Small,
Journal Year:
2023,
Volume and Issue:
19(17)
Published: Jan. 24, 2023
Abstract
CRISPR/Cas9‐based
gene
therapy
and
photodynamic
both
show
promise
for
cancer
treatment
but
still
have
their
drawbacks
limited
by
tumor
microenvironment
long
duration.
Herein,
CRISPR/Cas9
genome
editing
strategy
a
synergistic
anti‐tumor
therapeutic
modality
is
merged.
Chlorophyll
(Chl)
extracted
from
natural
green
vegetables
encapsulated
in
Pluronic
F127
(F127)
micelles
Histidine‐tagged
Cas9
can
be
effectively
chelated
onto
via
metal
coordination
simple
incubation,
affording
Cas9‐Chl@F127
micelles.
Mg
2+
acts
as
an
enzyme
cofactor
to
correlatively
enhance
gene‐editing
activity.
Upon
laser
irradiation,
Chl
effective
photosensitizer
generates
reactive
oxygen
species
(ROS)
kill
cells.
Meanwhile,
CRISPR/Cas9,
mediated
dual
deliberately
designed
gRNAs
of
APE1
NRF2,
reprogram
the
increasing
intracellular
accumulation
impairing
oxidative
defense
system
responsively
release
presence
abundant
ATP
or
low
pH
In
murine
model,
complexed
with
including
NRF2
significantly
inhibits
growth.
Taken
together,
micelles,
representing
first
Chl‐based
biomaterial
delivery
Cas9,
great
PDT
editing.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(16)
Published: June 18, 2021
Metal-coordinated
supramolecular
nanoassemblies
have
recently
attracted
extensive
attention
as
materials
for
cancer
theranostics.
Owing
to
their
unique
physicochemical
properties,
metal-coordinated
self-assemblies
can
bridge
the
boundary
between
traditional
inorganic
and
organic
materials.
By
tailoring
structural
components
of
metal
ions
binding
ligands,
numerous
multifunctional
theranostic
nanomedicines
be
constructed.
modulate
tumor
microenvironment
(TME),
thus
facilitating
development
TME-responsive
nanomedicines.
More
importantly,
organic-inorganic
hybrid
nanomaterials
constructed
in
vivo
by
exploiting
self-assembly
a
variety
functional
which
is
promising
strategy
enhancing
accumulation
molecules.
In
this
review,
recent
advancements
design
fabrication
theranostics
are
highlighted.
These
compounds
classified
according
order
coordinated
appear
periodic
table.
Furthermore,
prospects
challenges
both
technical
advances
clinical
translation
discussed.
particular,
superiority
elaborated,
with
an
emphasis
on
strategies
that
enhance
tumors
ideal
outcome.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(37), P. 12234 - 12247
Published: Jan. 1, 2021
As
a
necessary
substance
to
maintain
the
body's
normal
life
activities,
metal
ions
are
ubiquitous
in
organisms
and
play
major
role
various
complex
physiological
biochemical
processes,
such
as
material
transportation,
energy
conversion,
information
transmission,
metabolic
regulation,
etc.
Their
abnormal
distribution/accumulation
cells
can
interfere
with
these
causing
irreversible
physical
damage
or
activating
reactions
induce
cell
death.
Therefore,
be
exploited
against
wide
spectrum
of
cancers
high
efficiency
without
drug
resistance,
which
effectively
inhibit
growth
cancer
by
triggering
biocatalysis,
breaking
osmotic
balance,
affecting
metabolism,
interfering
signal
transduction,
damaging
DNA,
This
perspective
systematically
summarizes
latest
research
progress
ion-based
anti-tumor
therapy,
emphasizes
challenges
development
directions
this
type
therapeutic
strategy,
hoping
provide
general
implication
for
future
research.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(10), P. 16286 - 16297
Published: Oct. 15, 2021
Nanocatalytic
medicine
is
one
of
the
most
recent
advances
in
development
nanomedicine,
which
catalyzes
intratumoral
chemical
reactions
to
produce
toxins
such
as
reactive
oxygen
species
situ
for
cancer
specific
treatment
by
using
exogenous-delivered
catalysts
Fenton
agents.
However,
overexpression
reductive
glutathione
and
Cu-Zn
superoxide
dismutase
cells
will
significantly
counteract
therapeutic
efficacy
species-mediated
oxidative
damages.
Additionally,
direct
delivery
iron-based
agents
may
arouse
undesired
detrimental
effects
anaphylactic
reactions.
In
this
study,
instead
exogenously
delivering
agents,
endogenous
copper
ions
from
intracellular
have
been
employed
source
Fenton-like
chelating
Cu
a
common
metal
ion
chelator,
N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine
(TPEN),
followed
TPEN-Cu(II)
chelate
reduction
TPEN-Cu(I)
glutathione.
