Journal of Nanobiotechnology,
Journal Year:
2021,
Volume and Issue:
19(1)
Published: June 28, 2021
Abstract
It
is
of
utmost
urgency
to
achieve
effective
and
safe
anticancer
treatment
with
the
increasing
mortality
rate
cancer.
Novel
drugs
strategies
need
be
designed
for
enhanced
therapeutic
efficacy.
Fenton-
Fenton-like
reaction-based
chemodynamic
therapy
(CDT)
are
new
enhance
efficacy
due
their
capacity
generate
reactive
oxygen
species
(ROS)
(O
2
).
On
one
hand,
generated
ROS
can
damage
cancer
cells
directly.
other
O
relieve
hypoxic
condition
in
tumor
microenvironment
(TME)
which
hinders
efficient
photodynamic
therapy,
radiotherapy,
etc.
Therefore,
CDT
used
together
many
synergistically
combination
therapy.
The
antitumor
applications
nanomaterials
will
discussed
this
review,
including:
(iþ)
producing
abundant
in-situ
kill
directly,
(ii)
enhancing
efficiency
indirectly
by
Fenton
reaction-mediated
(iii)
diagnosis
monitoring
These
exhibit
potential
CDT-based
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(10), P. 6013 - 6041
Published: Jan. 1, 2021
In
this
review,
we
systematically
survey
the
most
recent
progress
in
engineering
nanomedicine
for
intracellular
glutathione
consumption-augmented
cancer
therapy.
Small,
Journal Year:
2021,
Volume and Issue:
18(6)
Published: Nov. 2, 2021
Abstract
Chemodynamic
therapy
(CDT),
a
novel
cancer
therapeutic
strategy
defined
as
the
treatment
using
Fenton
or
Fenton‐like
reaction
to
produce
•OH
in
tumor
region,
was
first
proposed
by
Bu,
Shi,
and
co‐workers
2016.
Recently,
with
rapid
development
of
nanomaterials,
CDT
has
attracted
tremendous
attention
because
its
unique
advantages:
1)
It
is
tumor‐selective
low
side
effects;
2)
process
does
not
depend
on
external
field
stimulation;
3)
it
can
modulate
hypoxic
immunosuppressive
microenvironment;
4)
cost
low.
In
addition
Fe‐involved
strategies,
reaction‐mediated
strategies
have
also
been
proposed,
which
are
based
many
other
metal
elements
including
copper,
manganese,
cobalt,
titanium,
vanadium,
palladium,
silver,
molybdenum,
ruthenium,
tungsten,
cerium,
zinc.
Moreover,
combined
therapies
like
chemotherapy,
radiotherapy,
phototherapy,
sonodynamic
therapy,
immunotherapy
for
achieving
enhanced
anticancer
effects.
Besides,
there
studies
that
extend
application
antibacterial
field.
This
review
introduces
latest
advancements
nanomaterials‐involved
from
2018
present
proposes
current
limitations
well
future
research
directions
related
Frontiers in Molecular Biosciences,
Journal Year:
2022,
Volume and Issue:
9
Published: March 4, 2022
Conventional
cancer
therapies
suffer
from
severe
off-target
effects
because
most
of
them
target
critical
facets
cells
that
are
generally
shared
by
all
rapidly
proliferating
cells.
The
development
new
therapeutic
agents
should
aim
to
increase
selectivity
and
therefore
reduce
side
effects.
In
addition,
these
overcome
cell
resistance
stem
Some
copper
ionophores
have
shown
promise
in
this
direction
thanks
an
intrinsic
preferentially
inducing
cuproptosis
compared
normal
Here,
Cu
discussed
with
a
focus
on
towards
the
mechanisms
responsible
for
selectivity.
proposed
strategies,
further
improve
targeting
ionophores,
also
reported.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(4)
Published: Oct. 26, 2021
At
present,
some
progress
has
been
made
in
the
field
of
cancer
theranostics
based
on
nanocatalysts
(NCs),
but
achieving
precise
response
to
specific
tumor
microenvironment
(TME)
remains
a
major
challenge.
Herein,
TME-responsive
upconversion
nanoparticles
(UCNPs)-based
smart
UCNPs@Cu-Cys-GOx
(UCCG)
nanosystem
is
engineered,
which
combines
natural
enzymes
and
nanozymes
so
as
amplify
reactive
oxygen
species
(ROS)
generation
situ
for
starvation/chemodynamic/immunotherapy.
