“Three‐in‐One” Nanozyme Composite for Augmented Cascade Catalytic Tumor Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Oct. 18, 2023

Abstract Cascade catalytic reaction exhibits simple procedure and high efficiency, such as that from the orderly assembly of different enzymes in biological systems. Mimicking natural cascade becomes critical, but is still challenging. Herein, single Au–Pt nanozyme reported with “three‐in‐one” functions to initiate conversions for O 2 supply mimic catalase, H production its glucose oxidase‐like property, • OH generation peroxidase chemodynamic therapy (CDT). Thus, complex cross‐talk among are avoided. To this end, metastable Cu NPs, scaffolds, used anchor ultrasmall nanozyme, while metal–organic framework (MOF) encapsulate tumor microenvironment response shielding protein adsorption. Pluronic F127 then modified on surface improve hydrophilicity biocompatibility composite. The endogenous acidity glutathione degrade MOF expose CDT. photothermal conversion ability also enhances CDT, 2+ ions consume GSH further CDT efficiency augmented therapy. a new paradigm provided drug‐free improving therapeutic efficacy minimizing side effects.

Language: Английский

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Exploring the Specificity of Nanozymes

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 2533 - 2540

Published: Jan. 12, 2024

Nanozymes, nanomaterials exhibiting enzyme-like activities, have emerged as a prominent interdisciplinary field over the past decade. To date, 1200 different been identified nanozymes, covering four catalytic categories: oxidoreductases, hydrolases, isomerases, and lyases. Catalytic activity specificity are two pivotal benchmarks for evaluating enzymatic performance. Despite substantial progress being made in quantifying optimizing of there is still lack in-depth research on preventing formation consensual knowledge impeding more refined systematic classification nanozymes. Recently, debates regarding whether nanozymes could possess similar to that enzymes. This Perspective discusses by referring enzymes, highlights gap between concludes offering our perspective future

Language: Английский

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Biomedicine meets nanozyme catalytic chemistry

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215245 - 215245

Published: May 22, 2023

Language: Английский

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Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(10), P. 849 - 868

Published: July 18, 2024

Language: Английский

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Recent advances in multi‐metallic‐based nanozymes for enhanced catalytic cancer therapy

BMEMat, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 19, 2023

Abstract Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest exploration in the utilization nanozymes for targeted cancer treatment. Recent advancements interdisciplinary research, nanotechnology, biotechnology, technology led emergence multi‐metallic‐based nanozymes, which exhibit tremendous further development. review focuses on investigating synergistic effects aiming enhance our understanding their activities facilitate broader applications. We comprehensively survey remarkable achievements synthesis, mechanisms, latest therapy. Furthermore, we identify current limitations prospects development new materials application novel technologies, along challenges associated underscores significance emphasizes need continued well impact realization breakthroughs

Language: Английский

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Two-Site Enhanced Porphyrinic Metal–Organic Framework Nanozymes and Nano-/Bioenzyme Confined Catalysis for Colorimetric/Chemiluminescent Dual-Mode Visual Biosensing

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(44), P. 16383 - 16391

Published: Oct. 26, 2023

The rational design of efficient nanozymes and the immobilization enzymes are great significance for construction high-performance biosensors based on nano-/bioenzyme catalytic systems. Herein, a novel V-TCPP(Fe) metal-organic framework nanozyme with two-dimensional nanosheet morphology is rationally designed by using V2CTx MXene as metal source iron tetrakis(4-carboxyphenyl)porphine (FeTCPP) ligand an organic linker. It exhibits enhanced peroxidase- catalase-like activities luminol-H2O2 chemiluminescent (CL) behavior. Based experimental theoretical results, these excellent enzyme-like derived from two-site synergistic effect between V nodes FeTCPP ligands in V-TCPP(Fe). Furthermore, confined system developed zeolitic imidazole (ZIF) coencapsulation bioenzyme. Using acetylcholinesterase (AChE) model, our constructed V-TCPP(Fe)/AChE@ZIF was successfully used colorimetric/CL dual-mode visual biosensing organophosphorus pesticides. This work expected to provide new insights into systems, encouraging applications catalysis biosensing.