Briefly,
TPEN
was
loaded
disulfide
bond-containing
link
poly(acrylic
acid)
shell-coated
hybrid
mesoporous
silica/organosilicate
(MSN@MON)
nanocomposite
glutathione-responsive
nanoplatform,
features
inter-related
triple
functions:
disruption
release;
accompanying
consumption
deactivation
dismutase;
reaction
catalyzed
agent
generated
remaining
cells,
thereby
cutting
off
self-protection
pathway
under
severe
oxidation
stress
ensuring
cell
apoptosis
produced
catalytic
Such
nanocatalyst
demonstrates
excellent
biosafety
augmented
simultaneous
nanocatalytic
damage
intrinsic
protection
breakage
cells.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(38)
Published: Aug. 1, 2022
Abstract
The
intelligent
nanomachine
usually
has
a
control
center
to
carry
out
self‐regulation.
Unfortunately,
most
of
the
nanomaterials
for
chemodynamic
therapy
(CDT)
do
not
have
such
sense
and
process
chemical
or
biological
signals,
which
greatly
weakens
selectivity
efficiency
CDT.
To
address
this
problem,
here
an
was
constructed
with
DNAzyme
logic
gate
as
center,
metal
organic
framework
actuator.
well‐designed
showed
enhanced
killing
effect
on
cancer
cells
but
posed
no
harm
normal
cells,
acquiring
better
than
clinical
chemotherapy
drugs
(doxorubicin
cisplatin).
best
our
knowledge,
is
first
reported
cell‐specific
CDT
by
guidance
gate.
Our
work
highlights
great
potential
DNAzymes
in
response
networks,
extends
implementation
nanomachines
precision
medicine.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 2, 2023
Copper,
a
transition
metal,
serves
as
an
essential
co-factor
in
numerous
enzymatic
active
sites
and
constitutes
vital
trace
element
the
human
body,
participating
crucial
life-sustaining
activities
such
energy
metabolism,
antioxidation,
coagulation,
neurotransmitter
synthesis,
iron
tetramer
deposition.
Maintaining
equilibrium
of
copper
ions
within
biological
systems
is
paramount
importance
prevention
atherosclerosis
associated
cardiovascular
diseases.
Copper
induces
cellular
demise
through
diverse
mechanisms,
encompassing
reactive
oxygen
species
responses,
apoptosis,
necrosis,
pyroptosis,
mitochondrial
dysfunction.
Recent
research
has
identified
dubbed
novel
regulatory
cell
death
modality—”cuprotosis”—wherein
bind
to
acylated
proteins
tricarboxylic
acid
cycle
respiration,
resulting
protein
aggregation,
subsequent
downregulation
iron-sulfur
cluster
expression,
induction
proteotoxic
stress,
eventual
death.
Scholars
have
synthesized
complexes
by
combining
with
various
ligands,
exploring
their
significance
applications
cancer
therapy.
This
review
comprehensively
examines
multiple
pathways
copper-induced
death,
current
status
treatment.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(12), P. 11290 - 11308
Published: June 5, 2023
Cancer
phototheranostics
have
the
potential
for
significantly
improving
therapeutic
effectiveness,
as
it
can
accurately
diagnose
and
treat
cancer.
However,
current
phototheranostic
platforms
leave
much
to
be
desired
are
often
limited
by
tumor
hypoxia.
Herein,
a
Schottky
junction
nanozyme
has
been
established
between
manganese-bridged
cobalt-phthalocyanines
complex
Ti3C2Tx
MXene
nanosheets
(CoPc-Mn/Ti3C2Tx),
which
serve
an
integrative
type
I
II
photosensitizer
enhancing
cancer
efficacy
via
photoacoustic
imaging-guided
multimodal
chemodynamic/photothermal/photodynamic
therapy
strategy
under
near-infrared
(808
nm)
light
irradiation.
The
not
only
possessed
narrow-bandgap,
enhanced
electron-hole
separation
ability
exhibited
potent
redox
but
also
enabled
improved
H2O2
O2
supplying
performances
in
vitro.
Accordingly,
AS1411
aptamer-immobilized
CoPc-Mn/Ti3C2Tx
illustrated
high
accuracy
excellent
anticancer
efficiency
through
vitro
vivo
experiments.
This
work
presents
valuable
method
designing
constructing
multifunctional
nanocatalytic
medicine
platform
synergistic
of
solid
tumors.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(21), P. 7549 - 7578
Published: Jan. 1, 2023
Various
binding
modes
of
tunable
metal
organic
frameworks
(MOFs)
and
functional
DNAzymes
(Dzs)
synergistically
catalyze
the
emergence
abundant
nanoplatforms.