One
biggest
merits
this
material
that
it
can
be
preserved
inert
(off)
normal
tissues,
only
TME
specifically
activated
(on)
through
series
enzymatic
cascades
boost
ROS
production
via
strategy
open
source
(H2
O2
self-supplying
ability)
reduce
expenditure
(glutathione
(GSH)
consuming
ability).
More
importantly,
enhanced
oxidative
stress
by
UCCG
NCs
reverses
immunosuppressive
TME,
facilitates
antitumor
immune
responses.
Meanwhile,
starvation/chemodynamic
synergistic
therapy
triggered
combined
with
PD-L1
antibody
effectively
inhibits
growth
primary
tumors
metastasis.
In
addition,
UCNPs
present
luminescence
enhancement,
exploited
visualize
reinforced
real
time.
Collectively,
work
provides
an
original
method
devising
exploitation
UCNPs-based
catalytic
immunotherapy.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: March 7, 2022
Chemodynamic
therapy
(CDT)
has
emerged
to
be
a
frontrunner
amongst
reactive
oxygen
species-based
cancer
treatment
modalities.
CDT
utilizes
endogenous
H
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(31), P. 16763 - 16776
Published: March 9, 2021
Abstract
Metal–organic
frameworks
(MOFs)
hold
great
promise
for
biomedical
applications
owing
to
their
unique
properties.
The
porous
structures
make
MOFs
excellent
candidates
the
delivery
of
different
drugs;
flexibility
in
choosing
metal
ions
and
organic
ligands
makes
it
feasible
prepare
with
intrinsic
antitumor
activities
further
devise
MOF–drug
synergistic
systems;
many
other
types
agents
could
also
be
developed
using
as
precursors/templates.
Thus,
past
two
decades
have
witnessed
development
MOF‐based
drugs,
especially
field.
This
Minireview
mainly
focuses
on
design
agents.
Four
aspects
covering
whole
field
are
introduced:
carriers,
agents,
systems,
MOF‐derived
challenges
opportunities
clinical
discussed.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
16(1), P. 617 - 630
Published: Dec. 27, 2021
Recently,
various
metal
peroxide
nanomaterials
have
drawn
increasing
attention
as
an
efficient
hydrogen
(H2O2)
self-supplying
agent
for
enhanced
tumor
therapy.
However,
a
single
kind
of
is
insufficient
to
achieve
more
effective
antitumor
performance.
Here,
hyaluronic
acid
modified
calcium
and
copper
peroxides
nanocomposite
has
been
synthesized
by
simple
one-step
strategy.
After
accumulation
at
the
site
due
permeability
retention
(EPR)
effect
specific
recognition
hyaluronate
with
CD44
protein
on
surface
cells,
plenty
Ca2+,
Cu2+,
H2O2
can
be
simultaneously
released
in
hyaluronidase
overexpressed
microenvironment
(TME),
generating
abundant
hydroxyl
radical
through
Fenton-type
reaction
between
Cu2+
assistance
glutathione
depletion.
Overloaded
Ca2+
lead
mitochondria
injury
thus
enhance
oxidative
stress
cells.
Moreover,
unbalanced
transport
channel
caused
further
promote
calcification
necrosis,
which
generally
defined
ion-interference
As
result,
synergistic
Fenton-like
dysfunction
ROS
generation
performed.
Therefore,
TME-responsive
based
integration
successfully
established
exhibits
satisfactory
efficiency
than
any
peroxide.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(26), P. 14324 - 14328
Published: April 6, 2021
Abstract
Despite
the
great
efforts
of
using
DNAzyme
for
gene
therapy,
its
clinical
success
is
limited
by
lack
simple
delivery
systems
and
anticancer
efficacy.
Here,
we
develop
a
approach
synthesis
hybrid
nanostructures
that
exclusively
consist
Cu
2+
with
ultra‐high
loading
capacity.
The
Cu–DNAzyme
nanohybrids
allow
to
effectively
co‐deliver
into
cancer
cells
combinational
catalytic
therapy.
released
can
be
reduced
+
glutathione
then
catalyze
endogenous
H
2
O
form
cytotoxic
hydroxyl
radicals
chemodynamic
therapy
(CDT),
while
10–23
enables
cleavage
VEGFR2
mRNA
activates
silencing
We
demonstrate
system
efficiently
accumulate
in
tumor
exhibit
amplified
cascade
antitumor
effects
negligible
systemic
toxicity.
Our
work
paves
an
extremely
way
integrate
CDT
dual‐catalytic
treatment.
