Conquering the Hypoxia Limitation for Photodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due the hypoxic nature characteristic of many solid tumors, PDT is frequently limited therapeutic effect. Moreover, consumption O2 during may further aggravate tumor condition, which promotes proliferation, metastasis, invasion resulting poor prognosis treatment. Therefore, numerous efforts have been made increase content with goal enhancing efficacy. Herein, these strategies developed past decade are comprehensively reviewed alleviate hypoxia, including 1) delivering exogenous directly, 2) generating situ, 3) reducing cellular by inhibiting respiration, 4) regulating TME, (e.g., normalizing vasculature or disrupting extracellular matrix), 5) hypoxia-inducible factor 1 (HIF-1) signaling pathway relieve hypoxia. Additionally, -independent Type-I also discussed as an alternative strategy. By reviewing progress, it hoped that this review will provide innovative perspectives new nanomaterials designed combat hypoxia avoid associated limitation PDT.

Language: Английский

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BODIPY‐Based Photodynamic Agents for Exclusively Generating Superoxide Radical over Singlet Oxygen

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(36), P. 19912 - 19920

Published: July 6, 2021

Abstract Developing Type‐I photosensitizers is considered as an efficient approach to overcome the deficiency of traditional photodynamic therapy (PDT) for hypoxic tumors. However, it remains a challenge design generating reactive oxygen species by process. Herein, we report series α,β‐linked BODIPY dimers and trimer that exclusively generate superoxide radical (O 2 −. ) process upon light irradiation. The triplet formation originates from effective excited‐state relaxation initially populated singlet (S 1 (T states via intermediate state. low reduction potential ultralong lifetime T state facilitate generation O inter‐molecular charge transfer molecular oxygen. energy gap ‐S 0 smaller than between 3 thereby precluding Type‐II exhibits superior PDT performance under environment.

Language: Английский

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Photodynamic therapy for hypoxic tumors: Advances and perspectives

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 438, P. 213888 - 213888

Published: March 16, 2021

Language: Английский

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Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(25), P. 11326 - 11337

Published: June 16, 2022

Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing attention as promising approach to cancer immunotherapy. However, biocompatible strategies activate pyroptosis remain rare. Here, we show that photocatalytic superoxide radical (O2-•) generator, NI-TA, triggers in cells. NI-TA was designed take advantage an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed the triggered by under conditions photoexcitation proceeds through caspase-3/gasdermin E (GSDME) pathway rather than via canonical processes involving caspase-1/gasdermin-D (GSDMD). found function partial-O2-recycling mode action and trigger provide for effective ablation even hypoxia (≤2% O2). In case T47D 3D multicellular spheroids, good antitumor efficiency stemness inhibition are achieved. This work highlights how chemistry may be leveraged develop pyroptosis-inducing agents.

Language: Английский

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Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 19, 2022

Abstract Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare PSs is of great importance, but remains a challenge. Here, we report supramolecular strategy for the preparation photodynamic agents, which simultaneously generate strong oxidizing cationic radicals and superoxide radicals, by introducing electron acceptors existing Type-II PSs. As proof-of-concept, three were designed co-assembled with classical PS produce quadruple hydrogen-bonded agents. The photo-induced transfer from adjacent acceptor occurs efficiently, leading generation +• an anionic radical acceptor, further transfers oxygen form O 2 −• . In addition, these agents induce direct photocatalytic oxidation NADH turnover frequency as high 53.7 min −1 , offers oxygen-independent mechanism damage tumors.

Language: Английский

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A Bacteria‐Responsive Porphyrin for Adaptable Photodynamic/Photothermal Therapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(23)

Published: March 25, 2022

Abstract We report a cationic porphyrin 5,10,15,20‐tetrakis‐(4‐ N ‐methylpyridyl)‐porphyrin (TMPyP) that can respond to specific bacteria, followed by adaptable photodynamic/photothermal therapy processes. TMPyP could be reduced phlorin facultative anaerobes with strong reducing ability such as E. coli and S. typhimurium in hypoxic environments, possessing NIR absorption remarkable photothermal conversion capacity, thus demonstrating excellent antimicrobial activity (>99 %) therapy. While an aerobic environment functioned typical photosensitizer killed bacteria effectively (>99.9 photodynamic By forming host–guest complex cucurbit[7]uril, the biocompatibility of significantly improved. This kind bacteria‐responsive shows specificity adaptivity treatment holds potential non‐invasive treatments bacterial infections.

