosphors. Their emissions are governed slow liberation trapped charge carriers isolated traps impurities, defects, or ions through thermal stimulation low luminescence efficiency. However, these suffer some intrinsic disadvantages, including high cost, toxicity, instability aqueous environments. order solve problems, purely organic should good choice. kinds really scarce ones response characteristic.To develop effect, we scientists tried lot. Luckily, progresses made. this Account, present our recent progress on stimulus-responsive room mainly focusing internal mechanism First, fundamental knowledge is described illustrate importance main principles effect. Then, typical based different mechanisms discussed. Mainly, were introduced, namely, single-component multicomponent ones. Correspondingly, dynamic property occurred distinct mechanisms. For changes molecular structure, packing, conformation, played significant role corresponding As changed oxygen concentration matrix intermolecular distance between components found more during process. Accordingly, applications explored processes. With classification mechanisms, design strategy well proposed, thus guiding further development research field.

Language: Английский

Citations

207

Aggregation-Induced Emission (AIE), Life and Health DOI Creative Commons
Haoran Wang, Qiyao Li, Parvej Alam

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

Citations

189

Colloidal Alloyed Quantum Dots with Enhanced Photoluminescence Quantum Yield in the NIR-II Window DOI
Hongchao Yang, Renfu Li, Yejun Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(6), P. 2601 - 2607

Published: Feb. 5, 2021

Semiconductor quantum dots (QDs) with photoluminescence (PL) emission at 900–1700 nm (denoted as the second near-infrared window, NIR-II) exhibit much-depressed photon absorption and scattering, which has stimulated extensive researches in biomedical imaging NIR devices. However, it is very challenging to develop NIR-II QDs a high yield (PLQY) excellent biocompatibility. Herein, we designed synthesized an alloyed silver gold selenide (AgAuSe) QD bright from 820 1170 achieved record absolute PLQY of 65.3% 978 among without toxic element long lifetime 4.58 μs. It proved that are mainly attributed prevented nonradiative transition excitons, probably resulted suppressing cation vacancies crystal defects mobility Ag ions by alloying Au atoms. These high-PLQY nontoxic heavy metal great application potential bioimaging, light emitting diodes (LEDs), photovoltaic

Language: Английский

Citations

170

Xanthene-Based NIR-II Dyes for In Vivo Dynamic Imaging of Blood Circulation DOI

Diankai Liu,

Zixu He, Yanyan Zhao

et al.

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(41), P. 17136 - 17143

Published: Oct. 11, 2021

Fluorescence bioimaging through the second near-infrared window (NIR-II, 1000–1700 nm) has attracted much attention due to its deep penetration and high contrast. However, exploring new fluorescent materials, especially small molecular fluorophores with long wavelength brightness, is still quite challenging. By expanding π-conjugation enhancing intramolecular charge transfer effect, herein we report a series of xanthene-based NIR-II dyes, named VIXs. Among these VIX-4 exhibits best performance fluorescence emission at 1210 nm brightness been used for dynamically imaging blood flow mice 200 fps. virtue spatiotemporal resolution dynamic imaging, can distinguish directly artery vein direction measure volume by videos. This study provides not only an effective tool spatial temporal but also promising conjugated skeleton dyes.

Language: Английский

Citations

153

Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects DOI

Shuang Zeng,

Xiaosheng Liu, Yves S. Kafuti

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(16), P. 5607 - 5651

Published: Jan. 1, 2023

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to good optical physical properties. Accordingly, they emerged a powerful tool visualization living systems. In addition fluorescence bioimaging, molecular design derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important construction libraries diagnostic integration. However, reviews focusing on integrated strategies dye-based diagnosis treatment wide application are extremely rare. this review, first, brief history development dyes, transformation from bioimaging therapy, concept optics-based integration its significance human presented. Next, systematic review several excellent rhodamine-based well treatment, Finally, challenges practical future outlook clinical translation also discussed.

Language: Английский

Citations

153