Language: Английский

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Rational Design of Orally Administered Cascade Nanozyme for Inflammatory Bowel Disease Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(44)

Published: Aug. 23, 2023

Inflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric reactive oxygen species (ROS) play critical roles in the physiology and pathology IBD. Nanozymes hold great promise for treatment IBD because their exceptional ability to regulate redox homeostasis during ROS-related inflammation. However, rapid development orally administered, acid-tolerant, antioxidant nanozymes therapy is challenging. Here, a nine-tier high-throughput screening strategy established address multifaceted demands, including intrinsic stability, radioactivity, solubility, gut microbiome toxicity, biomimetic elements, intermediate frontier molecular orbitals, reaction energy barriers, negative charges, acid tolerance. Ni3 S4 selected as best matching material from 146 323 candidates, which exhibits superoxide dismutase-catalase bienzyme-like activity 3.13- 1.80-fold more active than natural enzymes. As demonstrated mouse model, stable gastrointestinal tract without toxicity specifically targets diseased colon alleviate oxidative stress. RNA 16S rRNA sequencing analyses show that effectively inhibits cellular pathways pro-inflammatory factors restores microbiota. This study not develops highly efficient administered cascade nanozyme offers next-generation paradigm rational design nanomedicine through data-driven approaches.

Language: Английский

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Data-Driven Evolutionary Design of Multienzyme-like Nanozymes

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(11), P. 7565 - 7574

Published: March 6, 2024

Multienzyme-like nanozymes are nanomaterials with multiple enzyme-like activities and the focus of nanozyme research owing to their ability facilitate cascaded reactions, leverage synergistic effects, exhibit environmentally responsive selectivity. However, multienzyme-like varying under different conditions, making them difficult precisely regulate according design requirements. Moreover, individual activity in a may accelerate, compete, or antagonize each other, rendering overall complex interplay these factors rather than simple sum single activity. A theoretically guided strategy is highly desired accelerate nanozymes. Herein, information was collected from 4159 publications build database covering element type, ratio, chemical valence, shape, pH, etc. Based on clustering correlation coefficients information, material features distinct classifications were reorganized generate compositional for advanced methods developed, including quantum mechanics/molecular mechanics method analyzing surface adsorption binding energies substrates, transition states, products reaction pathways, along machine learning algorithms identify optimal pathway, aid evolutionary This approach culminated creating CuMnCo7O12, active nanozyme. process named genetic-like because it resembles biological genetic evolution nature offers feasible protocol theoretical foundation constructing

Language: Английский

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

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Protein Corona-Mediated Inhibition of Nanozyme Activity: Impact of Protein Shape

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(15), P. 10478 - 10488

Published: April 5, 2024

During biomedical applications, nanozymes, exhibiting enzyme-like characteristics, inevitably come into contact with biological fluids in living systems, leading to the formation of a protein corona on their surface. Although it is acknowledged that molecular adsorption can influence catalytic activity there dearth understanding regarding impact nanozyme and its determinant factors. In order address this gap, we employed AuNR@Pt@PDDAC [PDDAC, poly(diallyldimethylammonium chloride)] nanorod (NR) as model multiple activities, including peroxidase, oxidase, catalase-mimetic investigate inhibitory effects activity. After identification major components plasma NR, observed spherical proteins fibrous induced distinct nanozymes. To elucidate underlying mechanism, uncovered adsorbed assembled surface forming networks (PNs). Notably, PNs derived from exhibited screen mesh-like structure smaller pore sizes compared those formed by proteins. This structural disparity resulted reduced efficiency for permeation substrate molecules, more robust inhibition These findings underscore significance shape crucial factor influencing revelation provides valuable insights rational design application nanozymes fields.

Language: Английский

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