Metal ion crosslinked polysaccharide hydrogels: A review on their potential for therapeutic delivery and tissue engineering DOI

Riya Hazra,

Md Sahil Shanawaz Alam,

Ashim Malakar

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143467 - 143467

Published: April 23, 2025

Language: Английский

Mild‐Photothermal Effect Induced High Efficiency Ferroptosis‐Boosted‐Cuproptosis Based on Cu2O@Mn3Cu3O8 Nanozyme DOI Creative Commons
Wei Chen,

Wenyu Xie,

Zhimin Gao

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(33)

Published: Oct. 11, 2023

Abstract A core‐shell‐structured Cu 2 O@Mn 3 O 8 (CMCO) nanozyme is constructed to serve as a tumor microenvironment (TME)‐activated copper ionophore achieve safe and efficient cuproptosis. The Mn shell not only prevents exposure of normal tissues the core reduce systemic toxicity but also exhibits enhanced enzyme‐mimicking activity owing better band continuity near Fermi surface. glutathione oxidase (GSHOx)‐like CMCO depletes (GSH), which diminishes ability chelate ions, thereby exerting inducing cuproptosis in cancer cells. catalase (CAT)‐like catalyzes overexpressed H TME, generating tricarboxylic acid (TCA) cycle enhance More importantly, Fenton‐like reaction based on release ions inactivation peroxidase 4 induced by elimination GSH results ferroptosis, accompanied accumulation lipid peroxidation reactive oxygen species that can cleave stress‐induced heat shock proteins compromise their protective capacity cells further sensitize nanozymes are partially sulfurized hydrogen sulfide colorectal exhibiting excellent photothermal properties activity. mild effect enhances nanozymes, thus high‐efficiency ferroptosis‐boosted‐cuproptosis.

Language: Английский

Citations

50
Metal Complexes in Cancer Treatment: Journey So Far DOI
Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(4)

Published: Feb. 24, 2023

Abstract Metal complexes in cancer therapy have attracted much interest mainly because metals exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and bonding, Lewis acid properties etc . In 1965, Barnett Rosenberg serendipitously discovered the metal‐based compound cisplatin, an outstanding breakthrough history of anticancer led to a new area drug discovery. Many compounds been studied for their potential properties. Some these FDA approval clinical use, while others are now undergoing trials detection. present study, we highlighted primary mode action metallic all FDA‐approved/under trial drugs with reference treatment. This review also focuses on recent progress platinum, ruthenium, iron, activities.

Language: Английский

Citations

45
Development of tumor-evolution-targeted anticancer therapeutic nanomedicineEVT DOI
Lingpu Zhang,

Jia‐Zhen Yang,

Jia Huang

et al.

Chem, Journal Year: 2024, Volume and Issue: 10(5), P. 1337 - 1356

Published: Jan. 25, 2024

Language: Английский

Citations

22
Programmed cell death in nasopharyngeal carcinoma: Mechanisms and therapeutic targets DOI

Shen’er Qian,

Guolin Tan, Guang Lei

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(1), P. 189265 - 189265

Published: Jan. 13, 2025

Language: Английский

Citations

2
New anti-cancer explorations based on metal ions DOI Creative Commons
Han Hu, Qi Xu,

Zhimin Mo

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Oct. 23, 2022

Abstract Due to the urgent demand for more anti-cancer methods, new applications of metal ions in cancer have attracted increasing attention. Especially three kinds mode cell death, including ferroptosis, calcicoptosis, and cuproptosis, are great concern. Meanwhile, many been found induce death through different approaches, such as interfering with osmotic pressure, triggering biocatalysis, activating immune pathways, generating prooxidant effect. Therefore, varieties strategies based on above approaches studied applied applications. Moreover, contrast agents gradually become core components bioimaging technologies, MRI, CT, fluorescence imaging, which exhibit guiding significance diagnosis. Besides, nano-theranostic platforms experimentally shown efficient response endogenous exogenous stimuli, realizes simultaneous therapy diagnosis a controlled nano-system. However, most metal-based still early stages, clinical trials necessary confirm or not current expectations. This article will focus these explorations ions, hoping provide some theoretical support ideas.

Language: Английский

Citations

67
Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics DOI Creative Commons
Zhaoyu Ma, Heyou Han,

Yanli Zhao

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 293, P. 121947 - 121947

Published: Dec. 6, 2022

Language: Английский

Citations

51
Bone targeted nano-drug and nano-delivery DOI Creative Commons
Yilun Wu, Bing Sun, Ying Tang

et al.

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 4, 2024

Language: Английский

Citations

12
Mechanism of metal ion-induced cell death in gastrointestinal cancer DOI Open Access

Muhua Luan,

Zhaotian Feng,

Wenshuai Zhu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116574 - 116574

Published: April 8, 2024

Gastrointestinal (GI) cancer is one of the most severe types cancer, with a significant impact on human health worldwide. Due to urgent demand for more effective therapeutic strategies against GI cancers, novel research metal ions treating cancers has attracted increasing attention. Currently, accumulating relationship between and therapy, several have been discovered induce cell death. In particular, three modes death, including ferroptosis, cuproptosis, calcicoptosis, become focal points in field cancer. Meanwhile, other also found trigger death through various mechanisms. Accordingly, this review focuses mechanisms ion-induced hoping provide theoretical support further therapies.

Language: Английский

Citations

9
Engineered nano-aluminum adjuvant for cancer immunotherapy: Progress, challenges and opportunities towards preclinical/clinical application DOI Creative Commons
Chong Gao, Jianping Jiang, Jing Zhao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216109 - 216109

Published: Aug. 1, 2024

Immunotherapy is a promising strategy to inhibit the progression of solid tumors. However, current vaccine adjuvants represented by aluminum adjuvant (Alum) fail tumor antigens initiate effective T cell immunity. Despite efforts have been made optimize physical characteristics Alum, lack specific immunostimulatory functions still results in their inability effectively induce cytotoxic immune responses. Encouragingly, an iterative layered double hydroxide (LDH) nano‑aluminum (NanoAlum) re-engineered from clinical AlOOH Alum and Mg(OH)2 antacid has shown efficacy evoking both potent humoral cellular Notably, it can also serve as microenvironmental immunomodulator reshape aberrant physicochemical attributes microenvironment. Interestingly, highly flexible crystal structure chemical composition offer variety LDH-based candidates (NanoMAlum) doping with body essential nutritional metal ions (M), which show great potential amplify immunotherapy. In this review, we summarize development progress LDH NanoAlum its variants NanoMAlum for cancer By rethinking challenges that hindered preclinical/clinical application, charted research pathway based on engineered organoids accelerate applications these NanoMAlums review.

Language: Английский

Citations

9
Metal coordination micelles for anti-cancer treatment by gene-editing and phototherapy DOI
Chen Zhang, Xiaojie Wang,

Gengqi Liu

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 357, P. 210 - 221

Published: April 5, 2023

Language: Английский

Citations

18