Metal–Organic-Framework-Based Materials for Antimicrobial Applications

ACS Nano, Journal Year: 2021, Volume and Issue: 15(3), P. 3808 - 3848

Published: Feb. 25, 2021

To address the serious threat of bacterial infection to public health, great efforts have been devoted development antimicrobial agents for inhibiting growth, preventing biofilm formation, and sterilization. Very recently, metal–organic frameworks (MOFs) emerged as promising materials various applications owing their different functions including controlled/stimulated decomposition components with bactericidal activity, strong interactions membranes, formation photogenerated reactive oxygen species (ROS) well high loading sustained releasing capacities other materials. This review focuses on recent advances in design, synthesis, MOF-based materials, which are classified by roles component-releasing (metal ions, ligands, or both), photocatalytic, chelation carriers or/and synergistic functional (antibiotics, enzymes, metals/metal oxides, carbon etc.). The constituents, fundamental mechanisms, evaluation activities these highlighted present design principles efficient prospects challenges this research field proposed.

Language: Английский

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Microenvironment Modulation in Metal–Organic Framework-Based Catalysis

Accounts of Materials Research, Journal Year: 2021, Volume and Issue: 2(5), P. 327 - 339

Published: Feb. 26, 2021

ConspectusThe fine design and regulation of catalysts play critical roles in the development catalysis. The microenvironment, which gives rise to unique spatial structures electronic properties around catalytic sites, has been proven dramatically regulate behavior enzymes homogeneous However, understanding microenvironment modulation (MEM) sites remains challenging very limited heterogeneous catalysis mainly due lack structural precision and/or tailorability traditional solid catalysts. Among diverse materials, metal–organic frameworks (MOFs), a class porous crystalline solids, have intensively studied as recent years. atomically precise well tunable MOFs make them an ideal platform for rationally regulating surrounding sites. Accordingly, their well-defined hold great promise elucidating how affects resulting performance. Nevertheless, investigations accurate control over modulated are still limited. Therefore, it is importance summarize related results provide in-depth insights into MOF-based catalysis, accelerating future this emerging research topic.In Account, we presented summary our attempts optimize performance materials via modulation. In view component advantages MOFs, deliver general fundamentals rational Initially, opportunities brought about by engineering, including origin abundant active flexible strategies, structure, introduced detail. next section, focus on specific strategies dominate molecular/electron-transfer process intrinsic activity Meanwhile, chemical basis underlying structure–property relationship behind enhanced will be highlighted. Finally, major challenges outlooks further discussed. It expected that Account would afford significant inspiration toward engineering

Language: Английский

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Integration of metal-organic frameworks and covalent organic frameworks: Design, synthesis, and applications

Matter, Journal Year: 2021, Volume and Issue: 4(7), P. 2230 - 2265

Published: July 1, 2021

Language: Английский

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An overview of the use of nanozymes in antibacterial applications

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 418, P. 129431 - 129431

Published: March 21, 2021

Language: Английский

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Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy

Chemical Communications, Journal Year: 2021, Volume and Issue: 57(93), P. 12417 - 12435

Published: Jan. 1, 2021

The controlled synthesis methods and the applications of nanoscale covalent organic frameworks in cancer therapy are summarized this feature article.

Language: Английский

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Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Language: Английский

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Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6307 - 6416

Published: Jan. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Language: Английский

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Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry

Chemical Science, Journal Year: 2021, Volume and Issue: 13(4), P. 863 - 889

Published: Nov. 29, 2021

Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is most significant feature of chemodynamic (CDT). Owing to mild acid and overexpressed H2O2 TME, more cytotoxic hydroxyl radicals (˙OH) are generated cells via Fenton-like reactions. Without external stimulus drug resistance generation, reactive oxygen species (ROS)-mediated CDT exhibits a specific desirable anticancer effect has been seen as promising strategy therapy. However, optimizing treatment efficiency TME still challenging because limited catalytic agents strong antioxidant capacity TME. Hence, scientists trying their best design fabricate many with excellent activity remodeling optimal CDT. In this perspective, latest progress discussed, some representative examples presented. Consequently, strategies further guided by provided. Most importantly, several feasible ways developing future offered reference.

Language: Английский

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Rational Design and Growth of MOF‐on‐MOF Heterostructures

Small, Journal Year: 2021, Volume and Issue: 17(36)

Published: July 10, 2021

Abstract Multiporous metal‐organic frameworks (MOFs) have emerged as a subclass of highly crystalline inorganic‐organic materials, which are endowed with high surface areas, tunable pores, and fascinating nanostructures. Heterostructured MOF‐on‐MOF composites recently becoming research hotspot in the field chemistry materials science, focus on assembly two or more different homogeneous heterogeneous MOFs various structures morphologies. Compared one single MOF, dual exhibit unprecedented tunability, hierarchical nanostructure, synergistic effect, enhanced performance. Due to difference inorganic metals organic ligands, lattice parameters , b c directions crystal cells could bring about subtle large structural difference. It will result composite material distinct growth methods obtain secondary MOF grown from initial MOF. In this review, authors wish mainly outline latest synthetic strategies heterostructured MOF‐on‐MOFs their derivatives, including ordered epitaxial growth, random etc., show tutorial guidelines for further development MOF‐on‐MOFs.

Language: Английский

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Biosystem‐Inspired Engineering of Nanozymes for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 9, 2023

Abstract Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to become surrogates of natural enzymes in many fields by virtue their advantages high catalytic stability, ease functionalization, and low cost. However, due the lack predictable descriptors, most nanozymes reported past been obtained mainly through trial‐and‐error strategies, efficacy, substrate specificity, as well practical application effect under physiological conditions, are far inferior that enzymes. To optimize efficacies functions biomedical settings, recent studies introduced biosystem‐inspired strategies into nanozyme design. In this review, advances engineering leveraging refined structure enzymes, simulating behavior changes process, mimicking specific biological processes or living organisms, introduced. Furthermore, currently involved applications summarized. More importantly, current opportunities challenges design discussed. It is hoped based on bioinspired will be beneficial for constructing new generation broadening applications.

Language: Английский

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