Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near‐Infrared Construction

Small, Journal Year: 2021, Volume and Issue: 17(6)

Published: Jan. 15, 2021

Photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention in disease diagnosis treatment. Although many exogenous contrast agents been developed for PA PTT, the design guidelines to amplify their performances remain challenging are highly demanded. Semiconducting polymer nanoparticles (SPNs) composed of polymers with π-electron delocalized backbones can be designed PTT performance, because clear structure-property relation versatility modifying molecular structures tune photophysical properties. This review summarizes recent advances photoacoustic applications semiconducting a focus on signal amplification second near-infrared (NIR-II, 1000-1700 nm) construction. The strategies such as screening, fluorescence quenching, accelerated heat dissipation, size-dependent dissipation first discussed brightness SPNs vivo PA. approaches shifting absorption NIR-II then introduced so improve tissue penetration depth therapy. At last, current challenges perspectives field discussed.

Language: Английский

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The concept and examples of type-III photosensitizers for cancer photodynamic therapy

Chem, Journal Year: 2021, Volume and Issue: 8(1), P. 197 - 209

Published: Nov. 4, 2021

Language: Английский

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Nanoplatform-based cascade engineering for cancer therapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(24), P. 9057 - 9094

Published: Jan. 1, 2020

This review provides a comprehensive overview of the recent advances in nanoplatform-based cascade engineering for cancer therapy, by concentrating on design smart nanoplatforms and implementation specific processes.

Language: Английский

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Enhanced photodynamic therapy for overcoming tumor hypoxia: From microenvironment regulation to photosensitizer innovation

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 427, P. 213604 - 213604

Published: Oct. 12, 2020

Language: Английский

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Covalent Assembly of Two‐Dimensional COF‐on‐MXene Heterostructures Enables Fast Charging Lithium Hosts

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(25)

Published: April 16, 2021

Abstract 2D heterostructured materials combining ultrathin nanosheet morphology, defined pore configuration, and stable hybrid compositions, have attracted increasing attention for fast mass transport charge transfer, which are highly desirable features efficient energy storage. Here, the chemical space of 2D–2D heterostructures is extended by covalently assembling covalent organic frameworks (COFs) on MXene nanosheets. Unlike most COFs, generally produced as solid powders, COF‐LZU1 grows in situ aminated Ti 3 C 2 T x nanosheets with bonding, producing a robust MXene@COF heterostructure high crystallinity, hierarchical porosity, conductive frameworks. When used lithium hosts Li metal batteries, storage significantly improved. Both spectroelectrochemical theoretical analyses demonstrate that lithiated COF channels important + layers, ions can be precisely nucleated. This affords dendrite‐free fast‐charging anodes, would difficult to achieve using individual components.

Language: Английский

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Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer

Theranostics, Journal Year: 2021, Volume and Issue: 11(7), P. 3167 - 3182

Published: Jan. 1, 2021

Rationale: Iron-saturated Lf (Holo-Lactoferrin, Holo-Lf) exhibits a superior anticancer property than low iron-saturated (Apo-Lf). Ferroptosis is an iron-dependent cell death characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). Radiotherapy also exerts its therapeutic effect through ROS. Methods: The different on ferroptosis radiotherapy were tested triple-negative breast cancer (TNBC) line MDA-MB-231 non-TNBC MCF-7. Results: Holo-Lf significantly increased total iron content, promoted ROS generation, end product, malondialdehyde (MDA), enhanced cells. By contrast, Apo-Lf upregulated SLC7a11 expression, GSH generation inhibited However, MCF-7 cells resistant to Holo-Lf-induced because have higher redox balance capacity More importantly, downregulated HIF-1α ameliorated hypoxia microenvironment in subcutaneous tumors, radiation-induced DNA damage hypoxic Finally, efficacy tumors was Holo-Lf. Conclusion: could induce sensitize radiotherapy.