Language: Английский

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Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 11047 - 11136

Published: Sept. 7, 2023

Advances in nanotechnology and nanomaterials have attracted considerable interest play key roles scientific innovations diverse fields. In particular, increased attention has been focused on carbon-based exhibiting extended structures unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, nanodiamonds, dots, possess excellent bioaffinities superior fluorescence properties that make suitable for application to environmental biological sensing, imaging, therapeutics. This review provides a systematic overview of the classification structural properties, design principles preparation methods, optical sensing applications nanomaterials. Recent interesting breakthroughs sensitive selective imaging heavy metal pollutants, hazardous substances, bioactive molecules as well information encryption, super-resolution photoacoustic phototherapy nanomedicine delivery are main focus this review. Finally, future challenges prospects materials highlighted envisaged. presents comprehensive basis directions designing, developing, applying fascinating fluorescent sensors fabricated based specific requirements numerous research

Language: Английский

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Highly Efficient Far‐Red/NIR‐Absorbing Neutral Ir(III) Complex Micelles for Potent Photodynamic/Photothermal Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(32)

Published: July 5, 2021

A critical issue in photodynamic therapy (PDT) is inadequate reactive oxygen species (ROS) generation tumors, causing inevitable survival of tumor cells that usually results recurrence and metastasis. Existing photosensitizers frequently suffer from relatively low light-to-ROS conversion efficiency with far-red/near-infrared (NIR) light excitation due to low-lying excited states lead rapid non-radiative decays. Here, a neutral Ir(III) complex bearing distyryl boron dipyrromethene (BODIPY-Ir) reported efficiently produce both ROS hyperthermia upon far-red activation for potentiating vivo suppression through micellization BODIPY-Ir form "Micelle-Ir". absorbs strongly at 550-750 nm band maximum 685 nm, possesses long-lived triplet state sufficient Upon micellization, forms J-type aggregates within Micelle-Ir, which boosts singlet the photothermal effect high molar extinction coefficient amplification light-to-ROS/heat conversion, severe cell apoptosis. Bifunctional Micelle-Ir accumulates tumors completely destroys orthotopic 4T1 breast via synergistic PDT/photothermal (PTT) damage under irradiation, enables remarkable metastatic nodules lungs, together without significant dark cytotoxicity. The present study offers an emerging approach develop far-red/NIR toward potent cancer therapy.

Language: Английский

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De Novo Design of Reversibly pH-Switchable NIR-II Aggregation-Induced Emission Luminogens for Efficient Phototheranostics of Patient-Derived Tumor Xenografts

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 145(1), P. 334 - 344

Published: Dec. 27, 2022

Phototheranostics has received sustained attention due to its great potential in revolutionizing conventional strategies of cancer treatment. However, trapped by the complexity, poor reproducibility, insufficient phototheranostic outputs, and inevitable damage normal tissue most multicomponent systems, clinical translation been severely hindered. Therefore, exploration "one for all" smart agents with versatile functionalities remains an appealing yet enormously challenging task. Herein, a reversibly pH-switchable near-infrared second photosensitizer featuring aggregation-induced emission was tactfully designed molecular engineering precise tumor-targeting fluorescence imaging-guided phototherapy. Thanks strong intramolecular charge transfer, enhanced highly efficient intersystem crossing, sufficient motion, developed agent DTTVBI endowed boosted type-I superoxide anion radical generation excellent photothermal performance under 808 nm laser irradiation. More importantly, nanoparticles high biocompatibility exhibit remarkably photodynamic/photothermal therapy tumor region, thus offering significant antitumor effects both vitro patient-derived xenograft model colon cancer. This work sheds new light on development superior phototheranostics therapy.

Language: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

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