Language: Английский

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Bioengineered nanogels for cancer immunotherapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 5136 - 5174

Published: Jan. 1, 2022

Recent years have witnessed increasingly rapid advances in nanocarrier-based biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as multipurpose and constructed vectors formed via intramolecular cross-linking to generate drug delivery systems, which is attributed predominantly their satisfactory biocompatibility, bio-responsiveness, high stability, low toxicity. Recently, immunotherapy has experienced unprecedented growth become the preferred strategy cancer treatment, mainly involves mobilisation of immune system an enhanced anti-tumour immunity tumour microenvironment. Despite inspiring success, immunotherapeutic strategies are limited due response rates immune-related adverse events. Like other nanomedicines, nanogels comparably by lower focal enrichment upon introduction into organism injection. Because three-dimensional cross-linked aqueous materials that exhibit similar properties natural tissues structurally stable, they can comfortably cope with shear forces serum proteins bloodstream, longer circulation life increases chance nanogel accumulation tumour, conferring deep penetration. The large specific surface area reduce or eliminate off-target effects introducing stimuli-responsive functional groups, allowing multiple physical chemical modifications purposes improve targeting cell subpopulations organs, increasing bioavailability drug, a events on therapies. slow release reaching site facilitates long-term awakening host's system, ultimately achieving therapeutic effects. As effective candidate immunotherapy, nanogel-based been widely used. In this review, we summarize recent deliver immunomodulatory small molecule drugs, antibodies, genes cytokines, target antigen presenting cells, form vaccines, enable chimeric receptor (CAR)-T therapy. Future challenges well expected feasible prospects clinical also highlighted.

Language: Английский

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Metabolic Control by Heat Stress Determining Cell Fate to Ferroptosis for Effective Cancer Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 15(4), P. 7179 - 7194

Published: April 16, 2021

Flexible manipulation of the fate cancer cells through exogenous stimulation-induced metabolic reprogramming could handle cellular plasticity-derived therapies resistance, which provides an effective paradigm for treatment refractory and relapsing tumors in clinical settings. Herein, we demonstrated that moderate heat (45 °C) significantly regress expression antioxidants trigger specific lipid synergized with iron oxide nanoparticles (Fe3O4 NPs). This control behavior destroyed tumor redox homeostasis produced overwhelming peroxides, consequently sensitizing to ferroptosis. Based on these findings, a heat-triggered tumor-specific ferroptosis strategy was proposed by rational design polypeptide-modified 1H-perfluoropentane (1H-PFP)-encapsulated Fe3O4-containing nanoformulation (GBP@Fe3O4). When irradiated 808 nm laser, phase transition 1H-PFP triggered localized °C), leading burst release Fe3O4 situ produce potent reactive oxygen species Fenton reaction microenvironment. Together antioxidant inhibition response distinctive stress, this oxidative damage amplified induce achieve sufficient antitumor effects. Importantly, confirmed ACSBG1, acyl-CoA synthetase, key pro-ferroptotic factor heat-induced process. Moreover, knockout gene realize cell death conversion from non-ferroptotic death. work mechanistic insights practical strategies reduce potential side effects direct inducers highlights regulating under stress.

Language: Английский

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Water‐Soluble Organic Nanoparticles with Programable Intermolecular Charge Transfer for NIR‐II Photothermal Anti‐Bacterial Therapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(21), P. 11758 - 11762

Published: March 16, 2021

Abstract Extensive recent efforts have been put on the design of high‐performance organic near‐infrared (NIR) photothermal agents (PTAs), especially over NIR‐II bio‐window (1000–1350 nm). So far, development is mainly limited by rarity molecules with good response. Here, we report nanoparticles intermolecular charge‐transfer complexes (CTCs) easily programmable optical absorption. By employing different common donor and acceptor to form CTC (CT NPs), absorption peaks CT NPs can be controllably tuned from NIR‐I region. Notably, formed perylene TCNQ a considerably red‐shifted peak at 1040 nm achieves conversion efficiency 42 % under 1064 excitation. These were used for antibacterial application effective activity towards both Gram‐negative Gram‐positive bacteria. This work opens new avenue into efficient PTAs.

Language: Английский

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Coordinating the Mechanisms of Action of Ferroptosis and the Photothermal Effect for Cancer Theranostics

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(13)

Published: Dec. 21, 2021

Combination therapy based on different mechanisms of cell death has shown promise in tumor therapy. However, when modalities are integrated, the maximum synergy therapeutic effects is often lacking design. Herein, we report a cancer theranostic nanomedicine formula developed by considering action ferroptosis and photothermal effect combination The croconaine molecule was encapsulated as both converter an iron-chelating agent with BSA, thus leading to biocompatible stable Cro-Fe@BSA nanoparticles (NPs). NPs milieu showed activated enhanced radical formation owing temperature-dependent Fenton reaction kinetics, while during turn prevented heat-induced heat shock proteins self-protection mechanism cells response heat. activatable photoacoustic magnetic resonance imaging performance also enabled safe reliable theranostics.

Language: Английский

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